The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.
Open accessAbstract
In a recent preliminary study it was reported that a severe head injury resulted in the deposition of beta amyloid protein (beta AP) in the cortical ribbon of 30% of patients who survived for less than two weeks. Multiple cortical areas have now been examined from 152 patients (age range 8 weeks-81 years) after a severe head injury with a survival time of between four hours and 2.5 years. This series was compared with a group of 44 neurologically normal controls (age range 51 to 80 years). Immunostaining with an antibody to beta AP confirmed the original findings that 30% of cases of head injury have beta AP deposits in one or more cortical areas. Increasing age seemed to accentuate the extent of beta AP deposition and potential correlations with other pathological changes associated with head injury were also investigated. In addition, beta amyloid precursor protein (beta APP) immunoreactivity was increased in the perikarya of neurons in the vicinity of beta AP deposits. The data from this study support proposals that increased expression of beta APP is part of an acute phase response to neuronal injury in the human brain, that extensive overexpression of beta APP can lead to deposition of beta AP and the initiation of an Alzheimer disease-type process within days, and that head injury may be an important aetiological factor in Alzheimer's disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The rapid accumulation of Aβ after TBI is well documented in both humans and experimental animal models.12–17”
From Controlled Cortical Impact Results in an Extensive Loss of Dendritic Spines that Is Not Mediated by Injury-Induced Amyloid-Beta Accumulation (2013) · cites this paper as [15]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Third, accumulation of APP and extracellular deposition of the 40- to 42-amino acid Aβ peptide in senile plaques has been identified in human brain tissue soon after severe TBI (29, 30).”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [29]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Clinical studies indicate that Aβ accumulates within hours after severe TBI and is spread throughout the cerebral cortex compared to age-matched controls (29, 31).”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [29]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The co-occurrence of TBI and APP mutation in the clinical setting is rare (29) thereby restricting the results of many of these studies.”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [29]
Experimental — accuracy not yet measuredIn the citing paper
“a rapid generation and deposition of Aβ in stroke and after head trauma, which could benefit to maintain the BBB integrity and inhibit the leakage of serum components into the brain, leading to neuroinflammation.436”
From Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future (2023) · cites this paper as [436]
In the citing paper
“Individuals, including children, who died following coma not long after severe head trauma were shown to develop amorphous cerebral Aβ plaques [152].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [152]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Amyloid deposition as the central event in the aetiology of Alzheimer’s disease
Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schiossmacher, M., Whaley, J., Swindlehurst, C., et al. (1992) · Nature · doi:10.1038/359325a0 · Cited by 1,731
Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., et al. (1992) · Science · doi:10.1126/science.1439760 · Cited by 1,447
Diffuse axonal injury in head injury: definition, diagnosis and grading
Adams, J. H., Doyle, D., Ford, I., Gennarelli, T. A., Graham, D. I., & Mclellan, D. R. (1989) · Histopathology · doi:10.1111/j.1365-2559.1989.tb03040.x · Cited by 1,176
Self-citationThe Role of Interleukin-1 in Disease
Epstein, F. H., Dinarello, C. A., & Wolff, S. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301143280207 · Cited by 954
Corsellis, J. A. N., Bruton, C. J., & Freeman-Browne, D. (1973) · Psychological Medicine · doi:10.1017/s0033291700049588 · Cited by 836
β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury
Gentleman, S. M., Nash, M. J., Sweeting, C. J., Graham, D. I., & Roberts, G. W. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90398-5 · Cited by 570
Self-citationThe occult aftermath of boxing.
Roberts, G. W., Allsop, D., & Bruton, C. (1990) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.5.373 · Cited by 518
Self-citationIschaemic brain damage is still common in fatal non-missile head injury.
Graham, D. I., Ford, I., ADAMS, J. H., Doyle, D., Teasdale, G. M., Lawrence, A. E., & McLellan, D. R. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.3.346 · Cited by 494
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Anon editorial. Head injury victims in the UK: undeservedly underserved. Lancet 1990;i:886-7.
- Mortimer JA, van Duijn CM, Chandra V, et al. Head injury as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. Int 7 Epidemiol 1991;20:S28.
