The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works

Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice

Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works

A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study

Le Gall, J.-R. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.270.24.2957 · Cited by 7,773 · see citing works

The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination

Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746 · see citing works

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124 · see citing works

The Acute Respiratory Distress Syndrome

Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,924 · see citing works

The Acute Respiratory Distress Syndrome

Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

An Expanded Definition of the Adult Respiratory Distress Syndrome

Murray, J. F., Matthay, M. A., Luce, J. M., & Flick, M. R. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.3.720 · Cited by 2,641 · see citing works

Thrombin signalling and protease-activated receptors

Coughlin, S. R. (2000) · Nature · doi:10.1038/35025229 · Cited by 2,495 · see citing works

Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.

Drake, T. A., Morrissey, J. H., & Edgington, T. S. (1989) · Europe PMC (PubMed Central) · Cited by 1,192 · see citing works

Alveolar Fluid Clearance Is Impaired in the Majority of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome

Ware, L. B., & Matthay, M. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.6.2004035 · Cited by 901 · see citing works

Pulmonary Dead-Space Fraction as a Risk Factor for Death in the Acute Respiratory Distress Syndrome

Nuckton, T. J., Alonso, J. A., Kallet, R. H., Daniel, B. M., Pittet, J., Eisner, M. D., & Matthay, M. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012835 · Cited by 888 · see citing works

STRUCTURAL ALTERATIONS OF LUNG PARENCHYMA IN THE ADULT RESPIRATORY DISTRESS SYNDROME

Bachofen, M., & Weibel, E. R. (1982) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00143-x · Cited by 595 · see citing works

Intact Epithelial Barrier Function Is Critical for the Resolution of Alveolar Edema in Humans

Matthay, M. A., & Wiener-Kronish, J. P. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.6_pt_1.1250 · Cited by 588 · see citing works

The Structural Biology of Expression and Function of Tissue Factor

Edgington, T. S., Mackman, N., Brand, K., & Ruf, W. (1991) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646375 · Cited by 550 · see citing works

Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome.

Idell, S., James, K. K., Levin, E. G., Schwartz, B. S., Manchanda, N., Maunder, R. J., Martin, T. R., McLarty, J., & Fair, D. S. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114217 · Cited by 325 · see citing works

Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome

Albertine, K. H., Soulier, M. F., Wang, Z., Ishizaka, A., Hashimoto, S., Zimmerman, G. A., Matthay, M. A., & Ware, L. B. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64455-0 · Cited by 288 · see citing works

Regulation of the Tissue Factor Gene

Mackman, N. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657623 · Cited by 274 · see citing works

Protein C and thrombomodulin in human acute lung injury

Ware, L. B., Fang, X., & Matthay, M. A. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00442.2002 · Cited by 235 · see citing works

Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport

Johnson, M. D., Bao, H., Helms, M. N., Chen, X., Tigue, Z., Jain, L., Dobbs, L. G., & Eaton, D. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600855103 · Cited by 190 · see citing works

Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia

Yan, S.-F., Zou, Y. S., Gao, Y. J., Zhai, C., Mackman, N., Lee, S., Milbrandt, J., Pinsky, D. J., Kisiel, W., & Stern, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8298 · Cited by 177 · see citing works

Interferon-γ and Lipopolysaccharide Potentiate Monocyte Tissue Factor Induction by C-Reactive Protein

Nakagomi, A., Freedman, B., & Geczy, C. L. (2000) · Circulation · doi:10.1161/01.cir.101.15.1785 · Cited by 175 · see citing works

Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion

Golino, P., Ragni, M., Cirillo, P. L., Avvdimento, V. E., Feliciello, A., Esposito, N., Scognamiglio, A., Trimarco, B., Iaccarino, G., Condorelli, M., et al. (1996) · Nature Medicine · doi:10.1038/nm0196-35 · Cited by 174 · see citing works

Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse.

