CIRCADIAN RHYTHMS: Basic Neurobiology and Clinical Applications

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

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Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms.

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A retinohypothalamic projection in the rat

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Persistence of circadian rhythmicity in a mammalian hypothalamic “island” containing the suprachiasmatic nucleus

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The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia

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Melatonin and the Mammalian Pineal Gland

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Neurophysiology of the suprachiasmatic circadian pacemaker in rodents

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Circadian Rhythms in Cultured Mammalian Retina

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Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve

Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992) · Chronobiology International · doi:10.3109/07420529209064550 · Cited by 693 · see citing works

Suppression of Melatonin Secretion in Some Blind Patients by Exposure to Bright Light

Czeisler, C. A., Shanahan, T. L., Klerman, E. B., Martens, H., Brotman, D. J., Emens, J. S., Klein, T., & Rizzo, J. F. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501053320102 · Cited by 654 · see citing works

A human phase-response curve to light

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Melatonin receptors: Localization, molecular pharmacology and physiological significance

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The Circadian System of Man

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Resetting the Biological Clock: Mediation of Nocturnal Circadian Shifts by Glutamate and NO

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Circadian rhythmicity restored by neural transplant. Immunocytochemical characterization of the graft and its integration with the host brain

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GABA is the principal neurotransmitter of the circadian system

Moore, R. Y., & Speh, J. C. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90120-a · Cited by 555 · see citing works

The Circadian System of Man

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Retinohypothalamic projection in mammals: a comparative study

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Light-Induced Degradation of TIMELESS and Entrainment of the Drosophila Circadian Clock

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Neuropeptide Y: Role in light-dark cycle entrainment of hamster circadian rhythms

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Effects of melatonin on vertebrate circadian systems

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Neural control of the pineal gland

Moore, R. Y. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00083-6 · Cited by 385 · see citing works

Changes in the Sleep and Waking EEGs of Nondemented and Demented Elderly Subjects

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The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells

Moore, R. Y., Speh, J. C., & Card, J. P. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903520304 · Cited by 350 · see citing works

Melatonin Replacement Therapy of Elderly Insomniacs

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Loss of entrainment and anatomical plasticity after lesions of the hamster retinohypothalamic tract

Johnson, R. F., Moore, R. Y., & Morin, L. P. (1988) · Brain Research · doi:10.1016/0006-8993(88)90374-5 · Cited by 325 · see citing works

Intergeniculate leaflet: An anatomically and functionally distinct subdivision of the lateral geniculate complex

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Circadian rhythms of melatonin and cortisol in aging

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Chapter 8 Entrainment pathways and the functional organization of the circadian system

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Changes in circadian rhythms and sleep quality with aging: Mechanisms and interventions

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In defense of cell volume?

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Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: A case study

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Dark Goggles and Bright Light Improve Circadian Rhythm Adaptation to Night-Shift Work

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Comparative Anatomy of the Mammalian Hypothalamic Suprachiasmatic Nucleus

Cassone, V. M., Speh, J. C., Card, J. P., & Moore, R. Y. (1988) · Journal of Biological Rhythms · doi:10.1177/074873048800300106 · Cited by 182 · see citing works

Lateral geniculate lesions block circadian phase-shift responses to a benzodiazepine.

Johnson, R. F., Smale, L., Moore, R. Y., & Morin, L. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5301 · Cited by 181 · see citing works

Synaptogenesis in the rat suprachiasmatic nucleus demonstrated by electron microscopy and synapsin I immunoreactivity

Moore, R. Y., & Bernstein, M. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-06-02151.1989 · Cited by 177 · see citing works

Lateral geniculate lesions alter circadian activity rhythms in the hamster

Johnson, R. F., Moore, R. Y., & Morin, L. P. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90068-3 · Cited by 167 · see citing works

Effects of Stimulated Physical Activity on the Circadian Pacemaker of Vertebrates 1

Turek, F. W. (1989) · Journal of Biological Rhythms · doi:10.1177/074873048900400204 · Cited by 163 · see citing works

Chronopharmacology: Cellular and biochemical interactions

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Circadian actions of melatonin at the suprachiasmatic nucleus

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Chronopharmacology; Cellular and biochemical interactions

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Local administration of EAA antagonists blocks light-induced phase shifts and c-fos expression in hamster SCN

Rea, M. A., Buckley, B. A., & Lutton, L. M. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.5.r1191 · Cited by 125 · see citing works