- Barton A. Studies ofgene expression in the central nervous system in relation to Alzheimer's disease. London: University of London, 1991. (PhD thesis.)
Cited by
Sorted by citations
Items 101–200 of 569
Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies
Carvajal, F. J., Mattison, H. A., & Cerpa, W. F. (2016) · Neural Plasticity · doi:10.1155/2016/2701526 · Cited by 154
Oxidative Imbalance in Alzheimer's Disease
Zhu, X., Lee, H., Casadesús, G., Ávila, J., Drew, K. L., Perry, G. L., & Smith, M. A. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:205 · Cited by 146
Katsumoto, A., Takeuchi, H., & Tanaka, F. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00980 · Cited by 151
Distribution of β‐amyloid protein in the brain following severe head injury
Graham, D. I., Gentleman, S., Lynch, A., & Roberts, G. (1995) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1995.tb01025.x · Cited by 140
Self-citationSinson, G. P., PERRI, B. R., Trojanowski, J. Q., Flamm, E. S., & McIntosh, T. K. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.86.3.0511 · Cited by 144
Apolipoprotein E &egr;4 and short-term recovery from predominantly mild brain injury
Liberman, J., Stewart, W., Wesnes, K., & Troncoso, J. (2002) · Neurology · doi:10.1212/wnl.58.7.1038 · Cited by 129
Alzheimer’s disease: Insights from epidemiology
McDowell, I. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03351474 · Cited by 140
Current Concepts in the Pathogenesis of Alzheimer’s Disease
Carr, D. B., Goate, A., Phil, D., & Morris, J. C. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00262-3 · Cited by 143
Six-month recovery from mild to moderate Traumatic Brain Injury: the role of APOE- 4 allele
Chamelian, L. (2004) · Brain · doi:10.1093/brain/awh296 · Cited by 141
Olsson, A., Csajbok, L. Z., �st, M., H�glund, K., Nyl�n, K., Rosengren, L., Nellg�rd, B., & Blennow, K. (2004) · Journal of Neurology · doi:10.1007/s00415-004-0451-y · Cited by 139
Amyloid-β in Alzheimer Disease: The Null versus the Alternate Hypotheses
Lee, H., Zhu, X., Castellani, R. J., Nunomura, A., Perry, G. L., & Smith, M. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.114009 · Cited by 142
Marklund, N., Blennow, K., Zetterberg, H., Ronne-Engström, E., Enblad, P., & Hillered, L. (2009) · Journal of neurosurgery · doi:10.3171/2008.9.jns08584 · Cited by 138
What is the Relationship of Traumatic Brain Injury to Dementia?
Mendez, M. F. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161002 · Cited by 141
Teasdale, G. M. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.5.526 · Cited by 135
van den Heuvel, C., Blumbergs, P. C., Finnie, J. W., Manavis, J., Jones, N. R., Reilly, P. L., & Pereira, R. A. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7150 · Cited by 130
Genetic association studies in patients with traumatic brain injury
Dardiotis, E., Fountas, K. N., Dardioti, M., Xiromerisiou, G., Kapsalaki, E. Z., Τάσιου, Α., & Hadjigeorgiou, G. M. (2009) · Neurosurgical FOCUS · doi:10.3171/2009.10.focus09215 · Cited by 131
DeKosky, S. T., Abrahamson, E. E., Ciallella, J. R., Paljug, W. R., Wisniewski, S. R., Clark, R. S. B., & Ikonomovic, M. D. (2007) · Archives of Neurology · doi:10.1001/archneur.64.4.541 · Cited by 152
APOE, APOE Promoter, and Tau Genotypes and Risk for Concussion in College Athletes
Terrell, T. R., Bostick, R. M., Abramson, R., Xie, D., Barfield, W. R., Cantu, R. C., Stanek, M. K., & Ewing, T. (2008) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e31815c1d4c · Cited by 129
