Why is the amyloid beta peptide of Alzheimer’s disease neurotoxic?

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

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Copper, iron and zinc in Alzheimer's disease senile plaques

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The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

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3D structure of Alzheimer's amyloid-β(1–42) fibrils

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Intracellular amyloid-β in Alzheimer's disease

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Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)

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Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

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Amyloid pores from pathogenic mutations

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

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Experimental Constraints on Quaternary Structure in Alzheimer's β-Amyloid Fibrils

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Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

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Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

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Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

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Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

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Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand

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Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

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Opposing activities protect against age-onset proteotoxicity

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Oxidative Alterations in Alzheimer's Disease

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Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

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Amyloid diseases: Abnormal protein aggregation in neurodegeneration

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Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides: Identification of an Attomolar‐Affinity Copper Binding Site on Amyloid β1‐42

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Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

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Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies

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Isoform-specific binding of apolipoprotein E to beta-amyloid.

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Solution Structure of Amyloid β-Peptide(1−40) in a Water−Micelle Environment. Is the Membrane-Spanning Domain Where We Think It Is?,

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Regulation of APP cleavage by α‐, β‐ and γ‐secretases

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Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies

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Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease

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Different Conformations of Amyloid β Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons

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Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion

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Amyloid Precursor Protein, Presenilins, and α-Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer’s Disease

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Copper Binding to the Amyloid-β (Aβ) Peptide Associated with Alzheimer's Disease

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Intracellular accumulation of β-amyloid1–42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer’s disease

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Assembly of Aβ Amyloid Protofibrils: An in Vitro Model for a Possible Early Event in Alzheimer's Disease

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Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

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Amyloid Peptide Aβ1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors

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M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice

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SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

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Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc

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Lipid peroxidation products and antioxidants in human disease.

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Different Mechanisms of Oxidative Stress and Neurotoxicity for Alzheimer‘s Aβ(1−42) and Aβ(25−35)

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The Alzheimer's Peptide Aβ Adopts a Collapsed Coil Structure in Water

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Structure of Amyloid A4‐(1–40)‐Peptide of Alzheimer's Disease

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Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Aβ42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease

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Deciphering the Genetic Basis of Alzheimer's Disease

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Certain Inhibitors of Synthetic Amyloid β-Peptide (Aβ) Fibrillogenesis Block Oligomerization of Natural Aβ and Thereby Rescue Long-Term Potentiation

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Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target

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Increased Superoxide Production in Coronary Arteries in Hyperhomocysteinemia

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Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer’s disease

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Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain.

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High-resolution Atomic Force Microscopy of Soluble Aβ42 Oligomers

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Controlling Amyloid β-Peptide Fibril Formation with Protease-stable Ligands

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Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease

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Fresh and globular amyloid β protein (1–42) induces rapid cellular degeneration: evidence for AβP channel‐mediated cellular toxicity

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Novel Metabolism of Docosahexaenoic Acid in Neural Cells

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Reduction of amyloid load and cerebral damage in transgenic mouse model of Alzheimer's disease by treatment with a β‐sheet breaker peptide

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Tau-dependent microtubule disassembly initiated by prefibrillar β-amyloid

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Cerebrospinal fluid -amyloid 1-42 concentration may predict cognitive decline in older women

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Homocysteine-Induced Inhibition of Endothelium-Dependent Relaxation in Rabbit Aorta

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Pharmacological Profiles of Peptide Drug Candidates for the Treatment of Alzheimer's Disease

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Oligomerization and Toxicity of β-Amyloid-42 Implicated in Alzheimer's Disease

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N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure

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Inhibitors of Amyloid Toxicity Based on β-sheet Packing of Aβ40 and Aβ42

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Models of β-Amyloid Ion Channels in the Membrane Suggest That Channel Formation in the Bilayer Is a Dynamic Process

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Oxidation of Cholesterol by Amyloid Precursor Protein and β-Amyloid Peptide

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Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease

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Vascular oxidative stress in Alzheimer disease

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Approaches to discovery and characterization of inhibitors of amyloid β-peptide polymerization

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Amyloid-β-Induced Mitochondrial Dysfunction

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Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease

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Amyloid-β Binds Cu ²⁺ in a Mononuclear Metal Ion Binding Site

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Pathogenesis of cerebral amyloid angiopathy

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Effects of Structure on αC−H Bond Enthalpies of Amino Acid Residues: Relevance to H Transfers in Enzyme Mechanisms and in Protein Oxidation

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Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicity

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Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red.

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Oxidative processes in Alzheimer's disease: the role of Aβ-metal interactions

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Promotion of transition metal-induced reactive oxygen species formation by β-amyloid

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