Dopamine loss alters the hippocampus-nucleus accumbens synaptic transmission in the Tg2576 mouse model of Alzheimer’s disease
Open accessAbstract
The functional loop involving the ventral tegmental area (VTA), dorsal hippocampus and nucleus accumbens (NAc) plays a pivotal role in the formation of spatial memory and persistent memory traces. In particular, the dopaminergic innervation from the VTA to the hippocampus is critical for hippocampal-related memory function and alterations in the midbrain dopaminergic system are frequently reported in Alzheimer's disease (AD), contributing to age-related decline in memory and non-cognitive functions. However, much less is known about the hippocampus-NAc connectivity in AD. Here, we evaluated the functioning of the hippocampus-to-NAc core connectivity in the Tg2576 mouse model of AD that shows a selective and progressive degeneration of VTA dopaminergic neurons. We show that reduced dopaminergic innervation in the Tg2576 hippocampus results in reduced synaptic plasticity and excitability of dorsal subiculum pyramidal neurons. Importantly, the glutamatergic transmission from the hippocampus to the NAc core is also impaired. Chemogenetic depolarisation of Tg2576 subicular pyramidal neurons with an excitatory Designer Receptor Exclusively Activated by Designer Drugs, or systemic administration of the DA precursor levodopa, can both rescue the deficits in Tg2576 mice. Our data suggest that the dopaminergic signalling in the hippocampus is essential for the proper functioning of the hippocampus-NAc excitatory synaptic transmission.
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Degeneration of VTA DA neurons in the Tg2576 mouse model of AD is detectable since the age of 3 months and worsens over time.
“Degeneration of VTA DA neurons in the Tg2576 mouse model of AD is detectable since the age of 3 months, and it worsens over time.”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Cordella et al., 2018
Loss of TH+ terminals in the dorsal hippocampus and NAc shell results in a prominent drop of DA outflow to these projection areas and in a deficit of synaptic plasticity, followed by impairments in memory and reward performance in 6-month-old Tg2576 mice.
“Loss of tyrosine hydroxylase positive (TH + ) terminals in the dorsal hippocam pus and NAc shell results in a prominent drop of DA outflow to these projection areas and in a deficit of synaptic plasticity, followed by im pairments in memory and reward performance in 6-month-old Tg2576 mice (Cordella et al., 2018; Nobili et al., 2017).”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Cordella et al., 2018
In the Tg2576 mouse model, degeneration of DA neurons results in lower DA outflow to projection areas including hippocampus and NAc shell, and correlates with impairment of the VTA-hippocampus-NAc circuit and with deficits in memory and reward performances.
“In the Tg2576 mouse model, the degeneration of DA neurons results in a lower DA outflow to the projection areas, including the hippocampus and NAc shell, and correlates with the impairment of the VTA-hippocampus-NAc circuit and with deficits in memory and reward performances”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Cordella et al., 2018
VTA degeneration in Tg2576 mice results in lower DA innervation in the dorsal hippocampus, leading to lower DA outflow.
“VTA degeneration in Tg2576 mice results in lower DA innervation in the dorsal hippocampus, leading to lower DA outflow (Cordella et al., 2018; Nobili et al., 2017).”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Cordella et al., 2018
Multiple functional alterations in Tg2576 DA neurons contribute to cell vulnerability and eventually lead to progressive degeneration and overt cognitive and non-cognitive deficits in older animals.
“The present data confirm the hypothesis that multiple functional alterations in Tg2576 DA neurons contribute to cell vulnerability and eventually lead to progressive degeneration and overt cognitive and non-cognitive deficits in older animals (Cordella et al., 2018; Nobili et al., 2017).”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Cordella et al., 2018
All these deficits could be rescued by systemic treatment with the DA precursor levodopa.
“All these deficits could be rescued by systemic treatment with the DA precursor levodopa (Cordella et al., 2018; Nobili et al., 2017).”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Cordella et al., 2018
This reduction in DA levels was associated with deficits in pyramidal neuron excitability and synaptic plasticity, and with dysfunctional hippocampal-related memory performance in Tg2576 mice.
