Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

Normal gut microbiota modulates brain development and behavior

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228

Recognition of microorganisms and activation of the immune response

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The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530

Gut microbiome alterations in Alzheimer’s disease

Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871

Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

Rivière, A., Selak, M., Lantin, D., Leroy, F., & Vuyst, L. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00979 · Cited by 1,810

Gastrointestinal exposure to silica nanoparticles induced Alzheimer’s disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC

Du, L., Wang, B., Wang, X., Wang, L., Wang, R., Zhang, Y., Hong, Z., Han, X., & Wang, Y. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03481-0 · Cited by 13

The Therapeutic Potential of Flavonols in Alzheimer's Disease: Inhibiting Amyloid‐β, Oxidative Stress, and Neuroinflammation

Zamanian, M. Y., Khachatryan, L., Heidari, M., Darabi, R., Golmohammadi, M., Al-Aouadi, R. F. A., & Akkol, E. K. (2025) · BioFactors · doi:10.1002/biof.70047 · Cited by 14

Using Stems to Bear Fruit: Deciphering the Role of Alzheimer’s Disease Risk Loci in Human-Induced Pluripotent Stem Cell-Derived Microglia

Wickstead, E. S. (2023) · Biomedicines · doi:10.3390/biomedicines11082240 · Cited by 11

Sample preparation for fatty acid analysis in biological samples with mass spectrometry-based strategies

Yang, L. C., Yuan, J., Yu, B., Hu, S., & Bai, Y. (2024) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-024-05185-0 · Cited by 11

The molecular interplay between human and bacterial amyloids: Implications in neurodegenerative diseases

Jain, N. (2024) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2024.141018 · Cited by 11

Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular nucleus

Liu, C., Yu, H. N., Xia, H., Wang, Z., Li, B., Xue, H., Jin, S., Xiao, L., Wu, Y., & Guo, Q. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024092 · Cited by 15

Jiawei Xionggui Decoction promotes meningeal lymphatic vessels clearance of β-amyloid by inhibiting arachidonic acid pathway

Liu, X., Zhang, H., Xiang, J., Luo, W., Zhang, H., Wang, P., & Xu, S. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156041 · Cited by 11

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

Li, H., Huang, J., Zhao, D., Zhu, L., Zhang, Z., Yi, M., & Peng, W. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01979 · Cited by 12

Short chain fatty acids mediates complement C1q pathway alleviation of perioperative neurocognitive disorders

Liu, X., Tan, X., Yu, Y., Niu, J., Zhao, B., & Wang, Q. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110266 · Cited by 12

Study on the Influence and Mechanism of Resveratrol on Cognitive Impairment in Chronic Kidney Disease Rats Through Regulating Gut Microbiota and the TLR4/NFκB Pathway

Shao, B., Nong, Y., Lin, Y., Meng, Y., Zhou, Y., Huang, M., Huang, F., & Wang, J. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s510867 · Cited by 11

Therapeutic potential of traditional chinese medicine polysaccharides in alzheimer's disease via modulation of gut microbiota: A review

Wang, T., Gao, C., Dong, X., & Li, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146160 · Cited by 12

Inhibition of the HMGB1-RAGE Axis Attenuates Microglial Inflammation and Ameliorates Hypoxia-Induced Cognitive Impairment

Liu, C., Zhang, H., Guan, R., Zou, Y., Chen, M., Du, M., Luo, W., & Zhang, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188782 · Cited by 11

Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice

Kong, L., Sun, R., Zhou, H., Shi, Q., Liu, Y., Han, M., Li, W., Qun, S., & Li, W. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114350 · Cited by 10

The Human Superorganism: Using Microbes for Freedom vs. Fear

Dietert, R. R., & Dietert, J. M. (2023) · Applied Microbiology · doi:10.3390/applmicrobiol3030061 · Cited by 12

Gastrointestinal Dysfunction in Neurological and Neurodegenerative Disorders

Raber, J., & Sharpton, T. J. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771459 · Cited by 12

