The substantia nigra and ventral tegmental area in Alzheimer’s disease and Down’s syndrome
Open accessAbstract
Degenerative changes in the substantia nigra and ventral tegmental area were investigated in 104 cases of Alzheimer's disease and 13 cases of Down's syndrome. Frequencies of tangles in three groups of patients with Alzheimer's disease were 86%, 44% and 46% (54% overall) respectively. About half of those with tangles, but no Lewy bodies, had excess nigral cell loss, and 16% had moderate or severe neuronal fallout, but none had a Parkinsonian syndrome. Cases with nigral tangles were younger, tended to have more hippocampal and cortical tangles and plaques, and lower activities of cortical choline acetyltransferase. In most cases of Alzheimer's disease degeneration in nigral and tegmental areas was greater than controls, and tangles were evenly distributed. All the cases of Down's syndrome had tangles in the nigra and eight showed mild cell loss. Mild degenerative changes accompanied by tangles in the substantia nigra and ventral tegmental area are common in Alzheimer's disease, but severe cell loss is rare. When a Parkinsonian syndrome occurs in Alzheimer's disease it is likely to be due to Lewy body pathology.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple studies have established an early link between AD and deficits in mesocorticolimbic DA signalling.
“multiple studies established an early link be tween AD and deficits in mesocorticolimbic DA signalling”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Gibb et al., 1989
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Progressive Supranuclear Palsy
Steele, J. C. (1964) · Archives of Neurology · doi:10.1001/archneur.1964.00460160003001 · Cited by 1,930 · see citing works
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159 · see citing works
Bondareff, W., Mountjoy, C. Q., & Roth, M. (1982) · Neurology · doi:10.1212/wnl.32.2.164 · Cited by 693 · see citing works
Self-citationA POST-MORTEM STUDY OF THE CHOLINERGIC AND GABA SYSTEMS IN SENILE DEMENTIA
Rossor, M. N., Garrett, N., Johnson, A. L., Mountjoy, C. Q., Roth, M., & Iversen, L. L. (1982) · Brain · doi:10.1093/brain/105.2.313 · Cited by 460 · see citing works
Self-citationCell loss in the locus coeruleus in senile dementia of Alzheimer type
Tomlinson, B. E., Irving, D., & Blessed, G. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90031-9 · Cited by 453 · see citing works
PARKINSONISM-DEMENTIA COMPLEX, AN ENDEMIC DISEASE ON THE ISLAND OF GUAM
Hirano, A., Kurland, L. T., Krooth, R. S., & Lessell, S. (1961) · Brain · doi:10.1093/brain/84.4.642 · Cited by 419 · see citing works
Alzheimer's disease in Down's syndrome: Clinicopathologic studies
Wisniewski, K. E., Dalton, A. J., McLachlan, D. R. C., Wen, G. Y., & Wisniewski, H. M. (1985) · Neurology · doi:10.1212/wnl.35.7.957 · Cited by 417 · see citing works
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1984) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1984.tb00351.x · Cited by 345 · see citing works
Self-citationBurger, P. C., & Vogel, F. S. (1973) · PubMed · Cited by 342 · see citing works
Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons
Yamamoto, T., & Hirano, A. (1985) · Annals of Neurology · doi:10.1002/ana.410170608 · Cited by 338 · see citing works
Aral, H., Kosaka, K., & Iizuka, R. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb00913.x · Cited by 308 · see citing works
Biochemical changes in Dementia disorders of Alzheimer type (AD/SDAT)
Gottfries, C., Adolfsson, R., Aquilonius, S., Carlsson, A., Eckernäs, S. ‐., Nordberg, A. K., Oreland, L., Svennerholm, L. T., Wiberg, Å., & Winblad, B. G. (1983) · Neurobiology of Aging · doi:10.1016/0197-4580(83)90002-7 · Cited by 304 · see citing works
