Psychological aspects of multiple sclerosis

Sá, Maria José

doi:10.1016/j.clineuro.2007.10.001

Cited by 155Multiple Sclerosis Research StudiesCancer survivorship and careTryptophan and brain disorders

Psychological aspects of multiple sclerosis

Sá, Maria José·2008·Clinical Neurology and Neurosurgery

DOI 10.1016/j.clineuro.2007.10.001

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Abstract

A significant incidence and prevalence of psychological disorders in multiple sclerosis (MS) has been reported. Their underlying mechanisms and the extent to which they are reactive to psychosocial factors or symptoms of the pathological process itself, remain unclear. Depression is the predominant psychological disturbance with lifetime prevalence around 50% and annual prevalence of 20%. Depression is commoner during relapses, may exacerbate fatigue and cognitive dysfunction and no firm evidence exists of its induction by interferon; instead, treating depression improves adherence to disease-modifying drugs. Anxiety is also frequent, occurs in newly diagnosed patients, and its co-morbidity with depression has been suggested to increase the rate of suicidal ideation. The relationship between stress and MS is an attractive issue because some studies pointed to an association between stressful life-events and MS onset/relapses; however, the evidence supporting this hypothesis is not conclusive so far. Other psychiatric illnesses, as bipolar affective disorder, pathological laughing and crying or psychosis occur less frequently in MS. Therapeutic strategies include psychotherapy, cognitive behavioural therapy, strengthen of coping, and specific medications. The "art" of the MS team in providing the best individualized care is emphasized, aiming to reduce the burden of the disease and improve the patients' quality of life.

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Anxiety can aggravate disease symptoms, such as fatigue and cognitive complaints, and has a negative influence on one's work and social life.
“Anxiety can aggravate disease symptoms, such as fatigue and cognitive complaints, and has a negative influence on one’s work and social life.4”
From EMDR treatment for anxiety in MS patients: A pilot study (2020) · cites this paper as [4]

Psychological stress and the coping process
Lazarus, R. S. (1966) · Medical Entomology and Zoology · Cited by 7,164 · see citing works
Cognitive dysfunction in multiple sclerosis.
Rao, S. M., Leo, G. J., Bernardin, L., & Unverzagt, F. W. (1991) · Neurology · doi:10.1212/wnl.41.5.685 · Cited by 2,136 · see citing works
The Cochrane Library
Charbonneau, D. H. (2005) · Europe PMC (PubMed Central) · Cited by 2,041 · see citing works
Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis
Jacobs, L. D., Beck, R. W., Simon, J. H., Kinkel, R. P., Brownscheidle, C. M., Murray, T. J., Simonian, N. A., Slasor, P., & Sandrock, A. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431301 · Cited by 1,498 · see citing works
Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model.
Miller, G. E., Cohen, S., & Ritchey, A. K. (2002) · Health Psychology · doi:10.1037//0278-6133.21.6.531 · Cited by 977 · see citing works
McAlpine's Multiple Sclerosis
(2006) · Elsevier eBooks · doi:10.1016/b978-0-443-07271-0.x5001-0 · Cited by 769 · see citing works
Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model
Miller, G. E., Cohen, S., & Ritchey, A. K. (2002) · Health Psychology · doi:10.1037/0278-6133.21.6.531 · Cited by 769 · see citing works
Depression in multiple sclerosis: a review
Siegert, R. J. (2005) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054635 · Cited by 718 · see citing works
Depression and multiple sclerosis
Sadovnick, A. D., Remick, R. A., Allen, J. B., Swartz, E. S., Yee, I. M. L., Eisen, K., Farquhar, R., Hashimoto, S. A., Hooge, J. P., Kastrukoff, L. F., et al. (1996) · Neurology · doi:10.1212/wnl.46.3.628 · Cited by 536 · see citing works
Major depression in multiple sclerosis
Patten, S. B., Beck, C. A., Williams, J. V. A., Barbui, C., & Metz, L. M. (2003) · Neurology · doi:10.1212/01.wnl.0000095964.34294.b4 · Cited by 530 · see citing works
Symptomatic fatigue in multiple sclerosis.
Freal, J. E., Kraft, G. H., & Coryell, J. K. (1984) · PubMed · Cited by 526 · see citing works
Multiple sclerosis-related cognitive changes: A review of cross-sectional and longitudinal studies
Amato, M. P., Zipoli, V., & Portaccio, E. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.08.019 · Cited by 523 · see citing works
Anxiety disorders and their clinical correlates in multiple sclerosis patients
Korostil, M., & Feinstein, A. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506071161 · Cited by 424 · see citing works
Association between stressful life events and exacerbation in multiple sclerosis: a meta-analysis
Mohr, D. C., Hart, S. L., Julian, L., Cox, D., & Pelletier, D. (2004) · BMJ · doi:10.1136/bmj.38041.724421.55 · Cited by 401 · see citing works
Cause of death in patients attending multiple sclerosis clinics
Sadovnick, A. D., Eisen, K., Ebers, G. C., & Paty, D. W. (1991) · Neurology · doi:10.1212/wnl.41.8.1193 · Cited by 401 · see citing works
Mood Disorder and Multiple Sclerosis
Joffe, R. T., Lippert, G. P., Gray, T. A., Sawa, G. M., & Horvath, Z. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520160018007 · Cited by 387 · see citing works
The Measurement of Fatigue in Patients With Multiple Sclerosis
Vercoulen, J. H. M. M. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550070080014 · Cited by 382 · see citing works
Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis.
Mohr, D. C., Boudewyn, A. C., Goodkin, D. E., Bostrom, A., & Epstein, L. (2001) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.69.6.942 · Cited by 334 · see citing works
The Goldman Consensus statement on depression in multiple sclerosis
Goldman Consensus Group (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1162oa · Cited by 329 · see citing works
An examination of suicidal intent in patients with multiple sclerosis
Feinstein, A. (2002) · Neurology · doi:10.1212/wnl.59.5.674 · Cited by 326 · see citing works
Treatment of Depression Improves Adherence to Interferon Beta-1b Therapy for Multiple Sclerosis
Mohr, D. C., Goodkin, D., Likosky, W., Gatto, N. M., Baumann, K. A., & Rudick, R. A. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550170015009 · Cited by 306 · see citing works
The social impact of multiple sclerosis - a study of 305 patients and their relatives
Hakim, E. A., Bakheit, A. M. O., Bryant, T. N., Roberts, M. W. H., McIntosh‐Michaelis, S. A., Spackman, A., Martin, J. P., & McLellan, D. L. (2000) · Disability and Rehabilitation · doi:10.1080/096382800296755 · Cited by 304 · see citing works
Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners: <b>Quality of life and emotional well-being in MS</b>
Janssens, A. C. J. W., van Doorn, P. A., de Boer, J. B., van der Meché, F. G. A., Passchier, J., & Hintzen, R. Q. (2003) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2003.00166.x · Cited by 294 · cited 2× · see citing works
“[72] Janssens ACJW, van Doorn PA, de Boer JB, van der Meche FGA,”
Background
Structural brain abnormalities in multiple sclerosis patients with major depression
Feinstein, A., Roy, P., Lobaugh, N., Feinstein, K., O’Connor, P., & Black, S. (2004) · Neurology · doi:10.1212/01.wnl.0000110316.12086.0c · Cited by 294 · cited 3× · see citing works
“Regarding his subject, a right/left asymmetry was found with predomnance of the lesions in left [26–28] than in the right [29] emisphere.”
