Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS
Open accessAbstract
Objective: The intestinal lumen contains several proteases. Our aim was to determine the role of faecal proteases in mediating barrier dysfunction and symptoms in IBS. Design: 39 patients with IBS and 25 healthy volunteers completed questionnaires, assessments of in vivo permeability, ex vivo colonic barrier function in Ussing chambers, tight junction (TJ) proteins, ultrastructural morphology and 16 s sequencing of faecal microbiota rRNA. A casein-based assay was used to measure proteolytic activity (PA) in faecal supernatants (FSNs). Colonic barrier function was determined in mice (ex-germ free) humanised with microbial communities associated with different human PA states. Results: Patients with IBS had higher faecal PA than healthy volunteers. 8/20 postinfection IBS (PI-IBS) and 3/19 constipation- predominant IBS had high PA (>95th percentile). High-PA patients had more and looser bowel movements, greater symptom severity and higher in vivo and ex vivo colonic permeability. High-PA FSNs increased paracellular permeability, decreased occludin and increased phosphorylated myosin light chain (pMLC) expression. Serine but not cysteine protease inhibitor significantly blocked high-PA FSN effects on barrier. The effects on barrier were diminished by pharmacological or siRNA inhibition of protease activated receptor-2 (PAR-2). Patients with high-PA IBS had lower occludin expression, wider TJs on biopsies and reduced microbial diversity than patients with low PA. Mice humanised with high-PA IBS microbiota had greater in vivo permeability than those with low-PA microbiota. Conclusion: A subset of patients with IBS, especially in PI-IBS, has substantially high faecal PA, greater symptoms, impaired barrier and reduced microbial diversity. Commensal microbiota affects luminal PA that can influence host barrier function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevated proteolytic activity is observed in stool supernatants from inflammatory bowel disease and irritable bowel syndrome patients compared to healthy subjects.
“Elevated PA was also observed in stool supernatants from IBD and IBS patients compared to samples from healthy subjects, suggesting that enhanced PA in IBD and IBS may be due to elevations in PA from both host and microbial origin.12,13”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [13]
Enhanced proteolytic activity in inflammatory bowel disease and irritable bowel syndrome may be due to elevations from both host and microbial origin.
“suggesting that enhanced PA in IBD and IBS may be due to elevations in PA from both host and microbial origin.12,13”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [13]
Studies in mice and humans have provided evidence that host- and bacterial-derived proteases may contribute to irritable bowel syndrome pathogenesis and symptom generation.
“Similar to IBD, studies in mice and humans have provided evidence that host- and bacterial-derived proteases may contribute to pathogenesis and symptom generation.7,13,57,58”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular and Biotechnological Aspects of Microbial Proteases
Rao, M. B., Tanksale, A. M., Ghatge, M. S., & DESHPANDE, V. V. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.3.597-635.1998 · Cited by 2,274 · see citing works
Rawlings, N. D., Barrett, A. J., Thomas, P. D., Huang, X., Bateman, A., & Finn, R. D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1134 · Cited by 1,749 · see citing works
Tight Junction Pore and Leak Pathways: A Dynamic Duo
Shen, L., Weber, C. R., Raleigh, D. R., Yu, D., & Turner, J. R. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142150 · Cited by 867 · see citing works
A sensitive new substrate for chymotrypsin
DelMar, E. G., Largman, C., Brodrick, J. W., & Geokas, M. C. (1979) · Analytical Biochemistry · doi:10.1016/s0003-2697(79)80013-5 · Cited by 593 · see citing works
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · see citing works
Klem, F., Wadhwa, A., Prokop, L. J., Sundt, W. J., Farrugia, G., Camilleri, M., Singh, S., & Grover, M. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.039 · Cited by 474 · see citing works
Self-citationNew Fluorogenic Substrates for α-Thrombin, Factor Xa, Kallikreins, and Urokinase1
Morita, T., Kato, H., Iwanaga, S., Takada, K., Kimura, T., & Sakakibara, S. (1977) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131840 · Cited by 382 · see citing works
Buhner, S., Li, Q., Vignali, S., Barbara, G., De Giorgio, R., Stanghellini, V., Cremon, C., Zeller, F., Langer, R., Daniel, H., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.005 · Cited by 351 · see citing works
Gecse, K., Róka, R., Ferrier, L., Leveque, M., Eutamene, H., Cartier, C., Ait-Belgnaoui, A., Rosztóczy, A., Izbéki, F., Fioramonti, J., et al. (2008) · Gut · doi:10.1136/gut.2007.140210 · Cited by 314 · see citing works