The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease
Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128
Hemodynamic Consequences of Deformed Microvessels in the Brain in Alzheimer's Disease
de la Torre, J. C. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48462.x · Cited by 129
Chronic neurodegenerative consequences of traumatic brain injury
Chauhan, N. B. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-130354 · Cited by 133
Genetic susceptibility to Alzheimer disease
Pericak‐Vance, M. A., & Haines, J. L. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89161-1 · Cited by 126
Craniocerebral Trauma: Protection and Retrieval of the Neuronal Population after Injury
Teasdale, G. M., & Graham, D. I. (1998) · Neurosurgery · doi:10.1097/00006123-199810000-00001 · Cited by 122
Self-citationThe Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease
Zhang, X., Fu, Z., Meng, L., He, M., & Zhang, Z. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00359 · Cited by 127
Schaffert, J., LoBue, C., White, C. L., Chiang, H.-S., Didehbani, N., Lacritz, L., Rossetti, H., Dieppa, M., Hart, J., & Cullum, C. M. (2018) · Neuropsychology · doi:10.1037/neu0000423 · Cited by 120
Finnie, J. W., & Blumbergs, P. C. (2002) · Veterinary Pathology · doi:10.1354/vp.39-6-679 · Cited by 122
Amyloid-beta and tau protein beyond Alzheimer’s disease
Abyadeh, M., Gupta, V., Paulo, J. A., Mahmoudabad, A. G., Shadfar, S., Mirshahvaladi, S., Gupta, V. B., Nguyen, C. T. O., Finkelstein, D. I., You, Y., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.386406 · Cited by 126
The keystone of Alzheimer pathogenesis might be sought in Aβ physiology
Puzzo, D., Gulisano, W., Arancio, O., & Palmeri, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.039 · Cited by 116
Iwata, A., Chen, X., McIntosh, T. K., Browne, K. D., & Smith, D. H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.12.1056 · Cited by 116
Iatrogenic cerebral amyloid angiopathy: an emerging clinical phenomenon
Banerjee, G., Samra, K., Adams, M. E., Jaunmuktane, Z., Parry‐Jones, A., Grieve, J., Toma, A. K., Farmer, S. F., Sylvester, R. J., Houlden, H., et al. (2022) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-328792 · Cited by 119
The Pathogenesis of Alzheimer′s Disease: A Reevaluation of the “Amyloid Cascade Hypothesis”
Armstrong, R. A. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/630865 · Cited by 117
Inflammatory pathogenesis in Alzheimer's disease: biological mechanisms and cognitive sequeli
Gahtan, E., & Overmier, J. B. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00058-x · Cited by 114
The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention
Giunta, B., Obregon, D., Velisetty, R., Sanberg, P. R., Borlongan, C. V., & Tan, J. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-185 · Cited by 112
Tsitsopoulos, P. P., & Marklund, N. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00079 · Cited by 120
A critical analysis of the ‘amyloid cascade hypothesis’
A. Armstrong, R. (2014) · Folia Neuropathologica · doi:10.5114/fn.2014.45562 · Cited by 110
Alzheimer’ s disease, oxidative stress and gammahydroxybutyrate
Mamelak, M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.008 · Cited by 108
Cofilin-mediated neurodegeneration in alzheimer’s disease and other amyloidopathies
Maloney, M. T., & Bamburg, J. R. (2007) · Molecular Neurobiology · doi:10.1007/bf02700622 · Cited by 115
ApoE genotype, past adult lead exposure, and neurobehavioral function.