Ishii, T. (1966) · Acta Neuropathologica · doi:10.1007/bf00686763 · Cited by 303 · see citing works
Cortical neuronal counts in normal elderly controls and demented patients
Mountjoy, C. Q., Roth, M., Evans, N. J. R., & Evans, H. M. (1983) · Neurobiology of Aging · doi:10.1016/0197-4580(83)90048-9 · Cited by 291 · see citing works
Self-citationPRESENILE DEMENTIA AND ALZHEIMER'S DISEASE IN MONGOLISM
Olson, M. I., & Shaw, C. (1969) · Brain · doi:10.1093/brain/92.1.147 · Cited by 290 · see citing works
Changes in the Monoamine Containing Neurones of the Human Cns in Senile Dementia
Mann, D. M. A., Lincoln, J., Yates, P. O., Stamp, J., & Toper, S. (1980) · The British Journal of Psychiatry · doi:10.1192/bjp.136.6.533 · Cited by 285 · see citing works
Self-citationYates, C. M., Simpson, J. A., Gordon, A., Maloney, A. F. J., Allison, Y., Ritchie, I. M., & Urquhart, A. L. (1983) · Brain Research · doi:10.1016/0006-8993(83)91179-4 · Cited by 251 · see citing works
PARKINSONISM-DEMENTIA COMPLEX, AN ENDEMIC DISEASE ON THE ISLAND OF GUAM
HIRANO, A., Malamud, N., & Kurland, L. T. (1961) · Brain · doi:10.1093/brain/84.4.662 · Cited by 247 · see citing works
Nucleus Raphe Dorsalis in Dementia of the Alzheimer Type
Curcio, C. A., & Kemper, T. L. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198407000-00001 · Cited by 225 · see citing works
Presenile dementia in Down's syndrome
Ellis, W. G., McCULLOCH, J. R., & CORLEY, C. L. (1974) · Neurology · doi:10.1212/wnl.24.2.101 · Cited by 220 · see citing works
Abnormalities of the nucleus basalis in Down's syndrome
Casanova, M. F., Walker, L. C., Whitehouse, P. J., & Price, D. L. (1985) · Annals of Neurology · doi:10.1002/ana.410180306 · Cited by 202 · see citing works
The noradrenergic system in Alzheimer and multi-infarct dementias.
Mann, D., Yates, P. O., & Hawkes, J. (1982) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.45.2.113 · Cited by 185 · see citing works
Self-citationThe pathology of the human locus ceruleus.
Mann, D. M. A., Yates, P. O., & Hawkes, J. (1983) · PubMed · Cited by 161 · see citing works
Self-citationALZHEIMER'S DISEASE AND RELATED DISORDERS
Raskind, M. A., & Peskind, E. R. (2001) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70341-2 · Cited by 161 · see citing works
Extrapyramidal signs in Alzheimer's disease
Mölsä, P. K., Marttila, R. J., & Rinne, U. K. (1984) · Neurology · doi:10.1212/wnl.34.8.1114 · Cited by 153 · see citing works
Monoamine metabolism in senile dementia of Alzheimer type
Cross, A. J., Crow, T. J., Johnson, J. A., Joseph, M. H., Perry, E. K., Perry, R. H., Blessed, G., & Tomlinson, B. E. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90149-1 · Cited by 150 · see citing works
Roth, M. (1986) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072097 · Cited by 149 · see citing works
RECENT ADVANCES IN NEUROPATHOLOGY
Perry, R. H. (1986) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072096 · Cited by 132 · see citing works
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90439-2 · Cited by 127 · see citing works
Self-citationAlzheimer's disease and senile dementia of Alzheimer type
Sulkava, R. O. (1982) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1982.tb03117.x · Cited by 125 · see citing works
The Extrapyramidal Disorder of Alzheimer’s Disease
Pearce, J. M. S. (2008) · European Neurology · doi:10.1159/000114608 · Cited by 114 · see citing works
Dm, M., Yates, P. O., & Marcyniuk, B. (1985) · PubMed · Cited by 100 · see citing works
PATHOLOGICAL EVIDENCE FOR NEUROTRANSMITTER DEFICITS IN DOWN'S SYNDROME OF MIDDLE AGE
Mann, D. M. A., Yates, P. O., Marcyniuk, B., & Ravindra, C. (1985) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1985.tb00320.x · Cited by 97 · see citing works
Self-citationDopaminergic neurotransmitter systems in Alzheimer's disease and in Down's syndrome at middle age.