Background
Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis
Feuillet, L., Françoise Reuter, A., Audoin, B., Irina Malikova, A., Barrau, K., Chérif, A. A., & Pelletier, J. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506071196 · Cited by 261 · see citing works
The Neuropsychiatry of Multiple Sclerosis
Feinstein, A. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900302 · Cited by 252 · see citing works
Symptomatic therapy and neurorehabilitation in multiple sclerosis
Kesselring, J., & Beer, S. M. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70193-9 · Cited by 250 · see citing works
Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects
Zorzon, M., de Masi, R., Nasuelli, D., Ukmar, M., Pozzi Mucelli, R., Cazzato, G., Bratina, A., & Zivadinov, R. (2001) · Journal of Neurology · doi:10.1007/s004150170184 · Cited by 249 · cited 4× · see citing works
“Regarding his subject, a right/left asymmetry was found with predomnance of the lesions in left [26–28] than in the right [29] emisphere.”
BackgroundInfluential
Lectures ON DISEASES OF THE NERVOUS SYSTEM.
(1872) · The Lancet · doi:10.1016/s0140-6736(02)56646-0 · Cited by 234 · see citing works
Suicide and multiple sclerosis: an epidemiological investigation.
Stenager, E., Stenager, E., Koch–Henriksen, N., Brønnum‐Hansen, H., Hyllested, K., Jensen, K., & Bille‐Brahe, U. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.7.542 · Cited by 218 · see citing works
Depression in multiple sclerosis: Relationship to working memory capacity.
Arnett, P. A., Higginson, C. I., Voss, W. D., Bender, W. I., Wurst, J. M., & Tippin, J. (1999) · Neuropsychology · doi:10.1037//0894-4105.13.4.546 · Cited by 205 · see citing works
Cognition in the early stage of multiple sclerosis
Schulz, D., Kopp, B., Kunkel, A., & Faiss, J. H. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0145-8 · Cited by 195 · see citing works
A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic
Edwards, L. J., & Constantinescu, C. S. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1087oa · Cited by 194 · see citing works
Psychological stress and the subsequent appearance of new brain MRI lesions in MS
Mohr, D. C., Goodkin, D. E., Bacchetti, P., Boudewyn, A. C., Huang, L., Marietta, P., Cheuk, W., & Dee, B. (2000) · Neurology · doi:10.1212/wnl.55.1.55 · Cited by 190 · see citing works
Prevalence and Neurobehavioral Correlates of Pathological Laughing and Crying in Multiple Sclerosis
Feinstein, A., Feinstein, K., Gray, T., & O'Connor, P. W. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550210050012 · Cited by 189 · see citing works
Severely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis.
Grant, I., Brown, G. W., Harris, T., McDonald, W. I., Patterson, T. L., & Trimble, M. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.1.8 · Cited by 187 · see citing works
Depressed mood in multiple sclerosis: Relationship to capacity-demanding memory and attentional functioning.
Arnett, P. A., Higginson, C. I., Voss, W. D., Wright, B. N., Bender, W. I., Wurst, J. M., & Tippin, J. (1999) · Neuropsychology · doi:10.1037/0894-4105.13.3.434 · Cited by 187 · see citing works
Correlates of cognitive impairment and depressive mood disorder in multiple sclerosis
Möller, A. A., Wiedemann, G., Rohde, U., Backmund, H., & Sonntag, A. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb01497.x · Cited by 186 · see citing works
The nature of fatigue in multiple sclerosis
Ford, H. L., Trigwell, P. J., & Johnson, M. H. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00004-x · Cited by 184 · see citing works
Effects of Treatment for Depression on Fatigue in Multiple Sclerosis
Mohr, D. C., Hart, S. L., & Goldberg, A. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000074757.11682.96 · Cited by 183 · see citing works
Disease activity and emotional state in multiple sclerosis
Dalos, N. P., Rabins, P. V., Brooks, B. R., & O'Donnell, P. V. (1983) · Annals of Neurology · doi:10.1002/ana.410130517 · Cited by 183 · see citing works
Association between bipolar affective disorder and multiple sclerosis
Schiffer, R. B., WINEMAN, N. M., & WEITKAMP, L. R. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.1.94 · Cited by 167 · see citing works
Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population
Patten, S. B., Metz, L. M., & Reimer, M. A. (2000) · Multiple Sclerosis Journal · doi:10.1177/135245850000600210 · Cited by 166 · see citing works
Benign multiple sclerosis
Amato, M. P., Zipoli, V., Goretti, B., Portaccio, E., Caro, M. F. D., Ricchiuti, L., Siracusa, G., Masini, M., Sorbi, S., & Trojano, M. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0161-8 · Cited by 164 · see citing works
Managing the symptoms of multiple sclerosis: A multimodal approach
Crayton, H. J., & Rossman, H. S. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.04.005 · Cited by 159 · see citing works
Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis
Pujol, J., Bello, J., Deus, J., Martí-Vilalta, J. L., & Capdevila, A. (1997) · Neurology · doi:10.1212/wnl.49.4.1105 · Cited by 159 · see citing works
Emotional stress and the development of multiple sclerosis: Case-control evidence of a relationship
Warren, S., Greenhill, S., & Warren, K. G. (1982) · Journal of Chronic Diseases · doi:10.1016/0021-9681(82)90047-9 · Cited by 157 · see citing works
Treatment of depression in multiple sclerosis: Review and meta-analysis.
Mohr, D. C., & Goodkin, D. E. (1999) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.6.1.1 · Cited by 155 · see citing works
Depression in multiple sclerosis: Relationship to working memory capacity.
Arnett, P. A., Higginson, C. I., Voss, W. D., et al. (1999) · Neuropsychology · doi:10.1037/0894-4105.13.4.546 · Cited by 155 · see citing works
Symptomatic Treatment of Multiple Sclerosis
Henze, T., Rieckmann, P., & Toyka, K. V. (2006) · European Neurology · doi:10.1159/000095699 · Cited by 154 · see citing works
Increased Depression in Multiple Sclerosis Patients
Schubert, D. S. P., & Foliart, R. H. (1993) · Psychosomatics · doi:10.1016/s0033-3182(93)71902-7 · Cited by 151 · see citing works
Leçons sur les maladies du système nerveux
Charcot, J.-M. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9781139105361 · Cited by 149 · see citing works
The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis
Feinstein, A., O'Connor, P., Gray, T., & Feinstein, K. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500504 · Cited by 147 · see citing works
Psychotic Illness in Multiple Sclerosis
Feinstein, A., du Boulay, G. H., & Ron, M. A. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.161.5.680 · Cited by 137 · see citing works
Psychiatric morbidity in multiple sclerosis: a clinical and MRI study
Ron, M. A., & Logsdail, S. (1989) · Psychological Medicine · doi:10.1017/s0033291700005602 · Cited by 136 · see citing works
A comparison of neuropsychiatric characteristics in chronic fatigue syndrome, multiple sclerosis, and major depression
Pepper, C. M., Krupp, L., Friedberg, F., Doscher, C., & Coyle, P. K. (1993) · Journal of Neuropsychiatry · doi:10.1176/jnp.5.2.200 · Cited by 133 · see citing works
Illness intrusiveness, uncertainty, and distress in individuals with multiple sclerosis.