“We had previously demonstrated that this reduction in DA levels was associated with deficits in pyramidal neuron excitability and synaptic plasticity, and with dysfunctional hippocam pal- related memory performance in Tg2576 mice.”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Cordella et al., 2018
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Pathological mechanisms and therapeutic strategies for Alzheimer’s disease
Tam, K. Y., & Ju, Y. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320970 · Cited by 415 · see citing works
Krashia, P., Cordella, A., Nobili, A., La Barbera, L., Federici, M., Leuti, A., Campanelli, F., Natale, G., Marino, G., Calabrese, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11928-w · Cited by 188 · see citing works
La Barbera, L., Vedele, F., Nobili, A., Krashia, P., Spoleti, E., Latagliata, E. C., Cutuli, D., Cauzzi, E., Marino, R., Viscomi, M. T., et al. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102031 · Cited by 98 · see citing works
“All these deficits could be rescued by systemic treatment with the DA precursor levodopa (Cordella et al., 2018; Nobili et al., 2017).”
Robison, L. S., Gannon, O. J., Thomas, M. A., Salinero, A. E., Abi‐Ghanem, C., Poitelon, Y., Belin, S., & Zuloaga, K. L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01956-5 · Cited by 78 · see citing works
La Barbera, L., Mauri, E., D’Amelio, M., & Gori, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.939855 · Cited by 74 · see citing works
The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases
Possemato, E., Barbera, L. L., Nobili, A., Krashia, P., & D’Amelio, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101907 · Cited by 75 · see citing works
Krashia, P., Nobili, A., & D’Amelio, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00123 · Cited by 70 · see citing works
Sala, A., Caminiti, S. P., Presotto, L., Pilotto, A., Liguori, C., Chiaravalloti, A., Garibotto, V., Frisoni, G. B., D’Amelio, M., Paghera, B., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00925-1 · Cited by 66 · see citing works
Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s disease
Eteleeb, A. M., Novotny, B. C., Tarraga, C. S., Sohn, C., Dhungel, E., Brase, L., Nallapu, A., Buss, J., Farias, F., Bergmann, K., et al. (2024) · PLOS Biology · doi:10.1371/journal.pbio.3002607 · Cited by 64 · see citing works
Chaudhary, S., Zhornitsky, S., Chao, H. H., van Dyck, C. H., & Li, C.-S. R. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221082834 · Cited by 61 · see citing works
Spoleti, E., Barbera, L. L., Cauzzi, E., Paolis, M. L. D., Saba, L., Marino, R., Sciamanna, G., Lazzaro, V. D., Keller, F., Nobili, A., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02408-9 · Cited by 61 · see citing works
Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease
Chen, A. P. F., Chen, L., Kim, T. A., & Xiong, Q. (2021) · Biomedicines · doi:10.3390/biomedicines9060647 · Cited by 55 · see citing works
Regulation of Melatonin and Neurotransmission in Alzheimer’s Disease
Roy, J., Tsui, K. C., Ng, J., Fung, M., & Lim, L. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136841 · Cited by 56 · see citing works
Bayassi-Jakowicka, M., Lietzau, G., Czuba, E., Patrone, C., & Kowiański, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052618 · Cited by 52 · see citing works
Barbera, L. L., Nobili, A., Cauzzi, E., Paoletti, I., Federici, M., Saba, L., Giacomet, C., Marino, R., Krashia, P., Melone, M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00580-6 · Cited by 49 · see citing works
Ceyzériat, K., Gloria, Y., Tsartsalis, S., Fossey, C., Cailly, T., Fabis, F., Millet, P., & Tournier, B. B. (2021) · Brain Communications · doi:10.1093/braincomms/fcab029 · Cited by 47 · see citing works
Ortiz‐Guerrero, G., González-Reyes, R. E., de‐la‐Torre, A., Medina-Rincón, G. J., & Nava-Mesa, M. O. (2020) · Brain Sciences · doi:10.3390/brainsci10060369 · Cited by 46 · see citing works
Du, X., Shi, Q., Zhao, Y., Xie, Y., Li, X., Liu, Q., Iqbal, J., Zhang, H., Liu, X., & Shen, L. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00549 · Cited by 38 · see citing works
The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer's disease
Krashia, P., Spoleti, E., & D’Amelio, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1039725 · Cited by 39 · see citing works
