Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

Neuroinflammation in Alzheimer's disease

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Host microbiota constantly control maturation and function of microglia in the CNS

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Normal gut microbiota modulates brain development and behavior

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Recognition of microorganisms and activation of the immune response

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The gut microbiota influences blood-brain barrier permeability in mice

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Gut microbiome alterations in Alzheimer’s disease

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Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

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Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

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Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration

Kern, L., Mastandrea, I., Melekhova, A., & Elinav, E. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.08.014 · Cited by 27

How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells

Schaible, P., Henschel, J., & Erny, D. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03371-0 · Cited by 32

From Microbial Homeostasis to Systemic Pathogenesis: A Narrative Review on Gut Flora’s Role in Neuropsychiatric, Metabolic, and Cancer Disorders

Yan, X., Shi, L., Zhu, X.-L., Zhao, Y., Luo, J., Li, Q., Xu, Z., & Zhao, J. J. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s531671 · Cited by 28

Metagenomic association analysis of cognitive impairment in community-dwelling older adults

Li, J., Zhu, S., Wang, Y., Fan, M., Dai, J., Zhu, C., Xu, K., Cui, M., Suo, C., Li, J., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106081 · Cited by 26

Gut check: Unveiling the influence of acute exercise on the gut microbiota

Grosicki, G. J., Langan, S. P., Bagley, J. R., Galpin, A. J., Garner, D., Hampton‐Marcell, J., Allen, J. M., & Robinson, A. T. (2023) · Experimental Physiology · doi:10.1113/ep091446 · Cited by 27

An integrated neuroimaging-omics approach for the gut-brain communication pathways in Alzheimer’s disease

Sheng, C., Du, W., Liang, Y., Xu, P., Ding, Q., Chen, X., Jia, S., & Wang, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1211979 · Cited by 28

Fecal Microbiota Transplantation in Alzheimer’s Disease: Mechanistic Insights Through the Microbiota–Gut–Brain Axis and Therapeutic Prospects

Ren, J., Wang, Q., Hong, H., & Tang, C. (2025) · Microorganisms · doi:10.3390/microorganisms13081956 · Cited by 28

Environmental cadmium exposure facilitates mammary tumorigenesis via reprogramming gut microbiota-mediated glutamine metabolism in MMTV-Erbb2 mice

Yue, Y., Zhang, H., Deng, P., Tan, M., Chen, C., Tang, B., Li, J., Chen, F., Zhao, Q., Li, L., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165348 · Cited by 26

Slow gut transit increases the risk of Alzheimer’s disease: An integrated study of the bi-national cohort in South Korea and Japan and Alzheimer’s disease model mice

Kang, J., Lee, M., Park, M.-C., Lee, J., Lee, S., Park, J., Koyanagi, A., Smith, L., Nehs, C. J., Yon, D. K., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.12.010 · Cited by 27

Extracellular vesicles: Critical bilateral communicators in periphery-brain crosstalk in central nervous system disorders

Wang, D., Guan, S., Lu, P., Li, Y., & Xu, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114354 · Cited by 24

Gegen Qinlian tablets delay Alzheimer's disease progression via inhibiting glial neuroinflammation and remodeling gut microbiota homeostasis

Wang, L., Lu, Y., Liu, J., Wang, S., Fei, Z., Zhang, K., Zhang, D., & Jin, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155394 · Cited by 27

Correlation between Alzheimer’s Disease and Gastrointestinal Tract Disorders

Kuźniar, J., Kozubek, P., Czaja, M., & Leszek, J. (2024) · Nutrients · doi:10.3390/nu16142366 · Cited by 27

Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer’s pathophysiology

Hochuli, N., Kadyan, S., Park, G., Patoine, C., & Nagpal, R. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.39 · Cited by 24

Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice

He, D., Gao, X., Wen, J., Zhang, Y., Yang, S., Sun, X., Cui, M., Li, Z., Fu, S., Liu, J., et al. (2024) · Food & Function · doi:10.1039/d3fo04714h · Cited by 25

C/ EBPβ : A transcription factor associated with the irreversible progression of Alzheimer's disease

