Effect of testosterone cypionate on postexercise ST segment depression.
Open accessAbstract
A randomised double blind study was carried out with 50 men who had ST segment depression of 0.1 mV or more after a modified two-step exercise test. Rate and duration of exercise were the same for the last of each subject's several pretreatment tests as for his tests after 4 and 8 weeks of treatment with placebo or testosterone cypionate, 200 mg, intramuscularly weekly. The sum of ST segment depression in leads II, V4, V5, and V6 taken immediately, and 2, 4, and 6 minutes after exercise did not change significantly after 4 or 8 weeks of placebo treatment, but did decrease by 32 per cent (P less than 0.0001) and 51 per cent (P less than 0.0001) after 4 and 8 weeks, respectively, of testosterone cypionate treatment. The mechanism by which testosterone cypionate treatment results in lessened postexercise ST segment depression is not established.
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Testosterone therapy with intramuscular, intravenous, and transdermal preparations has a beneficial anti-ischaemic effect in men with coronary disease.
“A number of research groups have reported that testosterone therapy with intramuscular, 14 intravenous, 15 and transdermal preparations had a beneficial anti-ischaemic effect in men with coronary disease.16”
From Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life (2004) · cites this paper as [14]
In the past 30 years, at least six studies of various design have reported effects of androgen therapy on coronary ischaemia; all but one reported a beneficial effect.
“In the past 30 years, at least six studies of various design have reported the effects of androgen therapy on coronary ischaemia 14-16 44-46 ; all but one have reported a beneficial effect.46”
From Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life (2004) · cites this paper as [14]
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- Authors
- Jaffe, M. D.
- Corresponding author
- Jaffe, M D
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1977-11-01
- Volume
- 39
- Issue
- 11
- Pages
- 1217-1222
- ISSN
- 1355-6037 (ISSN-L)
- PMC
- PMC483399
- OpenAlex
- W1973233466
- Cited by
- 155
- References
- 19
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 8 · 2012: 4
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- testosterone cypionate, exercise-induced ST-segment depression, androgen therapy, male hypogonadism, exercise testing, myocardial ischemia
- MeSH terms
- Adult, Aged, Blood Pressure, Clinical Trials as Topic, Coronary Disease, Electrocardiography, Exercise Test, Physical Exertion, Heart Rate, Humans, Male, Middle Aged, Testosterone
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