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International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis
Open accessAbstract
OBJECTIVE: In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. DESIGN: International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research. RESULTS: Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field.The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis. CONCLUSION: Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.
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“Increasing data indicate that changes in the intestinal microbiome allow environmental risk factors to initiate and promote CRC.6, 7”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [7]
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“Researchers have discovered associations between elements of the intestinal microbiome (including specific microbes, signaling pathways, and microbiota-related metabolites) and risk of colorectal cancer (CRC).”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [7]
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Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
Routy, B., Le Chatelier, E., Derosa, L., Duong, C. P. M., Alou, M. T., Daillère, R., Fluckiger, A., Messaoudene, M., Rauber, C., Roberti, M. P., et al. (2018) · Science · doi:10.1126/science.aan3706 · Cited by 5,671
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Self-citationHelicobacter pylori Infection and the Development of Gastric Cancer
Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N., & Schlemper, R. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa001999 · Cited by 4,492
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Cited by
Sorted by citations
Items 101–200 of 287
Redrawing therapeutic boundaries: microbiota and cancer
Sholl, J., Sepich‐Poore, G. D., Knight, R. D., & Pradeu, T. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.10.008 · Cited by 31
Cortés‐Martín, A., Iglesias‐Aguirre, C. E., Meoro, A., Selma, M. V., & Espín, J. C. (2020) · Microorganisms · doi:10.3390/microorganisms8030416 · Cited by 27
Multi-Omic Approaches in Colorectal Cancer beyond Genomic Data
Sardo, E., Napolitano, S., Corte, C. M. D., Ciardiello, D., Raucci, A., Arrichiello, G., Troiani, T., Ciardiello, F., Martinelli, E., & Martini, G. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020128 · Cited by 27
The role of the gut microbiome in the development of hepatobiliary cancers
Daniel, N., Genua, F., Jenab, M., Mayén, A., Chatziioannou, A. C., Keski‐Rahkonen, P., & Hughes, D. J. (2023) · Hepatology · doi:10.1097/hep.0000000000000406 · Cited by 30
Self-citationQu, R., Zhang, Y., Kim, B., Zeng, G., Wang, P., Shaoyong, W., Huang, Y., Guo, W., Chen, Y., Wang, P., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.06.002 · Cited by 29
Liu, F., Liu, M., Liu, Y., Guo, C., Zhou, Y., Li, F., Xu, R., Liu, Z., Deng, Q., Li, X., et al. (2020) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2020.06.07 · Cited by 25
Powles, S., Gallagher, K., Chong, L. W., Alexander, J. L., Mullish, B. H., Hicks, L., McDonald, J. A. K., Marchesi, J. R., Williams, H. R. T., & Orchard, T. R. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02301-1 · Cited by 26
Self-citationImplication of gut microbes and its metabolites in colorectal cancer
Kumar, A., Ali, A., Kapardar, R. K., Dar, G. M., Nimisha, Apurva, A., Sharma, A. K., Verma, R., Sattar, R. S. A., Ahmad, E., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04422-2 · Cited by 26
Exosomes: Mediators in microenvironment of colorectal cancer
Yao, J., Chen, Y., & Lin, Z. (2023) · International Journal of Cancer · doi:10.1002/ijc.34471 · Cited by 27
Gut microbiota in women: The secret of psychological and physical well-being
Marano, G., Traversi, G., Gaetani, E., Gasbarrini, A., & Mazza, M. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i45.5945 · Cited by 29
Singh, P., Meenatchi, R., Ahmed, Z., Thacharodi, A., Rohinth, M., Kumar, R. R., K, H. V. M., & Hassan, S. (2023) · Medicine in Microecology · doi:10.1016/j.medmic.2023.100096 · Cited by 30
Cancer and the Microbiome of the Human Body
Herrera‐Quintana, L., Vázquez‐Lorente, H., López-Garzón, M., Cortés‐Martín, A., & Plaza‐Díaz, J. (2024) · Nutrients · doi:10.3390/nu16162790 · Cited by 25
Probiotics and live biotherapeutic products aiming at cancer mitigation and patient recover
Schemczssen-Graeff, Z., & Pileggi, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.921972 · Cited by 24
Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer
Mori, G., & Pasca, M. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031312 · Cited by 28
Li, Y., Ma, A., Johnson, W. E., Eng, C., De, S., Jiang, S., Li, Z., Spakowicz, D. J., & Ma, Q. (2025) · Nature Methods · doi:10.1038/s41592-025-02807-y · Cited by 25
Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms
Shi, Z., & Zhang, M. (2021) · Clinical Medicine Insights Oncology · doi:10.1177/11795549211024197 · Cited by 23
Differences in the gut microbiome by physical activity and BMI among colorectal cancer patients.