Weber, C. R., Raleigh, D. R., Su, L., Shen, L., Sullivan, E. A., Wang, Y., & Turner, J. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064808 · Cited by 296 · see citing works
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance
Tsai, P.-Y., Zhang, B., He, W., Zha, J., Odenwald, M. A., Singh, G., Tamura, A., Shen, L., Sailer, A., Yeruva, S., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.05.009 · Cited by 267 · see citing works
Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
Motta, J.-P., Bermúdez-Humarán, L. G., Deraison, C., Martin, L., Rolland, C., Rousset, P., Boue, J., Dietrich, G., Chapman, K., Kharrat, P., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004212 · Cited by 257 · see citing works
Santis, S. D., Galleggiante, V., Scandiffio, L., Liso, M., Sommella, E., Sobolewski, A., Spilotro, V., Pinto, A., Campiglia, P., Serino, G., et al. (2017) · Nutrients · doi:10.3390/nu9070706 · Cited by 252 · see citing works
Contribution of the microflora to proteolysis in the human large intestine
Macfarlane, G. T., Allison, C., Gibson, S. A. W., & Cummings, J. H. (1988) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1988.tb02427.x · Cited by 237 · see citing works
Protease inhibition as new therapeutic strategy for GI diseases
Vergnolle, N. (2016) · Gut · doi:10.1136/gutjnl-2015-309147 · Cited by 226 · see citing works
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases
Guo, C., Chang, F., Wyche, T. P., Backus, K. M., Acker, T. M., Funabashi, M., Taketani, M., Donia, M. S., Nayfach, S., Pollard, K. S., et al. (2017) · Cell · doi:10.1016/j.cell.2016.12.021 · Cited by 215 · see citing works
Reed, D. E., Barajas‐Lopez, C., Cottrell, G., Velazquez‐Rocha, S., Dery, O., Grady, E. F., Bunnett, N. W., & Vanner, S. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032011 · Cited by 192 · see citing works
Increased Proteasome-Mediated Degradation of Occludin in Irritable Bowel Syndrome
Coëffier, M., Gloro, R., Boukhettala, N., Aziz, M., Lecleire, S., Vandaele, N., Antonietti, M., Savoye, G., Bôle-Feysot, C., Déchelotte, P., et al. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.700 · Cited by 185 · see citing works
Substrate specificity of trypsin investigated by using a genetic selection.
Evnin, L. B., Vásquez, J. R., & Craik, C. S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6659 · Cited by 167 · see citing works
Current knowledge of intestinal absorption of bioactive peptides
Shen, W., & Matsui, T. (2017) · Food & Function · doi:10.1039/c7fo01185g · Cited by 153 · see citing works
Significance of microflora in proteolysis in the colon
Gibson, S. A., McFarlan, C., Hay, S., & Macfarlane, G. T. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.3.679-683.1989 · Cited by 147 · see citing works
Wilcz‐Villega, E., McClean, S., & OʼSullivan, M. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.92 · Cited by 135 · see citing works
Róka, R., Rosztoczy, A. I., Leveque, M., Izbéki, F., Nagy, F. T., Molnár, T., Lonovics, J., Villar, R. G., Fioramonti, J., Wittmann, T., et al. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.004 · Cited by 132 · see citing works
Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis
Motta, J., Magne, L., Descamps, D., Rolland, C., Squarzoni–Dale, C., Rousset, P., Martin, L., Cenac, N., Balloy, V., Huerre, M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.12.050 · Cited by 130 · see citing works
Epithelial expression and function of trypsin-3 in irritable bowel syndrome
Rolland-Fourcade, C., Denadai-Souza, A., Cirillo, C., Lopez, C., Jaramillo, J. O., Desormeaux, C., Cenac, N., Motta, J.-P., Larauche, M., Taché, Y., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-312094 · Cited by 126 · see citing works
Schmid, M., Fellermann, K., Fritz, P., Wiedow, O., Stange, E. F., & Wehkamp, J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906581 · Cited by 116 · see citing works
Annaházi, A., Gecse, K., Dabek, M., Ait-Belgnaoui, A., Rosztóczy, A., Róka, R., Molnár, T., Theodorou, V., Wittmann, T., Bueno, L., et al. (2009) · Pain · doi:10.1016/j.pain.2009.04.017 · Cited by 112 · see citing works
Wegener, J., Abrams, D., Willenbrink, W., Galla, H., & Janshoff, A. (2004) · BioTechniques · doi:10.2144/04374st03 · Cited by 104 · see citing works
Biancheri, P., Sabatino, A. D., Corazza, G. R., & MacDonald, T. T. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1390-z · Cited by 99 · see citing works
IM-TORNADO: A Tool for Comparison of 16S Reads from Paired-End Libraries
Jeraldo, P., Kalari, K. R., Chen, X., Bhavsar, J., Mangalam, A. K., White, B. A., Nelson, H., Kocher, J.-P. A., & Chia, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114804 · Cited by 99 · see citing works
