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Cited by 3,481Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingDeep Brain Stimulation and Movement Disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

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Gibb, W R, Lees, A J·1988·Journal of Neurology, Neurosurgery & Psychiatry
DOI 10.1136/jnnp.51.6.745PMC PMC1033142
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Abstract

The Lewy body is a distinctive neuronal inclusion that is always found in the substantia nigra and other specific brain regions in Parkinson's disease. It is mainly composed of structurally altered neurofilament, and occurs wherever there is excessive loss of neurons. It occurs in some elderly individuals and rarely in other degenerative diseases of the central nervous system. In 273 brains of patients dying from disorders other than Parkinson's disease, the age-specific prevalence of Lewy bodies increased from 3.8% to 12.8% between the sixth and ninth decades. Associated pathological findings suggest that these cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease. In view of the common and widespread occurrence of this disorder we propose that endogenous mechanisms operating in early life may be more important than environmental agents in the pathogenesis of Lewy bodies and Parkinson's disease.

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Citations

Cites

Research works printed but not linked: 7

  1. Gibb WRG. The Lewy body and Parkinson's disease. In: Clifford Rose F, ed. Parkinson's Disease: Clinical and Experimental Advances. London: John Libbey and Co, 1987:3-11.
  2. Oppenheimer D. Neuropathology of progressive autonomic failure. In: Bannister R, ed. Autonomic failure. Oxford University Press, London, 1983:267-83.
  3. Sigwald J, Lapresle J, Raverdy P, Recondo NJ. Atrophie cerebelleuse familiale avec association de lesions nigeriennes et spinales. Presse Med 1964;72:557-62.
  4. Vogt C, Vogt 0. Erkrankungen der GroBhirnrinde im Lichte der Topistik, Pathoklise und Pathoarchitektonik. J Psychol Neurol 1922;28:1-171.
  5. Hamada S, Ishii T. The Lewy body in the brain of the aged. Adv Neurol Sci 1963;7:184-6.
  6. Hirai S. Ageing of the substantia nigra. Adv Neurol Sci 1968;12:845-9.
  7. Hassler R. Zur Pathologie der Paralysis agitans und des postenzephalitischen Parkinsonismus. J Psychol Neurol 1938;48:387-476.

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Metadata

Authors
Gibb, W. R., & Lees, A. J.
ORCID
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
1988-06-01
Volume
51
Issue
6
Pages
745-752
ISSN
0022-3050 (ISSN-L)
DOI
10.1136/jnnp.51.6.745
PMC
PMC1033142
OpenAlex
W2132881915
Semantic Scholar
354cd1cf28ad23a8038bb3c576ff7791b3c74543
Cited by
3,481
References
39
Citations by year
2026: 78 · 2025: 130 · 2024: 152 · 2023: 143 · 2022: 131 · 2021: 158 · 2020: 164 · 2019: 152 · 2018: 138 · 2017: 156 · 2016: 163 · 2015: 115 · 2014: 149 · 2013: 123 · 2012: 138
FWCI
3.24
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
Lewy bodies, Parkinson's disease, pathogenesis, neurofilaments, substantia nigra, incidental Lewy body disease, age-related prevalence, neuronal loss
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Brain, Brain Damage, Chronic, Inclusion Bodies, Child, Humans, Middle Aged, Nerve Degeneration, Parkinson Disease, Substantia Nigra

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