Cerebrospinal fluid -amyloid 1-42 concentration may predict cognitive decline in older women
Open accessAbstract
BACKGROUND: Low levels of cerebrospinal fluid (CSF) beta-amyloid 1-42 (Abeta42) and high total tau (T-tau) are diagnostic for manifest Alzheimer's disease. It is not known, however, whether these biomarkers may be risk indicators for cognitive decline in otherwise healthy older people. METHODS: The longitudinal relationship between CSF markers, Abeta42 and T-tau, measured in 1992, and change in Mini-Mental State Examination (deltaMMSE) score between 1992 and 2002 were investigated in 55 women (aged 70-84 years, mean (SD) MMSE score = 28.3 (1.5)), who were participants in the Prospective Population Study of Women in Gothenburg, Sweden. These women did not have dementia when they experienced lumbar puncture in 1992-3. RESULTS: Over the 8-year follow-up period, deltaMMSE (range = +3 to -21 points) was correlated with Abeta42 (Spearman's r = 0.40, p = 0.002), such that lower levels of Abeta42 were related to greater decline. This was also observed after excluding 4 women who developed dementia between 1992 and 2002 (Spearman's r = 0.34, p = 0.019). A multivariate logistic regression model predicting a decline of > or = 5 points on the MMSE (observed in six women), or a risk of developing dementia over the 8-year follow-up period (observed in four women), including age, education, Abeta42 and T-tau as covariates, showed that Abeta42 was the sole predictor of significant cognitive decline or dementia (OR per 100 pg/ml Abeta42 = 2.24, 95% CI 1.19 to 4.22, p = 0.013). CONCLUSIONS: Low levels of CSF Abeta42 may predict cognitive decline among older women without dementia.
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Cognitively unimpaired individuals with abnormal amyloid biomarkers have more rapid progression of atrophy, hypometabolism, and clinical/cognitive decline than individuals without biomarker evidence of Aβ deposition.
“Numerous studies have shown that CU individuals with abnormal amyloid biomarkers have more rapid progression of atrophy, hypometabolism, and clinical/cognitive decline than individuals without biomarker evidence of Aβ deposition [13,33,80,93–99]”
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- Authors
- Gustafson, D. R., Skoog, I., Rosengren, L., Zetterberg, H., & Blennow, K.
- Affiliations
- University of Gothenburg (SE)
- Corresponding author
- Gustafson, D. R
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2006-10-20
- Volume
- 78
- Issue
- 5
- Pages
- 461-464
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC2117838
- OpenAlex
- W2075275965
- Cited by
- 214
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 8 · 2020: 11 · 2019: 9 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 21 · 2014: 16 · 2013: 16 · 2012: 23
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (5r03ag026098-02)
- National Institute on Aging (1R03AG026098-01A1, R03 AG026098)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebrospinal fluid, amyloid-beta 42, total tau, cognitive decline, dementia risk, Alzheimer's disease biomarkers, older women, Mini-Mental State Examination, lumbar puncture, dementia prediction
- MeSH terms
- Aged, Aged, 80 and over, Cognition Disorders, Dementia, Female, Humans, Longitudinal Studies, Mental Status Schedule, Peptide Fragments, Predictive Value of Tests, Risk Factors, Biomarkers, Amyloid beta-Peptides
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