Cited by 70Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCerebrospinal fluid and hydrocephalus

The application of cerebrospinal fluid biomarkers in early diagnosis of Alzheimer disease

Blennow, Kaj, Zetterberg, Henrik·2013·Medical Clinics of North America

Abstract

This article gives an updated account of the clinical application of cerebrospinal fluid (CSF) biomarkers for Alzheimer disease (AD). The clinically most relevant biomarkers, total tau, phospho-tau and Aβ42 are discussed, and how they may be used, together with other diagnostic investigations, to make a predementia diagnosis of AD. Recent findings in sporadic and genetic preclinical AD are also discussed and, more specifically, what the biomarkers have taught us on the sequence of events in the pathogenic process underlying AD.

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Crossref · 10.1016/j.mcna.2012.12.012

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Authors
Blennow, K., & Zetterberg, H.
Affiliations
University of Gothenburg (SE)
Corresponding author
Blennow, Kaj
Venue
Medical Clinics of North America
Publisher
Elsevier BV
Published
2013-05
Volume
97
Issue
3
Pages
369-376
ISSN
0025-7125 (ISSN-L)
OpenAlex
W1985030911
Cited by
69
References
42
Citations by year
2025: 3 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 12 · 2014: 16 · 2013: 5
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Locations
  • Medical Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords
Alzheimer's disease, cerebrospinal fluid biomarkers, early diagnosis, total tau, phosphorylated tau, amyloid-beta 42, preclinical Alzheimer's disease, sporadic Alzheimer's disease, Alzheimer disease pathogenesis
MeSH terms
Aged, Alzheimer Disease, Atrophy, Brain, Humans, Magnetic Resonance Imaging, Nerve Degeneration, Neurons, Peptide Fragments, Phosphorylation, Predictive Value of Tests, Software Design, Synapses, Biomarkers, Amyloid beta-Peptides, tau Proteins, Genetic Predisposition to Disease, Early Diagnosis, Positron-Emission Tomography, Asymptomatic Diseases, Cognitive Dysfunction, Prodromal Symptoms

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