Olman, M. A., Mackman, N., Gladson, C. L., Moser, K. M., & Loskutoff, D. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118201 · Cited by 165 · see citing works

Blockade of Tissue Factor: Treatment for Organ Injury in Established Sepsis

Carraway, M. S., Welty‐Wolf, K. E., Miller, D. L., Ortel, T. L., Idell, S., Ghio, A. J., Petersen, L. C., & Piantadosi, C. A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200204-287oc · Cited by 140 · see citing works

Serial abnormalities of fibrin turnover in evolving adult respiratory distress syndrome

Idell, S., Koenig, K. B., Fair, D. S., Martin, T. R., McLarty, J., & Maunder, R. J. (1991) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1991.261.4.l240 · Cited by 132 · see citing works

Contribution of Tissue Factor Associated with Factor VII

Idell, S., Gonzalez, K. K., Bradford, H. N., MacArthur, C. K., Fein, A. M., Maunder, R. J., Garcia, J. G. N., Griffith, D. E., Weiland, J. E., Martin, T. R., et al. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.6.1466 · Cited by 132 · see citing works

Tissue Factor (Thromboplastin): Localization to Plasma Membranes by Peroxidase-Conjugated Antibodies

Zeldis, S. M., Nemerson, Y., Pitlick, F. A., & Lentz, T. L. (1972) · Science · doi:10.1126/science.175.4023.766 · Cited by 105 · see citing works

Lipopolysaccharide Induction of Tissue Factor Expression in Rabbits

Erlich, J., Fearns, C., Mathison, J. C., Ulevitch, R. J., & Mackman, N. (1999) · Infection and Immunity · doi:10.1128/iai.67.5.2540-2546.1999 · Cited by 92 · see citing works

Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage.

Idell, S., Peters, J., James, K. K., Fair, D. S., & Coalson, J. J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114139 · Cited by 80 · see citing works

Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure

Welty‐Wolf, K. E., Carraway, M. S., Ortel, T. L., Ghio, A. J., Idell, S., Egan, J. O., Zhu, X., Jiao, J., Wong, H. C., & Piantadosi, C. A. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00155.2005 · Cited by 74 · see citing works

Differential Response of Human Lung Epithelial Cells to Fas-Induced Apoptosis

Nakamura, M., Matute‐Bello, G., Liles, W. C., Hayashi, S., Kajikawa, O., Lin, S., Frevert, C. W., & Martin, T. R. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63755-8 · Cited by 67 · see citing works

Tissue Factor Procoagulant Expression by Rat Alveolar Epithelial Cells

Gross, T. J., Simon, R. H., & Sitrin, R. G. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.4.397 · Cited by 49 · see citing works

Temporal changes in pulmonary expression of key procoagulant molecules in rabbits with endotoxin-induced acute lung injury: elevated expression levels of protease-activated receptors

Jesmin, S., Matsuda, N., Sakuma, I., Kobayashi, S., Sakuraya, F., Hattori, Y., & Gando, S. (2004) · Thrombosis and Haemostasis · doi:10.1160/th04-03-0160 · Cited by 42 · see citing works

A quantitative real-time PCR method for tissue factor mRNA

Mälarstig, A., Tenno, T., Jossan, S., Åberg, M., & Siegbahn, A. G. (2003) · Thrombosis Research · doi:10.1016/j.thromres.2003.11.001 · Cited by 30 · see citing works

Alveolar Epithelial Cells Express Both Plasminogen Activator and Tissue Factor

Marshall, B. C., Brown, B. R., Rothstein, M. A., Rao, N. V., Hoidal, J. R., & Rodgers, G. M. (1991) · CHEST Journal · doi:10.1378/chest.99.3_supplement.25s · Cited by 16 · see citing works

Tissue factor is the only activator of coagulation in cultured human lung cancer cells

Keller, T., Salge, U., König, H., Dodt, J., Heiden, M., & Seitz, R. (2001) · Lung Cancer · doi:10.1016/s0169-5002(00)00196-3 · Cited by 14 · see citing works

The role of protein C in sepsis

Looney, M. R., & Matthay, M. A. (2007) · Current Infectious Disease Reports · doi:10.1007/s11908-007-1008-x · Cited by 10 · see citing works

Procoagulant activity in bronchoalveolar lavage in the adult respiratory distress syndrome: contribution of tissue factor associated with factor VII