Contreras, J. A., Aslanyan, V., Sweeney, M. D., Sanders, L. M. J., Sagare, A. P., Zloković, B. V., Toga, A. W., Han, S. D., Morris, J. C., Fagan, A. M., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.013 · Cited by 41 · see citing works
Serra, L., D’Amelio, M., Esposito, S., Domenico, C. D., Koch, G., Marra, C., Mercuri, N. B., Caltagirone, C., Artusi, C. A., Lopiano, L., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210171 · Cited by 34 · see citing works
omairi, N. E. A., Albrakati, A., Kassab, R. B., Lokman, M. S., Elmahallawy, E. K., Amin, H. K., & Moneim, A. E. A. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00407-2 · Cited by 31 · see citing works
Potential of food-derived bioactive peptides in alleviation and prevention of Alzheimer's disease
Zhao, L., Li, D., Qi, X., Guan, K., Chen, H., Wang, R., & Ma, Y. (2022) · Food & Function · doi:10.1039/d2fo02278h · Cited by 29 · see citing works
Spoleti, E., Krashia, P., Barbera, L. L., Nobili, A., Lupaşcu, C. A., Giacalone, E., Keller, F., Migliore, M., Renzi, M., & D’Amelio, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113969 · Cited by 28 · see citing works
Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease
Kim, S., Nam, Y., Kim, H. S., Jung, H., Jeon, S. G., Hong, S. B., & Moon, M. (2022) · Biomedicines · doi:10.3390/biomedicines10040845 · Cited by 28 · see citing works
Zong, B., Yu, F., Zhang, X., Zhao, W., Sun, P., Li, S., & Li, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.869507 · Cited by 26 · see citing works
Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease
Shaikh, A., Ahmad, F., Teoh, S., Kumar, J., & Yahaya, M. F. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1292858 · Cited by 20 · see citing works
Ascorbate deficiency decreases dopamine release in gulo–/– and APP/PSEN1 mice
Consoli, D. C., Brady, L. J., Bowman, A. B., Calipari, E. S., & Harrison, F. E. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15151 · Cited by 23 · see citing works
Structure, Function, and Molecular Landscapes of the Aging Retina
Zhu, J. D., Tarachand, S. P., Abdulwahab, Q., & Samuel, M. A. (2023) · Annual Review of Vision Science · doi:10.1146/annurev-vision-112122-020950 · Cited by 23 · see citing works
Changes in neurotransmitter-related functional connectivity along the Alzheimer’s disease continuum
Manca, R., Marco, M. D., Soininen, H. S., Ruffini, L., & Venneri, A. (2024) · Brain Communications · doi:10.1093/braincomms/fcaf008 · Cited by 22 · see citing works
Autophagy status as a gateway for stress-induced catecholamine interplay in neurodegeneration
Fornai, F., & Puglisi‐Allegra, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.015 · Cited by 20 · see citing works
Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease
Patthy, Á., Murai, J., Hanics, J., Pintér, A., Zahola, P., Hökfelt, T. G. M., Harkany, T., & Alpár, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081555 · Cited by 18 · see citing works
Dopaminergic deficits along the spectrum of Alzheimer’s disease
Pilotto, A., Galli, A., Sala, A., Caminiti, S. P., Presotto, L., Liguori, C., Mercuri, N. B., Premi, E., Garibotto, V., Frisoni, G. B., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02913-5 · Cited by 17 · see citing works
Palanivelu, L., Chang, C.-W., Li, S., Liang, Y., Lo, Y., & Chen, Y. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00063 · Cited by 17 · see citing works
Paolis, M. L. D., Loffredo, G., Krashia, P., Barbera, L. L., Nobili, A., Cauzzi, E., Babicola, L., Segni, M. D., Coccurello, R., Puglisi‐Allegra, S., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01736-4 · Cited by 16 · see citing works
Mandino, F., Yeow, L. Y., Bi, R., Sejin, L., Bae, H. G., Baek, S. H., Lee, C.-Y., Mohammad, H., Teoh, C. L., Horien, C. L., et al. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221082016 · Cited by 16 · see citing works
Probing the nature of episodic memory in rodents
Huston, J. P., & Chao, O. Y.-H. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104930 · Cited by 16 · see citing works
Lansdell, T. A., Xu, H., Galligan, J., & Dorrance, A. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-220905 · Cited by 10 · see citing works
Barbera, L. L., Krashia, P., Loffredo, G., Cauzzi, E., Paolis, M. L. D., Montanari, M., Saba, L., Spoleti, E., Ficchì, S., Zaccone, C., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00893-2 · Cited by 16 · see citing works
