Cited by 76Epigenetics and DNA MethylationGenomics and Chromatin DynamicsNeuroscience and Neuropharmacology Research

Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications

Szyf, Moshe·2015·European Neuropsychopharmacology

Abstract

Aberrant changes in gene function are believed to be involved in a wide spectrum of human disease including behavioral, cognitive and neurodegenerative pathologies. Most of the attention in last few decades have focused on changes in gene sequence as a cause of gene dysfunction leading to disease and mental health disorders. Germ line mutations or other alterations in the sequence of DNA that associate with different behavioral and neurological pathologies have been identified. However, sequence alterations explain only a small fraction of the cases. In addition there is evidence for "gene-environment" interactions in the brain suggesting mechanisms that alter gene function and the phenotype through environmental exposure. Genes are programmed by "epigenetic" mechanisms such as chromatin structure, chromatin modification and DNA methylation. These mechanisms confer on similar sequences different identities during cellular differentiation. Epigenetic differences are proposed to be involved in differentiating gene function in response to different environmental contexts and could result in alterations in functional gene networks that lead to brain disease. Epigenetic markers could serve important biomarkers in brain and behavioral diseases. Moreover, epigenetic processes are potentially reversible pointing to epigenetic therapeutics in psychotherapy.

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Crossref · 10.1016/j.euroneuro.2014.01.009

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Authors
Szyf, M.
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2015-05
Volume
25
Issue
5
Pages
682-702
ISSN
0924-977X (ISSN-L)
OpenAlex
W1985697930
Cited by
76
References
248
Citations by year
2026: 2 · 2025: 5 · 2024: 7 · 2023: 14 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 7 · 2014: 3
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
epigenetics, central nervous system disorders, chromatin modification, DNA methylation, gene-environment interaction, epigenetic biomarkers, epigenetic therapy, neurodegenerative diseases, mental illness, chromatin structure, cell differentiation
MeSH terms
Animals, Central Nervous System Agents, Central Nervous System Diseases, Humans, Epigenesis, Genetic

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