Cleynen, I., Vazeille, E., Artieda, M., Verspaget, H. W., Szczypiorska, M., Bringer, M.-A., Lakatos, P. L., Seibold, F., Parnell, K. S., Weersma, R. K., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303205 · Cited by 99 · see citing works
Annaházi, A., Ferrier, L., Bézirard, V., Lévêque, M., Eutamène, H., Ait-Belgnaoui, A., Coëffier, M., Ducrotté, P., Róka, R., Inczefi, O., et al. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.152 · Cited by 96 · see citing works
METHODS FOR THE ASSESSMENT OF SMALL BOWEL AND COLONIC TRANSIT
Szarka, L., & Camilleri, M. (2012) · Seminars in nuclear medicine · doi:10.1053/j.semnuclmed.2011.10.004 · Cited by 96 · see citing works
Ibeakanma, C. O., Ochoa‐Cortés, F., Miranda‐Morales, M., McDonald, T. G., Spreadbury, I., Cénac, N., Cattaruzza, F., Hurlbut, D. J., Vanner, S., Bunnett, N. W., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.08.006 · Cited by 92 · see citing works
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease
Denadai-Souza, A., Bonnart, C., Tapias, N. S., Marcellin, M., Gilmore, B., Alric, L., Bonnet, D., Burlet-Schiltz, O., Hollenberg, M. D., Vergnolle, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26282-y · Cited by 91 · see citing works
Tooth, D., Garsed, K., Singh, G., Marciani, L., Lam, C., Fordham, I., Fields, A., Banwait, R., Lingaya, M., Layfield, R., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-304042 · Cited by 87 · see citing works
Enterococcus faecalis Gelatinase Mediates Intestinal Permeability via Protease-Activated Receptor 2
Maharshak, N., Huh, E. Y., Paiboonrungruang, C., Shanahan, M., Thurlow, L., Herzog, J., Djukic, Z., Orlando, R., Pawlinski, R., Ellermann, M., et al. (2015) · Infection and Immunity · doi:10.1128/iai.00425-15 · Cited by 86 · see citing works
Novel Role of the Serine Protease Inhibitor Elafin in Gluten-Related Disorders
Galipeau, H. J., Wiepjes, M., Motta, J., Schulz, J. D., Jury, J., Natividad, J. M., Pinto-Sanchez, I., Sinclair, D., Rousset, P., Martín, R., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.48 · Cited by 72 · see citing works
Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery
Baldwin, E. A., Walther-Antonio, M. R. S., Maclean, A., Gohl, D. M., Beckman, K. B., Chen, J., White, B. A., Creedon, D. J., & Chia, N. (2015) · PeerJ · doi:10.7717/peerj.1398 · Cited by 72 · see citing works
Self-citationMcCarville, J. L., Dong, J., Caminero, A., Bermudez-Brito, M., Jury, J., Murray, J. A., Duboux, S., Steinmann, M., Delley, M., Tangyu, M., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01323-17 · Cited by 71 · see citing works
Fecal Protease Activity Is Associated with Compositional Alterations in the Intestinal Microbiota
Carroll, I. M., Ringel‐Kulka, T., Ferrier, L., Wu, M. C., Siddle, J. P., Bueno, L. P., & Ringel, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078017 · Cited by 70 · see citing works
Pruteanu, M., Hyland, N. P., Clarke, D. J., Kiely, B., & Shanahan, F. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21475 · Cited by 67 · see citing works
Sabotič, J., Bleuler-Martinez, S. A., Renko, M., Caglič, P. A., Kallert, S., Štrukelj, B., Türk, V., Aebi, M., Kos, J., & Künzler, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.285304 · Cited by 60 · see citing works
13C mannitol as a novel biomarker for measurement of intestinal permeability
Grover, M., Camilleri, M., Hines, J., Burton, D. D., Ryks, M. D., Wadhwa, A., Sundt, W. J., Dyer, R. B., & Singh, R. J. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12802 · Cited by 59 · see citing works
Self-citationProtease-Mediated Suppression of DRG Neuron Excitability by Commensal Bacteria
Sessenwein, J. L., Baker, C. C., Pradhananga, S., Maitland, M. E., Petrof, E. O., Allen-Vercoe, E., Noordhof, C., Reed, D. E., Vanner, S. J., & Lomax, A. E. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1672-17.2017 · Cited by 58 · see citing works
Ceuleers, H., Hanning, N., Heirbaut, J., Van Remoortel, S., Joossens, J., Van Der Veken, P., Francque, S. M., De bruyn, M., Lambeir, A., De Man, J. G., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14396 · Cited by 49 · see citing works
Grover, M., Camilleri, M., Smith, K., Linden, D. R., & Farrugia, G. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12304 · Cited by 48 · see citing works
Self-citationBühner, S., Hahne, H., Hartwig, K., Li, Q., Vignali, S., Ostertag, D., Meng, C., Hörmannsperger, G., Braak, B., Pehl, C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193943 · Cited by 48 · see citing works
Edwards, J. V., Prevost, N. T., French, A. D., Concha, M. C., & Condon, B. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.04.067 · Cited by 43 · see citing works
Mkaouar, H., Akermi, N., Mariaule, V., Boudebbouze, S., Gaci, N., Szukala, F., Pons, N., Marquez, J., Gargouri, A. F., Maguin, E., et al. (2016) · Microbial Cell Factories · doi:10.1186/s12934-016-0596-2 · Cited by 43 · see citing works