Impact of Donepezil Supplementation on Alzheimer’s Disease-like Pathology and Gut Microbiome in APP/PS1 Mice

Li, Y., Wu, M., Kong, M., Sui, S., Wang, Q., He, Y., & Gu, J. (2023) · Microorganisms · doi:10.3390/microorganisms11092306 · Cited by 12

Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles

Li, Z., Ma, H., Wang, M., & Qian, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1036120 · Cited by 11

Research Progress of Lipid Metabolism-Mediated Neuroinflammation in Alzheimer’s Disease

Shen, Y., Wang, X., Liu, X., Wang, G., Hou, X., & Zhou, X. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01648-9 · Cited by 12

Association of antibiotic exposure with survival in patients with extensive‐stage small cell lung cancer receiving immune checkpoint inhibitor therapy

Zhong, J., Xiong, D., Liu, Y., & Yuan, S. (2023) · Thoracic Cancer · doi:10.1111/1759-7714.15172 · Cited by 9

The infant gut microbiome and cognitive development in malnutrition

Shennon, I., Wilson, B. C., Behling, A. H., Portlock, T., Haque, R., Forrester, T., Nelson, C. A., & O'Sullivan, J. M. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.03.029 · Cited by 14

From Gut Microbiota to Brain Waves: The Potential of the Microbiome and EEG as Biomarkers for Cognitive Impairment

Krothapalli, M., Buddendorff, L., Yadav, H., Schilaty, N. D., & Jain, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126678 · Cited by 11

Akkermansia muciniphila Modulates Central Nervous System Autoimmune Response and Cognitive Impairment by Inhibiting Hippocampal NLRP3 ‐Mediated Neuroinflammation

Li, X., Lin, D., Hu, X., Shi, X., Huang, W., Ouyang, Y., Chen, X., Xiong, Y., Wu, X., Hong, D., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70320 · Cited by 10

Neuroglia and the microbiota-gut-brain axis

Blair, H., Morales, L., Cryan, J. F., & Aburto, M. R. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00001-2 · Cited by 12

Food for the mind: The journey of probiotics from foods to anti-Alzheimer’s disease therapeutics

Anand, A., Khurana, N., Kumar, R., & Sharma, N. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102323 · Cited by 12

Characterization of serum polyunsaturated fatty acid profile in patients with inflammatory bowel disease

Jiang, J., Chen, L., Sun, R., Yu, T., Jiang, S., & Chen, H. (2023) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223231156826 · Cited by 10

Association of dietary live microbe intake with various cognitive domains in US adults aged 60 years or older

Lv, J.-J., Li, X., Wang, J.-B., Yang, X., Yin, M.-Y., & Yang, C.-H. (2024) · Scientific Reports · doi:10.1038/s41598-024-51520-x · Cited by 13

Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis

Ma, B.-Q., Jia, J., Wang, H., Li, S., Yang, Z.-J., Wang, X., & Yan, X.-S. (2024) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2338914 · Cited by 11

Effects of gut microbiota-derived short-chain fatty acids on cognitive impairment: An in-silico study

Nguyen, H. D., Vu, G. H., & Kim, W. (2024) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2024.100047 · Cited by 9

Is anxiety and depression transmissible? Depressed mother rats transmit anxiety- and depression-like phenotypes to cohabited rat pups through gut microbiota assimilation

Zhang, H., Wei, H., Qin, X., Song, H., Yang, M., Zhang, L., Liu, Y., Wang, Z., Zhang, Y., Lai, Y., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.08.164 · Cited by 9

Rosmarinic Acid Attenuates Salmonella enteritidis-Induced Inflammation via Regulating TLR9/NF-κB Signaling Pathway and Intestinal Microbiota

Yi, D., Wang, M., Liu, X., Qin, L., Liu, Y., Zhao, L., Peng, Y., Liang, Z., & He, J. (2024) · Antioxidants · doi:10.3390/antiox13101265 · Cited by 10

Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator‐Induced Brain Hemorrhagic Transformation After Ischemic Stroke

