Selected Findings from the Religious Orders Study and Rush Memory and Aging Project
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The Religious Orders Study and the Rush Memory and Aging Project are both cohort studies of aging and dementia that include organ donation at death. Together, more than 2,700 persons have agreed to annual clinical evaluation and brain donation at death. A subset of participants also participated in a substudy that included ante-mortem imaging. We highlight recent findings that have been highly cited over the past five years. The findings fall into three general categories. The first relates to the neuropathology of probable Alzheimer's disease, mild cognitive impairment, and those without dementia or mild cognitive impairment. The second relates to risk factors for Alzheimer's disease and neuropathology. The third are clinical and imaging studies of mild cognitive impairment. The findings illustrate the range of insights that can be gained into cognitive aging by incorporating neuropathologic indices into well designed, prospective cohort studies.
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AD pathology (mainly neurofibrillary tangles and neuritic plaques) is the main morphological substrate of clinical dementia.
“These data add further evidence for AD pathology (mainly neurofibrillary tangles and neuritic plaques) being the main morphological substrate of clinical dementia [51],[79],[80].”
From The overlap between vascular disease and Alzheimer’s disease - lessons from pathology (2014) · cites this paper as [51]
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Self-citationAlzheimer’s Disease and ncRNAs
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Watershed microinfarct pathology and cognition in older persons
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Self-citation
- Authors
- Bennett, D. A., Wilson, R. S., Arvanitakis, Z., Boyle, P. A., de Toledo-Morrell, L., & Schneider, J. A.
- Affiliations
- Rush University Medical Center (US)
- Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2012-12-27
- Volume
- 33
- Issue
- s1
- Pages
- S397-S403
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC3434299
- OpenAlex
- W1789491764
- Cited by
- 69
- References
- 67
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 3
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG017917, P30-AG 10161, P01 AG09466, R01-AG34374, R01‐AG17917, R01 AG15819, R01AG015819, P30AG010161, P01AG009466, R01AG034374)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- Alzheimer's disease, mild cognitive impairment
- MeSH terms
- Aging, Brain, Cognition Disorders, Dementia, Humans, Memory, Neuropsychological Tests, Cohort Studies
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