Cited by 130Smoking Behavior and CessationChronic Obstructive Pulmonary Disease (COPD) ResearchHealth Promotion and Cardiovascular Prevention

A randomised controlled trial of the effect on middle-aged men of advice to stop smoking.

Open access
Rose, G, Hamilton, P J·1978·Journal of Epidemiology and Community Health

Abstract

A randomised controlled trial of smoking cessation is reported in 1445 male smokers aged 40-59 at high risk of cardiorespiratory disease. The 714 men in the intervention group were recalled for a series of personal interviews with a doctor. After one year, 51% of the intervention group reported that they were not smoking any cigarettes, and most of the others reported a reduction. Compared with the "normal care" group, the men in the intervention group showed a decline in the prevalence of sputum production and dyspnoea; ventilatory function did not improve but its rate of decline was significantly slowed. There were no evident effects on blood pressure levels, nor on electrocardiographic findings over three years, nor on sickness absence over one year. Mortality follow-up has continued for an average of 7.9 years; 98 (13.7%) of the intervention group have died, compared with 94 (12.9%) of the "normal care" group. The 95% confidence limits on mortality range from 2.63% in favour of intervention to 4.37% in favour of normal care. The power of the trial has been reduced by smoking cessation in the "normal care" group. It is concluded that smoking cessation in these middle-aged men improved the symptoms and progress of chronic bronchitis; but the reversibility of the risk of cigarettes to the smoker's life may have been overestimated in observational studies.

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Crossref · 10.1136/jech.32.4.275

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  • The remaining two trials (n=807) reported no clear difference in the rates of smoking cessation among those randomized to nicotine e-cigarettes versus placebo e-cigarettes or nicotine gum at 6 to 12 months' followup.

    “The remaining two trials (n=807) reported no clear difference in the rates of smoking cessation among those randomized to nicotine e-cigarettes versus placebo e-cigarettes[76](#R76) or nicotine gum at 6 to 12 months’ followup.[89](#R89)”

    From Interventions for Tobacco Cessation in Adults, Including Pregnant Persons (2021) · cites this paper as [89]

    The CHOICE OF SAMPLE SIZE and COMPOSITION OF THE GROUPS sections describe a trial of doctors’ advice to stop smoking versus normal care, not nicotine e-cigarettes versus nicotine gum. The reported groups comprised 714 and 731 men, rather than the claimed two trials totaling 807 participants. (LLM, conf=0.88)

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  • One randomized clinical trial (N=1,445) reported the results of a behavioral tobacco cessation intervention on health outcomes.

    “One RCT (N=1,445) reported the results of a behavioral tobacco cessation intervention on health outcomes.[91](#R91)”

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Research works printed but not linked: 1

  1. [3]3. Kahn, H. A. (1966). The Dorn study of smoking and mortality among US veterans: report on 84 years of observation. National Cancer Institute Monograph No. 19, pp. 1-125. Bethesda, Maryland.

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Authors
Rose, G., & Hamilton, P. J.
Affiliations
London School of Hygiene & Tropical Medicine (GB)
ORCID
Rose, G
Venue
Journal of Epidemiology and Community Health
Publisher
BMJ
Published
1978-12
Volume
32
Issue
4
Pages
275-281
ISSN
  • 0141-7681 (ISSN-L)
  • 1470-2738
OpenAlex
W2022009674
Cited by
129
References
11
Citations by year
2022: 2 · 2021: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 2
FWCI
9.05
Type
journal article
Language
en
Open access
Locations
  • Journal of Epidemiology & Community Health (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
London School of Hygiene and Tropical Medicine
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Keywords
smoking cessation, middle-aged men, chronic bronchitis, sputum production, dyspnea, cardiovascular risk, mortality, cardiopulmonary disease, blood pressure, electrocardiographic abnormalities, sick leave
MeSH terms
Absenteeism, Smoking Prevention, Blood Pressure, Bronchitis, Clinical Trials as Topic, Coronary Disease, Dyspnea, Humans, Male, Middle Aged, Random Allocation, Respiratory Function Tests, Smoking

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