The DOI matches its Crossref record.
Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
Open accessAbstract
Cerebrospinal fluid (CSF) S-adenosylmethionine (SAM) levels were significantly lower in severely depressed patients than in a neurological control group. The administration of SAM either intravenously or orally is associated with a significant rise of CSF SAM, indicating that it crosses the blood-brain barrier in humans. These observations provide a rational basis for the antidepressant effect of SAM, which has been confirmed in several countries. CSF SAM levels were low in a group of patients with Alzheimer's dementia suggesting a possible disturbance of methylation in such patients and the need for trials of SAM treatment.
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Metadata
- Authors
- Bottiglieri, T., Godfrey, P., Flynn, T., Carney, M. W., Toone, B. K., & Reynolds, E. H.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1990-12-01
- Volume
- 53
- Issue
- 12
- Pages
- 1096-1098
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2030208175
- Cited by
- 258
- References
- 0
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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