Mullins, L. L., Cote, M. P., Fuemmeler, B. F., Jean, V. M., Beatty, W. W., & Paul, R. H. (2001) · Rehabilitation Psychology · doi:10.1037/0090-5550.46.2.139 · Cited by 132 · see citing works
Therapeutic expectations of patients with multiple sclerosis upon initiating interferon beta-lb: Relationship to adherence to treatment
Mohr, D. C., Goodkin, D. E., Likosk, W., Gatto, N., Neilley, L. K., Griffin, C., & Stiebling, B. (1996) · Multiple Sclerosis Journal · doi:10.1177/135245859600200502 · Cited by 131 · see citing works
Neuropsychology of multiple sclerosis
Calabrese, P. (2006) · Journal of Neurology · doi:10.1007/s00415-006-1103-1 · Cited by 131 · see citing works
A Replicated Prospective Investigation of Life Stress, Coping, and Depressive Symptoms in Multiple Sclerosis
Aikens, J., Fischer, J., Namey, M., & Rudick, R. (2004) · Journal of behavioral medicine · doi:10.1023/a:1025547431847 · Cited by 125 · see citing works
Emotional stress and coping in multiple sclerosis (MS) exacerbations
Warren, S., Warren, K. G., & Cockerill, R. W. (1991) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(91)90005-9 · Cited by 124 · see citing works
Mood disorders in multiple sclerosis and the effects on cognition.
Feinstein, A. (2006) · Journal of Neurological Sciences · doi:10.1016/j.jns.2005.08.020 · Cited by 120 · see citing works
Psychological stress as risk factor for exacerbations in multiple sclerosis
Nisipeanu, P., & Korczyn, A. D. (1993) · Neurology · doi:10.1212/wnl.43.7.1311 · Cited by 117 · see citing works
Neurobehavioral Aspects of Multiple Sclerosis
Heston, L. L. (1991) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199104000-00018 · Cited by 116 · see citing works
The relationship among depression, subjective cognitive impairment, and neuropsychological performance in multiple sclerosis
Julian, L. J., Merluzzi, N., & Mohr, D. C. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506070255 · Cited by 110 · see citing works
Longitudinal course of depression symptoms in multiple sclerosis
Arnett, P. A. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.047712 · Cited by 107 · see citing works
Prediction of anxiety and distress following diagnosis of multiple sclerosis: a two-year longitudinal study
Janssens, A. C., Buljevac, D., van Doorn, P. A., van der Meché, F. G., Polman, C. H., Passchier, J., & Hintzen, R. Q. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070935 · Cited by 107 · see citing works
Multiple Sclerosis, interferon beta-1b and depression
Feinstein, A., O’Connor, P., & Feinstein, K. (2002) · Journal of Neurology · doi:10.1007/s00415-002-0725-0 · Cited by 103 · see citing works
Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation
BURKS, J. S., & Johnson, K. P. (2000) · Medical Entomology and Zoology · Cited by 100 · see citing works
Fatigue in multiple sclerosis persists over time
Téllez, N., Río, J., Tintoré, M., Nos, C., Galán, I., & Montalbán, X. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0247-3 · Cited by 100 · see citing works
The symptoms and signs of multiple sclerosis
McDonald, I., & Compston, A. (2006) · Elsevier eBooks · doi:10.1016/b978-0-443-07271-0.50008-2 · Cited by 99 · see citing works
Mood and self-esteem of persons with multiple sclerosis following an exacerbation
McCabe, M. P. (2005) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2005.04.010 · Cited by 97 · see citing works
Hypomanic reactions to ACTH and prednisone treatment for multiple sclerosis
Minden, S. L., Orav, J., & Schildkraut, J. J. (1988) · Neurology · doi:10.1212/wnl.38.10.1631 · Cited by 93 · see citing works
Responses to Chronic Illness
Pollock, S. E., Christian, B. J., & Sands, D. (1990) · Nursing Research · doi:10.1097/00006199-199009000-00014 · Cited by 92 · see citing works
Neurobehavioral Aspects of Multiple Sclerosis
Ebers, G. C. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530210023005 · Cited by 91 · see citing works
The Clinical Neuropsychiatry of Multiple Sclerosis
Feinstein, A. (2005) · CNS Spectrums · doi:10.1017/s1092852900022720 · Cited by 90 · see citing works
Emotional changes with multiple sclerosis and Parkinson's disease.
Rao, S. M., Huber, S. J., & Bornstein, R. A. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.3.369 · Cited by 88 · see citing works
Multiple sclerosis presenting with acute remitting psychiatric symptoms.
Matthews, W. B. (1979) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.42.9.859 · Cited by 86 · see citing works
Involvement of the limbic system in multiple sclerosis patients with depressive disorders
Sabatini, U., Pozzilli, C., Pantano, P., Koudriavtseva, T., Padovani, A., Millefiorini, E., Biasi, C. D., Gualdi, G. F., Salvetti, M., & Lenzi, G. L. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00291-x · Cited by 85 · see citing works
Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex
Feinstein, A., O'Connor, P. W., Gray, T., & Feinstein, K. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500201 · Cited by 83 · see citing works
Interferon β-1a and depression in relapsing - remitting multiple sclerosis: an analysis of depression data from the PRISMS clinical trial
Patten, S. B., & Metz, L. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700406 · Cited by 83 · see citing works
Relationship between stress and relapse in multiple sclerosis: part I. Important features
Brown, R. F., Tennant, C. C., Sharrock, M., Hodgkinson, S. J., Dunn, S. M., & Pollard, J. D. (2006) · Multiple Sclerosis Journal · doi:10.1191/1352458506ms1295oa · Cited by 81 · see citing works
Cognitive impairment in newly diagnosed multiple sclerosis patients: A 4-year follow-up study
Jønsson, A., Andresen, J., Storr, L. K., Tscherning, T., Sørensen, P. S., & Ravnborg, M. H. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.09.016 · Cited by 78 · see citing works
Mood disorders in multiple sclerosis: diagnosis and treatment.
