Cited by 69Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAging and Gerontology Research

Selected Findings from the Religious Orders Study and Rush Memory and Aging Project

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Bennett, David A., Wilson, Robert S., Arvanitakis, Zoe, Boyle, Patricia A., de Toledo-Morrell, Leyla, Schneider, Julie A.·2012·Journal of Alzheimer's Disease

Abstract

The Religious Orders Study and the Rush Memory and Aging Project are both cohort studies of aging and dementia that include organ donation at death. Together, more than 2,700 persons have agreed to annual clinical evaluation and brain donation at death. A subset of participants also participated in a substudy that included ante-mortem imaging. We highlight recent findings that have been highly cited over the past five years. The findings fall into three general categories. The first relates to the neuropathology of probable Alzheimer's disease, mild cognitive impairment, and those without dementia or mild cognitive impairment. The second relates to risk factors for Alzheimer's disease and neuropathology. The third are clinical and imaging studies of mild cognitive impairment. The findings illustrate the range of insights that can be gained into cognitive aging by incorporating neuropathologic indices into well designed, prospective cohort studies.

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  • AD pathology (mainly neurofibrillary tangles and neuritic plaques) is the main morphological substrate of clinical dementia.

    “These data add further evidence for AD pathology (mainly neurofibrillary tangles and neuritic plaques) being the main morphological substrate of clinical dementia [51],[79],[80].”

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  1. [36]James BD Bennett DA Boyle PA Leurgans S Schneider JA Dementia in the old versus oldest old: the role of Alzheimer's and mixed pathologies Journal of the American Medical Association In press

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Authors
Bennett, D. A., Wilson, R. S., Arvanitakis, Z., Boyle, P. A., de Toledo-Morrell, L., & Schneider, J. A.
Affiliations
  • Rush University Medical Center (US)
  • Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Venue
Journal of Alzheimer's Disease
Published
2012-12-27
Volume
33
Issue
s1
Pages
S397-S403
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1789491764
Cited by
69
References
67
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 3
FWCI
3.42
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG017917, P30-AG 10161, P01 AG09466, R01-AG34374, R01‐AG17917, R01 AG15819, R01AG015819, P30AG010161, P01AG009466, R01AG034374)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
Keywords
Alzheimer's disease, mild cognitive impairment
MeSH terms
Aging, Brain, Cognition Disorders, Dementia, Humans, Memory, Neuropsychological Tests, Cohort Studies

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