Xie, G., Jiang, G., Huang, L., Sun, S., Li, X., Wu, B., Wang, H., Zhang, Z., Ye, K., Yu, Y., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70345 · Cited by 11

Short-Chain Fatty Acids Alleviate Perioperative Neurocognitive Disorders Through BDNF/PI3K/Akt Pathway in Middle-Aged Rats

Liu, X., Cui, J., Tan, X., Yu, Y., Niu, J., & Wang, Q. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04964-9 · Cited by 11

C/EBPβ as a master regulator of inflammasome signaling in neurodegenerative diseases: mechanisms and therapeutic implications

Wang, J., Li, Y., & Xia, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1656165 · Cited by 10

The complement cascade in Alzheimer’s disease: modern implications of an ancient immune protagonist

Papavergi, M.-T., Bathini, P., Singh, B. B., & Lemere, C. A. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00916-y · Cited by 12

Alzheimer's disease: from molecular pathways to therapies

Feng, J.-Q., Yang, L.-L., Ya-xi, L., & Yao, X. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00443-2 · Cited by 10

Suppression of hnRNP A1 binding to HK1 RNA leads to glycolytic dysfunction in Alzheimer’s disease models

Ji, X., Liu, T., Wei, A., Lei, H.-P., Chen, Y., Wu, L.-N., Liu, J., Zhang, Y., Yan, F., Chen, M., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1218267 · Cited by 9

The effect of sevoflurane exposure on cell‐type‐specific changes in the prefrontal cortex in young mice

Zhao, B., Song, S., Zhao, W., Xu, H., Peng, K., Shan, X.-S., Chen, Q., Liu, H., Liu, H., & Ji, F. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16068 · Cited by 9

Development of a simultaneous quantification method for the gut microbiota-derived core nutrient metabolome in mice and its application in studying host-microbiota interaction

Xu, H., Wang, J., Liu, Y., Wang, Y., Zhong, X., Li, C., Wang, K., Guo, X., & Xie, C. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341039 · Cited by 9

Imbalances in the gut microbiota and metabolome are associated with functional constipation in pregnancy

Pan, R., Chen, Y., Lin, G., Wang, H., Xu, X., Wang, L., Tian, P., Zhao, J., Chen, W., & Wang, G. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103852 · Cited by 9

Gut microbiota as a potential therapeutic target for children with cerebral palsy and epilepsy

Wu, H., Huang, C., & Xiong, S. (2024) · Brain and Development · doi:10.1016/j.braindev.2024.09.002 · Cited by 9

Elucidating the Role of Trem2 in Lipid Metabolism and Neuroinflammation

Zhao, C., Qi, W., Lv, X., Gao, X.-L., Liu, C.-N., & Zheng, S.-M. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70338 · Cited by 7

Gut microbiota-derived phenylacetylglutamine mitigates neuroinflammation induced by intracerebral hemorrhage in mice

Zhang, W., Lin, H., He, X., Gu, Q., Ma, Y., Fu, X., & Fan, L. (2025) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2025.108357 · Cited by 8

Advances in Autophagy–Lysosomal Pathway and Neurodegeneration via Brain–Gut Axis

Yao, P., & Han, H. (2025) · Biomedicines · doi:10.3390/biomedicines13061390 · Cited by 10

A new perspective on cognitive impairment in major depressive disorder: Changes in gut microbiota and their inflammatory regulatory mechanisms

Song, X., Zhong, Q., Zhang, R., Lai, S., Wu, Y., Yin, J., Liu, Y., Sun, J., Zhang, J., Lü, X., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119648 · Cited by 9

Ketogenic Diet Modulates Gut Microbiota–Brain Metabolite Axis in a Sex‐ and Genotype‐Specific Manner in APOE4 Mice

Ivanich, K. L., Yackzan, A. T., Flemister, A., Chang, Y., Xing, X., Chen, A., Yanckello, L. M., Sun, M., Aware, C. B., Govindarajan, M., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70216 · Cited by 8