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.3.341 · Cited by 97 · see citing works
Self-citationAlzheimer's Disease and Down's Syndrome*
Price, D. L., Whitehouse, P. J., Struble, R. G., Coyle, J. T., Clark, A. W., DeLong, M. R., Cork, L. C., & Hedreen, J. C. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb26850.x · Cited by 94 · see citing works
MENTAL ILLNESS AND THE AGEING BRAIN
Cumings, J. N. (1963) · Journal of Clinical Pathology · doi:10.1136/jcp.16.1.98-c · Cited by 93 · see citing works
Recent Advances in Parkinson's Disease.
MCDOWELL, F. H., & Markham, C. H. (1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-3-527_1 · Cited by 92 · see citing works
Rb, C. (1982) · PubMed · Cited by 74 · see citing works
Tabaton, M., Schenone, A. E., Romagnoli, P., & Mancardi, G. (1985) · Acta Neuropathologica · doi:10.1007/bf00690198 · Cited by 69 · see citing works
DOPAMINE IN ALZHEIMER'S DISEASE AND SENILE DEMENTIA
Yates, C., Allison, Y., Simpson, J., Maloney, A. F. J., & Gordon, A. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92202-5 · Cited by 62 · see citing works
EXTRAPYRAMIDAL DEMENTIA AND LEVODOPA
Drachman, D. A., & Stahl, S. M. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92479-4 · Cited by 49 · see citing works
The estimation of neuronal population density by a robust distance method
Aherne, W., & Diggle, P. J. (1978) · Journal of Microscopy · doi:10.1111/j.1365-2818.1978.tb00138.x · Cited by 31 · see citing works
Alzheimer's Disease and Related Disorders
Bigl, V. (1987) · Neurochemistry International · doi:10.1016/0197-0186(87)90089-1 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dopamine and the regulation of cognition and attention
Nieoullon, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00011-4 · Cited by 1,131 · see citing works
Pathology of Parkinson’s disease
Jellinger, K. A. (1991) · Molecular and Chemical Neuropathology · doi:10.1007/bf03159935 · Cited by 682 · see citing works
Nobili, A., Latagliata, E. C., Viscomi, M. T., Cavallucci, V., Cutuli, D., Giacovazzo, G., Krashia, P., Rizzo, F. R., Marino, R., Federici, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms14727 · Cited by 514 · see citing works
Dopaminergic reward system: a short integrative review
Arias-Carrión, Ó., Stamelou, M., Murillo‐Rodríguez, E., Menéndez‐González, M., & Pöppel, E. (2010) · International Archives of Medicine · doi:10.1186/1755-7682-3-24 · Cited by 413 · see citing works
Negative symptoms: the ‘pathology’ of motivation and goal-directed behaviour
Brown, R. G., & Pluck, G. C. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01626-x · Cited by 297 · see citing works
“Is dopamine involved in Alzheimer's disease?”
Martorana, A., & Koch, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00252 · Cited by 276 · see citing works
Dopamine, learning, and reward-seeking behavior
Arias-Carrión, Ó., & Pöppel, E. (2007) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2007-1664 · Cited by 274 · see citing works
Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis
Lyness, S. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00057-x · Cited by 240 · see citing works
Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
Frozza, R. L., Lourenco, M. V., & Felice, F. G. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00037 · Cited by 202 · see citing works
Gaspar, P., Stepniewska, I., & Kaas, J. H. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903250102 · Cited by 180 · see citing works
The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs
Burns, J. M., Galvin, J. E., Roe, C. M., Morris, J. C., & McKeel, D. W. (2005) · Neurology · doi:10.1212/01.wnl.0000158423.05224.7f · Cited by 175 · see citing works
Pathological correlates of extrapyramidal signs in Alzheimer's disease
Liu, Y., Stern, Y., Chun, M. R., Jacobs, D. M., Yau, P. O., & Goldman, J. E. (1997) · Annals of Neurology · doi:10.1002/ana.410410312 · Cited by 129 · see citing works
Theofilas, P., Dunlop, S. R., Heinsen, H., & Grinberg, L. T. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142682 · Cited by 118 · see citing works
Music and Memory in Alzheimer’s Disease and The Potential Underlying Mechanisms
Peck, K. J., Girard, T. A., Russo, F., & Fiocco, A. J. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150998 · Cited by 118 · see citing works
Hallucinations and associated factors in Alzheimer's disease
Gilley, D. W., Whalen, M. E., Wilson, R. S., & Bennett, D. A. (1991) · Journal of Neuropsychiatry · doi:10.1176/jnp.3.4.371 · Cited by 112 · see citing works
Down Syndrome: Advances in Molecular Biology and the Neurosciences
Capone, G. T. (2001) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200102000-00007 · Cited by 110 · see citing works
La Barbera, L., Vedele, F., Nobili, A., Krashia, P., Spoleti, E., Latagliata, E. C., Cutuli, D., Cauzzi, E., Marino, R., Viscomi, M. T., et al. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102031 · Cited by 98 · see citing works
“deficits in mesocorticolimbic DA signalling (Allard et al., 1990; Costa et al., 2016; Gibb et al., 1989; Joyce et al., 1997; Kemppainen et al., 2003; Koch et al., 2014; Kumar and Patel, 2007; Murray et al., 1995; Rinne et al., 1986a, 1986b; Storga et al., 1996).”