Désormeaux, C., Bautzová, T., Garcia‐Caraballo, S., Rolland, C., Barbaro, M. R., Brierley, S. M., Barbara, G., Vergnolle, N., & Cénac, N. (2018) · Pain · doi:10.1097/j.pain.0000000000001208 · Cited by 42 · see citing works
Characterization of Proteases Formed by Bacteroides fragilis
Gibson, S. A. W., & Macfarlane, G. T. (1988) · Microbiology · doi:10.1099/00221287-134-8-2231 · Cited by 40 · see citing works
Garcia-Ferrer, I., Arêde, P., Gómez-Blanco, J., Luque, D., Duquerroy, S., Castón, J. R., Goulas, T., & Gomis‐Rüth, F. X. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506538112 · Cited by 35 · see citing works
Róka, R., Ait-Belgnaoui, A., Salvador–Cartier, C., Garcia-Villar, R., Fioramonti, J., Eutamène, H., & Bueno, L. P. (2007) · Gut · doi:10.1136/gut.2006.115352 · Cited by 33 · see citing works
Prevention of cancer and inflammation by protease inhibitors
Kobayashi, H. (2013) · Frontiers in Bioscience-Elite · doi:10.2741/e676 · Cited by 32 · see citing works
Edgington‐Mitchell, L. E., Barlow, Ν., Aurelio, L., Samha, A., Szabó, M., Graham, B., & Bunnett, N. W. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.11.064 · Cited by 32 · see citing works
Goulas, T., Książęk, M., Garcia-Ferrer, I., Sochaj-Gregorczyk, A. M., Waligórska, I., Wasylewski, M., Potempa, J., & Gomis‐Rüth, F. X. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.786533 · Cited by 26 · see citing works
Thornton, R. F., Murphy, E. C., Kagawa, T. F., O’Toole, P. W., & Cooney, J. C. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-190 · Cited by 25 · see citing works
Genell, S., Gustafsson, B. E., & OHLSSON, K. (1977) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365527709181724 · Cited by 21 · see citing works
Impaired Enteric Degradation of Pancreatic Endopeptidases in Antibiotic-Treated Rats
Genell, S., & Gustafsson, B. E. (1977) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365527709181723 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Paracellular permeability and tight junction regulation in gut health and disease
Horowitz, A., Chánez-Paredes, S. D., Haest, X., & Turner, J. R. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00766-3 · Cited by 725 · see citing works
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome
Mars, R. A. T., Yang, Y., Ward, T., Houtti, M., Priya, S., Lekatz, H. R., Tang, X., Sun, Z., Kalari, K. R., Korem, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.007 · Cited by 456 · see citing works
“, 2013), and intestinal permeability (Edogawa et al., 2020) differences associated with IBS-C and IBS-D were replicated in gnotobiotic mice following transplantation of fecal microbiota from patients.”
Self-citationInflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 420 · see citing works
Intestinal Barrier Dysfunction in Irritable Bowel Syndrome: A Systematic Review
Hanning, N., Edwinson, A. L., Ceuleers, H., Peters, S. A., De Man, J. G., Hassett, L. C., De Winter, B. Y., & Grover, M. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284821993586 · Cited by 197 · see citing works
Self-citationThe Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases
Fogelson, K. A., Dorrestein, P. C., Zarrinpar, A., & Knight, R. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.02.022 · Cited by 177 · see citing works
Vanuytsel, T., Berčík, P., & Boeckxstaens, G. E. (2023) · Gut · doi:10.1136/gutjnl-2020-320633 · Cited by 157 · see citing works
Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome
Hillestad, E. M. R., van der Meeren, A., Nagaraja, B. H., Bjørsvik, B. R., Haleem, N., Benítez‐Páez, A., Sanz, Y., Hausken, T., Lied, G. A., Lundervold, A., et al. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i4.412 · Cited by 145 · see citing works
Bhattarai, Y., Si, J., Pu, M., Ross, O. A., McLean, P. J., Till, L., Moor, W., Grover, M., Kandimalla, K. K., Margolis, K. G., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1866974 · Cited by 126 · see citing works
Self-citationWei, L., Singh, R., Ro, S., & Ghoshal, U. C. (2021) · JGH Open · doi:10.1002/jgh3.12528 · Cited by 127 · see citing works
Edwinson, A. L., Yang, L., Peters, S., Hanning, N., Jeraldo, P., Jagtap, P., Simpson, J. B., Yang, T.-Y., Kumar, P., Mehta, S., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01103-1 · Cited by 105 · see citing works
Self-citationRole of prebiotics in enhancing the function of next-generation probiotics in gut microbiota
Fei, Y., Chen, Z., Han, S., Zhang, S., Zhang, T., Lu, Y., Berglund, B., Xiao, H., Li, L., & Yao, M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1958744 · Cited by 103 · see citing works
The emerging roles of bacterial proteases in intestinal diseases