Himbert, C., Stephens, W. Z., Gigic, B., Hardikar, S. S., Holowatyj, A. N., Lin, T., Ose, J., Swanson, E., Ashworth, A., Warby, C. A., et al. (2022) · PubMed Central · Cited by 24
Lipid metabolic reprogramming in colorectal cancer: mechanisms and therapeutic strategies
Liu, W., Dong, S., Hao, F., Gao, Y., & Wei, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1603032 · Cited by 25
Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment
Zhao, X., Liu, Z., & Chen, T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030948 · Cited by 25
From the Colon to the Liver: How Gut Microbiota May Influence Colorectal Cancer Metastatic Potential
Mignini, I., Piccirilli, G., Galasso, L., Termite, F., Esposto, G., Ainora, M. E., Gasbarrini, A., & Zocco, M. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020420 · Cited by 25
Immunogenic cell death: A link between gut microbiota and anticancer effects
Chen, W., Wang, S., Wu, Y., Shen, X., Guo, Z., Li, Q., & Xing, D. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.103983 · Cited by 22
Park, R., Umar, S., & Kasi, A. (2020) · Current Colorectal Cancer Reports · doi:10.1007/s11888-020-00456-1 · Cited by 21
Nutrition and upper gastrointestinal cancers: An overview of current understandings
Kayamba, V. J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.004 · Cited by 22
Sholl, J., Mailing, L. J., & Wood, T. R. (2021) · mBio · doi:10.1128/mbio.00579-21 · Cited by 23
Daniel, N., Farinella, R., Belluomini, F., Fajkić, A., Rizzato, C., Souček, P., Campa, D., & Hughes, D. J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.03.002 · Cited by 23
Self-citationWang, X., Undi, R. B., Ali, N., & Huycke, M. M. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048793 · Cited by 20
Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Hurník, P., Chyra, Z., Ševčíková, T., Štembírek, J., Trtková, K. S., Gaykalova, D. A., Buchtová, M., & Hrubá, E. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.848557 · Cited by 21
The microbiome and gynecologic cancer: cellular mechanisms and clinical applications
Chalif, J., Wang, H., Spakowicz, D. J., Quick, A. M., Arthur, E. K., O’Malley, D. M., & Chambers, L. (2023) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-2023-004894 · Cited by 26
Biswas, V., Praveen, A., Marisetti, A. L., Sharma, A., Kumar, V., Sahu, S. K., & Tewari, D. (2022) · Dietetics · doi:10.3390/dietetics1030017 · Cited by 25
Gastric Cancer: The Microbiome Beyond Helicobacter pylori
Mendes-Rocha, M., Pereira‐Marques, J., Ferreira, R. M., & Figueiredo, C. (2023) · Current topics in microbiology and immunology · doi:10.1007/978-3-031-47331-9_6 · Cited by 22
Cruz, B. C. D. S., Duarte, V. D. S., Dias, R. S., Bernardes, A. L., de Paula, S. O., Ferreira, C. L. D. L. F., & Pelúzio, M. D. C. G. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111379 · Cited by 18
Li, B., Han, Y., Fu, Z., Chai, Y., Guo, X., Du, S., Li, C. K., & Wang, D. W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1397485 · Cited by 18
Intratumoral Fusobacterium nucleatum in Pancreatic Cancer: Current and Future Perspectives
D’Antonio, D. L., Zenoniani, A., Umme, S., Piattelli, A., & Curia, M. C. (2024) · Pathogens · doi:10.3390/pathogens14010002 · Cited by 21
Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
Ibragimova, S., Ramachandran, R., Ali, F. R., Lipovich, L., & Ho, S. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725821 · Cited by 18
Okuda, S., Hirose, Y., Takihara, H., Okuda, A., Ling, Y., Tajima, Y., Shimada, Y., Ichikawa, H., Takizawa, K., Sakata, J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-12658-8 · Cited by 19