BackgroundD’Amelio, M., Puglisi‐Allegra, S., & Mercuri, N. B. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.016 · Cited by 95 · see citing works
Bell, M. J., & Zempel, H. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0152 · Cited by 91 · see citing works
Differential Diagnosis of Parkinson’s Disease and the Parkinsonism Plus Syndromes
Stacy, M. A., & Jankovic, J. J. (1992) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30214-7 · Cited by 86 · see citing works
Dementia and Parkinson's Disease
Gibb, W. R. G. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.5.596 · Cited by 86 · see citing works
Self-citationNigrostriatal Dysfunction in Familial Alzheimer's Disease-Linked APPswe/PS1ΔE9 Transgenic Mice
Perez, S. E., Lazarov, O., Koprich, J. B., Chen, E., Rodriguez‐Menendez, V., Lipton, J. W., Sisodia, S. S., & Mufson, E. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2773-05.2005 · Cited by 84 · see citing works
Cordella, A., Krashia, P., Nobili, A., Pignataro, A., La Barbera, L., Viscomi, M. T., Valzania, A., Keller, F., Ammassari-Teule, M., Mercuri, N. B., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.05.006 · Cited by 82 · see citing works
Taniguchi, S., McDonagh, A. M., Pickering-Brown, S. M., Umeda, Y., Iwatsubo, T., Hasegawa, M., & Mann, D. M. A. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2003.00481.x · Cited by 75 · see citing works
Self-citationSala, A., Caminiti, S. P., Presotto, L., Pilotto, A., Liguori, C., Chiaravalloti, A., Garibotto, V., Frisoni, G. B., D’Amelio, M., Paghera, B., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00925-1 · Cited by 66 · see citing works
Tyrrell, P. J., Sawle, G. V., Ibanez, V., Bloomfield, P. M., Leenders, K. L., Frackowiak, R. S. J., & Rossor, M. N. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120062011 · Cited by 65 · see citing works
Antidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance
Costello, H., Roiser, J. P., & Howard, R. (2023) · Psychological Medicine · doi:10.1017/s003329172200397x · Cited by 60 · see citing works
Improved Detection of Substantia Nigra Pathology in Alzheimer's Disease
Schneider, J. A., Bienias, J. L., Gilley, D. W., Kvarnberg, D. E., Mufson, E. J., & Bennett, D. A. A. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000111 · Cited by 57 · see citing works
Henjum, K., Watne, L. O., Godang, K., Halaas, N. B., Eldholm, R. S., Blennow, K., Zetterberg, H., Saltvedt, I. T., Bollerslev, J., & Knapskog, A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01901-5 · Cited by 56 · see citing works
Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease
Chen, A. P. F., Chen, L., Kim, T. A., & Xiong, Q. (2021) · Biomedicines · doi:10.3390/biomedicines9060647 · Cited by 55 · see citing works
Detection of Lewy Bodies in Trisomy 21 (Down's Syndrome)
Raghavan, R., Khin-Nu, C., Brown, A., Irving, D., Ince, P. G., Day, K. A., Tyrer, S. P., & Perry, R. H. (1993) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100047405 · Cited by 54 · see citing works
Neuropathology of Parkinsonism in Patients with Pure Alzheimer's Disease
Horvath, J. E., Burkhard, P. R., Herrmann, F. R., Bouras, C., & Kövari, E. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131289 · Cited by 48 · see citing works
Tiernan, C. T., Ginsberg, S. D., He, B., Ward, S., Guillozet-Bongaarts, A. L., Kanaan, N. M., Mufson, E. J., & Counts, S. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.05.021 · Cited by 47 · see citing works
Wang, Z., Zheng, P., Xie, Y., Chen, X., Solowij, N., Green, K., Chew, Y. L., & Huang, X. (2021) · The FASEB Journal · doi:10.1096/fj.202002724r · Cited by 47 · see citing works
Selective loss of nigral neurons in Alzheimer's disease: a morphometric study