Stewart, W. F., Schwartz, B. S., Simon, D., Kelsey, K. T., & Todd, A. C. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110501 · Cited by 111
Weiner, M. W., Harvey, D. J., Hayes, J., Landau, S. M., Aisen, P. S. S., Petersen, R. C., Tosun, D., Veitch, D. P., Jack, C. R., DeCarli, C. S., et al. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.02.005 · Cited by 106
Iatrogenic Alzheimer’s disease in recipients of cadaveric pituitary-derived growth hormone
Banerjee, G., Farmer, S. F., Hyare, H., Jaunmuktane, Z., Mead, S., Ryan, N. S., Schott, J. M., Werring, D. J., Rudge, P., & Collinge, J. (2024) · Nature Medicine · doi:10.1038/s41591-023-02729-2 · Cited by 115
Imaging Correlates of Memory and Concussion History in Retired National Football League Athletes
Strain, J. F., Womack, K. B., Didehbani, N., Spence, J. S., Conover, H., Hart, J., Kraut, M. A., & Cullum, C. M. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0206 · Cited by 117
Stone, J., Johnstone, D. M., Mitrofanis, J., & O’Rourke, M. F. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141884 · Cited by 113
Costanza, A., Weber, K., Gandy, S., Bouras, C., Hof, P. R., Giannakopoulos, P., & Canuto, A. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01186.x · Cited by 109
Brain injury, neuroinflammation and Alzheimer's disease
Breunig, J. J., Guillot‐Sestier, M., & Town, T. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00026 · Cited by 106
Yu, F., Zhang, Y., & Chuang, D. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2449 · Cited by 110
Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids
Harel, A., Kvist, M., Salla, N., & Välimaa, L. (2016) · eNeuro · doi:10.1523/eneuro.0294-16.2016 · Cited by 105
Hook, G., Jacobsen, J. S., Grabstein, K. H., Kindy, M. S., & HOOK, V. Y. H. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00178 · Cited by 110
Traumatic brain injury and cognition
Cristofori, I., & Levin, H. S. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63521-1.00037-6 · Cited by 115
Washington, P. M., Morffy, N., Parsadanian, M., Zapple, D. N., & Burns, M. P. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3017 · Cited by 103
Genetics of Alzheimer's Disease. A Rapidly Evolving Field
Serretti, A., Olgiati, P., & Ronchi, D. D. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12108 · Cited by 105
Military Risk Factors for Cognitive Decline, Dementia and Alzheimer’s Disease
Veitch, D. P., Friedl, K. E., & Weiner, M. W. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990142 · Cited by 103
Stone, J. R., Okonkwo, D. O., Singleton, R. H., Mutlu, L. K., Helm, G. A., & Povlishock, J. T. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753754073 · Cited by 101
Epidemiology of the dementias: recent developments and new approaches.
van Duijn, C. M. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.5.478 · Cited by 102
Traumatic Brain Injury as a Trigger of Neurodegeneration
Johnson, V. E., Stewart, W. B., Jr., Arena, J. D., & Smith, D. H. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-57193-5_15 · Cited by 103
MURAKAMI, N., YAMAKI, T., IWAMOTO, Y., SAKAKIBARA, T., KOBORI, N., FUSHIKI, S., & UEDA, S. (1998) · Journal of Neurotrauma · doi:10.1089/neu.1998.15.993 · Cited by 100
Iverson, G. L., Gardner, A. J., Shultz, S. R., Solomon, G. S., McCrory, P. R., ZAFONTE, R. D., Perry, G. L., Hazrati, L., Keene, C. D., & Castellani, R. J. (2019) · Brain · doi:10.1093/brain/awz286 · Cited by 105
Cortical Cholinergic Dysfunction After Human Head Injury
MURDOCH, I., PERRY, E. K., COURT, J. A., GRAHAM, D. I., & DEWAR, D. (1998) · Journal of Neurotrauma · doi:10.1089/neu.1998.15.295 · Cited by 121
Self-citationSaber, M., Kokiko‐Cochran, O. N., Puntambekar, S. S., Lathia, J. D., & Lamb, B. T. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4401 · Cited by 97
Amyloid β‐Protein, APOE Genotype and Head Injury
Nicoll, J. A. R., Roberts, G. W., & Graham, D. I. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34431.x · Cited by 96