Research progress on plant-derived natural compounds regulating the MAPK signaling pathway for the prevention and therapy of Alzheimer’s disease

Zhang, X., Huang, S., Xu, H., Hu, Y., & Gao, L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1666082 · Cited by 9

The role of the microbiota-gut-brain axis in schizophrenia: an immunological perspective

Su, B.-W., Li, Y., Yang, L.-Y., Yang, H., Wang, W., Ren, H., Bao, Y.-N., Lao, J.-Y., & Luan, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1711756 · Cited by 11

Unveiling the gut-brain axis: How chronic exposure to arsenic-induced microglial pyroptosis drives Alzheimer's disease-like pathology

Qu, J., Jiang, X. S., Ma, Y., Sheng, X., Pi, C., Wang, Y., Xu, Q., Li, R., Wang, P., Qian, D., et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141087 · Cited by 8

Novel insights into the activating transcription factor 4 in Alzheimer’s disease and associated aging-related diseases: Mechanisms and therapeutic implications

Zhang, N., Nao, J., Zhang, S., & Dong, X. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101144 · Cited by 8

Surface nanocoating-based universal platform for programmed delivery of microorganisms in complicated digestive tract

Du, Y., Guo, H. L., Su, X., Guo, M., Li, B., Wang, H., Gao, X., Yuan, Q., Teng, Y., Wang, T., et al. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.06.093 · Cited by 8

Embryonic exposure to 6:2 fluorotelomer alcohol mediates autism spectrum disorder-like behavior by dysfunctional microbe-gut-brain axis in mice

Xia, Y., Hu, L., Ren, K., Han, X., Sun, Y., & Li, D. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136739 · Cited by 9

Acupuncture modulates the gut microbiota in Alzheimer’s disease: current evidence, challenges, and future opportunities

Yan, L., Li, H., Qian, Y., Liu, Q., Cong, S., Dou, B., Wang, Y., Wang, M., & Yu, T. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1334735 · Cited by 8

Effects of donepezil treatment on plasma and urine metabolites in amyloid beta-induced Alzheimer's disease rats

Huang, H., Fang, C., Niu, H., Yin, X., Ruan, J., Wei, M., & Zhou, Y. (2023) · Journal of Chromatography B · doi:10.1016/j.jchromb.2023.123766 · Cited by 7

Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease

Huiping, X., Han, X., & Tang, Q. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114746 · Cited by 7

A Bidirectional Mendelian Randomization Study of Gut Microbiota and Cerebral Small Vessel Disease

Huang, C., Zhang, Y., Liu, Y., Zhang, M., Li, Z., Li, M., Ren, M., Yin, J., Zhou, Y., Zhou, X., et al. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.04.024 · Cited by 8

Research progress on the correlation between intestinal flora and colorectal cancer

Wang, X., Zhang, Q., Xu, R., Li, X., & Hong, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1416806 · Cited by 7

Natural products: Harnessing the power of gut microbiota for neurological health

Cheng, H., Liu, J., Zhang, D., Wu, J., Wu, J., Zhou, Y., Tan, Y., Feng, W., & Peng, C. Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156019 · Cited by 7

Linking gut microbiota dysbiosis to molecular pathways in Alzheimer’s disease

Asadifard, E., Hokmabadi, M., Hashemi, M., & Bereimipour, A. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149242 · Cited by 9

Mechanism of Dendrobium officinale polysaccharide in alleviating Alzheimer's disease: Insights from metabolomics, lipidomics, and proteomics analysis

Fu, J. F., Liang, Z., Chen, Z., Chen, W., Zhou, Y., Xiong, F., Meng, L., Liang, Q., & Gao, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145531 · Cited by 7

Bacteroides ovatus Has the Potential to Be a Next-Generation Probiotic Strain

Shen, Y., Meng, L., Li, Y., & Yang, J. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10699-9 · Cited by 8

Huanglian Jiedu Decoction improves the"central-peripheral"inflammatory microenvironment and enhances the cognitive function of APP/PS1 mice by inhibiting the activation of NLRP3 inflammasome mediated by gut microbiota

