The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Time course of recovery of health status following an infective exacerbation of chronic bronchitis
Open accessAbstract
BACKGROUND: The magnitude and time course of effect of an acute exacerbation of chronic bronchitis (AECB) on health status are not known. Data from the GLOBE study, a randomised double blind trial of antibiotic therapy, were used to investigate these effects. METHODS: 438 patients with AECB received either gemifloxacin 320 mg once daily for 5 days (214 patients) or clarithromycin 500 mg twice daily for 7 days (224 patients) and were followed up for 26 weeks. St George's Respiratory Questionnaire (SGRQ) scores were obtained at baseline and after 4, 12, and 26 weeks. RESULTS: At presentation during an exacerbation SGRQ scores were worse (Total score difference 5.4 units, 95% CI 1.9 to 8.8, p=0.002) in patients who had a subsequent exacerbation during follow up. The greatest improvement in SGRQ score occurred within the first 4 weeks (mean 8.9 units, 95% CI 6.5 to 11.5, p<0.0001). Subsequently, scores improved more rapidly in patients with no further exacerbations. At 26 weeks the difference between the two groups was 9.6 units (95% CI 5.7 to 13.4, p<0.0001). In patients with no further exacerbations the SGRQ score improved between 4 and 12 weeks by a further 4.1 units (95% CI 2.2 to 5.9, p<0.0001). CONCLUSIONS: A single infective AECB has a sustained effect on health status. The recovery period is long even in patients who have no further exacerbations. A second episode within 6 months limits recovery markedly. Treatments that reduce exacerbation frequency could have a significant impact on health status.
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Cites
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Cited by
Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938
Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease
Puhan, M. A., Gimeno-Santos, E., Cates, C. J., & Troosters, T. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005305.pub4 · Cited by 991
Physical Activity and Hospitalization for Exacerbation of COPD
Pitta, F., Troosters, T., Probst, V. S., Spruit, M. A., Decramer, M., & Gosselink, R. (2006) · Chest · doi:10.1378/chest.129.3.536 · Cited by 688
Impact of preventing exacerbations on deterioration of health status in COPD
Spencer, S., Calverley, P. M. A., Burge, P. S., & Jones, P. W. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00121404 · Cited by 441
Self-citationPulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease
Puhan, M. A., Gimeno-Santos, E., Scharplatz, M., Troosters, T., Walters, E. H., & Steurer, J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005305.pub3 · Cited by 379
Metadata
- Authors
- Spencer, S.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2003-07-01
- Volume
- 58
- Issue
- 7
- Pages
- 589-593
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2146257741
- Cited by
- 331
- References
- 23
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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