Self-citationTau immunohistochemistry in acute brain injury
Smith, C., Graham, D. I., Murray, L. S., & Nicoll, J. A. R. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00488.x · Cited by 110
Self-citationCiallella, J. R., Ikonomovic, M. D., Paljug, W. R., Wilbur, Y. I., Dixon, C. E., Kochanek, P. M., Marion, D. W., & DeKosky, S. T. (2002) · Journal of Neurotrauma · doi:10.1089/089771502762300229 · Cited by 94
Apoptotic and behavioral sequelae of mild brain trauma in mice
Tweedie, D., Milman, A., Holloway, H., Li, Y.-Z., Harvey, B., Shen, H., Pistell, P., Lahiri, D., Hoffer, B., Wang, Y., et al. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21160 · Cited by 96
Association between apolipoprotein E genotype and outcome of traumatic brain injury
Chiang, M.-F., Chang, J., & Hu, C. (2003) · Acta Neurochirurgica · doi:10.1007/s00701-003-0069-3 · Cited by 95
Injury cascades in TBI-related neurodegeneration
DeKosky, S. T., & Asken, B. M. (2017) · Brain Injury · doi:10.1080/02699052.2017.1312528 · Cited by 96
Nadler, Y., Alexandrovich, A. G., Grigoriadis, N., Hartmann, T., Rao, K. S. J., Shohami, E., & Stein, R. (2008) · Glia · doi:10.1002/glia.20638 · Cited by 97
Laskowitz, D. T., Song, P., Wang, H., Mace, B. E., Sullivan, P. M., Vitek, M. P., & Dawson, H. N. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1396 · Cited by 91
Abrahamson, E. E., Ikonomovic, M. D., Ciallella, J. R., Hope, C. E., Paljug, W. R., Isanski, B. A., Flood, D. G., Clark, R. S. B., & DeKosky, S. T. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.10.011 · Cited by 90
Ojo, J. O., Mouzon, B., & Crawford, F. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.06.003 · Cited by 89
Vincent, A. S., Roebuck‐Spencer, T., & Cernich, A. N. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.006 · Cited by 92
APP as a Protective Factor in Acute Neuronal Insults
Hefter, D., & Draguhn, A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00022 · Cited by 97
Strack, S., Zaucha, J. A., Ebner, F. F., Colbran, R. J., & Wadzinski, B. E. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980323)392:4 · Cited by 181
Amyloid-beta and tau pathology following repetitive mild traumatic brain injury
Edwards, G., Moreno-Gonzalez, I., & Soto, C. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.123 · Cited by 96
β‐Amyloid (Aβ)42(43), Aβ42, Aβ40 and apoE immunostaining of plaques in fatal head injury
Horsburgh, K. J., Cole, G. M., Yang, F., Savage, M. J., Greenberg, B., Gentleman, S. M., Graham, D. I., & Nicoll, J. A. R. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.026002124.x · Cited by 88
Self-citationSimvastatin therapy prevents brain trauma‐induced increases in β‐amyloid peptide levels
Abrahamson, E. E., Ikonomović, M. D., Dixon, C. E., & DeKosky, S. T. (2009) · Annals of Neurology · doi:10.1002/ana.21731 · Cited by 89
Johnson, V. E., Stewart, W., Trojanowski, J. Q., & Smith, D. H. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0909-9 · Cited by 87
Brain Injury–Mediated Neuroinflammatory Response and Alzheimer’s Disease
Kempuraj, D., Ahmed, M. E., Selvakumar, G. P., Thangavel, R., Dhaliwal, A. S., Dubova, I., Mentor, S., Premkumar, K., Saeed, D., Zahoor, H., et al. (2019) · The Neuroscientist · doi:10.1177/1073858419848293 · Cited by 90
Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia
Abrahamson, E. E., & Ikonomović, M. D. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113257 · Cited by 91
Plaques and tangles and the pathogenesis of Alzheimer's disease.
Armstrong, R. A. (2006) · PubMed · Cited by 91
Winston, C. N., Chellappa, D., Wilkins, T., Barton, D. J., Washington, P. M., Loane, D. J., Zapple, D. N., & Burns, M. P. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2960 · Cited by 84
Tian, L., Guo, R., Yue, X., Lv, Q., Ye, X., Wang, Z., Chen, Z., Wu, B., Xu, G., & Liu, X. (2012) · Brain Research · doi:10.1016/j.brainres.2011.12.059 · Cited by 84
Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats.