Zhang, Y., Wang, J., Li, X., Guo, R., Wang, L., Liu, Y., Yu, Y., & Kong, L. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01180-4 · Cited by 7

Cistanche deserticola Polysaccharides Mitigate Alzheimer’s Disease Progression by Dynamic Regulation of Gut Microbiota Composition and Metabolites

Gao, Y. Z., Zhang, C., Yan, L., Gao, J., Liu, Y., Bu, R., Liu, H., Du, X.-L., Sun, L., Li, B., et al. (2025) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x25500661 · Cited by 7

Cistanche tubulosa glycosides ameliorate cognitive decline in APP/PS1 mice via modulation of gut microbiota and fatty acid metabolism: insights from multi-omics and experimental validation

Hou, R., Song, W., Nan, Y., Gong, Y., Liu, J. Y., & Liu, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1662336 · Cited by 7

Alternate day fasting alleviates neuroinflammation in diabetic mice by regulating δ-valerobetaine-carnitine-microglia axis via enrichment of Akkermansia muciniphila

Gong, K., Zhang, S., Pan, Y., Cai, Q., Wu, M., Yin, X., Ma, J., Ji, H., Wang, Z., Wu, W., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02196-6 · Cited by 8

Exploring the gut-brain-microbiome axis in Alzheimer's disease: Integrating metagenomics, metabolomics, and artificial intelligence for next-generation biomarker discovery

Oso, T. A., Ahmed, M. M., Okesanya, O. J., Adebayo, U. O., Obadeyi, K. B., Othman, Z. K., & Lucero‐Prisno, D. E. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251407700 · Cited by 9

Evaluation of the protective bioactivity and molecular mechanism verification of lactoferrin in an Alzheimer's mouse model with ulcerative enteritis

Ran, L., Shi, J., Lin, Y., Xu, C., Han, Z., Tian, S., Qin, X., Zhao, L., Zhang, T., Li, H., et al. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-24206 · Cited by 7

Microglia-Associated Neuroinflammation in Alzheimer’s Disease and Its Therapeutic Potential

Shah, S., & Jain, H. (2024) · Neuroglia · doi:10.3390/neuroglia5040029 · Cited by 10

Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research

Wang, H., Chen, S., Jiang, L., Liu, X., Tang, R., & Tang, M. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1485657 · Cited by 7

Frequent fecal microbiota transplantation improves cognitive impairment and pathological changes in Alzheimer's disease FAD4T mice via the microbiota-gut-brain axis

Zou, Z., Lei, D., Yin, Y., Xu, R., Luo, H., Chen, T., Liu, M., & Li, X. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42925 · Cited by 7

Impact of gut–brain interaction in emerging neurological disorders

Lin, M.-S., Wang, Y., Chen, W., & Kung, W. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i1.1 · Cited by 7

Physiopathological Roles of White Adiposity and Gut Functions in Neuroinflammation

Spinedi, E., & Docena, G. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111741 · Cited by 7

Deconstruct the link between gut microbiota and neurological diseases: application of Mendelian randomization analysis

Li, J., Hu, X., Tao, X., Li, Y., Jiang, W., Zhao, M., Ma, Z., Chen, B., Sheng, S., Tong, J., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1433131 · Cited by 6

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

Xu, G., An, Y., Du, Y., Cao, Z., Zheng, J., Wang, J., Li, T., Lei, X. G., & Lu, Y. (2025) · iMetaOmics. · doi:10.1002/imo2.70020 · Cited by 7

Buyang Huanwu Decoction Modulates the Gut Microbiota–C/EBPβ/ AEP Axis to Ameliorate Cognitive Impairment in Alzheimer's Disease Mice

Liang, J., Dong, X., Yang, J., Hu, N., Luo, X., Cong, S., Chen, J., Zhao, W., & Liu, B. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70480 · Cited by 7

Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Bu, X., Zhu, W., Wang, Q.-H., Liu, Z., Bao, Y.-Y., Bai, Y., Li, J.-H., Liu, Z.-H., Zhao, J.-L., Xiang, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60748-8 · Cited by 8