Uchihara, T., Kondo, H., Kosaka, K., & Tsukagoshi, H. (1992) · Acta Neuropathologica · doi:10.1007/bf00296789 · Cited by 44 · see citing works
Chen, S., Lu, F. F., Seeman, P. M., & Liu, F. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0874-2 · Cited by 43 · see citing works
Iaccarino, L., Sala, A., Caminiti, S. P., Presotto, L., Perani, D., & Initiative, F. T. A. D. N. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190954 · Cited by 40 · see citing works
The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer's disease
Krashia, P., Spoleti, E., & D’Amelio, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1039725 · Cited by 39 · see citing works
Divergence in the metabolome between natural aging and Alzheimer’s disease
Hunsberger, H. C., Greenwood, B. P., Tolstikov, V., Narain, N. R., Kiebish, M. A., & Denny, C. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68739-z · Cited by 36 · see citing works
Caligiore, D., Giocondo, F., & Silvetti, M. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.09.007 · Cited by 36 · see citing works
Dementia with Lewy bodies: a review
Rampello, L., Cerasa, S., Alvano, A., Buttà, Raffaele, R., Vecchio, I., Cavallaro, T., Cimino, E., Incognito, T., & Nicoletti, F. (2004) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2003.11.003 · Cited by 29 · see citing works
Computational Modeling of Catecholamines Dysfunction in Alzheimer’s Disease at Pre-Plaque Stage
Caligiore, D., Silvetti, M., D’Amelio, M., Puglisi‐Allegra, S., & Baldassarre, G. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200276 · Cited by 28 · see citing works
Spoleti, E., Krashia, P., Barbera, L. L., Nobili, A., Lupaşcu, C. A., Giacalone, E., Keller, F., Migliore, M., Renzi, M., & D’Amelio, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113969 · Cited by 28 · see citing works
Neuromelanin in the Human Brain: A Review and Atlas of Pigmented Cells in the Substantia Nigra
Usunoff, K. G., Itzev, D. E., Ovtscharoff, W. A., & Marani, E. (2002) · Archives of Physiology and Biochemistry · doi:10.1076/apab.110.4.257.11827 · Cited by 27 · see citing works
Daniele, A., Bartolomeo, P., Cassetta, E., Bentivoglio, A. R., Gainotti, G., Albanese, A., & Partolomeo, B. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.3.288 · Cited by 27 · see citing works
Kouhnavardi, S., Ecevitoglu, A., Dragačević, V., Sanna, F., Arias‐Sandoval, E., Kalaba, P., Kirchhofer, M., Lubec, J., Niello, M., Holy, M., et al. (2022) · Biomolecules · doi:10.3390/biom12070881 · Cited by 24 · see citing works
Selective loss of nigral neurons in Pick's disease: a morphometric study
Uchihara, T., Tsuchiya, K., & Kosaka, K. (1990) · Acta Neuropathologica · doi:10.1007/bf00334504 · Cited by 24 · see citing works
Alzheimer-type pathology in melanin-bleached sections of substantia nigra
Uchihara, T., Kondo, H., Ikeda, K., & Kosaka, K. (1995) · Journal of Neurology · doi:10.1007/bf00867417 · Cited by 23 · see citing works
Oyanagi, K., Makifuchi, T., Ohtoh, T., Chen, K.-M., Gajdusek, D. C., Chase, T. N., & Ikuta, F. (1994) · Acta Neuropathologica · doi:10.1007/bf00294504 · Cited by 23 · see citing works
Gai, W., Vickers, J. C., Blumbergs, P. C., & Blessing, W. W. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.9.1039 · Cited by 23 · see citing works
Neurological Soft Signs in Nursing Home Residents with Alzheimer's Disease
Seidl, U., Thomann, P. A., & Schröder, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1159 · Cited by 22 · see citing works
EXTRAPYRAMIDAL SIGNS IN DEMENTIA OF ALZHEIMER TYPE
Tyrrell, P. J., & Rossor, M. N. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91580-8 · Cited by 22 · see citing works
Extrapyramidal features in advanced Down's syndrome: clinical evaluation and family history.