Large phase-shifts of circadian rhythms caused by induced running in a re-entrainment paradigm: The role of pulse duration and light

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Neuropeptide Y and optic chiasm stimulation of affect suprachiasmatic nucleus circadian function in vitro

Shibata, S., & Moore, R. Y. (1993) · Brain Research · doi:10.1016/0006-8993(93)91118-c · Cited by 98 · see citing works

Phase shifting the human circadian clock using melatonin

Lewy, A. J., Ahmed, S., & Sack, R. L. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00084-8 · Cited by 94 · see citing works

Sensitivity of the Human Circadian Pacemaker to Moderately Bright Light

Boivin, D. B., Duffy, J. F., Kronauer, R. E., & Czeisler, C. A. (1994) · Journal of Biological Rhythms · doi:10.1177/074873049400900311 · Cited by 91 · see citing works

Glutamate shifts the phase of the circadian neuronal firing rhythm in the rat suprachiasmatic nucleus in vitro

Shirakawa, T., & Moore, R. Y. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90286-0 · Cited by 91 · see citing works

The circadian system and the therapeutics of the affective disorders

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Electrical and metabolic activity of suprachiasmatic nucleus neurons in hamster hypothalamic slices.

Shibata, S., & Moore, R. (1988) · Brain Research · doi:10.1016/0006-8993(88)91367-4 · Cited by 88 · see citing works

Neural control of pineal function in mammals and birds.

Moore, R. Y. (1978) · PubMed · Cited by 72 · see citing works

Circadian Temperature Variation in Healthy Aged and in Alzheimer's Disease

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Preliminary Studies on the Immediate Phase-Shifting Effects of Light and Exercise on the Human Circadian Clock

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Glutamic Acid Decarboxylase Message Isoforms in Human Suprachiasmatic Nucleus

Gao, B., & Moore, R. Y. (1996) · Journal of Biological Rhythms · doi:10.1177/074873049601100209 · Cited by 28 · see citing works

Chronobiology Implications for cancer chemotherapy

Bjarnason, G. A. (1995) · Acta Oncologica · doi:10.3109/02841869509094037 · Cited by 27 · see citing works

Special Topic: Circadian Rhythms

Menaker, M. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.003301 · Cited by 7 · see citing works

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329 · see citing works

Sleep Patterns and Predictors of Disturbed Sleep in a Large Population of College Students

Lund, H. G., Reider, B. D., Whiting, A. B., & Prichard, J. R. (2010) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2009.06.016 · Cited by 1,907 · see citing works

Mop3 is an essential component of the master circadian pacemaker in mammals.

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Molecular analysis of mammalian circadian rhythms

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Sleep, circadian rhythms, and delayed phase in adolescence

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Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus

Yamaguchi, S., Isejima, H., Matsuo, T., Okura, R., Yagita, K., Kobayashi, M., & Okamura, H. (2003) · Science · doi:10.1126/science.1089287 · Cited by 934 · see citing works

Melatonin: Nature’s most versatile biological signal?

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Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

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The cortisol awakening response: More than a measure of HPA axis function

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Light activates the adrenal gland: Timing of gene expression and glucocorticoid release

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The Trigeminovascular System in Humans: Pathophysiologic Implications for Primary Headache Syndromes of the Neural Influences on the Cerebral Circulation

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Association of intrinsic circadian period with morningness–eveningness, usual wake time, and circadian phase.

Duffy, J. F., Rimmer, D. W., & Czeisler, C. A. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.895 · Cited by 571 · see citing works

Relationship of Endogenous Circadian Melatonin and Temperature Rhythms to Self-Reported Preference for Morning or Evening Activity in Young and Older People

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Pathophysiology of cluster headache: a trigeminal autonomic cephalgia

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Oscillation quenching mechanisms: Amplitude vs. oscillation death

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Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes

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Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses

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Metabolism and the Control of Circadian Rhythms

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A model of phototransduction by the human circadian system

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The short-period mutant, toc1-1, alters circadian clock regulation of multiple outputs throughout development in Arabidopsis thaliana

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Melatonin and sleep in aging population

Pandi-Perumal, S. R., Zisapel, N., Srinivasan, V. J., & Cardinali, D. P. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.08.009 · Cited by 367 · see citing works