Yao, Q., Long, C., Yi, P., Zhang, G., Wan, W., Rao, X., Ying, J., Liang, W., & Hua, F. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14721 · Cited by 25

Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson’s disease

Ahn, E. H., Liu, X., Alam, A. M., Kang, S. S., & Ye, K. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01910-2 · Cited by 22

Gut flora in multiple sclerosis: implications for pathogenesis and treatment

Zhang, W., Wang, Y., Zhu, M., Liu, K., & Zhang, H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.387974 · Cited by 24

Palmatine Protects PC12 Cells and Mice from Aβ25-35-Induced Oxidative Stress and Neuroinflammation via the Nrf2/HO-1 Pathway

Wang, Y., Pei, H., Chen, W., Du, R., Li, J., & He, Z. (2023) · Molecules · doi:10.3390/molecules28247955 · Cited by 22

Ginkgo biloba Extract Drives Gut Flora and Microbial Metabolism Variation in a Mouse Model of Alzheimer’s Disease

Yu, T., Xing, Y., Gao, Q., Wang, D., Chen, H., Wang, H., & Zhang, Y. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122746 · Cited by 22

Metabolic Insights into Caffeine’s Anti-Adipogenic Effects: An Exploration through Intestinal Microbiota Modulation in Obesity

Fortunato, I. M., Pereira, Q. C., Oliveira, F. D. S., Alvarez, M. C., dos Santos, T. W., & Ribeiro, M. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031803 · Cited by 24

Role of the Insulin-like Growth Factor System in Neurodegenerative Disease

LEWITT, M. S., & Boyd, G. W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084512 · Cited by 25

Gut microbiota-associated taurine metabolism dysregulation in a mouse model of Parkinson’s disease

Cui, C., Song, H., Han, Y., Yu, H., Li, H., Yang, Y., & Zhang, B. (2023) · mSphere · doi:10.1128/msphere.00431-23 · Cited by 21

Gut instincts: Unveiling the connection between gut microbiota and Alzheimer's disease

Peddinti, V., Avaghade, M. M., Suthar, S. U., Rout, B., Gomte, S. S., Agnihotri, T. G., & Jain, A. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.02.019 · Cited by 24

Interactions of non-starch polysaccharides with the gut microbiota and the effect of non-starch polysaccharides with different structures on the metabolism of the gut microbiota: A review

Sun, Y., Yao, J., Gao, R., Hao, J., Liu, Y., & Liu, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.139664 · Cited by 22

Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer’s Disease

Momen, Y. S., Mishra, J., & Kumar, N. (2024) · Nutrients · doi:10.3390/nu16152558 · Cited by 26

Gut Microbiota and Immunotherapy for Alzheimer’s Disease

Dai, C., Liu, F., Iqbal, K., & Gong, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315230 · Cited by 22

Nutrition in Alzheimer’s disease: a review of an underappreciated pathophysiological mechanism

Jiang, J., Shi, H., Jiang, S., Wang, A., Zou, X., Wang, Y., Li, W., Zhang, Y., Sun, M., Ren, Q., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2276-6 · Cited by 20

Lipopolysaccharide-producing Veillonella infantium and Escherichia fergusonii cause vagus nerve-mediated cognitive impairment in mice

Ma, X., Kim, J.-K., Shin, Y.-J., Park, H.-S., Lee, D.-Y., Yim, S., & Kim, D. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.031 · Cited by 20

Antipsychotic drug-induced behavioral abnormalities in common carp: The potential involvement of the gut microbiota-brain axis

Chang, X., Shen, Y., Yang, M., Yun, L., Liu, Z., Feng, S., Yang, G., Meng, X., & Su, X. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134444 · Cited by 21

The potential influence of microplastics on the microbiome and disease susceptibility in sea turtles

Iurk, V. B., Ingles, M., Correa, G. S., Silva, C. R., Staichak, G., Pileggi, S. A. V., Christo, S. W., Domit, C., & Pileggi, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174298 · Cited by 21