Caminero, A., Guzman, M., Libertucci, J., & Lomax, A. E. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181922 · Cited by 92 · see citing works
Molecular Mechanisms of Microbiota-Mediated Pathology in Irritable Bowel Syndrome
Mishima, Y., & Ishihara, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228664 · Cited by 89 · see citing works
Mujagic, Z., Kasapi, M., Jonkers, D. M. A. E., García‐Pérez, I., Vork, L., Weerts, Z. Z. R. M., Serrano-Contreras, J. I., Zhernakova, A., Kurilshikov, A., Scotcher, J., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2063016 · Cited by 77 · see citing works
Zhang, Z., Tanaka, I., Pan, Z., Ernst, P. B., Kiyono, H., & Kurashima, Y. (2022) · European Journal of Immunology · doi:10.1002/eji.202149532 · Cited by 69 · see citing works
Post-infection Irritable Bowel Syndrome
Berumen, A., Edwinson, A. L., & Grover, M. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.02.007 · Cited by 60 · see citing works
Self-citationCampylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans
Peters, S., Pascoe, B., Wu, Z., Bayliss, S., Zeng, X., Edwinson, A. L., Gurunathan, S. V., Jawahir, S., Calland, J. K., Mourkas, E., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02554-8 · Cited by 56 · see citing works
Self-citationMars, R. A. T., Frith, M., & Kashyap, P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.10.058 · Cited by 54 · see citing works
Self-citationEmerging role of the gut microbiome in post-infectious irritable bowel syndrome: A literature review
Lupu, V. V., Ghiciuc, C. M., Ștefănescu, G., Mihai, C. M., Popp, A., Săsăran, M. O., Bozomitu, L. I., Stârcea, I. M., Răileanu, A. A., & Lupu, A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i21.3241 · Cited by 50 · see citing works
Intestinal Permeability in Disorders of Gut–Brain Interaction: From Bench to Bedside
Grover, M., Vanuytsel, T., & Chang, L. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.08.033 · Cited by 43 · see citing works
Self-citationMicrobiome Shifts and Their Impact on Gut Physiology in Irritable Bowel Syndrome
Aggeletopoulou, I., & Triantos, C. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212395 · Cited by 45 · see citing works
Camilleri, M., Carlson, P., BouSaba, J., McKinzie, S., Vijayvargiya, P., Magnus, Y., Sannaa, W., Wang, X., Chedid, V. G., Zheng, T., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327471 · Cited by 42 · see citing works
Self-citationXia, B., Lin, T., Li, Z., Wang, J., Sun, Y., Wang, D., Ye, J., Zhang, Y., Kou, R.-W., Zhao, B., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c03087 · Cited by 45 · see citing works
Emerging Role of the Gut Microbiome in Irritable Bowel Syndrome
Singh, P., & Lembo, A. J. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.03.003 · Cited by 39 · see citing works
Serine proteases at the cutting edge of IBD: Focus on gastrointestinal inflammation
Kriaa, A., Jablaoui, A., Mkaouar, H., Akermi, N., Maguin, E., & Rhimi, M. (2020) · The FASEB Journal · doi:10.1096/fj.202000031rr · Cited by 38 · see citing works
Hou, J.-J., Wang, X., Wang, Y.-M., & Wang, B.-M. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.2018401 · Cited by 36 · see citing works
Global Research Trends in Irritable Bowel Syndrome: A Bibliometric and Visualized Study
Zhang, T., Ma, X., Tian, W., Zhang, J., Wei, Y., Zhang, B., Wang, F., & Tang, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.922063 · Cited by 34 · see citing works
Corrigendum: Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.790387 · Cited by 34 · see citing works
Grover, M., Berumen, A., Peters, S., Wei, T., Breen‐Lyles, M. K., Harmsen, W. S., Busciglio, I. A., Burton, D. D., Roque, M. V., DeVault, K. R., et al. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16591 · Cited by 33 · see citing works
Self-citationMetabolomics changes in brain-gut axis after unpredictable chronic mild stress
Xu, Q., Jiang, M. C., Gu, S., Zhang, X., Feng, G., Ma, X., Xu, S., Wu, E., Huang, J. H., & Wang, F. (2022) · Psychopharmacology · doi:10.1007/s00213-021-05958-w · Cited by 31 · see citing works
Chen, D., Shen, C., Zeng, X., Sun, L., Luo, F., Wan, R., Zhang, Y., Chen, X., Hou, Y., Wang, W., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1515364 · Cited by 29 · see citing works
Gut microbiota and irritable bowel syndrome
Zhao, Y., & Zou, D. (2023) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13204 · Cited by 29 · see citing works
Recent advances in clinical practice: mastering the challenge—managing IBS symptoms in IBD
Wellens, J., Sabino, J., Vanuytsel, T., Tack, J. F., & Vermeire, S. (2024) · Gut · doi:10.1136/gutjnl-2024-333565 · Cited by 29 · see citing works
Probiotics in Psychosocial Stress and Anxiety. A Systematic Review
Vitellio, P., Chira, A., Angelis, M. D., Dumitrascu, D. L., & Portincasa, P. (2020) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-352 · Cited by 25 · see citing works