Minden, S. L. (2000) · PubMed · Cited by 77 · see citing works
Relationship between stress and relapse in multiple sclerosis: part II. Direct and indirect relationships
Brown, R. F., Tennant, C. C., Sharrock, M., Hodgkinson, S. J., Dunn, S. M., & Pollard, J. D. (2006) · Multiple Sclerosis Journal · doi:10.1191/1352458506ms1296oa · Cited by 76 · see citing works
The relationship between depressive symptoms and cognitive dysfunction in multiple sclerosis
Demaree, H. A., Gaudino, E. A., & DeLuca, J. (2003) · Cognitive Neuropsychiatry · doi:10.1080/13546800244000265 · Cited by 73 · see citing works
The emotional and psychological impact of multiple sclerosis relapses
Kalb, R. C. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.061 · Cited by 73 · see citing works
Multiple sclerosis and depression: influence of interferon b therapy
Zéphir, H., Seze, J. D., Stojkovic, T., Delisse, B., Ferriby, D., Cabaret, M., & Vermersch, P. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms915oa · Cited by 73 · see citing works
Symptomatic therapy for underrecognized manifestations of multiple sclerosis
Krupp, L., & Rizvi, S. (2002) · Neurology · doi:10.1212/wnl.58.8_suppl_4.s32 · Cited by 70 · see citing works
Course of Depression During the Initiation of Interferon Beta-1a Treatment for Multiple Sclerosis
Mohr, D. C., Likosky, W., Dwyer, P., Wende, J. V. D., Boudewyn, A. C., & Goodkin, D. (1999) · Archives of Neurology · doi:10.1001/archneur.56.10.1263 · Cited by 68 · see citing works
Stress and multiple sclerosis
Mohr, D. C. (2007) · Journal of Neurology · doi:10.1007/s00415-007-2015-4 · Cited by 67 · see citing works
Emotional changes with multiple sclerosis and Parkinson's disease
Rao, S. M., Huber, S. J., & Bornstein, R. A. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.60.3.369 · Cited by 67 · see citing works
Lectures on Diseases of the Nervous System
H, &. J. H. (1880) · The American Journal of the Medical Sciences · doi:10.1097/00000441-188001000-00027 · Cited by 67 · see citing works
Cognitive changes in early MS: A call for a common framework
Achiron, A., & Barak, Y. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.05.019 · Cited by 62 · see citing works
A new approach to affective symptoms in relapsing-remitting multiple sclerosis
Noy, S., Achiron, A., Gabbay, U., Barak, Y., Rotstein, Z., Laor, N., & Sarova-Pinhas, I. (1995) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(95)90121-3 · Cited by 61 · see citing works
Multiple sclerosis. Diagnosis, Medical Management and Rehabilitation
Zajicek, J. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.3.421b · Cited by 58 · see citing works
Multiple sclerosis: correlation of anxiety, physical impairment and cognitive dysfunction
Stenager, E., Knudsen, L., & Jensen, K. B. (1994) · Neurological Sciences · doi:10.1007/bf02340120 · Cited by 57 · see citing works
Patients with multiple sclerosis presenting to psychiatric hospitals.
Pine, D. S., Douglas, C. J., Charles, E., Davies, M., & Kahn, D. A. (1995) · PubMed · Cited by 55 · see citing works
Teaching patients to self-inject: pilot study of a treatment for injection anxiety and phobia in multiple sclerosis patients prescribed injectable medications
Mohr, D. C., Cox, D., Epstein, L. A., & Boudewyn, A. C. (2002) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/s0005-7916(02)00011-3 · Cited by 53 · see citing works
Stress and Its Relationship to Acute Exacerbations in Multiple Sclerosis
Franklin, G. M., Nelson, L. M., Heaton, R. K., BURKS, J. S., & Thompson, D. S. (1988) · Neurorehabilitation and neural repair · doi:10.1177/136140968800200102 · Cited by 53 · see citing works
From Symptom to Diagnosis: Illness Experiences of Multiple Sclerosis Patients
Isaksson, A., & Ahlström, G. (2006) · Journal of Neuroscience Nursing · doi:10.1097/01376517-200608000-00005 · Cited by 51 · see citing works
Self-Injection Anxiety Training: a treatment for patients unable to self-inject injectable medications
Mohr, D. C., Cox, D., & Merluzzi, N. (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1146oa · Cited by 51 · see citing works
Multiple sclerosis and hysteria. Lessons learned from their association
Caplan, L. R. (1980) · JAMA · doi:10.1001/jama.243.23.2418 · Cited by 45 · see citing works
Depression and mood disorders in multiple sclerosis.
Minden, S. L., & Schiffer, R. B. (1991) · Neuropsychiatry, neuropsychology, and behavioral neurology · Cited by 40 · see citing works
Stress regulation in multiple sclerosis – current issues and concepts
Heesen, C., Mohr, D. C., Huitinga, I., Bergh, F. T., Gaab, J., Otte, C., & Gold, S. M. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506070772 · Cited by 39 · see citing works
Psychological aspects of multiple sclerosis and its treatment: Toward a biopsychosocial perspective.
VanderPlate, C. (1984) · Health Psychology · doi:10.1037//0278-6133.3.3.253 · Cited by 38 · see citing works
Interferon beta treatment of multiple sclerosis
Klapper, J. A. (1994) · Neurology · doi:10.1212/wnl.44.1.188-a · Cited by 34 · see citing works
Trauma, stress and multiple sclerosis
Martinelli, V. (2000) · Neurological Sciences · doi:10.1007/s100720070024 · Cited by 33 · see citing works
Into the Unknown
Barker-Collo, S. L., Cartwright, C., & Read, J. (2006) · Journal of Neuroscience Nursing · doi:10.1097/01376517-200612000-00008 · Cited by 31 · see citing works
Long-term emotional state of multiple sclerosis patients treated with interferon beta
Porcel, J., Río, J., Sánchez-Betancourt, A., Arévalo, M. J., Tintoré, M., Téllez, N., Borrás, C., Nos, C., & Montalbán, X. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070748 · Cited by 30 · see citing works
Depression in Multiple Sclerosis Associated with Interferon Beta-1a (Rebif)
Pandya, R., & Patten, S. B. (2002) · The Canadian Journal of Psychiatry · doi:10.1177/070674370204700720 · Cited by 28 · see citing works
Psychological aspects of multiple sclerosis and its treatment: Toward a biopsychosocial perspective.
VanderPlate, C. (1984) · Health Psychology · doi:10.1037/0278-6133.3.3.253 · Cited by 24 · see citing works
The History of Multiple Sclerosis
McDonald, W. I. (2001) · CRC Press eBooks · doi:10.1201/9780824741846-5 · Cited by 17 · see citing works
Treatment of neuropsychiatric conditions associated with multiple sclerosis
Ameis, S. H., & Feinstein, A. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.10.1555 · Cited by 13 · see citing works
Assessing the Psychosocial Impact of Multiple Sclerosis: Learning from Research on Rheumatoid Arthritis
Schiaffino, K. M., Shawaryn, M. A., & Blum, D. (1996) · Neurorehabilitation and neural repair · doi:10.1177/154596839601000201 · Cited by 10 · see citing works
Assessment of Psychosocial Outcomes
LaRocca, N. G., Kalb, R., Foley, F. W., & Caruso, L. S. (1993) · Neurorehabilitation and neural repair · doi:10.1177/136140969300700305 · Cited by 7 · see citing works
Multiple Sclerosis: Tissue Destruction and Repair
Johnson, K. P., Kappos, L., Kesselring, J., & Radue, E. W. (2007) · Cited by 7 · see citing works
Neuropsychiatry: cognition and mood disorders
Foong, J., & Ron, M. A. (2003) · UCL Discovery (University College London) · Cited by 4 · see citing works
Tissue destruction and repair
Cawston, T. E., Young, D. A., & Rowan, A. D. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-06551-1.00017-8 · Cited by 3 · see citing works
Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.