The emerging roles of microbiome and short-chain fatty acids in the pathogenesis of bronchopulmonary dysplasia

Gao, Y., Wang, K., Lin, Z., Cai, S., Peng, A., He, L., Qi, H., Jin, Z., & Qian, X. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1434687 · Cited by 23

Bidirectional regulation of the brain–gut–microbiota axis following traumatic brain injury

You, X., Niu, L., Fu, J., Ge, S., Shi, J., Zhang, Y., & Zhuang, P. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00088 · Cited by 23

A systematic review of lifestyle-based interventions for managing Alzheimer's disease: Insights from randomized controlled trials

Martínez‐López, S., Tabone, M., Clemente-Velasco, S., González-Soltero, R., Bailén, M., de Lucas, B., Bressa, C., Domínguez-Balmaseda, D., Marín, J., Antúnez, C., et al. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241292829 · Cited by 21

Immune Modulation in Alzheimer’s Disease: From Pathogenesis to Immunotherapy

Balkhi, S., Spirito, A. D., Poggi, A. D., & Mortara, L. (2025) · Cells · doi:10.3390/cells14040264 · Cited by 21

Microecologics and Exercise: Targeting the Microbiota–Gut–Brain Axis for Central Nervous System Disease Intervention

Peng, Z., Hou, T., Yang, K., Zhang, J., Mao, Y.-H., & Hou, X. (2025) · Nutrients · doi:10.3390/nu17111769 · Cited by 21

Vagus nerve and brain–gut communication in neurodegenerative diseases: Mechanism and therapeutic perspectives

Luo, S., Pan, M., Fu, G., Meng, X., Zhao, Z., Yu, H., Yue, G.-X., & Lei, T. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107974 · Cited by 19

Rhizoma Gastrodiae Water Extract Modulates the Gut Microbiota and Pathological Changes of P-TauThr231 to Protect Against Cognitive Impairment in Mice

Zhao, W., Wang, J., Latta, M., Wang, C., Liu, Y., Ma, W., Zhou, Z., Hu, S., Chen, P., & Liu, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.903659 · Cited by 20

Application of Dominant Gut Microbiota Promises to Replace Fecal Microbiota Transplantation as a New Treatment for Alzheimer’s Disease

Li, M., Yang, H., Shao, C., Liu, Y., Shu, W., & Tang, L. (2023) · Microorganisms · doi:10.3390/microorganisms11122854 · Cited by 19

N-3 PUFA Ameliorates the Gut Microbiota, Bile Acid Profiles, and Neuropsychiatric Behaviours in a Rat Model of Geriatric Depression

Tung, T.-H., Chen, Y., Lin, Y., & Huang, S. (2022) · Biomedicines · doi:10.3390/biomedicines10071594 · Cited by 19

Exploring new avenues of health protection: plant-derived nanovesicles reshape microbial communities

Chen, X., He, L., Zhang, C., Zheng, G., Lin, S., Zou, Y., Lu, Y., Feng, Y., & Zheng, D. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02500-w · Cited by 24

Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence

Liu, C., Wong, P. Y., Chow, S. K., Cheung, W., & Wong, R. M. Y. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.10.001 · Cited by 18

Trust the gut: Outcomes of gut microbiota transplant in metabolic and cognitive disorders

Guzzardi, M. A., Rosa, F. L., & Iozzo, P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105143 · Cited by 20

Chuanxiong Renshen Decoction Inhibits Alzheimer’s Disease Neuroinflammation by Regulating PPARγ/NF-κB Pathway

Hou, J., Wang, X., Zhang, J., Shen, Z., Li, X., & Yang, Y. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s462266 · Cited by 21

Prevention and Treatment of Alzheimer's Disease Via the Regulation of the Gut Microbiota With Traditional Chinese Medicine

Long, J., Zhang, J., Zeng, X., Wang, M., & Wang, N. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70101 · Cited by 18

From Amyloid to Synaptic Dysfunction: Biomarker-Driven Insights into Alzheimer’s Disease