Yang, Y., Han, Z., Gao, Z., Chen, J., Song, C., Xu, J., Wang, H., Huang, A., Shi, J., & Gu, J. F. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002421 · Cited by 19
Xu, K., Motiwala, Z. Y., Corona‐Avila, I., Makhanasa, D., Alkahalifeh, L., & Khan, M. W. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338251331960 · Cited by 22
Dan, W., Peng, L., Yan, B., Li, Z., & Pan, F. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.791274 · Cited by 16
The challenge posed by young-onset rectal cancer
Denost, Q. (2020) · British journal of surgery · doi:10.1002/bjs.11591 · Cited by 16
Ji, G., Zhao, J., Si, X., & Song, W. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115345 · Cited by 16
Grover, K., Gregory, S., Gibbs, J. F., & Emenaker, N. J. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-2019-gi-07 · Cited by 16
Oh, S., & Li, R. W. (2024) · Advanced Science · doi:10.1002/advs.202400458 · Cited by 15
Zhang, H., Lee, B. J. Y., Wang, T., Xiang, X., Tan, Y., Han, Y., Bi, Y., Zhi, F., Wang, X., He, F., et al. (2025) · hLife · doi:10.1016/j.hlife.2025.04.004 · Cited by 19
The multi-kingdom cancer microbiome
Dohlman, A. B., Pan, X., Zitvogel, L., & Iliev, I. D. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02103-7 · Cited by 16
New approaches to secondary metabolite discovery from anaerobic gut microbes
Butkovich, L. V., Vining, O. B., & O’Malley, M. (2025) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-024-13393-y · Cited by 14
Jiang, Z., Li, L., Chen, J., Wei, G., Ji, Y., Chen, X., Liu, J., & Huo, J.-G. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104946 · Cited by 14
The Role of Intestinal Microbiota and Immune System Interactions in Autoimmune Diseases
Yurtseven, B., Aydemir, E., & Ayaz, F. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s569016 · Cited by 19
The influence of the gastrointestinal microbiome on colorectal metastasis: a narrative review
Stakelum, Á., Zaborowski, A. M., Collins, D., & Winter, D. C. (2019) · Colorectal Disease · doi:10.1111/codi.14930 · Cited by 13
Review of Personalized Cancer Treatment with Machine Learning
Ahmed, H., Hamad, S. H., Shedeed, H. A., & Saad, A. (2022) · International Conference on Computing and Informatics (ICCI) · doi:10.1109/icci54321.2022.9756124 · Cited by 13
Nutrition and Microbiome Interactions in Human Cancer
Daschner, P. J., Ross, S., Seifried, H. E., Kumar, A., & Flores, R. (2022) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2022.10.004 · Cited by 15
Potential role of intratumor bacteria outside the gastrointestinal tract: More than passengers
Liu, Z., Hong, L., & Ling, Z. (2023) · Cancer Medicine · doi:10.1002/cam4.6298 · Cited by 12
Oral Microbiota-Driven Cell Migration in Carcinogenesis and Metastasis
Bai, H., Yang, J., Meng, S., & Liu, C. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.864479 · Cited by 13
Bacteria and macrophages in the tumor microenvironment
Xu, S. S., Xiong, Y., Fu, B., Guo, D. L., Sha, Z., Lin, X., & Wu, H. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1115556 · Cited by 13
Song, Y., Shi, M., & Wang, Y. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00976-8 · Cited by 12
The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications
Huang, L., Jiang, C., Yan, M., Wan, W., Li, S., Xiang, Z., & Wu, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1413266 · Cited by 13
Pragasam, A. K., Maurya, S., Jain, K., Pal, S., Raja, C., Yadav, R., Kumar, S., Purohit, A., Pradhan, D., Kajal, K., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217621 · Cited by 13
Intestinal microbiota: The hidden gems in the gut?