PET and MRA findings in cluster headache and MRA in experimental pain

May, A., Bahra, A., Büchel, C., Frackowiak, R. S. J., & Goadsby, P. J. (2000) · Neurology · doi:10.1212/wnl.55.9.1328 · Cited by 336 · see citing works

Impact of Circadian Disruption on Cardiovascular Function and Disease

Chellappa, S. L., Vujović, N., Williams, J. S., & Scheer, F. A. J. L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.008 · Cited by 333 · see citing works

GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation

Lowrey, P. L., & Takahashi, J. S. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.533 · Cited by 293 · see citing works

Differential modulation of nociceptive dural input to 6hypocretin9 orexin A and B receptor activation in the posterior hypothalamic area*1

Bartsch, T., Levy, M. J., Knight, Y. E., & Goadsby, P. J. (2004) · Pain · doi:10.1016/j.pain.2004.02.005 · Cited by 305 · see citing works

Cellular circadian clocks in the pineal

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Synchronization patterns and chimera states in complex networks: Interplay of topology and dynamics

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Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat‐1 fibroblasts

Yagita, K., & Okamura, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01724-x · Cited by 258 · see citing works

A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus

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A clinical approach to circadian rhythm sleep disorders

Barion, A., & Zee, P. C. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.017 · Cited by 214 · see citing works

Sleep and sleep disturbances: biological basis and clinical implications

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Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease

Savaskan, E., Ayoub, M. A., Ravid, R., Angeloni, D., FRASCHINI, F., Meier, F., Eckert, A., Müller-Spahn, F., & Jockers, R. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00169.x · Cited by 207 · see citing works

Inversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome

Leersnyder, H. D., de Blois, M., Claustrat, B., Romana, S. P., Albrecht, U., von Kleist-Retzow, J., Delobel, B., Viot, G., Lyonnet, S., Vekemans, M. J. J., et al. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.115018 · Cited by 198 · see citing works

Suprachiasmatic nucleus: a central autonomic clock

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p53 regulates Period2 expression and the circadian clock

Miki, T., Matsumoto, T., Zhao, Z., & Lee, C. C. (2013) · Nature Communications · doi:10.1038/ncomms3444 · Cited by 184 · see citing works

Angiotensin II Induces Circadian Gene Expression of Clock Genes in Cultured Vascular Smooth Muscle Cells

Nonaka, H., Emoto, N., Ikeda, K., Fukuya, H., Rohman, M. S., Raharjo, S. B., Yagita, K., Okamura, H., & Yokoyama, M. (2001) · Circulation · doi:10.1161/hc4001.098048 · Cited by 183 · see citing works

Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders

Charrier, A., Olliac, B., Roubertoux, P. L., & Tordjman, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050938 · Cited by 182 · see citing works

Hypothalamic Deep Brain Stimulation in Positron Emission Tomography

May, A., Leone, M., Boecker, H., Sprenger, T., Juergens, T., Bussone, G., & Tölle, T. R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4609-05.2006 · Cited by 180 · see citing works

Melatonin receptors in rat hippocampus: molecular and functional investigations

Mußhoff, U., Riewenherm, D., Berger, E., Fauteck, J., & Speckmann, E. (2002) · Hippocampus · doi:10.1002/hipo.1105 · Cited by 169 · see citing works

Individual differences in light sensitivity affect sleep and circadian rhythms

Chellappa, S. L. (2021) · Sleep · doi:10.1093/sleep/zsaa214 · Cited by 163 · see citing works

BMAL1 Shuttling Controls Transactivation and Degradation of the CLOCK/BMAL1 Heterodimer

Kwon, I., Lee, J., Chang, S. H., Jung, N. C., Lee, B. J., Son, G. H., Kim, K., & Lee, K. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00337-06 · Cited by 163 · see citing works

Attenuated Circadian Rhythms in Mice Lacking theProkineticin 2Gene

Li, J., Hu, W., Boehmer, L. N., Cheng, M., Lee, A. G., Jilek, A., Siegel, J. M., & Zhou, Q. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3679-06.2006 · Cited by 160 · see citing works

Cycled light in the intensive care unit for preterm and low birth weight infants

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Gradients in the circadian expression of Per1 and Per2 genes in the rat suprachiasmatic nucleus

Yan, L., & Okamura, H. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01955.x · Cited by 146 · see citing works

Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression

Won, E., Na, K., & Kim, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010305 · Cited by 146 · see citing works

Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines

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