Pharmacological action, mechanism and structure-activity relationship of traditional Chinese medicine polysaccharide in the treatment of Alzheimer's disease: A review

Zhou, J., Guo, X., Yu, W., Bu, H., Du, Y., Li, S., Kuang, H., & Wu, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148017 · Cited by 6

Remember the gut: The emerging role of microbial SCFAs in cognitive health

de Paiva, I. H. R., Duarte-Silva, E. P., & Peixoto, C. A. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107838 · Cited by 8

Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease

Sampada, Naseem, M., Solanki, M., Sharma, R., Singh, C., & Sohal, A. (2025) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v16.i4.111029 · Cited by 6

The role of gut microbiota in neuropathic pain: insights into immune mechanisms

Gong, Z., Zou, J., Fang, Y., Li, J., Luo, Y., Xue, Q., Yu, B., Hua, B., & Liu, Z. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-02260-4 · Cited by 10

The gut as a central hub for multi-organ crosstalk in aging

Zhang, X., Li, R., Gao, Y., Zhang, W., Ni, T., & Liu, Y. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06129-w · Cited by 7

Gut Microbiota Dysbiosis and Neuroinflammation in Alzheimer’s Disease: a Systematic Review of Mechanistic Insights

Katsigianni, S., & Koutsouraki, E. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05914-9 · Cited by 7

The gut microbiome modulates the susceptibility to traumatic stress in a sex‐dependent manner

Shen, D., Chang, L., Su, F., Huang, S., Xu, H., Si, Y., Wang, F., & Xue, Y.-X. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25315 · Cited by 6

Gut microbiota–lncRNA/circRNA crosstalk: implications for different diseases

Zhang, L., Li, X., Gao, H., Chang, W., & Li, P. (2024) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2024.2375516 · Cited by 8

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu, M., Li, T., Liang, H., & Zhong, P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1416502 · Cited by 6

Novel insights into Cntnap4 in Alzheimer's disease: Intestinal flora interaction

Xiao, X., Guan, Y., Mo, H., Lv, K., Chen, J., Xie, J., Meng, Q., Liu, J., Lu, Y., Gao, F., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138508 · Cited by 6

Integrated multi-omics analysis and experimental validation reveals the mechanism of tenuifoliside A activity in Alzheimer's disease

Ma, H., Qiao, Q., Yu, Z., Wang, W., Li, Z., Xie, Z., Su, Y., Zhang, X., Sun, Y., Wang, P., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119797 · Cited by 5

Clinical insights into the mechanisms of infectious microbes and microbiota in chronic neurologic and psychiatric diseases

Faysal, M. F., Zehravi, M., Amin, M. A., Rab, S. O., Jahnavi, P., Arjun, U. V. N. V., Gupta, J. K., Billah, A. A. M., Vodeti, R., Prasad, P. D., et al. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156090 · Cited by 6

TNIP2 inhibits amyloidogenesis by regulating the 3′UTR of BACE1: An in vitro study

Chen, L., Wang, L., Zhou, G., Liu, Y., Chen, X., Xie, X., Wen, Q., Li, C., Yang, J., & Chen, G. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137265 · Cited by 6

An emerging role for the gut microbiome in tauopathy

Zhu, Y., Self, W. K., & Holtzman, D. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00423 · Cited by 6

Antidepressant effect of carvedilol on streptozotocin-induced diabetic peripheral neuropathy mice by altering gut microbiota

Wu, W., Zeng, C., Wu, C., Wu, T., Pang, J., Zhou, P., & Cao, Y. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150374 · Cited by 6

C/EBPβ in Alzheimer’s disease: An integrative regulator of pathological mechanisms

Luo, X., Liang, J., Lei, X., Sun, F., Gong, M., Liu, B., & Zhou, Z. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111198 · Cited by 6

Gpr35 Expression Mitigates Neuroinflammation and Enriches Gut Lactobacillus to Relieve Parkinson’s Disease