Piewngam, P., Mets, F. D., & Otto, M. J. (2020) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-020720-0897 · Cited by 14
The future of food and nutrition in ELIXIR
Balech, B., Brennan, L., Pau, E. C. D. S., Cavalieri, D., Coort, S. L., D’Elia, D., Dragsted, L. O., Eftimov, T., Evelo, C. T., Ferk, P., et al. (2022) · F1000Research · doi:10.12688/f1000research.51747.1 · Cited by 12
Arbeláez, M. C. S., Israeli, J. M., Tipton, C. D., Loloi, J., Deebel, N. A., Leong, J. Y., & Ramasamy, R. (2022) · European Urology Focus · doi:10.1016/j.euf.2022.11.010 · Cited by 12
Pinto, C. A., Aluai‐Cunha, C., & Santos, A. A. F. (2023) · Melanoma Research · doi:10.1097/cmr.0000000000000880 · Cited by 12
Challenges and Opportunities in Analyzing Cancer-Associated Microbiomes
Chia, M., Pop, M., Salzberg, S. L., & Nagarajan, N. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3629 · Cited by 11
Istvan, P., Birkeland, E. E., Avershina, E., Kværner, A. S., Bemanian, V., Pardini, B., Tarallo, S., de Vos, W. M., Rognes, T., Berstad, P. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46033-0 · Cited by 13
Effects of gut microbiota in breast cancer
Kang, L., Chen, H., He, C., & Li, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1617410 · Cited by 11
Gut–Vaginal Microbiome Crosstalk in Ovarian Cancer: Implications for Early Diagnosis
Zhang, H., Lin, H., Zeng, Z., Jia, Y., Zhang, H., Pang, J. M., & Chen, J. J. (2025) · Pathogens · doi:10.3390/pathogens14070635 · Cited by 11
Of microbes and women: BRCA1, vaginal microbiota, and ovarian cancer
Verstraelen, H. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30406-1 · Cited by 11
Self-citationBairi, K. E., Jabi, R., Trapani, D., Boutallaka, H., Bencheikh, B. O. A., Bouziane, M., Amrani, M., Afqir, S., & Maleb, A. (2020) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2020.1758063 · Cited by 11
Zhang, P., Feng, S., Liu, F., Han, S., Fan, T., Chen, H., Dong, X., Wang, X., Qin, Y., Chen, Y. X., et al. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05014 · Cited by 10
Dai, J., Fu, Y., Zhong, X., Cen, W., Ye, M.-F., Chen, X.-H., Pan, Y., & Ye, L. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.916565 · Cited by 10
Keane, J. M., Walsh, C. J., Cronin, P., Baker, K., Melgar, S., Cotter, P. D., Joyce, S. A., Gahan, C. G. M., Houston, A. M., & Hyland, N. P. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02062-4 · Cited by 9
Capozzi, V. A., Incognito, G. G., Scarpelli, E., Palumbo, M. A., Randazzo, C. L., Pino, A., Verde, M. L., Ronsini, C., Riemma, G., Gaiano, M., et al. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14040351 · Cited by 9
Paudel, D., Li, H., Holzhausen, E. A., Young, N., Platz, E. A., Walker, D. I., Liang, D., Aung, M. T., Goodrich, J. A., Setiawan, V. W., et al. (2025) · Environment International · doi:10.1016/j.envint.2025.109778 · Cited by 10
Use of Personalized Biomarkers in Metastatic Colorectal Cancer and the Impact of AI
Volovăț, S. R., Augustin, I. G., Zob, D., Boboc, D., Amurariti, F., Volovat, C. D., Ştefănescu, C., Stolniceanu, C. R., Ciocoiu, M., Dumitras, E. A., et al. (2022) · Cancers · doi:10.3390/cancers14194834 · Cited by 10
Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer
Shi, L., Xu, Y., & Feng, M. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07689-0 · Cited by 9
The role of nutrition in harnessing the immune system: a potential approach to prevent cancer
Xiaogang, H., Sharma, M., Saif, I., Ali, G., Li, X., & Salama, E. (2022) · Medical Oncology · doi:10.1007/s12032-022-01850-5 · Cited by 11
Prospect of bacteria for tumor diagnosis and treatment
Xu, Y., Zhao, C., Ma, X., & Zhang, H. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121215 · Cited by 9