Edwinson, A. L., Yang, L., Chen, J., & Grover, M. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1984105 · Cited by 24 · see citing works
Self-citationRome Foundation Working Team Report on overlap in disorders of gut–brain interaction
Barbara, G., Aziz, I., Ballou, S., Chang, L., Ford, A. C., Fukudo, S., Nurko, S., Olano, C., Saps, M., Sayuk, G. S., et al. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-01033-9 · Cited by 30 · see citing works
Unraveling the Pathophysiology of Irritable Bowel Syndrome: Mechanisms and Insights
Aggeletopoulou, I., Papantoniou, K., Pastras, P., & Triantos, C. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110598 · Cited by 23 · see citing works
The role of the gut microbiome in disorders of gut–brain interaction
Gawey, B. J., Mars, R. A. T., & Kashyap, P. (2024) · FEBS Journal · doi:10.1111/febs.17200 · Cited by 28 · see citing works
Self-citationNon-immune Traits Triggered by Blood Intake Impact Vectorial Competence
Talyuli, O. A. C., Bottino-Rojas, V., Polycarpo, C. R., de Oliveira, P. L., & Paiva‐Silva, G. O. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.638033 · Cited by 19 · see citing works
Torres-Maravilla, E., Holowacz, S., Delannoy, J., Lenoir, L., Jacouton, E., Gervason, S., Meynier, M., Boucard, A.-S., Carvalho, F. A., Barbut, F., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-21746-8 · Cited by 20 · see citing works
Choi, S. I., Kim, N., Nam, R. H., Jang, J. Y., Kim, E. H., Ha, S., Kang, K. S., Lee, W., Choi, H., Kim, Y.-R., et al. (2023) · Journal of Cancer Prevention · doi:10.15430/jcp.2023.28.3.93 · Cited by 20 · see citing works
Mucus and mucin: changes in the mucus barrier in disease states
Fan, F., Guo, R., Pan, K., Xu, H., & Chu, X. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2499752 · Cited by 19 · see citing works
Li, Y., Liu, J., Pongkorpsakol, P., Xiong, Z., Li, L., Jiang, X., Zhao, H., Yuan, D., Zhang, C., Guo, Y., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.903762 · Cited by 18 · see citing works
Hanning, N., bruyn, M. D., Ceuleers, H., Boogaerts, T., Berg, M., Smet, A., Schepper, H. U. D., Joossens, J., van Nuijs, A. L. N., Man, J. G. D., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060811 · Cited by 18 · see citing works
Gao, J., Lee, A. A., Abtahi, S., Turner, J. R., Grover, M., Schmidt, A., Schmidt, T. M., Nee, J. W., Iturrino, J., Lembo, A. J., et al. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.07.016 · Cited by 16 · see citing works
Self-citationA Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation
Lakemeyer, M., Latorre, R., Blažková, K., Wood, H. M., Jensen, D. D., Shakil, N., Thomas, S. C., Saxena, D. B., Mulpuri, Y., Poolman, D., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.09.010 · Cited by 24 · see citing works
The proteolytic activity in inflammatory bowel disease: insight from gut microbiota
Hou, J., Ding, L., Yang, T., Yang, Y.-F., Jin, Y., Zhang, X., Ma, A.-H., & Qin, Y. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106560 · Cited by 20 · see citing works
Quan, R., Decraecker, L., Appeltans, I., Cuende‐Estévez, M., Remoortel, S. V., Aguilera‐Lizarraga, J., Wang, Z., Hicks, G. A., Wykosky, J., McLean, P. G., et al. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003042 · Cited by 16 · see citing works
The relationship between gut microbiota and proteolytic activity in irritable bowel syndrome
Hou, J., Wang, X., Li, Y., Su, S., Wang, Y., & Wang, B. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.104995 · Cited by 16 · see citing works
Molecular Mechanisms and Pathways in Visceral Pain
Zhou, Q., & Verne, G. N. (2025) · Cells · doi:10.3390/cells14151146 · Cited by 15 · see citing works
Inhibition of Serine Proteases as a Novel Therapeutic Strategy for Abdominal Pain in IBS
Decraecker, L., Boeckxstaens, G. E., & Denadai‐Souza, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.880422 · Cited by 15 · see citing works
Imbrea, A.-M., Balta, I., Dumitrescu, G., McCleery, D., Peț, I., Iancu, T., Ştef, L., Corcionivoschi, N., & Liliana, P. (2024) · Applied Sciences · doi:10.3390/app14083373 · Cited by 15 · see citing works
Ríos, C. C. D. L., Falcón, B. S., Argüelles‐Arias, F., Pérez, E., Teruel, C., Geijo, F., & Rey, E. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211020570 · Cited by 15 · see citing works
Takakura, W., Kudaravalli, P., Chatterjee, C., Pimentel, M., & Riddle, M. S. (2022) · Pathogens and Disease · doi:10.1093/femspd/ftac003 · Cited by 15 · see citing works
Gastrointestinal disorders and intestinal bacteria: Advances in research and applications in therapy
Ohkusa, T., Nishikawa, Y., & Sato, N. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.935676 · Cited by 15 · see citing works
