A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up
Open accessAbstract
Objective The authors assessed whether brain changes detected by diffusion tensor (DT) MRI can improve the understanding of structural damage in Alzheimer's disease (AD) and are associated with different risks of conversion to AD in amnestic mild cognitive impairment (aMCI). Methods Twenty-one aMCI patients, 21 AD patients and 20 healthy subjects underwent conventional and DT MRI at baseline. All subjects were clinically followed up over 2 years; at the end of follow-up, aMCI were grouped into converters to AD (aMCI-C) and non-converters (aMCI-NC). The mean diffusivity (MD) and fractional anisotropy (FA) were obtained from total grey matter (GM) and white matter (WM), and from several GM and WM regions of interest (ROIs). On T1-weighted images, normalised volumes of the whole brain (NBV), GM (NGMV) and WM were measured. Results A significant 'trend' of worsening with a trajectory 'normal/aMCI/AD' was found for NBV and NGMV, total GM and WM MD, total WM FA, as well as for diffusivity abnormalities in several GM and WM ROIs, mainly located in posterior brain regions. aMCI-C had GM and WM changes similar to those seen in AD, whereas aMCI-NC showed a DT MRI pattern similar to that of healthy subjects. DT MRI metrics that better distinguished aMCI-C from aMCI-NC were MD of total GM and WM, hippocampi, anterior insulae, frontal and parietal WM, occipital GM and WM, and FA of temporal WM. Volumetric variables were not able to distinguish the two aMCI subgroups (aMCI-C and aMCI-NC).…
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Previous studies reported increases of mean diffusivity in mild cognitive impairment patients that converted to Alzheimer's disease compared to mild cognitive impairment subjects that remained stable over several years.
“as well as in MCI patients that converted to AD compared to MCI subjects that remained stable over a period of several years (Douaud et al., 2013, Fellgiebel et al., 2006, Scola et al., 2010, van Uden et al., 2016).”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Scola et al., 2010
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- Authors
- Scola, E., Bozzali, M., Agosta, F., Magnani, G., Franceschi, M., Sormani, M. P., Cercignani, M., Pagani, E., Falautano, M., Filippi, M., & Falini, A.
- Affiliations
- IRCCS Ospedale San Raffaele (IT)
- Fondazione Santa Lucia (IT)
- MultiMedica (IT)
- UCL Queen Square Institute of Neurology (GB)
- ORCID
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2010-04-14
- Volume
- 81
- Issue
- 7
- Pages
- 798-805
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W1995269864
- Cited by
- 98
- References
- 2
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 9
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (publishedVersion)
- HAL (submittedVersion, other-oa)
- Figshare (submittedVersion, cc-by)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- amnestic mild cognitive impairment, Alzheimer's disease, conversion to Alzheimer's disease, diffusion tensor imaging, mean diffusivity, fractional anisotropy, white matter microstructural damage, brain atrophy, hippocampus, posterior brain regions, prodromal Alzheimer's disease
- MeSH terms
- Aged, Alzheimer Disease, Amnesia, Brain, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Software, Infarction, Middle Cerebral Artery, Diffusion Magnetic Resonance Imaging
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