Cognitive Impairment in Alzheimer’s and Metabolic Diseases: A Catecholaminergic Hypothesis
Guzmán-Ramos, K. R., Osorio‐Gómez, D., & Bermúdez‐Rattoni, F. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.031 · Cited by 15 · see citing works
Sagheddu, C., Stojanovic, T., Kouhnavardi, S., Savchenko, A. A., Hussein, A. M., Pistis, M., Monje, F. J., Plasenzotti, R., Aufy, M., Studenik, C. R., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1357347 · Cited by 14 · see citing works
Dopamine System Dysfunction in Alzheimer's Disease
Moreira, I. P., Vieira‐Coelho, M. A., & Guimarães, J. (2025) · Psychogeriatrics · doi:10.1111/psyg.70097 · Cited by 12 · see citing works
Honey and Alzheimer’s Disease—Current Understanding and Future Prospects
Shaikh, A., Ahmad, F., Teoh, S. L., Kumar, J., & Yahaya, M. F. (2023) · Antioxidants · doi:10.3390/antiox12020427 · Cited by 17 · see citing works
Giménez, S., Millan, A., Mora-Morell, A., Ayuso, N., Gastaldo-Jordán, I., & Pardo, M. (2024) · Molecules · doi:10.3390/molecules29153580 · Cited by 10 · see citing works
Olivé, I., Makris, N., Densmore, M., McKinnon, M. C., & Lanius, R. A. (2021) · Human Brain Mapping · doi:10.1002/hbm.25454 · Cited by 9 · see citing works
Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer’s Disease
Farfán‐García, E. D., Márquez-Gómez, R., Barrón‐González, M., Pérez‐Capistran, T., Rosales‐Hernández, M. C., Pinto‐Almazán, R., & Soriano-Ursua, M. A. (2019) · Current Alzheimer Research · doi:10.2174/1570159x17666190409144558 · Cited by 10 · see citing works
Review on pathogenesis and treatment of Alzheimer's disease
Cai, J., Liu, Y., & Fan, H. (2024) · Developmental Dynamics · doi:10.1002/dvdy.762 · Cited by 9 · see citing works
Ostlund, S. B., Chen, G., Kosheleff, A. R., Lueptow, L. M., Zhuravka, I., Frautschy, S. A., Lam, H. A., & Maidment, N. T. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1572956 · Cited by 8 · see citing works
Fernandes, C., Macedo, I., Barbosa, F., & Teixeira, J. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.030 · Cited by 8 · see citing works
Piccialli, I., Sisalli, M. J., de Rosa, V., Boscia, F., Tedeschi, V., Secondo, A., & Pannaccione, A. (2022) · Cells · doi:10.3390/cells11182820 · Cited by 7 · see citing works
Armijo‐Weingart, L., Martín, L. S., Gallegos, S., Araya, A., Konar-Nié, M., Fernández-Pérez, E. J., & Aguayo, L. G. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102616 · Cited by 8 · see citing works
G protein-coupled receptors: A golden key to the treasure-trove of neurodegenerative diseases
Li, H., Qiao, Z., Xiao, X., Cao, X., Li, Z., Liu, M., Jiao, Q., Chen, X., Du, X., & Jiang, H. N. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.01.032 · Cited by 7 · see citing works
Electrophysiological insights into Alzheimer's disease: A review of human and animal studies
Calvin, K., McNeela, A. M., Osse, A. M. L., Bhasin, G., Ridenour, M., Kinney, J. W., & Hyman, J. M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105987 · Cited by 6 · see citing works
Ficchì, S., Cauzzi, E., Barbera, L. L., Paolis, M. L. D., Loffredo, G., Spoleti, E., Ferrari, I., Saba, L., Biamonte, F., Nobili, A., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03588-w · Cited by 6 · see citing works
Baek, S., Jang, J., Jung, H. J., Lee, H., & Choe, Y. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03823-9 · Cited by 7 · see citing works
The Critical Role of Hippocampal Dopamine in the Pathogenesis of Hepatic Encephalopathy
Chen, B., Yang, Y., Li', S., Zhu, X.-L., QI, Y., & HONG, F. (2021) · Physiological Research · doi:10.33549/physiolres.934563 · Cited by 5 · see citing works
Sex-specific factors and APOEε4 genotype alter functional connectivity at middle age
Lee, B. H., McGovern, A. J., Lieblich, S. E., Mitchell, S. V., Yin, J., Epp, J. R., & Galea, L. A. M. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107655 · Cited by 4 · see citing works
Amyloid and Tau Induce Cell Death Independently of TSPO Polymerization and Density Changes
Tournier, B. B., Ceyzériat, K., Bouteldja, F., & Millet, P. (2021) · ACS Omega · doi:10.1021/acsomega.1c01678 · Cited by 4 · see citing works
Shen, L., Tang, X., Zhang, H., Zhuang, H., Jing, L., Zhao, Y., & Liu, X. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03533-2 · Cited by 4 · see citing works