Iribarren, C., Nordlander, S., Sundin, J., Isaksson, S., Savolainen, O. I., Törnblom, H., Magnusson, M. K., Simrén, M., & Öhman, L. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14390 · Cited by 13 · see citing works
bruyn, M. D., Ceuleers, H., Hanning, N., Berg, M., Man, J. G. D., Hulpiau, P., Hermans, C., Stenman, U., Koistinen, H. K., Lambeir, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910711 · Cited by 13 · see citing works
Wang, Y., Huang, Y., Zhu, S.-L., Zhang, C., Chen, X., Hou, Q., & Liu, F. (2020) · Trials · doi:10.1186/s13063-020-04833-x · Cited by 12 · see citing works
UEG Week 2019 Oral Presentations
Tan, M., de Muckadell, O. B. S., & Jørgensen, M. T. (2019) · United European Gastroenterology Journal · doi:10.1177/2050640619854670 · Cited by 10 · see citing works
Rao, S. E., & Grover, M. (2023) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000972 · Cited by 10 · see citing works
Self-citationSoussou, S., Jablaoui, A., Mariaule, V., Kriaa, A., Boudaya, H., Wysocka, M., Amouri, A., Gargouri, A. F., Lesner, A., Maguin, E., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-44454-3 · Cited by 10 · see citing works
Agawa, S., Futagami, S., Yamawaki, H., Tsushima, R., Higuchi, K., Habiro, M., Kawawa, R., Kodaka, Y., Ueki, N., Watanabe, Y., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275341 · Cited by 10 · see citing works
The Role of Microbiota in Upper and Lower Gastrointestinal Functional Disorders
Mandarino, F. V., Sinagra, E., Raimondo, D., & Danese, S. (2023) · Microorganisms · doi:10.3390/microorganisms11040980 · Cited by 11 · see citing works
Microbial dipeptidyl peptidases of the S9B family as host-microbe isozymes
Aljumaah, M. R., Roach, J. M., Hu, Y., Gunstad, J., & Azcárate-Peril, M. A. (2025) · Science Advances · doi:10.1126/sciadv.ads5721 · Cited by 10 · see citing works
Velu, D. P. V. T., Fauzi, M. B., Jaafar, F., Mokhtar, N. M., Mokhtar, M. H., & Hamid, A. A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114722 · Cited by 8 · see citing works
Ceuleers, H., Hanning, N., bruyn, M. D., Man, J. G. D., Schepper, H. U. D., Li, Q., Liu, L., Abrams, S., Smet, A., Joossens, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.765744 · Cited by 8 · see citing works
A Non-Invasive Neonatal Signature Predicts Later Development of Atopic Diseases
Sérémé, Y., Michel, M., Mezouar, S., Guindo, C. O., Kaba, L., Grine, G., Mura, T., Mège, J., Tran, T.-A., Corbeau, P., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102749 · Cited by 8 · see citing works
Chinese Herbal Medicine for Irritable Bowel Syndrome: A Perspective of Local Immune Actions
Zhang, M., Wu, X., Gao, H.-Q., Zhang, L., Li, Y., Li, M., Zhao, C., Wei, P., & Li, O. (2024) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x24500800 · Cited by 5 · see citing works
Tanaka, K., Tanigawa, N., Song, I., Komatsu, T., Kuriki, Y., Tanaka, Y., Fukudo, S., Urano, Y., & Fukuda, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1179534 · Cited by 5 · see citing works
Stentz, R., Jones, E. J., Gul, L., Latousakis, D., Parker, A., Brion, A., Goldson, A. J., Gotts, K., & Carding, S. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094080 · Cited by 4 · see citing works
Practical approach to irritable bowel syndrome-diarrhea beyond low-FODMAP diet
Ríos, C. C. D. L., Cabezudo, M. A., Vallés, A. Z., & Rey, E. (2022) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2022.8749/2022 · Cited by 4 · see citing works
Zhang, C., Wang, J., Yao, T., Hu, J., Sun, F., Feng, C., Sun, Z., Shao, Y., Wang, Z., Wu, J., et al. (2024) · Aging Cell · doi:10.1111/acel.14344 · Cited by 3 · see citing works
Benrejdal, L., Hubená, P., Brodin, D., Castro, R. A. M., Rekha, R. S., Winberg, S., & Bergman, P. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111487 · Cited by 3 · see citing works
Gut Microbiome and Its Role in the Pathophysiology of Irritable Bowel Syndrome
Palma, G. D., & Berčík, P. (2021) · Acta gastroenteorológica latinoamericana/Acta gastroenterológica latinoamericana · doi:10.52787/dxfc9250 · Cited by 4 · see citing works
Sun, Y., Bai, X., Sun, K., Li, J., Liu, L., Chen, Y.-Y., Zeng, Z.-Y., Wang, Q., & Guo, Y. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i42.111706 · Cited by 2 · see citing works
Deng, K., Cao, J., Wang, Z., He, J., Jia, J., Nie, R., Wang, X., Dou, Z., Liu, Z., Deng, Y., et al. (2026) · Biomolecules · doi:10.3390/biom16030469 · Cited by 2 · see citing works
Interaction of Intestinal Microbiota with Medications
Liu, M., Xu, J., Jin, Q., & Li, Y. (2023) · Current Drug Metabolism · doi:10.2174/1389200224666230418104540 · Cited by 2 · see citing works
Kanazawa, M., Miyamoto, K., Kano, M., Inooka, K., Oka, K., Takahashi, M., Mano, N., & Fukudo, S. (2024) · Digestion · doi:10.1159/000542758 · Cited by 2 · see citing works
Bielefeldt, K., & Gebhart, G. F. (2022) · doi:10.1002/9781119701170.ch34 · Cited by 2 · see citing works