Vieregge, P., Ziemens, G., Freudenberg, M. A., Piosinski, A., Muysers, A., & Schulze, B. W. (1991) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.54.1.34 · Cited by 21 · see citing works
Gray matter volume covariance networks associated with social networks in older adults
Blumen, H. M., & Verghese, J. (2018) · Social Neuroscience · doi:10.1080/17470919.2018.1535999 · Cited by 20 · see citing works
Autophagy status as a gateway for stress-induced catecholamine interplay in neurodegeneration
Fornai, F., & Puglisi‐Allegra, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.015 · Cited by 20 · see citing works
Rodent Models of Alzheimer’s Disease: Past Misconceptions and Future Prospects
Collins, H. M., & Greenfield, S. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116222 · Cited by 19 · see citing works
Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease
Patthy, Á., Murai, J., Hanics, J., Pintér, A., Zahola, P., Hökfelt, T. G. M., Harkany, T., & Alpár, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081555 · Cited by 18 · see citing works
Allopregnanolone enhances the neurogenesis of midbrain dopaminergic neurons in APPswe/PSEN1 mice
Zhang, P., Xie, M. Q., Ding, Y., Liao, M., Qi, S. S., Chen, S. X., Gu, Q., Zhou, P., & Sun, C. Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.019 · Cited by 18 · see citing works
Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease.
Paskavitz, J., Lippa, C. F., Hamos, J. E., Pulaski-Salo, D., & Drachman, D. A. (1995) · PubMed · Cited by 18 · see citing works
Dopaminergic deficits along the spectrum of Alzheimer’s disease
Pilotto, A., Galli, A., Sala, A., Caminiti, S. P., Presotto, L., Liguori, C., Mercuri, N. B., Premi, E., Garibotto, V., Frisoni, G. B., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02913-5 · Cited by 17 · see citing works
Mann, D. M. A. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90015-c · Cited by 17 · see citing works
Self-citationThe effect of Lewy body (co-)pathology on the clinical and imaging phenotype of amnestic patients
Silva‐Rodríguez, J., Labrador‐Espinosa, M. Á., Zhang, L., Castro‐Labrador, S., López‐González, F. J., Moscoso, A., Sánchez‐Juan, P., Schöll, M., & Grothe, M. J. (2025) · Brain · doi:10.1093/brain/awaf037 · Cited by 16 · see citing works
Distinct FP-CIT PET patterns of Alzheimer’s disease with parkinsonism and dementia with Lewy bodies
Chung, S. J., Lee, Y. H., Yoo, H. S., Sohn, Y. H., Ye, B. S., Cha, J., & Lee, P. H. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04315-6 · Cited by 16 · see citing works
Cognitive Impairment in Alzheimer’s and Metabolic Diseases: A Catecholaminergic Hypothesis
Guzmán-Ramos, K. R., Osorio‐Gómez, D., & Bermúdez‐Rattoni, F. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.031 · Cited by 15 · see citing works
Down's syndrome and Parkinson's disease.