Noorbakhshnia, M., & Zarrinimehr, N. (2018) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2018.12.010 · Cited by 4 · see citing works
Perani, D., Sala, A., Caminiti, S. P., Presotto, L., Pilotto, A., Liguori, C., Chiaravalloti, A., Garibotto, V., Frisoni, G. B., D’Amelio, M., et al. (2021) · doi:10.21203/rs.3.rs-212818/v1 · Cited by 4 · see citing works
Gimenez, S., Millan, A., Mora-Morell, A., Ayuso, N., Gastaldo-Jordán, I., & Pardo, M. (2024) · Preprints.org · doi:10.20944/preprints202407.0196.v1 · Cited by 3 · see citing works
Riffo-Lepe, N., González-Sanmiguel, J., Armijo‐Weingart, L., Saavedra, P., Hernandez, D., Ramos, G., Martín, L. S., & Aguayo, L. G. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01052 · Cited by 2 · see citing works
Dai, J., Xie, R., Sun, Z., Kou, X., Zhang, J.-Q., Cui, Q., Liu, R., Gao, X., Wang, J., & Gao, J. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhac527 · Cited by 2 · see citing works
Florio, T. M. (2020) · AIMS neuroscience · doi:10.3934/neuroscience.2020010 · Cited by 3 · see citing works
Wakefulness regulation of memory encoding and retrieval: structure and activity
Luo, Y., Su, W.-K., Yao, W. F., Jiang, H., McHugh, T. J., & Li, Y. (2025) · National Science Review · doi:10.1093/nsr/nwaf520 · Cited by 2 · see citing works
Neuroplasticity and Alzheimer’s Disease
Gashtrodkhani, A. A., Shirkouhi, S. G., Khatami, S. S., Kamari, F., Ghaedi, S., Blaabjerg, M., & Andalib, S. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin48051 · Cited by 1 · see citing works
Jin, S., Guo, B., Hao, W., Su, X., Zhang, T., & Liu, C. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00582 · Cited by 1 · see citing works
Merle, L., Rastelli, M., Datiche, F., Véjux, A., Jacquin, A., Bouret, S. G., & Bénani, A. (2025) · Neuroendocrinology · doi:10.1159/000543499 · Cited by 1 · see citing works
Introna, M. D., Krashia, P., Sabetta, A., Barbera, L. L., Nobili, A., D’Amelio, M., Cecconi, F., Ammassari‐Teule, M., & Pignataro, A. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03271-0 · Cited by 1 · see citing works
The lateral entorhinal cortex is a hub for local and global dysfunction in pre-tauopathy statesPreprint
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Brain cross-omics integration in Alzheimer’s diseasePreprint
Eteleeb, A. M., Novotny, B. C., Soriano‐Tárraga, C., Sohn, C., Dhungel, E., Brase, L., Nallapu, A., Buss, J., Farias, F., Bergmann, K., et al. (2022) · medRxiv · doi:10.1101/2022.12.10.22283295
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VTA-forebrain connectivity moderates adaptive behavior
Sinza, S. I., Choi, K., Lim, I. E., Williams, M. A., & Ogundele, O. M. (2026) · Brain Structure and Function · doi:10.1007/s00429-026-03071-2
Neurobiological links between Alzheimer’s disease and reward system dysfunction
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Progress in pain mechanisms and management
Li, Y., Chen, Q.-Q., Zhang, F., Weng, R., Xu, T. W., Zhang, H.-H., Gao, R., 连莲, Li, R., & Xu, G. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02931-x
Sun, J., Gao, G., Wang, S., Li, S., Tang, J., Liu, H., & Tang, T.-S. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02776-4
- Authors
- Cordella, A., Krashia, P., Nobili, A., Pignataro, A., La Barbera, L., Viscomi, M. T., Valzania, A., Keller, F., Ammassari-Teule, M., Mercuri, N. B., Berretta, N., & D'Amelio, M.
- Affiliations
- University of Rome Tor Vergata (IT)
- Università Campus Bio-Medico (IT)
- Fondazione Santa Lucia (IT)
- Corresponding author
- Krashia, Paraskevi
- Berretta, Nicola
- ORCID
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 116
- Pages
- 142-154
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2803237253
- Cited by
- 82
- References
- 84
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 10 · 2023: 8 · 2022: 13 · 2021: 16 · 2020: 5 · 2019: 5 · 2018: 2
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, ventral tegmental area, hippocampus, nucleus accumbens, dopaminergic neurons, synaptic transmission, dorsal subiculum, glutamatergic neurotransmission, synaptic plasticity, memory, DREADD, levodopa
- MeSH terms
- Alzheimer Disease, Animals, Dopamine, Hippocampus, Male, Mice, Transgenic, Synaptic Transmission, Nucleus Accumbens, Organ Culture Techniques, Excitatory Postsynaptic Potentials, Mice, Dopaminergic Neurons
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