The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The nerve lesion in the carpal tunnel syndrome.
Open accessAbstract
The relative roles of pressure deformation and ischaemia in the production of compression nerve lesions remain a controversial issue. This paper concerns the genesis of the structural changes which follow compression of the median nerve in the carpal tunnel. The initial lesion is an intrafunicular anoxia caused by obstruction to the venous return from the funiculi as the result of increased pressure in the tunnel. This leads to intrafunicular oedema and an increase in intrafunicular pressure which imperil and finally destroy nerve fibres by impairing their blood supply and by compression. The final outcome is the fibrous tissue replacement of the contents of the funiculi.
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Citations
Cites
THE INTRANEURAL TOPOGRAPHY OF THE RADIAL, MEDIAN AND ULNAR NERVES
SUNDERLAND, S. (1945) · Brain · doi:10.1093/brain/68.4.243 · Cited by 426 · cited 3×
“They concluded that the findings pointed to a mechanical rather than an ischaemic cause for the fibre damage.”
BackgroundSelf-citationThe connective tissues of peripheral nerves
SUNDERLAND, S. (1965) · Brain · doi:10.1093/brain/88.4.841 · Cited by 199 · cited 1×
“PERINEURIUM Because of its tensile strength, the elastic perineurium resists and maintains an intrafunicular pressure (Sunderland, 1946, 1965; Sunderland and Bradley, 1952).”
BackgroundSelf-citationThe cross-sectional area of peripheral nerve trunks devoted to nerve fibres
SUNDERLAND, S., & BRADLEY, K. C. (1949) · Brain · doi:10.1093/brain/72.3.428 · Cited by 104 · cited 1×
“…the carpal tunnel the number of bundles constituting the median nerve varies from six to 40 with an average of 24 (20 specimens, Sunderland, 1945a) while the crosssectional area of the nerve devoted to the funiculi varies from 30 to 70% with an average value of 42% (Sunderland and Bradley, 1949).”
BackgroundSelf-citation
Cited by
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
Lundborg, G., Myers, R., & Powell, H. (1983) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.46.12.1119 · Cited by 316
Nerve and tendon gliding exercises and the conservative management of carpal tunnel syndrome
Rozmaryn, L. M., Dovelle, S., Rothman, E. R., Gorman, K., Olvey, K. M., & Bartko, J. J. (1998) · Journal of Hand Therapy · doi:10.1016/s0894-1130(98)80035-5 · Cited by 214
Metadata
- Authors
- Sunderland, S.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1976-07-01
- Volume
- 39
- Issue
- 7
- Pages
- 615-626
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2031692545
- Cited by
- 302
- References
- 3
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sunderland, S. (1976). The nerve lesion in the carpal tunnel syndrome. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.39.7.615
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