Browne, K., Iwata, A., Putt, M., & Smith, D. H. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.04.008 · Cited by 80
Tran, H. T., Sanchez, L., Esparza, T. J., & Brody, D. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025475 · Cited by 86
The Role of TDP-43 in Alzheimer’s Disease
Chang, X., Tan, M., Tan, L., & Yu, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9264-5 · Cited by 85
López-Rodríguez, A. B., Siopi, E., Finn, D. P., Marchand‐Leroux, C., García‐Segura, L. M., Jafarian-Tehrani, M., & Viveros, M. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht202 · Cited by 85
Kiraly, M. A., & Kiraly, S. J. (2007) · TheScientificWorldJournal · doi:10.1100/tsw.2007.269 · Cited by 90
Horsburgh, K. J., & Nicoll, J. A. R. (1996) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1996.tb01113.x · Cited by 84
Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy
Lesman‐Segev, O. H., Joie, R. L., Stephens, M. L., Sonni, I., Tsai, R. M., Bourakova, V., Visani, A. V., Edwards, L., O’Neil, J. P., Baker, S. L., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102025 · Cited by 83
The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer disease
Rottkamp, C. A., Atwood, C., Joseph, J. A., Nunomura, A., Perry, G. L., & Smith, M. A. (2002) · Peptides · doi:10.1016/s0196-9781(02)00069-4 · Cited by 81
Sundman, M. (2014) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000137 · Cited by 83
Takahata, K., Kimura, Y., Sahara, N., Koga, S., Shimada, H., Ichise, M., Saito, F., Moriguchi, S., Kitamura, S., Kubota, M., et al. (2019) · Brain · doi:10.1093/brain/awz238 · Cited by 79
Histone Deacetylase Inhibitors as Therapeutic Agents for Acute Central Nervous System Injuries
Shein, N. A., & Shohami, E. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00038 · Cited by 79
Webster, S. J., Van Eldik, L. J., Watterson, D. M., & Bachstetter, A. D. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0291-15.2015 · Cited by 80
Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death
Leong, Y. Q., Ng, K. Y., Chye, S. M., Ling, A. P. K., & Koh, R. Y. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00516-y · Cited by 80
Weiner, M. W., Veitch, D. P., Hayes, J., Neylan, T. C., Grafman, J. H., Aisen, P. S. S., Petersen, R. C., Jack, C. R., Jagust, W., Trojanowski, J. Q., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.005 · Cited by 81
Cardiovascular factors in Alzheimer's disease
Stewart, R. J. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.2.143 · Cited by 78
Chronic gliosis triggers Alzheimer’s disease-like processing of amyloid precursor protein
Bates, K. A., Fonte, J., Robertson, T. A., Martins, R. N., & Harvey, A. R. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00230-0 · Cited by 75
Traumatic brain injury and age at onset of cognitive impairment in older adults
Li, W., Risacher, S. L., McAllister, T. W., & Saykin, A. J. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8093-4 · Cited by 77
The Neuropathology of Chronic Traumatic Encephalopathy: The Status of the Literature
McKee, A. C. (2020) · Seminars in Neurology · doi:10.1055/s-0040-1713632 · Cited by 81
Traumatic brain injury: cause or risk of Alzheimer’s disease? A review of experimental studies
Szczygielski, J., Mautes, A. E. M., Steudel, W. I., Falkai, P., Bayer, T. A., & Wirths, O. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0326-0 · Cited by 75
Das, R. C., Rauf, A., Akhter, S., Islam, M. N., Emran, T. B., Mitra, S., Khan, I. N., & Mubarak, M. S. (2021) · Molecules · doi:10.3390/molecules26123696 · Cited by 79
Metadata
- Authors
- Roberts, G. W., Gentleman, S. M., Lynch, A., Murray, L., Landon, M., & Graham, D. I.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1994-04-01
- Volume
- 57
- Issue
- 4
- Pages
- 419-425
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1072869
- OpenAlex
- W2073009405
- Cited by
- 569
- References
- 42
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 22 · 2021: 22 · 2020: 18 · 2019: 28 · 2018: 18 · 2017: 21 · 2016: 29 · 2015: 31 · 2014: 20 · 2013: 28 · 2012: 26
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- severe traumatic brain injury, traumatic brain injury, Alzheimer's disease pathogenesis, amyloid precursor protein, immunostaining
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Brain Injuries, Child, Child, Preschool, Female, Humans, Immunohistochemistry, Infant, Male, Middle Aged, Amyloid beta-Peptides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