Hestnes, A., Daniel, S. E., Lees, A. J., & Brun, A. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.3.289 · Cited by 14 · see citing works
Self-citationRahmani, B., Ghashghaei, E., Zendehdel, M., Baghbanzadeh, A., & Khodadadi, M. (2022) · Physiology International · doi:10.1556/2060.2022.00019 · Cited by 13 · see citing works
Dekker, A. D., Vermeiren, Y., Carmona‐Iragui, M., Benejam, B., Videla, L., Gelpí, E., Aerts, T., Dam, D. V., Fernández, S., Lleó, A., et al. (2017) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.11.001 · Cited by 13 · see citing works
Localisation and association of pathomorphological changes at the brainstem in Alzheimer's disease
Giess, R., & Schlote, W. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01657-0 · Cited by 13 · see citing works
Dopamine System Dysfunction in Alzheimer's Disease
Moreira, I. P., Vieira‐Coelho, M. A., & Guimarães, J. (2025) · Psychogeriatrics · doi:10.1111/psyg.70097 · Cited by 12 · see citing works
Automated MRI Segmentation of Brainstem Nuclei Critical to Consciousness
Olchanyi, M., Augustinack, J. C., Haynes, R. L., Lewis, L. D., Cicero, N. G., Li, J., Destrieux, C., Folkerth, R. D., Kinney, H. C., Fischl, B. R., et al. (2025) · Human Brain Mapping · doi:10.1002/hbm.70357 · Cited by 12 · see citing works
No correlation between nigral degeneration and striatal plaques in Alzheimer's disease
Love, S., Wilcock, G., & Matthews, S. M. (1996) · Acta Neuropathologica · doi:10.1007/s004010050447 · Cited by 12 · see citing works
Lazarova, M. I., Tsvetanova, E. R., Georgieva, A. P., Stefanova, M. O., Uzunova, D. N., Denev, P. N., Vassileva, V., & Tasheva, K. N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031840 · Cited by 11 · see citing works
Cai, M., & Yang, E. J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.606480 · Cited by 11 · see citing works
Beyond the brain: early autonomic dysfunction in Alzheimer’s disease
Nanclares, C., Colmena, I., Muñoz-Montero, A., Baraibar, A. M., de Pascual, R., Wojnicz, A., Ruíz‐Nuño, A., Garcı́a, A. G., Gironda-Martínez, A., & Gandı́a, L. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02042-8 · Cited by 10 · see citing works
Askarani, M. F., Fang, F., Counts, S. E., & Sun, L.-L. (2025) · Proteomics · doi:10.1002/pmic.70041 · Cited by 10 · see citing works
Camedda, R., Bonomi, C. G., Donna, M. G. D., & Chiaravalloti, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010751 · Cited by 10 · see citing works
Clinical parkinsonism in dementia patients with substantia nigra Lewy bodies
Ala, T. A., Yang, K.-H., Sung, J. H., & Frey, W. H. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050140 · Cited by 10 · see citing works
Gibb, W. R. G. (1990) · Behavioural Neurology · doi:10.1155/1990/235953 · Cited by 9 · see citing works
Self-citationNeurotransmitter Changes in Alzheimer’s Disease
Halliday, G. M., & Cullen, K. M. (1995) · Advances in behavioral biology · doi:10.1007/978-1-4615-1853-2_12 · Cited by 8 · see citing works
Brito, G. N. O. (1992) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4615-9843-5_10 · Cited by 8 · see citing works
Neuropathology of Alzheimer’s disease in Down syndrome
Mann, D. M. A. (2018) · CRC Press eBooks · doi:10.1201/9781315376875-2 · Cited by 6 · see citing works
Self-citationBhowmik, A. D., Dutta, S., Sinha, S., Chattopadhyay, A., & Mukhopadhyay, K. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9581-9 · Cited by 6 · see citing works
The First Confirmed Case of Down Syndrome with Dementia with Lewy Bodies
Prasher, V. P., Airuehia, E., & Carey, M. (2010) · Journal of Applied Research in Intellectual Disabilities · doi:10.1111/j.1468-3148.2009.00526.x · Cited by 6 · see citing works
Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression
David, M., Kolanko, M., Parker, T. D., Nilforooshan, R., Zimmerman, K. A., Olivares, C. B., Hoang, K., Brandt, J., Triantafyllou, C., Lally, P., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70749 · Cited by 5 · see citing works
Zoila, F., de Stefano, M. I., Sgobbio, A., Panaro, M. A., Maffione, A. B., Antonucci, L., Tarek, B., Massaro, M., Gaban, S. V. F., Filannino, F. M., et al. (2025) · Sports · doi:10.3390/sports13120458 · Cited by 5 · see citing works