Yao, H., Liu, T., Chen, Y., She, L., Wu, T., Liu, D., Deng, Y., Han, Y., Chen, K., Deng, J., et al. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03900-4 · Cited by 8
Wang, X., Feng, S., Chen, H., Zhou, B., Fan, T., Qin, Y., Zhao, L., Jiang, Y., & Chen, Y. X. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c04132 · Cited by 8
Jastrząb, R., Tomecki, R., Jurkiewicz, A., Graczyk, D., Szczepankowska, A. K., Mytych, J., Wolman, D., & Siedlecki, P. S. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02345-w · Cited by 9
Multi-omics analysis and the remedial effects of Swertiamarin on hepatic injuries caused by CCl4
Li, L., Xiao, S., Dai, X., Tang, Z., Wang, Y., Ali, M., Ataya, F. S., Sahar, I., Iqbal, M., Wu, Y., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116734 · Cited by 8
Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections
Mignini, I., Ainora, M. E., Francesco, S. D., Galasso, L., Gasbarrini, A., & Zocco, M. A. (2023) · Cancers · doi:10.3390/cancers15123200 · Cited by 9
Predictive Values of Colon Microbiota in the Treatment Response to Colorectal Cancer
Ros, J. G., Ramos-Arenas, V., & Conesa‐Zamora, P. (2020) · Pharmacogenomics · doi:10.2217/pgs-2020-0044 · Cited by 9
Setting higher standards for reports of microbial species in human cancers
Salzberg, S. L., Chia, M., Tay, C. Y., de Miranda, N. F. C. C., Smit, V. T. H. B. M., Wesseling, J., Irizarry, R. A., Marshall, B. J., Willerslev, E., Neefjes, J., et al. (2026) · Nature Cancer · doi:10.1038/s43018-026-01121-6 · Cited by 8
Small Animals Gut Microbiome and Its Relationship with Cancer
Ferrarias, T. M., & Santos, A. A. F. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95780 · Cited by 7
Du, Y., Wang, Q., Zheng, Z., Zhou, H., Han, Y., Qi, A., Jiao, L., & Gong, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1425802 · Cited by 7
Intratumoral Microbiota: Insights from Anatomical, Molecular, and Clinical Perspectives
Lombardo, C., Fazio, R., Sinagra, M., Gattuso, G., Longo, F., Lombardo, C., Salmeri, M., Zanghì, G., & Loreto, C. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14111083 · Cited by 7
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Metadata
- Authors
- Scott, A. J., Alexander, J. L., Merrifield, C. A., Cunningham, D., Jobin, C., Brown, R., Alverdy, J., O’Keefe, S. J., Gaskins, H. R., Teare, J., Yu, J., Hughes, D. J., Verstraelen, H., Burton, J., O’Toole, P. W., Rosenberg, D. W., Marchesi, J. R., & Kinross, J. M.
- Affiliations
- Imperial College London (GB)
- Royal Marsden Hospital (GB)
- University of Florida Health (US)
- University of Chicago (US)
- University of Pittsburgh (US)
- University of Illinois Urbana-Champaign (US)
- Chinese University of Hong Kong (HK)
- University College Dublin (IE)
- Ghent University Hospital (BE)
- Lawson Health Research Institute (CA)
- University College Cork (IE)
- University of Connecticut (US)
- Department of Surgery and Cancer, Imperial College London, London, UK
- Corresponding author
- Marchesi, Julian R
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2019-05-15
- Volume
- 68
- Issue
- 9
- Pages
- 1624-1632
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC6709773
- OpenAlex
- W2945346908
- Cited by
- 288
- References
- 70
- Citations by year
- 2026: 29 · 2025: 43 · 2024: 34 · 2023: 37 · 2022: 49 · 2021: 50 · 2020: 38 · 2019: 8
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by-nc)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion, cc-by-nc)
- Funders
- Cancer Research UK
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- human microbiome, carcinogenesis, gut dysbiosis, association versus causation, longitudinal cohort
- MeSH terms
- Gastrointestinal Microbiome, Animals, DNA Damage, Humans, Inflammation, Neoplasms, Colorectal Neoplasms, Biomedical Research, Carcinogenesis, Microbiota, Dysbiosis
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