Agnello, L., Gambino, C. M., Ciaccio, A. M., Cacciabaudo, F., Massa, D., Masucci, A., Tamburello, M., Vassallo, R., Midiri, M., Scazzone, C., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47080580 · Cited by 21

The gut–brain axis in Alzheimer’s disease: how gut microbiota modulate microglial function

Wang, H., Yang, F., Gao, Z., Cheng, Z.-D., & Liang, X. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1704047 · Cited by 22

Long-term environmental enrichment overcomes depression, learning, and memory impairment in elderly CD-1 mice with maternal sleep deprivation exposure

Zhang, Y., Wei, R., Li, X., Feng, Y.-Z., Zhang, K., Ge, Y.-J., Kong, X.-Y., Liu, X., & Chen, G.-H. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1177250 · Cited by 18

Lipids, Gut Microbiota, and the Complex Relationship with Alzheimer’s Disease: A Narrative Review

Simão, D. O., Vieira, V. S., Tosatti, J. A. G., & Gomes, K. B. (2023) · Nutrients · doi:10.3390/nu15214661 · Cited by 21

Air pollution accelerates the development of obesity and Alzheimer’s disease: the role of leptin and inflammation - a mini-review

Campolim, C. M., Schimenes, B. C., Veras, M. M., Kim, Y., & Prada, P. O. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1401800 · Cited by 20

Microbiome and micronutrient in ALS: From novel mechanisms to new treatments

Sun, J., & Zhang, Y. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00441 · Cited by 20

Gut microbiota and Alzheimer's disease: Exploring natural product intervention and the Gut–Brain axis for therapeutic strategies

Pasupalak, J. K., Rajput, P., & Gupta, G. L. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177022 · Cited by 19

Intestinal homeostasis disrupted by Periodontitis exacerbates Alzheimer’s Disease in APP/PS1 mice

Qian, X., Lin, X., Hu, W., Zhang, L., Chen, W., Zhang, S., Ge, S., Xu, X., & Luo, K. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03256-8 · Cited by 17

Altered Gut Microbiota Contributes to Acute-Respiratory-Distress-Syndrome-Related Depression through Microglial Neuroinflammation

Zhu, B., Gu, Z., Hu, H., Huang, J., Zeng, Z., Liang, H., Yuan, Z., Huang, S., Qiu, Y., Sun, X., et al. (2025) · Research · doi:10.34133/research.0636 · Cited by 16

Advancements in the treatment of Alzheimer's disease: a comprehensive review

Rajanna, S., Gundale, P. P., & Mahadevaiah, A. D. (2025) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2024-0204 · Cited by 20

Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury

Zeng, Y., Wu, R., He, Y., Zhang, Q., Wang, Z., Qin, P., Yang, F., Han, Y., Hao, M., Zheng, Y., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.04.011 · Cited by 19

Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats

Xu, T., Lv, Y., Liu, Q.-Y., & Chen, D. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00311-x · Cited by 18

Contribution of preoperative gut microbiota in postoperative neurocognitive dysfunction in elderly patients undergoing orthopedic surgery

Bi, J., Xu, Y., Li, S., Zhan, G., Hua, D., Tan, J., Chi, X., Xiang, H., Guo, F., & Luo, A. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1108205 · Cited by 17

The Gut Microbiome and Residential Surrounding Greenness: a Systematic Review of Epidemiological Evidence

Pee, T. V., Nawrot, T. S., van Leeuwen, R., & Hogervorst, J. G. F. (2023) · Current Environmental Health Reports · doi:10.1007/s40572-023-00398-4 · Cited by 16

Causal relationship between gut microbiota with subcutaneous and visceral adipose tissue: a bidirectional two-sample Mendelian Randomization study

Cao, F., Pan, F., Gong, X., Wang, W., Xu, Y., Cao, P., & Wang, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1285982 · Cited by 17

Advances in the study of the effects of gut microflora on microglia in Alzheimer’s disease

Wu, J.-J., & Wei, Z. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1295916 · Cited by 16

The role of brain–liver–gut Axis in neurological disorders

Li, P., Xie, L., Yang, W., Feng, S., Mao, W., Ye, L., Cheng, H., Wu, X., & Mao, X. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf011 · Cited by 16