Levodopa-Responsive Early-Onset Parkinsonism in Down Syndrome
Padmini, P., Hickey, F. J., Patel, L., & Sannar, E. M. (2018) · Case Reports in Neurological Medicine · doi:10.1155/2018/2314791 · Cited by 5 · see citing works
Parkinsonian features in advanced Down’s syndrome
Vieregge, P., Ziemens, G., Piosinski, A., Freudenberg, M. A., & Kömpf, D. (1991) · Springer eBooks · doi:10.1007/978-3-7091-9135-4_19 · Cited by 5 · see citing works
An autopsied case of Down syndrome with Alzheimer pathology and α‐synuclein immunoreactivity
Marui, W., Iseki, E., Kosaka, K., Kato, M., Adachi, Y., & Uéda, K. (1999) · Neuropathology · doi:10.1046/j.1440-1789.1999.00265.x · Cited by 5 · see citing works
Olivares, C. B., David, M., Obeso, M. E., Giovane, M. D., Reeves, S., & Malhotra, P. (2025) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70142 · Cited by 4 · see citing works
Perani, D., Sala, A., Caminiti, S. P., Presotto, L., Pilotto, A., Liguori, C., Chiaravalloti, A., Garibotto, V., Frisoni, G. B., D’Amelio, M., et al. (2021) · doi:10.21203/rs.3.rs-212818/v1 · Cited by 4 · see citing works
Chung, S. J., Lee, S., Yoo, H. S., Baik, K., Lee, H. S., Jung, J. H., Choi, Y., Hong, J., Kim, Y. J., Ye, B. S., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.022 · Cited by 3 · see citing works
Parkinsonism-Plus Syndromes and Secondary Parkinsonian Disorders
Fahn, S., Jankovic, J. J., Hallett, M., & Jenner, P. G. (2007) · Elsevier eBooks · doi:10.1016/b978-0-443-07941-2.50013-9 · Cited by 3 · see citing works
PARKINSONISM AND DOWN SYNDROME
Sturman, S. G., & Williams, A. C. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91581-x · Cited by 3 · see citing works
Age-Related Changes in Subcortical Nuclei that Project to the Cerebral Cortex
Kemper, T. L. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_10 · Cited by 3 · see citing works
Alzheimer's disease traits in Parkinson's disease without α‐synuclein seeding
Gomes, B. F., Farris, C. M., Ma, Y., Concha‐Marambio, L., Nilsson, J., Forsberg, K., Lebovitz, R. M., Andréasson, U., Blennow, K., Zetterberg, H., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70284 · Cited by 2 · see citing works
Ota, Y., Kanel, P., Barr, J., Spears, C. C., & Bohnen, N. I. (2023) · Springer eBooks · doi:10.1007/978-3-031-35098-6_7 · Cited by 2 · see citing works
Atypical parkinsonism, parkinsonism-plus syndromes, and secondary parkinsonian disorders
Fahn, S., Jankovic, J. J., & Hallett, M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2369-4.00009-3 · Cited by 2 · see citing works
Aguilar, L. F., Zaikos, T. D., Rivera, I., Wright, S. T., Lou, J., Gawronski, B., Gonzalez, L., Berry, J. V., Rouanet, J. P., Edwards, N. C., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03028-z · Cited by 1 · see citing works
Age-related changes in the catecholaminergic neurons of the mesopontine tegmentum in the rat
Itzev, D. E., Ovtscharoff, W. A., Marani, E., & Usunoff, K. G. (2007) · Biomedical Reviews · doi:10.14748/bmr.v18.67 · Cited by 1 · see citing works
Brain stem lesions in Pick's disease
Teruyuki, O. D. A. (1991) · Okayama Igakkai Zasshi (Journal of Okayama Medical Association) · doi:10.4044/joma1947.103.11-12_1237 · Cited by 1 · see citing works
- Authors
- Gibb, W. R., Mountjoy, C. Q., Mann, D. M., & Lees, A. J.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1989-02-01
- Volume
- 52
- Issue
- 2
- Pages
- 193-200
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1032505
- OpenAlex
- W2015429211
- Cited by
- 122
- References
- 43
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 4 · 2023: 14 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 1
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- substantia nigra, ventral tegmental area, Alzheimer's disease, Down syndrome, neurofibrillary tangles, Lewy bodies, parkinsonism, choline acetyltransferase
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Inclusion Bodies, Cerebral Cortex, Down Syndrome, Female, Hippocampus, Humans, Male, Melanins, Middle Aged, Nerve Degeneration, Neurofibrils, Neurons, Substantia Nigra, Tegmentum Mesencephali
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