(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2 · see citing works
Mood Disorders and Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Multiple Sclerosis
Fassbender, K. C., Schmidt, R., Mößner, R., Kischka, U., Kühnen, J., Schwartz, A., & Hennerici, M. G. (1998) · Archives of Neurology · doi:10.1001/archneur.55.1.66

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A large-scale study of anxiety and depression in people with multiple sclerosis: a survey via the web portal of the UK MS register
Jones, K. H., Ford, D. V., Jones, P. A., John, A., Middleton, R. M., Lockhart-Jones, H., Osborne, L. A., & Noble, J. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041910 · Cited by 190 · see citing works
Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art
Silveira, C., Guedes, R., Maia, D., Curral, R., & Coelho, R. C. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.0106 · Cited by 181 · see citing works
Neuropsychiatric syndromes of multiple sclerosis
Murphy, R., O’Donoghue, S., Counihan, T. J., McDonald, C., Calabresi, P. A., Ahmed, M. A., Kaplin, A. I., & Hallahan, B. P. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-315367 · Cited by 170 · see citing works
Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis
Rossi, S., Studer, V., Motta, C., Polidoro, S., Perugini, J., Macchiarulo, G., Giovannetti, A., Pareja-Gutierrez, L., Calò, A., Colonna, I., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004411 · Cited by 151 · see citing works
Social-psychological adjustment to multiple sclerosis
Brooks, N. A., & Matson, R. R. (1982) · Social Science & Medicine · doi:10.1016/0277-9536(82)90262-3 · Cited by 166 · see citing works
An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial
Fischer, A., Schröder, J., Vettorazzi, E., Wolf, O. T., Pöttgen, J., Lau, S., Heesen, C., Moritz, S., & Gold, S. M. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00049-2 · Cited by 143 · see citing works
Characterization of functioning in multiple sclerosis using the ICF
Holper, L., Coenen, M., Weise, A., Stucki, G., Cieza, A., & Kesselring, J. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5282-4 · Cited by 132 · see citing works
Prediction of psychological adjustment to multiple sclerosis
Barnwell, A. M., & Kavanagh, D. J. (1997) · Social Science & Medicine · doi:10.1016/s0277-9536(96)00356-5 · Cited by 116 · see citing works
Validation of Mood Measures for People with Multiple Sclerosis
Watson, T. M., Ford, E., Worthington, E. J., & Lincoln, N. B. (2014) · International Journal of MS Care · doi:10.7224/1537-2073.2013-013 · Cited by 112 · see citing works
Anxiety and depression in patients with multiple sclerosis: The mediating effects of perceived social support
Henry, A., Tourbah, A., Camus, G., Deschamps, R., Mailhan, L., Castex, C., Gout, O., & Montreuil, M. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.09.039 · Cited by 95 · see citing works
Review: Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment
Haussleiter, I. S., Brüne, M., & Juckel, G. (2009) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285608100325 · Cited by 93 · see citing works
Social Cognition Impairments in Relapsing-Remitting Multiple Sclerosis
Henry, A., Tourbah, A., Chaunu, M., Rumbach, L., Montreuil, M., & Bakchine, S. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711001147 · Cited by 89 · see citing works
The effects of a group-based cognitive behavioral therapy on people with multiple sclerosis: a randomized controlled trial
Graziano, F., Calandri, E., Borghi, M., & Bonino, S. (2014) · Clinical Rehabilitation · doi:10.1177/0269215513501525 · Cited by 87 · see citing works
Quality of life in multiple sclerosis in France, Germany, and the United Kingdom
Murphy, N., Confavreux, C., Haas, J., Konig, N., Roullet, E., Sailer, M., Swash, M., Young, C., & J-L, M. (1998) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.4.460 · Cited by 119 · see citing works
Depression and anxiety in a Portuguese MS population: associations with physical disability and severity of disease.
da Silva, A. M., Vilhena, E., Lopes, A., Santos, E., Gonçalves, M. A., Pinto, C., Moreira, I., Mendonça, D., & Cavaco, S. (2011) · Journal of Neurological Sciences · doi:10.1016/j.jns.2011.03.042 · Cited by 86 · see citing works
Determinants of sexual dysfunction in women with multiple sclerosis
Mohammadi, K., Rahnama, P., Mohseni, S. M., Sahraian, M. A., & Montazeri, A. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-83 · Cited by 82 · see citing works
Meditation as an adjunct to the management of multiple sclerosis.
Levin, A. B., Hadgkiss, E. J., Weiland, T. J., & Jelinek, G. A. (2014) · Neurology Research International · doi:10.1155/2014/704691 · Cited by 77 · see citing works
Life issues in multiple sclerosis
Simmons, R. D. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.143 · Cited by 75 · see citing works
Quality of life in patients with multiple sclerosis and its association with depressive symptoms and physical disability
Ochoa, A., Mojica, T. G. H., Paz-Rodríguez, F., Jara‐Prado, A., Santos, Z. T.-D. L., Sánchez-Guzmán, M. A., Guerrero‐Camacho, J. L., Corona, T., Flores, J., Camacho‐Molina, A., et al. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101386 · Cited by 78 · see citing works
Autoimmune and inflammatory mechanisms of CNS damage
Kapadia, M., & Šakić, B. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.008 · Cited by 75 · see citing works
Psychiatric disorders in multiple sclerosis
Sparaco, M., Lavorgna, L., & Bonavita, S. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09426-6 · Cited by 79 · see citing works
Evaluation of an adjustment group forpeople with multiple sclerosis and lowmood: a randomized controlled trial
Lincoln, N. B., Yuill, F., Holmes, J., Drummond, A. E., Constantinescu, C. S., Armstrong, S., & Phillips, C. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511408753 · Cited by 73 · see citing works
Pilot evaluation of a resilience training program for people with multiple sclerosis
Pakenham, K. I., Mawdsley, M., Brown, F. L., & Burton, N. W. (2018) · Rehabilitation Psychology · doi:10.1037/rep0000167 · Cited by 71 · see citing works
Physical disability, anxiety and depression in people with MS: an internet-based survey via the UK MS Register
Jones, K. H., Jones, P. A., Middleton, R. M., Ford, D. V., Tuite-Dalton, K., Lockhart-Jones, H., Peng, J., Lyons, R. A., John, A., & Noble, J. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104604 · Cited by 69 · see citing works
Stress Management and Multiple Sclerosis: A Randomized Controlled Trial
Artemiadis, A., Vervainioti, A. A., Alexopoulos, E. C., Rombos, A., Anagnostouli, M. C., & Darviri, C. (2012) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acs039 · Cited by 100 · see citing works
Lifestyle factors, demographics and medications associated with depression risk in an international sample of people with multiple sclerosis
Taylor, K. L., Hadgkiss, E. J., Jelinek, G. A., Weiland, T. J., Pereira, N. G., Marck, C. H., & van der Meer, D. M. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0327-3 · Cited by 70 · see citing works
Difficulties with emotion regulation in multiple sclerosis: Links to executive function, mood, and quality of life
Phillips, L. H., Henry, J. D., Nouzová, E., Cooper, C., Radlak, B., & Summers, F. (2014) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2014.946891 · Cited by 64 · see citing works
Health-related quality of life outcomes at 1 and 5 years after a residential retreat promoting lifestyle modification for people with multiple sclerosis
Hadgkiss, E. J., Jelinek, G. A., Weiland, T. J., Rumbold, G., Mackinlay, C. A., Gutbrod, S., & Gawler, I. (2012) · Neurological Sciences · doi:10.1007/s10072-012-0982-4 · Cited by 63 · see citing works