(1988) · Journal of Critical Care · doi:10.1016/0883-9441(88)90130-x · Cited by 10 · see citing works

Expression of Tissue Factor in Experimental Bovine Pneumonic Pasteurellosis and Endotoxemia

Rashid, J., Weiss, D. J., Murtaugh, M. P., & Bach, R. R. (1997) · Veterinary Clinical Pathology · doi:10.1111/j.1939-165x.1997.tb00736.x · Cited by 7 · see citing works

Alveolar epithelial cells express both plasminogen activator and tissue factor. Potential role in repair of lung injury

Marshall, B. C., Brown, B. R., Rothstein, M. A., Rao, N., Hoidal, J. R., & Rodgers, G. M. (1991) · CHEST Journal · doi:10.1378/chest.99.3.25s · Cited by 5 · see citing works

Acute respiratory distress syndrome

Meyer, N. J., Gattinoni, L., & Calfee, C. S. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00439-6 · Cited by 1,186 · see citing works

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993 · see citing works

The Acute Respiratory Distress Syndrome Network

Jalilian, L., & Wiener-Kronish, J. P. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780190467654.003.0019 · Cited by 936 · see citing works

An aberrant STAT pathway is central to COVID-19

Matsuyama, T., Kubli, S. P., Yoshinaga, S. K., Pfeffer, K., & Mak, T. W. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00633-7 · Cited by 292 · see citing works

COVID–19-associated coagulopathy: An exploration of mechanisms

Colling, M. E., & Kanthi, Y. M. (2020) · Vascular Medicine · doi:10.1177/1358863x20932640 · Cited by 276 · see citing works

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

Frantzeskaki, F. G., Armaganidis, A., & Orfanos, S. E. (2016) · Respiration · doi:10.1159/000453002 · Cited by 276 · see citing works

Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

Wolthuis, E. K., Vlaar, A. P. J., Choi, G., Roelofs, J. J. T. H., Juffermans, N. P., & Schultz, M. J. (2009) · Critical Care · doi:10.1186/cc7688 · Cited by 248 · see citing works

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237 · see citing works

Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses

Mackman, N., Antoniak, S., Wolberg, A. S., Kasthuri, R. S., & Key, N. S. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314514 · Cited by 186 · see citing works

Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?

Chambers, R. C. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707603 · Cited by 175 · see citing works

Pathophysiology of pulmonary hypertension in acute lung injury

Price, L., McAuley, D. F., Marino, P. S., Finney, S. J., Griffiths, M., & Wort, S. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00355.2011 · Cited by 161 · see citing works

Asthma and coagulation

de Boer, J. D., Majoor, C. J., Veer, C. V. ′., Bel, E. H., & van der Poll, T. (2012) · Blood · doi:10.1182/blood-2011-11-391532 · Cited by 159 · see citing works

Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome

Bastarache, J. A., Fremont, R. D., Kropski, J. A., Bossert, F. R., & Ware, L. B. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00214.2009 · Cited by 153 · see citing works

A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome

Blondonnet, R., Constantin, J., Sapin, V., & Jabaudon, M. (2016) · Disease Markers · doi:10.1155/2016/3501373 · Cited by 153 · see citing works

Microparticles and acute lung injury

McVey, M. J., Tabuchi, A., & Kuebler, W. M. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00354.2011 · Cited by 143 · see citing works

Pulmonary Epithelium Is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis

Mercer, P. F., Johns, R., Scotton, C. J., Krupiczojc, M. A., Königshoff, M., Howell, D. C. J., McAnulty, R. J., Das, A., Thorley, A. J., Tetley, T., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200712-1827oc · Cited by 129 · see citing works

Coagulation and coagulation signalling in fibrosis

Mercer, P. F., & Chambers, R. C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.12.013 · Cited by 119 · see citing works

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

Chantrathammachart, P., Mackman, N., Sparkenbaugh, E., Wang, J.-G., Parise, L. V., Kirchhofer, D., Key, N. S., & Pawliński, R. (2012) · Blood · doi:10.1182/blood-2012-04-424143 · Cited by 116 · see citing works

