Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: A randomised controlled trial (the REVIVE trial).
Open accessAbstract
OBJECTIVE: To investigate the effectiveness of a 6-week exercise programme in patients discharged home following critical illness compared with standard care. DESIGN: Multicentre prospective phase II randomised controlled trial, with blinded outcome assessment after hospital discharge, following the 6-week intervention and at 6 months. PARTICIPANTS: 60 patients (30 per group) aged ≥18 years, mechanically ventilated >96 hours, and not in other rehabilitation, that is, cardiac or pulmonary rehabilitation programmes. Participants in the intervention group completed an individually tailored (personalised) exercise programme. OUTCOME MEASURES: Primary outcome measure was SF-36 physical functioning following the intervention. Secondary outcomes included a range of performance-based and patient-reported measures. RESULTS: Improvements in the primary outcome did not differ significantly between groups (mean difference (95% CI) 3.0 (-2.2 to 8.2), p=0.26). The intervention group showed significant improvement compared with the control group (mean difference (95% CI)) in SF-36 role physical (6.6 (0.73 to 12.5), p=0.03); incremental shuttle walk test (83.1 m (8.3 to 157.9), p=0.03); functional limitations profile (-4.8 (-8.7 to -0.9), p=0.02); self-efficacy to exercise (2.2 (0.8 to 3.7), p=0.01) and readiness to exercise (1.3 (0.8 to 1.9), p<0.001). These improvements were not sustained at 6 months except readiness to exercise. Improvements in all other secondary outcome measures were not significant. CONCLUSIONS: There was no statistically significant difference in the primary outcome measure of self-reported physical function following this 6-week exercise programme. Secondary outcome results will help inform future studies. TRIAL REGISTRATION NUMBER: NCT01463579. (results), https://clinicaltrials.gov/.
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Several randomized studies have assessed physical rehabilitation programs for survivors of critical illness.
“Several randomized studies have assessed physical rehabilitation programs for survivors of critical illness (581,606,(644)(645)(646)(647)(648)(649)(650)(651).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [646]
Several randomised studies have assessed physical rehabilitation programmes for survivors of critical illness.
“Several randomised studies have assessed physical rehabilitation programmes for survivors of critical illness [581, 606, 644–651].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [649]
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- [1]1. Critical care on July 20, 2023 by guest. Protected by copyright. http://thorax.bmj.com/ Thorax: first published as 10.1136/thoraxjnl-2016-208723 on 15 November 2016. Downloaded from REFERENCES
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- Authors
- McDowell, K., O'Neill, B., Blackwood, B., Clarke, C., Gardner, E., Johnston, P., Kelly, M., McCaffrey, J., Mullan, B., Murphy, S., Trinder, T. J., Lavery, G., McAuley, D. F., & Bradley, J. M.
- Affiliations
- University of Ulster (GB)
- Queen's University Belfast (GB)
- Craigavon Area Hospital (GB)
- Antrim Area Hospital (GB)
- Altnagelvin Area Hospital (GB)
- Belfast City Hospital (GB)
- Royal Victoria Hospital (GB)
- Ulster Hospital (GB)
- Corresponding author
- O'Neill, Brenda
- ORCID
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2016-11-15
- Volume
- 72
- Issue
- 7
- Pages
- 594.1-595
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- OpenAlex
- W2556581150
- Semantic Scholar
- 1faeddb6318f632931424298d064145d883f90a9
- Cited by
- 84
- References
- 43
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 10 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 10 · 2019: 10 · 2018: 4 · 2017: 4
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Ulster University Research Portal (Ulster University) (submittedVersion, other-oa)
- Research Portal (Queen's University Belfast) (submittedVersion, other-oa)
- Funders
- United Kingdom Clinical Research Collaboration
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- exercise programmes, physical function, critical illness, post-intensive care syndrome, hospital discharge, mechanical ventilation, SF-36, incremental shuttle walk test, functional limitations, self-efficacy
- MeSH terms
- Walk Test, Adult, Aged, Exercise Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Patient Discharge, Prospective Studies, Surveys and Questionnaires, Time Factors, Exercise, Single-Blind Method, Critical Illness, Self Efficacy
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