Meng, T., Zhang, Y., Fu, S., & Ma, S. (2025) · Research · doi:10.34133/research.0846 · Cited by 6

Probiotics and Cognitive-Related Health Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Controlled Trials

Liu, X., Ning, L., Fan, W., Jia, C., & Ge, L. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf156 · Cited by 6

The microbiota–gut–brain axis theory: A new perspective to unlock the pathological mechanism of constipation

Wan, M., Liu, W., Liu, Y., Jiang, S., Jiang, S., & Duan, J. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156236 · Cited by 7

Inulin alleviates high-salt diet-induced cognitive impairment: A study on multi-target regulation mechanisms via the gut-brain axis

Gao, H., Guo, Q., Qu, Q., Liu, J., Yang, F., Gao, X. J., Li, P., Mu, Y., Li, D., & Tan, X. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117949 · Cited by 5

Crosstalk mechanisms among gut microbiota, novel programmed cell death, and macrophage polarization

Zhang, Z., & Qin, H. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108091 · Cited by 5

Chlorpyrifos induced dysregulation of arginine biosynthesis pathway aggravates Alzheimer’s disease progression in 5XFAD mice via microbiota-gut-brain axis crosstalk

Wang, J., Zhang, N., Tu, Z., Wu, Z., Yang, J., Chen, X., Lu, Y., Le, W., & Luo, R. (2026) · Environment International · doi:10.1016/j.envint.2026.110064 · Cited by 5

Chronic Starch-Based Microplastic Exposure Enhances the Risk of Alzheimer’s Disease in Mice by Perturbing the Gut–Brain Axis

Liu, J., Xia, P., Zhang, X., Shen, R., Tan, H., Zhang, Y., Chen, D., & Deng, Y. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c12289 · Cited by 5

Reimagining GSK-3β Therapeutics in Alzheimer’s Disease: From Inhibition to Activity Normalization and Targeted Degradation

Manni, E., Al‐kuraishy, H. M., Eisawy, R., Abdelaziz, A. M., & Batiha, G. E. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02518-9 · Cited by 5

Probiotics: A potential strategy for improving diabetes mellitus complicated with cognitive impairment

Shen, X., Zhao, F., Zhao, Z., Yu, J. Z., & Sun, Z. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127960 · Cited by 5

Gut Microbiota Dysbiosis Drives Early Alzheimer’s Pathogenesis via Microglial TREM2/SYK/NF-κB Signaling Axis

Tian, M., Wang, D., Zhang, C., Fan, J., Li, W., Liu, X., & Shi, J. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00173 · Cited by 5

Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer’s Disease

Chen, Y., Fang, L., Chen, S., Zhou, H., Fan, Y., Li, L., Li, J., Xu, J., Chen, Y., Ma, Y., et al. (2020) · BioMed Research International · doi:10.1155/2020/8456596 · Cited by 153

The role of gut microbiota in the pathogenesis of Alzheimer’s disease: A review of the literature

Steć, G., Brzyska, A., Siemianowski, J., Kotnis, W., Pawlak, M., Prolejko, S., Gajęcki, B., Kopala, J., Kucharski, T., & Buczek, W. (2025) · Medical Science · doi:10.54905/disssi.v29i163.e165ms3654

Bacteroides Fragilis in the gut microbiomes of Alzheimer’s disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice

Xia, Y., Xiao, Y., Wang, Z.-H., Liu, X., Alam, A. M., Haran, J. P., McCormick, B. A., Shu, X., Wang, X., & Ye, K. (2023) · Nature Communications · doi:10.1038/s41467-023-41283-w · Cited by 108

Alzheimer’s disease pathology programmed by gut-derived disparity: A comprehensive understanding of neurodegenerationPreprint

Khabbaz, A., Hasani, A., Sadigh‐Eteghad, S., Hosseinzadeh, N., Hejazian, S. S., Hasani, R., Ahmadi, S., & Hasani, A. (2023) · doi:10.22541/au.168014711.14847244/v1