Association between Alzheimer’s disease and metabolic syndrome: Unveiling the role of dyslipidemia mechanisms

Yue, C., Fu, Y., Zhao, Y., Ou, Y., Sun, Y., & Tan, L. (2024) · Brain Network Disorders · doi:10.1016/j.bnd.2024.10.006 · Cited by 17

Oral Health and Cognitive Decline: A Systematic Review of the Periodontitis–Alzheimer’s Connection

Inchingolo, A. M., Inchingolo, A. D., Piras, F., Avantario, P., Ferrante, L., Paduanelli, G., Inchingolo, F., Palermo, A., Dipalma, G., & Corsalini, M. (2025) · Applied Sciences · doi:10.3390/app15126728 · Cited by 15

Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer’s disease

Li, J., Yuan, Z., Li, J., Liu, Z., Wang, Y., Cui, M., Suo, C., Li, J., Ding, D., Chen, X., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00851-6 · Cited by 17

Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis

Zhang, Y., Chen, Y., Yuan, S., Yu, Q., Fu, J., Chen, L., Liu, J., & He, Y. (2023) · Experimental Brain Research · doi:10.1007/s00221-023-06632-7 · Cited by 15

Periodontal Status and Saliva Metabolic Signature in Patients with Alzheimer’s Disease

Yang, Y., Lv, J., Bai, H., Ren, L., Yang, J. Y., Ding, Y., Liu, C., & Chen, X. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230291 · Cited by 16

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies

Das, V., Miller, J. H., Goud, A. C., Annadurai, N., Sanctis, J. B. D., Hrubá, L., & Hajdúch, M. (2024) · Medicinal Research Reviews · doi:10.1002/med.22033 · Cited by 16

Causal effects of PM2.5 exposure on neuropsychiatric disorders and the mediation via gut microbiota: A Mendelian randomization study.

Li, C., Chen, H., Gu, Y., Chen, W., Liu, M., Lei, Q., Li, Y., Liang, X., Wei, B., Huang, D.-P., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116257 · Cited by 13

Acorus tatarinowii oils exert protective effects on microglia-mediated inflammatory injury via restoring gut microbiota composition in experimental stroke rats

Huang, Y.-Y., Li, Y., Guan, D., Pan, Y., Yang, C., Liu, H., Chen, C., Chen, W., Liu, J., Wan, T., et al. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110990 · Cited by 16

Empagliflozin alleviates neuroinflammation by inhibiting astrocyte activation in the brain and regulating gut microbiota of high-fat diet mice

Huang, Q., Liu, L., Tan, X., Wang, S., Wang, S., Luo, J., Chen, J., Yang, N., Jiang, J., Liu, Y., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.05.150 · Cited by 16

Dietary N-6 Polyunsaturated Fatty Acid Intake and Brain Health in Middle-Aged and Elderly Adults

Gu, J., Bao, Y., Li, Y., Li, H., Deng, X., Zhang, Y., Zhu, X., & Ran, J. (2024) · Nutrients · doi:10.3390/nu16244272 · Cited by 17

Unveiling the multifaceted pathogenesis and therapeutic drugs of Alzheimer's disease: A comprehensive review

Peng, L., Zhang, Z., Li, Q., Song, Z., Yan, C., & Ling, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39217 · Cited by 18

Exploring the mechanism by which Zexie Tang regulates Alzheimer's disease: Insights from multi-omics analysis

Su, S., Huang, K., Cai, H., Wei, D., Ding, H., Lin, L., Wang, Y., Gu, J., & Wang, Q. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156453 · Cited by 14

Do immune system and microbiome–gut–brain axis interactions associate with major depressive disorder?