Pathogenic Mechanisms of Depression in Multiple Sclerosis
Vattakatuchery, J. J., Rickards, H. E., & Cavanna, A. E. (2011) · Journal of Neuropsychiatry · doi:10.1176/jnp.23.3.jnp261 · Cited by 65 · see citing works
Treating Post-traumatic Stress Disorder in Patients with Multiple Sclerosis: A Randomized Controlled Trial Comparing the Efficacy of Eye Movement Desensitization and Reprocessing and Relaxation Therapy
Carletto, S., Borghi, M., Bertino, G., Oliva, F., Cavallo, M., Hofmann, A., Zennaro, A., Malucchi, S., & Ostacoli, L. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00526 · Cited by 61 · see citing works
Depression, Positive and Negative Affect, Optimism and Health-Related Quality of Life in Recently Diagnosed Multiple Sclerosis Patients: The Role of Identity, Sense of Coherence, and Self-efficacy
Calandri, E., Graziano, F., Borghi, M., & Bonino, S. (2016) · Journal of Happiness Studies · doi:10.1007/s10902-016-9818-x · Cited by 55 · see citing works
Alexithymia in multiple sclerosis: A systematic review of literature
Chalah, M. A., & Ayache, S. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.07.034 · Cited by 56 · see citing works
The Neuroimmunological Basis of Behavior and Mental Disorders
Siegel, A., & Zalcman, S. S. (2008) · Springer eBooks · doi:10.1007/978-0-387-84851-8 · Cited by 50 · see citing works
Improving the quality of life and psychological well-being of recently diagnosed multiple sclerosis patients: preliminary evaluation of a group-based cognitive behavioral intervention
Calandri, E., Graziano, F., Borghi, M., & Bonino, S. (2017) · Disability and Rehabilitation · doi:10.1080/09638288.2016.1198430 · Cited by 49 · see citing works
Evaluation of an adjustment group for people with multiple sclerosis: a pilot randomized controlled trial
Forman, A., & Lincoln, N. (2010) · Clinical Rehabilitation · doi:10.1177/0269215509343492 · Cited by 54 · see citing works
In multiple sclerosis anxiety, not depression, is related to gender
Théaudin, M., Romero, K., & Feinstein, A. (2016) · Multiple Sclerosis · doi:10.1177/1352458515588582 · Cited by 46 · see citing works
Carnitine for fatigue in multiple sclerosis
Tejani, A. M., Wasdell, M. B., Spiwak, R. P., Rowell, G., & Nathwani, S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007280.pub3 · Cited by 43 · see citing works
Anxiety in multiple sclerosis is related to depressive symptoms and cognitive complaints
Wallis, O. C., Bol, Y., Köhler, S., & Heugten, C. M. V. (2019) · Acta Neurologica Scandinavica · doi:10.1111/ane.13191 · Cited by 43 · see citing works
Third wave cognitive behavioural therapies for people with multiple sclerosis: a scoping review
Zarotti, N., Eccles, F., Broyd, A., Longinotti, C., Mobley, A., & Simpson, J. (2023) · Disability and Rehabilitation · doi:10.1080/09638288.2022.2069292 · Cited by 40 · see citing works
Diagnostic accuracy for major depression in multiple sclerosis using self‐report questionnaires
Fischer, A., Fischer, M. M., Nicholls, R. A., Lau, S., Poettgen, J., Patas, K., Heesen, C., & Gold, S. M. (2015) · Brain and Behavior · doi:10.1002/brb3.365 · Cited by 40 · see citing works
Personality characteristics and disorders in multiple sclerosis patients: Assessment and treatment
Stathopoulou, A., Christopoulos, P., Soubasi, E., & Gourzis, P. (2010) · International Review of Psychiatry · doi:10.3109/09540261003589349 · Cited by 40 · see citing works
Economic Burden in a German Cohort of Patients with Multiple Sclerosis
Reese, J. P., John, A., Wienemann, G., Wellek, A., Sommer, N., Tackenberg, B., Balzer‐Geldsetzer, M., & Dodel, R. C. (2011) · European Neurology · doi:10.1159/000331043 · Cited by 39 · see citing works
Longitudinal Associations of Modifiable Lifestyle Factors With Positive Depression-Screen Over 2.5-Years in an International Cohort of People Living With Multiple Sclerosis
Taylor, K. L., Simpson, S., Jelinek, G. A., Neate, S. L., Livera, A. M. D., Brown, C. R., O’Kearney, E., Marck, C. H., & Weiland, T. J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00526 · Cited by 37 · see citing works
Longitudinal study of alexithymia and multiple sclerosis
Chahraoui, K., Duchene, C., Rollot, F., Bonin, B., & Moreau, T. (2013) · Brain and Behavior · doi:10.1002/brb3.194 · Cited by 37 · see citing works
Young adults’ adjustment to a recent diagnosis of multiple sclerosis: The role of identity satisfaction and self-efficacy
Calandri, E., Graziano, F., Borghi, M., & Bonino, S. (2018) · Disability and health journal · doi:10.1016/j.dhjo.2018.07.008 · Cited by 34 · see citing works
Physical Activity, Resilience, Sense of Coherence and Coping in People with Multiple Sclerosis in the Situation Derived from COVID-19
Reguera-García, M. M., Liébana‐Presa, C., Álvarez-Barrio, L., Gomes, L., & Fernández‐Martínez, E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218202 · Cited by 34 · see citing works
Psychological well-being in people with multiple sclerosis and its association with illness perception and self-esteem
Timková, V., Mikula, P., Fedičová, M., Szilasiová, J., & Nagyová, I. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103114 · Cited by 33 · see citing works
The effectiveness of whole-body cryotherapy and physical exercises on the psychological well-being of patients with multiple sclerosis: A comparative analysis
Pawik, M., Kowalska, J., & Rymaszewska, J. (2019) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/104529 · Cited by 32 · see citing works
The Mediating Role of Stigma, Internalized Shame, and Autonomous Motivation in the Relationship Between Depression, Anxiety, and Psychological Help-Seeking Attitudes in Multiple Sclerosis
Barta, T., & Kiropoulos, L. A. (2022) · International Journal of Behavioral Medicine · doi:10.1007/s12529-022-10078-6 · Cited by 30 · see citing works
The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration
Reiss, J. P., & King, R. (2013) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s34160 · Cited by 28 · see citing works
The Diagnosis of Psychosis
Cardinal, R. N., & Bullmore, E. T. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511686917 · Cited by 28 · see citing works
Quality of life in multiple sclerosis: Effects of current treatment options
Kargiotis, O., Paschali, A. N., Messinis, L., & Papathanasopoulos, P. (2010) · International Review of Psychiatry · doi:10.3109/09540261003589521 · Cited by 27 · see citing works
Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review
Kampaite, A., Gustafsson, R., York, E. N., Foley, P., MacDougall, N., Bastin, M. E., Chandran, S., Waldman, A. D., & Meijboom, R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299634 · Cited by 29 · see citing works
Multiple sclerosis and immunological-related risk factors: Results from a case-control study
Eftekharian, M. M., Mousavi, M., Hormoz, M. B., Roshanaei, G., & Mazdeh, M. (2015) · Human Antibodies · doi:10.3233/hab-150281 · Cited by 25 · see citing works
Elevated moral condemnation of third-party violations in multiple sclerosis patients
Patil, I., Young, L., Sinay, V. J., & Gleichgerrcht, E. L. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1175380 · Cited by 25 · see citing works
Cost-effectiveness of an adjustment group for people with multiple sclerosis and low mood: a randomized trial
Humphreys, I., Drummond, A. E., Phillips, C. J., & Lincoln, N. B. (2013) · Clinical Rehabilitation · doi:10.1177/0269215513488608 · Cited by 24 · see citing works
The Gap in the Current Research on the Link between Health Locus of Control and Multiple Sclerosis: Lessons and Insights from a Systematic Review
Bragazzi, N. L. (2013) · Multiple Sclerosis International · doi:10.1155/2013/972471 · Cited by 23 · see citing works
Anxiety and depressive symptoms in clinically isolated syndrome and multiple sclerosis.
Anhoque, C., Domingues, S. C. A., Carvalho, T., Teixeira, A., & Domingues, R. (2011) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2011000700006 · Cited by 31 · see citing works
Electroconvulsive Therapy in a Patient With Multiple Sclerosis and Recurrent Catatonia
Pontikes, T. K., & Dinwiddie, S. H. (2010) · Journal of Ect · doi:10.1097/yct.0b013e3181d039e6 · Cited by 23 · see citing works
Systematic Review of Cognitive Dysfunction in Pediatric and Juvenile Multiple Sclerosis
Cardoso, M. R. R., Olmo, N. R. S., & Fragoso, Y. D. (2015) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2015.06.007 · Cited by 22 · see citing works
Impaired recognition of facial emotional expressions in Multiple Sclerosis
Lenne, B., Barthélémy, R., Nandrino, J., Sequeira, H., Pinti, A., Mecheri, H., Kwiatkowski, A., & Hautecoeur, P. (2014) · Neuropsychological Trends · doi:10.7358/neur-2014-015-lenn · Cited by 22 · see citing works
Quality of Life in Patients With Multiple Sclerosis in Turkey: Relationship to Depression and Fatigue
Tanrıverdi, D., Okanl, A., Sezgin, S., & Ekinci, M. (2010) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0b013e3181ecb019 · Cited by 22 · see citing works
Pythagorean Self-Awareness Serves Successfully as a New Cognitive Behavioral-Based Technique in Multiple Sclerosis Physical and Psychosocial Well-Being and Quality of Life
Darviri, C., Zavitsanou, C., Delikou, A., Giotaki, A., Artemiadis, A., Anagnostouli, M. C., Varvogli, L., Vasdekis, S. N., & Chrousos, G. P. (2016) · Psychology · doi:10.4236/psych.2016.74059 · Cited by 21 · see citing works
Effect of Cognitive-Behavioral Group Therapy on Pain Self-efficacy, Fatigue, Life Expectancy and Depression in Patients With Multiple Sclerosis: A Randomized Controlled Clinical Trial
Department of Educational Sciences, F. O. L. A. H., Shareh, H., Robati, Z., & Department of Clinical Psychology, F. O. P. A. E. S. (2021) · Iranian Journal of Psychiatry and Clinical Psychology · doi:10.32598/ijpcp.26.3.225.11 · Cited by 20 · see citing works
Relationship Between Disease-Modifying Therapy and Depression in Multiple Sclerosis
Kirzinger, S. S., Jones, J. P., Siegwald, A., & Crush, A. B. (2013) · International Journal of MS Care · doi:10.7224/1537-2073.2012-036 · Cited by 17 · see citing works
EMDR treatment for anxiety in MS patients: A pilot study
Wallis, O. C., & de Vries, J. (2020) · Multiple Sclerosis Journal - Experimental, Translational and Clinical · doi:10.1177/2055217320974388 · Cited by 16 · see citing works
“cognitive complaints, and has a negative influence on one’s work and social life.(4) A high level of anx-”
Background
Fear of relapse in patients suffering from RRMS influence their quality of life
Khatibi, A., Weiland, T. J., & Dehghani, M. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103137 · Cited by 16 · see citing works
The mediating role of psychological flexibility in the relationship between resilience and distress and quality of life in people with multiple sclerosis
Pakenham, K. I., Landi, G., Grandi, S., & Tossani, E. (2023) · Journal of Health Psychology · doi:10.1177/13591053231182364 · Cited by 19 · see citing works
Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis
Michalski, D., Liebig, S., Thomae, E., Singer, S., Hinz, A., & Bergh, F. T. (2010) · Mental Illness · doi:10.4081/mi.2010.e5 · Cited by 17 · see citing works
Depression in multiple sclerosis.
Mrabet, S., Ali, N. B., Kchaou, M., & Belal, S. (2014) · Revue neurologique (Paris) · doi:10.1016/j.neurol.2014.07.017 · Cited by 10 · see citing works
The Self-Efficacy in Multiple Sclerosis (SEMS) Scale
Bonino, S., Graziano, F., Borghi, M., Marengo, D., Molinengo, G., & Calandri, E. (2016) · European Journal of Psychological Assessment · doi:10.1027/1015-5759/a000350 · Cited by 16 · see citing works
Perceived discrimination in patients with multiple sclerosis and depressive symptomatology
Ochoa, A., Fresán, A., Mojica, T. G. H., Jara‐Prado, A., Corona, T., Flores-Rivera, J. D. J., Rito-García, C., Rivas‐Alonso, V., Guerrero‐Camacho, J. L., & de Montellano, D. J. D. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102705 · Cited by 15 · see citing works
Diagnostik und Behandlung akuter psychoorganischer Syndrome
Thomas, C., Drießen, M., & Arolt, V. (2010) · Der Nervenarzt · doi:10.1007/s00115-010-3013-9 · Cited by 15 · see citing works
Evaluation of NeuroPage as a memory aid for people with multiple sclerosis: A randomised controlled trial
Goodwin, R. A., Lincoln, N. B., das Nair, R., & Bateman, A. (2018) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2018.1447973 · Cited by 14 · see citing works
Older age, higher perceived disability and depressive symptoms predict the amount and severity of work-related difficulties in persons with multiple sclerosis
Raggi, A., Giovannetti, A. M., Schiavolin, S., Brambilla, L., Brenna, G., Confalonieri, P. A., Cortese, F., Frangiamore, R., Leonardi, M., Mantegazza, R., et al. (2018) · Disability and Rehabilitation · doi:10.1080/09638288.2018.1461937 · Cited by 14 · see citing works
Effectiveness of Mindfulness-Based Cognitive Therapy on Psychological Aspects of Quality of Life, Depression, Anxiety, and Stress Among Patients With Multiple Sclerosis
Ghodspour, Z., Najafi, M., & Boogar, I. R. (2018) · Practice in Clinical Psychology · doi:10.32598/jpcp.6.4.215 · Cited by 14 · see citing works
The Development and Validation of the Impact of Multiple Sclerosis Scale and the Symptoms of Multiple Sclerosis Scale
McMillan, L., & Moore, K. (2006) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2006.01.024 · Cited by 14 · see citing works
Exploring change in a group-based psychological intervention for multiple sclerosis patients
Borghi, M., Bonino, S., Graziano, F., & Calandri, E. (2017) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1306588 · Cited by 13 · see citing works
[Anxiety and depressive psychopathological characteristics of patients with multiple sclerosis at different stages of disease].
Malygin, V., Boyko, A., Konovalova, O. E., Pahtusova, E. E., Dumbrova, E. V., Tishina, I. A., & Malygin, Y. (2019) · Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · doi:10.17116/jnevro20191192258 · Cited by 12 · see citing works
Neuropathic pain, cognitive fusion, and alexithymia in patients with multiple sclerosis: Cross‐sectional evidence for an explanatory model of anxiety symptoms
Carvalho, T., Gomes, C., Rodrigues, A., & da Motta, C. (2023) · Journal of Clinical Psychology · doi:10.1002/jclp.23483 · Cited by 13 · see citing works
Daily hassles reported by Dutch multiple sclerosis patients
van der Hiele, K., Kamminga, N. G. A., Ruimschotel, R. P., Middelkoop, H. A. M., & Visser, L. H. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.06.023 · Cited by 13 · see citing works
Development of a Web-Based Mindfulness Program for People With Multiple Sclerosis: Qualitative Co-Design Study
Sesel, A.-L., Sharpe, L., Beadnall, H. N., Barnett, M. H., Szabó, M., & Naismith, S. L. (2020) · Journal of Medical Internet Research · doi:10.2196/19309 · Cited by 12 · see citing works
A Pilot Randomised Control Trial of an Online Acceptance and Commitment Therapy (ACT) Resilience Training Program for People with Multiple Sclerosis
Pakenham, K. I., & Landi, G. (2023) · Sclerosis · doi:10.3390/sclerosis1010005 · Cited by 15 · see citing works
Facial Emotion Recognition and Faux Pas Interpretation in Multiple Sclerosis
Henry, A., Bakchine, S., Maarouf, A., Chaunu, M., Rumbach, L., Magnin, É., Tourbah, A., & Montreuil, M. (2015) · Brain Impairment · doi:10.1017/brimp.2015.33 · Cited by 12 · see citing works
Meaning of Self in Multiple Sclerosis: Implications for Treatment and Rehabilitation
Wilski, M., & Tasiemski, T. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-47861-6_4 · Cited by 12 · see citing works
Cognitive function alone is a poor predictor of health-related quality of life in employed patients with MS: results from a cross-sectional study
Giovannetti, A. M., Schiavolin, S., Brenna, G., Brambilla, L., Confalonieri, P. A., Cortese, F., Covelli, V., Frangiamore, R., Leonardi, M., Mantegazza, R., et al. (2016) · The Clinical Neuropsychologist · doi:10.1080/13854046.2016.1142614 · Cited by 11 · see citing works
Integrating Acupuncture Within a Wellness Intervention for Women With Multiple Sclerosis
Becker, H., Stuifbergen, A. M., Schnyer, R. N., Morrison, J. D., & Henneghan, A. M. (2016) · Journal of Holistic Nursing · doi:10.1177/0898010116644833 · Cited by 11 · see citing works
Cognitive impairment is correlated with reduced quality of life in patients with clinically isolated syndrome
Anhoque, C. F., Neto, L. B., Domingues, S. C. A., Teixeira, A. L., & Domingues, R. B. (2013) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2013005000004 · Cited by 10 · see citing works
The role of psychological well‑being in multiple sclerosis rehabilitation
Fanciullacci, C., Straudi, S., Basaglia, N., & Chisari, C. (2017) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.16.04158-7 · Cited by 11 · see citing works
Clinical and psychological factors associated with fear of relapse in people with multiple sclerosis: A cross-sectional study
Ghaffary, E. M., Panah, M. Y., Vaheb, S., Ghoshouni, H., Shaygannejad, A., Mazloomi, M., Shaygannejad, V., & Mirmosayyeb, O. (2025) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2025.111210 · Cited by 10 · see citing works
Adherence to Therapy, Physical and Mental Quality of Life in Patients with Multiple Sclerosis
Buja, A., Graffigna, G., Mafrici, S. F., Baldovin, T., Pinato, C., Bolzonella, U., Barello, S., Tognetto, A., & Damiani, G. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11070672 · Cited by 9 · see citing works
The relationship between psychopathology, psychosocial adjustment, social support and quality of life in multiple sclerosis
Kotan, V. O., Kotan, Z., Aydın, B., Taşkapılıoğlu, Ö., Alkan, B., Özkaya, G., Sarandöl, A., Turan, Ö. F., & Kırlı, S. (2018) · The European Research Journal · doi:10.18621/eurj.382894 · Cited by 8 · see citing works
A influência do sentido de vida e de fatores psicossociais na qualidade de vida de doentes com esclerose múltipla
Pinto, C. R., & Guerra, M. (2018) · Análise Psicológica · doi:10.14417/ap.1394 · Cited by 7 · see citing works
Anxiety, Depression, and Expanded Disability Status Scale Independently Predict the Perception of Disability in Persons With Multiple Sclerosis: A Cross‐Sectional Study
Curatoli, C., Marcassoli, A., Barbadoro, F., Fornari, A., Leonardi, M., Raggi, A., Schiavolin, S., Terragni, R., Antozzi, C. G., Brambilla, L., et al. (2025) · Behavioural Neurology · doi:10.1155/bn/2744955 · Cited by 7 · see citing works
The Relation between Fatigue Severity with Psychological Symptoms and Quality of Life in Multiple Sclerosis
Salehpoor, G., Kafi, S. M., Rezaei, S., Hosseininezhad, M., & Salehi, I. (2012) · Zahedan Journal of Research in Medical Sciences · Cited by 7 · see citing works
The challenges of healthcare delivery to people with multiple sclerosis in Iran
Abolhassani, S., Yazdannik, A., Taleghani, F., & Zamani, A. (2015) · Journal of Education and Health Promotion · doi:10.4103/2277-9531.171796 · Cited by 7 · see citing works
Efecto del apoyo social en los síntomas depresivos de pacientes portugueses con esclerosis múltiple
Costa, D. C., Sá, M. J., & Calheiros, J. M. (2011) · Revista de Neurología · doi:10.33588/rn.5308.2011161 · Cited by 6 · see citing works
Self-citation
Psychiatric Disorders, Stress, and Their Treatment Among People with Multiple Sclerosis
Mohr, D. C. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0029-6_8 · Cited by 6 · see citing works
Psychometric Properties of the Persian Version of Cognitive Fusion Questionnaire-Chronic Illness in Multiple Sclerosis
Soltani, E., Izadi, S., Sharifi, P., & Poursadeghfard, M. (2022) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.5812/ijpbs.113524 · Cited by 5 · see citing works
Moral Judgment: An Overlooked Deficient Domain in Multiple Sclerosis?
Ayache, S. S., & Chalah, M. A. (2018) · Behavioral Sciences · doi:10.3390/bs8110105 · Cited by 5 · see citing works

Authors: Sá, M. J.
Venue: Clinical Neurology and Neurosurgery
Publisher: Elsevier BV
Published: 2008-11
Volume: 110
Issue: 9
Pages: 868-877
ISSN: 0303-8467 (ISSN-L)
DOI: 10.1016/j.clineuro.2007.10.001
OpenAlex: W2075214874
Cited by: 155
References: 122
Citations by year: 2026: 5 · 2025: 5 · 2024: 3 · 2023: 9 · 2022: 8 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 10
FWCI: 0.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Neurology and Neurosurgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: multiple sclerosis, depression, anxiety, psychological comorbidity, relapse, fatigue, cognitive impairment, stress, life events, bipolar disorder, psychosomatic symptoms, psychosis, suicidal ideation, psychosocial factors, coping, cognitive behavioral therapy, psychotherapy, quality of life, individualized care
MeSH terms: Anxiety, Depression, Humans, Multiple Sclerosis, Psychotic Disorders, Stress, Psychological, Mood Disorders

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