Puentes, R., Mirzadzare, N., Hannawayya, R., Pérez-Pérez, L., Dies, A., Tiedje, K., Derakhshani, A., Young, D. W., Johnson, F., Golub, L. M., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115312 · Cited by 1 · see citing works
Faecal proteases and immune signatures drive subtype-specific enteric neuronal activation in IBS
Ridzal, L., Frieling, T., Róka, R., Inczefi, O., Bacsúr, P., Bajcsi, D., Neunlist, M., Cardaillac, C., Théodorou, V., Yoon, H., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-337949 · Cited by 1 · see citing works
Stentz, R., Wegmann, U., Guirro, M., Bryant, W., Ranjit, A., Goldson, A. J., Brion, A., Cross, K. L., Booth, C., Miquel-Clopés, A., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-124947/v1 · Cited by 1 · see citing works
Pearl, A., Bootz-Maoz, H., Melzer, E., Sharon, E., Abuchatzera, S., Amidror, S., Aretz, E., Shoval, I., Yaron, O., Malnick, S. D. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.15.456374 · Cited by 1 · see citing works
Proteolytische Aktivität bei Reizdarm
Reinshagen, M. (2022) · Gastro-News · doi:10.1007/s15036-022-2544-9
Interaction of Gut Microbiota with MedicationsPreprint
Liu, M., Xu, J., Jin, Q., & li, Y. (2022) · doi:10.22541/au.166523763.34733996/v1
Gut microbiota plays a role in irritable bowel syndrome by regulating 5-HT metabolism
Feng, Y., Hang, L., Zhou, Y., Jiang, F.-R., & Yuan, J. (2022) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v30.i21.941
Shiratori, W., Ohta, Y., Matsusaka, K., Ohyama, Y., Mamiya, Y., Nakazawa, H., Takahashi, S., Horio, R., Goto, C., Sonoda, M., et al. (2024) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000692
Breast Milk Bacteria: The Key to Regulating Defecation Frequency Changes in InfantsPreprint
Huang, Y., Zhang, Y., Liu, K., Chen, Y., Xie, Z., Li, M., Xiong, J., Li, Z., Xie, Y., Xiong, Z., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4146767/v1
Funktionelle Charakterisierung unbekannter Proteasen des Mikrobioms
Shakil, N., & Lakemeyer, M. (2025) · BIOspektrum · doi:10.1007/s12268-025-2403-2
Perry, R. W., Buemi, F., Guo, X., Radhakrishnan, S. T., Balarajah, S., Hicks, L., Marchesi, J. R., Williams, H. R. T., & Barry, R. E. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.116924
Mikołajczyk, A., Wardak, A., Głuszek, S., & Adamus-Białek, W. (2025) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.2478/am-2025-0007
Linking Gut Microbiota and Irritable Bowel Syndrome (Ibs): A Review
Karasek, M., Szyszko, M., Polański, K., Andrzejczuk, S., Kasela, M., & Kosikowska, U. (2025) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.2478/am-2025-0012
Wilson, M., Al‐Jumeily, D., Tang, L. P., Birkett, J. W., Khan, I., Abbas, I. I., Harper, M., & Assi, S. A. (2025) · Journal of Raman Spectroscopy · doi:10.1002/jrs.70066
Wang, Y., Huang, Y.-Q., Zhu, S.-L., Zhang, C.-R., Chen, X.-L., Hou, Q., & Liu, F.-B. (2020) · Figshare · doi:10.6084/m9.figshare.13185917
IRRITABLE BOWEL SYNDROME: THE ROLE OF GUT MICROBIOTA IN ETIOLOGY AND TREATMENT. A LITERATURE REVIEW
Cieślik-Porębska, M., & Cieślik, A. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.1(49).2026.4612
Edwinson, A. L., Peters, S., Breen‐Lyles, M. K., Lennon, R. J., Dasari, S., & Grover, M. (2026) · npj gut and liver. · doi:10.1038/s44355-026-00058-y
Self-citationSingh, D. P., & Grover, M. (2026) · Gastroenterology · doi:10.1053/j.gastro.2026.03.003
Self-citationMariaule, V. (2024) · theses.fr (ABES) · doi:10.70675/1d41e841zf788z4dd7z8784zc26304e24ea1
- Authors
- Edogawa, S., Edwinson, A. L., Peters, S. A., Chikkamenahalli, L. L., Sundt, W., Graves, S., Gurunathan, S. V., Breen-Lyles, M., Johnson, S., Dyer, R., Graham, R., Chen, J., Kashyap, P., Farrugia, G., & Grover, M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Grover, Madhusudan
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2019-03-28
- Volume
- 69
- Issue
- 1
- Pages
- 62-73
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC6765451
- OpenAlex
- W2933912422
- Cited by
- 101
- References
- 60
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 14 · 2023: 13 · 2022: 21 · 2021: 20 · 2020: 8 · 2019: 1
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- irritable bowel syndrome, serine protease, intestinal barrier dysfunction, colonic permeability, tight junction proteins, occludin, myosin light chain phosphorylation, protease-activated receptor 2, irritable bowel syndrome with constipation, gut microbiota, microbial diversity, symptom severity
- MeSH terms
- Gastrointestinal Microbiome, Adult, Animals, Biopsy, Colon, Feces, Female, Humans, Intestinal Absorption, Intestinal Mucosa, Male, Middle Aged, Permeability, Prospective Studies, Severity of Illness Index, Case-Control Studies, Caco-2 Cells, Irritable Bowel Syndrome, Mice, Serine Proteases, Proteolysis, Tight Junction Proteins, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