Zhao, H., Tao, L., Tang, C. W., Cai, W., & Shen, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07176-w · Cited by 23

Recent advances of engineered bacteria for therapeutic applications

Xiang, X., Zhou, Z., Rao, X., & Jiang, X. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.11.013 · Cited by 17

Akkermansia muciniphila reduces neuroinflammation and Aβ deposition via tryptophan metabolism in the APP/PS1 mouse model of Alzheimer’s disease

Wang, B., Pan, M., Yang, L., Xu, J., Ye, C., Li, Y., Gong, Q., Liu, C., Li, L., Qin, J., et al. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01880-x · Cited by 17

Corinthian Currants Supplementation Restores Serum Polar Phenolic Compounds, Reduces IL-1beta, and Exerts Beneficial Effects on Gut Microbiota in the Streptozotocin-Induced Type-1 Diabetic Rat

Kompoura, V., Prapa, I., Vasilakopoulou, P. B., Mitropoulou, G., Nelios, G., Balafas, E., Kostomitsopoulos, N. G., Chiou, A., Karathanos, V. Τ., Bezirtzoglou, E., et al. (2023) · Metabolites · doi:10.3390/metabo13030415 · Cited by 14

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

Zhu, G., Guo, M., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250084 · Cited by 16

Hydrobiome of Thermal Waters: Potential Use in Dermocosmetics

Mourelle, M. L., Gómez, C. P., & Legido, J. L. (2023) · Cosmetics · doi:10.3390/cosmetics10040094 · Cited by 15

Immune Remodeling during Aging and the Clinical Significance of Immunonutrition in Healthy Aging

Dou, L., Yang, P., Zhang, B., Yang, H., & Zheng, K. (2023) · Aging and Disease · doi:10.14336/ad.2023.0923 · Cited by 14

27-Hydroxycholesterol impairs learning and memory ability via decreasing brain glucose uptake mediated by the gut microbiota.

Hao, L., Wang, L., Ju, M., Feng, W., Guo, Z., Sun, X., & Xiao, R. (2023) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2023.115649 · Cited by 18

Intestinal flora study reveals the mechanism of Danggui Shaoyao San and its decomposed recipes to improve cognitive dysfunction in the rat model of Alzheimer’s disease

Jin, Y., Liang, S., Qiu, J., Jin, J., Zhou, Y., Huang, Y., He, C., Yu, W., Deng, S., Cheng, S., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1323674 · Cited by 15

Exerkine irisin mitigates cognitive impairment by suppressing gut-brain axis-mediated inflammation

Zhang, H., Liang, J., Huang, J., Wang, M., Wu, L., Wu, T., & Chen, N. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.10.031 · Cited by 16

Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis

Jian, J., & Wei, J. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl26265 · Cited by 14

Reshaping the gut microbiota: Tangliping decoction and its core blood-absorbed component quercetin improve diabetic cognitive impairment

Zhang, W., Yi, C., Song, Z., Yu, B., Jiang, X., Guo, L., Huang, S., Xia, T., Huang, F., Yan, Y., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156560 · Cited by 15

Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer’s Disease

Tun, X., Wang, E. J., Gao, Z., Lundberg, K. C., Xu, R., & Hu, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065697 · Cited by 14

Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia

Huang, Y., Zhang, X., Yu, C., Liu, Y., Kang, H., Liu, Y., Ni, Y., Xia, Y., Jiang, Z., Chen, J., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.07.018 · Cited by 16

The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction

Qian, W., Wu, M., Qian, T.-T., Xie, C., Gao, Y., & Qian, S. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1112148 · Cited by 14

Resveratrol alleviates perinatal methylmercury‐induced neurobehavioral impairments by modulating the gut microbiota composition and neurotransmitter disturbances

Chen, F., Zhang, L., Liu, Y., Zhang, A., & Wang, W. (2023) · Environmental Toxicology · doi:10.1002/tox.23973 · Cited by 13

Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition?