Pathobiology of Acute Respiratory Distress Syndrome

Sapru, A., Flori, H. R., Quasney, M. W., & Dahmer, M. K. (2015) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000431 · Cited by 113 · see citing works

Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence

van Haren, F. M. P., Page, C. P., Laffey, J. G., Artigas, A., Camprubí–Rimblas, M., Nunes, Q. M., Smith, R. J., Shute, J. K., Carroll, M., Tree, J. A., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03148-2 · Cited by 112 · see citing works

Coagulation Cascade Proteinases in Lung Injury and Fibrosis

Chambers, R. C., & Scotton, C. J. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201201-006aw · Cited by 105 · see citing works

Ventilator-associated lung injury: a search for better therapeutic targets

Oeckler, R. A., & Hubmayr, R. D. (2007) · European Respiratory Journal · doi:10.1183/09031936.00104907 · Cited by 103 · see citing works

Particulate Matter-Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through Distinct Mechanisms

Budinger, G. R. S., McKell, J. L., Urich, D., Foiles, N., Weiss, I. M., Chiarella, S. E., Gonzalez, A., Soberanes, S., Ghio, A. J., Niğdelioğlu, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018525 · Cited by 100 · see citing works

Tissue factor as an initiator of coagulation and inflammation in the lung

van der Poll, T. (2008) · Critical Care · doi:10.1186/cc7026 · Cited by 100 · see citing works

Cell-free hemoglobin: a novel mediator of acute lung injury

Shaver, C. M., Upchurch, C. P., Janz, D. R., Grove, B. S., Putz, N. D., Wickersham, N. E., Dikalov, S., Ware, L. B., & Bastarache, J. A. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00155.2015 · Cited by 95 · see citing works

Pulmonary vascular dysfunction in ARDS

Ryan, D., Fröhlich, S., & McLoughlin, P. (2014) · Annals of Intensive Care · doi:10.1186/s13613-014-0028-6 · Cited by 94 · see citing works

Development of animal models for the acute respiratory distress syndrome

Bastarache, J. A., & Blackwell, T. S. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001677 · Cited by 93 · see citing works

Pneumonia, thrombosis and vascular disease

Violi, F., Cangemi, R., & Calvieri, C. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12646 · Cited by 88 · see citing works

Therapeutic Modulation of Coagulation and Fibrinolysis in Acute Lung Injury and the Acute Respiratory Distress Syndrome

Sebag, S. C., Bastarache, J. A., & Ware, L. B. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111798281171 · Cited by 85 · see citing works

The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability

Shetty, S., Padijnayayveetil, J., Tucker, T. A., Stankowska, D. L., & Idell, S. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90349.2008 · Cited by 84 · see citing works

Anticoagulant therapy in acute respiratory distress syndrome

Camprubí–Rimblas, M., Tantinyà, N., Bringué, J., Guillamat‐Prats, R., & Artigas, A. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.01.08 · Cited by 73 · see citing works

The epithelium in acute lung injury/acute respiratory distress syndrome

Gropper, M. A., & Wiener-Kronish, J. P. (2008) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e3282f417a0 · Cited by 65 · see citing works

Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress

Bastarache, J. A., Sebag, S. C., Clune, J. K., Grove, B. S., Lawson, W. E., Janz, D. R., Roberts, L. J., Dworski, R., Mackman, N., & Ware, L. B. (2012) · Thorax · doi:10.1136/thoraxjnl-2012-201781 · Cited by 65 · see citing works

High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field

Pisani, C., Gaillard, J., Nouvel, V., Odorico, M., Armengaud, J., & Prat, O. (2015) · BMC Genomics · doi:10.1186/s12864-015-1521-5 · Cited by 64 · see citing works

Nebulized Heparin Attenuates Pulmonary Coagulopathy and Inflammation through Alveolar Macrophages in a Rat Model of Acute Lung Injury

Chimenti, L., Camprubí–Rimblas, M., Guillamat‐Prats, R., Gomez, M., Tijero, J., Blanch, L. L., & Artigas, A. (2017) · Thrombosis and Haemostasis · doi:10.1160/th17-05-0347 · Cited by 63 · see citing works

Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections

Peteranderl, C., Sznajder, J. I., Herold, S., & Lecuona, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00446 · Cited by 62 · see citing works

Fibrinolysis Shutdown in COVID-19: Clinical Manifestations, Molecular Mechanisms, and Therapeutic Implications

Meizoso, J. P., Moore, H. B., & Moore, E. E. (2021) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2021.02.019 · Cited by 59 · see citing works

The counter-intuitive role of the neutrophil in the acute respiratory distress syndrome

Vassallo, A. M., Wood, A. J. T., Subburayalu, J., Summers, C., & Chilvers, E. R. (2019) · British Medical Bulletin · doi:10.1093/bmb/ldz024 · Cited by 59 · see citing works

Measuring and regulating oxygen levels in microphysiological systems: design, material, and sensor considerations

Rivera, K. R., Yokus, M. A., Erb, P. D., Pozdin, V. A., & Daniele, M. (2019) · The Analyst · doi:10.1039/c8an02201a · Cited by 57 · see citing works

Pharmacological treatments for acute respiratory distress syndrome

Frank, A. J., & Thompson, B. (2009) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e328334b151 · Cited by 57 · see citing works

Activin-A Overexpression in the Murine Lung Causes Pathology That Simulates Acute Respiratory Distress Syndrome

Apostolou, E., Stavropoulos, A., Sountoulidis, A., Xirakia, C., Giaglis, S., Protopapadakis, E., Ritis, K., Mentzelopoulos, S. D., Pasternack, A. H., Foster, M. L., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201105-0784oc · Cited by 57 · see citing works

Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity

Bastarache, J. A., Wang, L., Wang, Z., Albertine, K. H., Matthay, M. A., & Ware, L. B. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00372.2007 · Cited by 56 · see citing works

Diagnostic and prognostic utility of tissue factor for severe sepsis and sepsis-induced acute lung injury

Xue, M., Sun, Z., Shao, M., Yin, J., Deng, Z., Zhang, J., Xing, L., Yang, X., Chen, B., Dong, Z., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0518-9 · Cited by 55 · see citing works

TGF-β1 Induces Tissue Factor Expression in Human Lung Fibroblasts in a PI3K/JNK/Akt-Dependent and AP-1–Dependent Manner

Wygrecka, M., Zakrzewicz, D., Taborski, B., Didiášová, M., Kwapiszewska, G., Preissner, K. T., & Markart, P. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0097oc · Cited by 55 · see citing works

Protective mechanisms of activated protein C in severe inflammatory disorders

Neyrinck, A., Liu, K. D., Howard, J. P., & Matthay, M. A. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00251.x · Cited by 54 · see citing works

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus‐infected mice

Antoniak, S., Tatsumi, K., Hisada, Y., Milner, J. J., Neidich, S. D., Shaver, C. M., Pawliński, R., Beck, M. A., Bastarache, J. A., & Mackman, N. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13307 · Cited by 53 · see citing works

Revista Española de Anestesiología y Reanimación

Macaya, M. B. (2016) · Cited by 52 · see citing works

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

Bazan‐Socha, S., Mastalerz, L., Cybulska, A., Zaręba, L., Kremers, R., Ząbczyk, M., Pulka, G., Iwaniec, T., Hemker, H. C., & Undas, A. (2016) · Clinical & Experimental Allergy · doi:10.1111/cea.12734 · Cited by 51 · see citing works

Regulation of Alveolar Procoagulant Activity and Permeability in Direct Acute Lung Injury by Lung Epithelial Tissue Factor

Shaver, C. M., Grove, B. S., Putz, N. D., Clune, J. K., Lawson, W. E., Carnahan, R. H., Mackman, N., Ware, L. B., & Bastarache, J. A. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0179oc · Cited by 49 · see citing works

Hydroxysafflor yellow a inhibits lipopolysaccharide-induced inflammatory signal transduction in human alveolar epithelial A549 cells

Song, L., Zhu, Y., