Night shift work and stomach cancer risk in the MCC-Spain study
Open accessAbstract
OBJECTIVES: Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach cancer risk in a population-based case-control study. METHODS: A total of 374 incident stomach adenocarcinoma cases and 2481 population controls were included from the MCC-Spain study. Detailed data on lifetime night shift work were collected including permanent and rotating shifts, and their cumulative duration (years). Adjusted unconditional logistic regression models were used in analysis. RESULTS: A total of 25.7% of cases and 22.5% of controls reported ever being a night shift worker. There was a weak positive, non-significant association between ever having had worked for at least 1 year in permanent night shifts and stomach cancer risk compared to never having worked night shifts (OR=1.2, 95% CI 0.9 to 1.8). However, there was an inverse 'U' shaped relationship with cumulative duration of permanent night shifts, with the highest risk observed in the intermediate duration category (OR 10-20 years=2.0, 95% CI 1.1 to 3.6) (p for trend=0.19). There was no association with ever having had worked in rotating night shifts (OR=0.9, 95% CI 0.6 to 1.2) and no trend according to cumulative duration (p for trend=0.68). CONCLUSION: We found no clear evidence concerning an association between night shift work and stomach cancer risk.
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Many human health effects are linked to misalignment of chronotype, including cancer, obesity, and diabetes.
“Many human health effects are linked to the misalignment of chronotype (Knutson and von Schantz 2018), including cancer, obesity (Gyarmati et al. 2016; Papantoniou et al. 2016, 2017; Gan et al. 2018; Shi et al. 2020; Yousef et al. 2020), and diabetes (Gan et al. 2015; Larcher et al. 2015, 2016).”
From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Gyarmati et al. 2016
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Archaic Introgression Shaped Human Circadian Traits
Velazquez-Arcelay, K., Colbran, L. L., McArthur, E., Brand, C. M., Rinker, D. C., Siemann, J. K., McMahon, D. G., & Capra, J. A. (2023) · Genome Biology and Evolution · doi:10.1093/gbe/evad203 · Cited by 18 · see citing works
“Many human health effects are linked to the misalignment of chronotype (Knutson and von Schantz 2018), including cancer, obesity (Gyarmati et al. 2016; Papantoniou et al. 2016, 2017; Gan et al. 2018; Shi et al. 2020; Yousef et al. 2020), and diabetes (Gan et al. 2015; Larcher et al. 2015, 2016).”
Background
- Authors
- Gyarmati, G., Turner, M. C., Castaño-Vinyals, G., Espinosa, A., Papantoniou, K., Alguacil, J., Costas, L., Pérez-Gómez, B., Martin Sanchez, V., Ardanaz, E., Moreno, V., Gómez-Acebo, I., Fernández-Tardon, G., Villanueva Ballester, V., Capelo, R., Chirlaque, M.-D., Santibáñez, M., Pollán, M., Aragonés, N., & Kogevinas, M.
- Affiliations
- Center for Research in Environmental Epidemiology (ES)
- University of Ottawa (CA)
- Universitat Pompeu Fabra (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Universidad de Cantabria (ES)
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Turner, Michelle C
- ORCID
- Venue
- Occupational and Environmental Medicine
- Publisher
- BMJ
- Published
- 2016-06-16
- Volume
- 73
- Issue
- 8
- Pages
- 520-527
- ISSN
- 0007-1072 (ISSN-L)
- 1351-0711
- 1470-7926
- OpenAlex
- W2440586806
- Cited by
- 20
- References
- 35
- Citations by year
- 2025: 3 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 2 · 2017: 5 · 2016: 1
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- Occupational and Environmental Medicine (publishedVersion)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- HighWire Press Open Archive (submittedVersion)
- UCrea (University of Cantabria) (submittedVersion, cc-by)
- Funders
- Canadian Institutes of Health Research
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- night shift work, gastric cancer, gastric adenocarcinoma, rotating shifts, cancer risk, occupational carcinogens, IARC classification
- MeSH terms
- Adenocarcinoma, Aged, Circadian Rhythm, Female, Humans, Male, Middle Aged, Occupational Diseases, Risk Factors, Spain, Stomach Neoplasms, Work Schedule Tolerance, Logistic Models, Odds Ratio, Case-Control Studies, Occupational Exposure
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