Does night work increase the risk of breast cancer? A systematic review and meta-analysis of epidemiological studies
Abstract
Objective To conduct a systematic review, with meta-analysis, of studies assessing the association between night work and the risk of breast cancer, using available epidemiological evidence.Method Relevant studies were identified by searching several databases and the reference lists of retrieved articles. We combined the relative risks (RR) from individual studies using a random-effects model. Subgroup analysis was carried out as the data showed statistically significant heterogeneity.Results Thirteen studies consisting of eight case-control studies and five cohort studies were included in the analysis. In the combined analysis of all studies, night work was associated with an increased risk for breast cancer (RR = 1.20, 95%CI = 1.08-1.33). The higher-quality studies showed a similar finding with a pooled RR of 1.40 (95%CI = 1.13-1.73). Both case-control studies (RR = 1.32, 95%CI = 1.17-1.50) and cohort studies (RR=1.08, 95%CI = 0.97-1.21) showed a positive association between night work and the risk of breast cancer. No publication bias was found either from Begg's funnel plot (P = 0.086) or the Egger's test (P = 0.107). Additional well-conducted and large-scale epidemiological studies are needed.
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Observational studies consistently suggest positive associations of night shift work with cardiovascular disease and cancer risk.
“Observational studies consistently suggest positive associations of night shift work and cardiovascular disease (CVD)2 and cancer risk.3-18”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [5]
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- Authors
- Jia, Y., Lu, Y., Wu, K., Lin, Q., Shen, W., Zhu, M., Huang, S., & Chen, J.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Wu, Kejin
- Venue
- Cancer Epidemiology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 37
- Issue
- 3
- Pages
- 197-206
- ISSN
- 1877-7821 (ISSN-L)
- OpenAlex
- W1987197677
- Cited by
- 174
- References
- 48
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 15 · 2020: 14 · 2019: 12 · 2018: 17 · 2017: 23 · 2016: 22 · 2015: 19 · 2014: 18 · 2013: 11
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- night work, breast cancer, shift work, circadian rhythm disruption, cancer risk, occupational exposure
- MeSH terms
- Breast Neoplasms, Circadian Rhythm, Female, Humans, Risk Factors, Work Schedule Tolerance, Cohort Studies, Incidence, Case-Control Studies
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