Kerman, B. E., Self, W. K., & Yassine, H. N. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000001007 · Cited by 14

GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer’s Disease Model Mice

Zhang, L., Jiang, Z., Hu, S., Ni, H., Zhao, Y., Tan, X., Yi, L., Na, R., Li, Y., Du, Q., et al. (2024) · Inflammation · doi:10.1007/s10753-024-02133-z · Cited by 15

Investigating the Impact of IL-6 and CXCL8 on Neurodegeneration and Cognitive Decline in Alzheimer Disease

Jin, D., Zhang, M., Shi, L., & Liu, H. (2024) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae038 · Cited by 14

Maturation, Morphology, and Function: The Decisive Role of Intestinal Flora on Microglia: A Review

Liu, L., Tong, F., Li, H., Bin, Y., Ding, P., Peng, L., Liu, Z., & Dong, X. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2203070 · Cited by 14

Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies

Zhao, W., Cui, H., Liu, J., Sun, H., Zhang, Z., Zhang, Z., & Ma, D. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01556-y · Cited by 12

The Interplay Between Exosomes and Gut Microbiota in Neuroinflammation: A New Frontier in Alzheimer’s Disease

Uceda, S., Reiriz, M., Echeverry‐Alzate, V., & Beltrán-Velasco, A. I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125828 · Cited by 14

Peripheral immune and metabolic regulation of Aβ and Tau by exercise in Alzheimer’s disease

Yu, Y., & Chen, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1678526 · Cited by 14

Intestinal Akkermansia muciniphila is Beneficial to Functional Recovery Following Ischemic Stroke

Li, K., Ding, W., Li, X., Gao, H., Wang, S., Li, T., Zhao, H., & Zhang, S. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10146-6 · Cited by 14

Current status and prospect of gut and oral microbiome in pancreatic cancer: Clinical and translational perspectives

Li, P., Zhang, H., & Dai, M. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217274 · Cited by 14

The gut microbiota mediates memory impairment under high‐altitude hypoxia via the gut–brain axis in mice

Li, W., Wang, Y., Shi, Y., He, F., Zhao, Z., Liu, J., Gao, Z., Zhang, J., & Shen, X. (2024) · FEBS Journal · doi:10.1111/febs.17365 · Cited by 12

Omega-3 EPA Supplementation Shapes the Gut Microbiota Composition and Reduces Major Histocompatibility Complex Class II in Aged Wild-Type and APP/PS1 Alzheimer’s Mice: A Pilot Experimental Study

Altendorfer, B., Benedetti, A., Mrowetz, H., Bernegger, S., Bretl, A., Preishuber‐Pflügl, J., de Sousa, D. M. B., Ladek, A., Koller, A., Faouder, P. L., et al. (2025) · Nutrients · doi:10.3390/nu17071108 · Cited by 12

Gut Microbiota Dysbiosis Drives Early Alzheimer’s Pathogenesis via Microglial TREM2/SYK/NF-κB Signaling Axis

Tian, M., Wang, D., Zhang, C., Fan, J., Li, W., Liu, X., & Shi, J. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00173 · Cited by 5

Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer’s Disease

Chen, Y., Fang, L., Chen, S., Zhou, H., Fan, Y., Li, L., Li, J., Xu, J., Chen, Y., Ma, Y., et al. (2020) · BioMed Research International · doi:10.1155/2020/8456596 · Cited by 153

The role of gut microbiota in the pathogenesis of Alzheimer’s disease: A review of the literature

Steć, G., Brzyska, A., Siemianowski, J., Kotnis, W., Pawlak, M., Prolejko, S., Gajęcki, B., Kopala, J., Kucharski, T., & Buczek, W. (2025) · Medical Science · doi:10.54905/disssi.v29i163.e165ms3654

Bacteroides Fragilis in the gut microbiomes of Alzheimer’s disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice

Xia, Y., Xiao, Y., Wang, Z.-H., Liu, X., Alam, A. M., Haran, J. P., McCormick, B. A., Shu, X., Wang, X., & Ye, K. (2023) · Nature Communications · doi:10.1038/s41467-023-41283-w · Cited by 108

Alzheimer’s disease pathology programmed by gut-derived disparity: A comprehensive understanding of neurodegenerationPreprint

Khabbaz, A., Hasani, A., Sadigh‐Eteghad, S., Hosseinzadeh, N., Hejazian, S. S., Hasani, R., Ahmadi, S., & Hasani, A. (2023) · doi:10.22541/au.168014711.14847244/v1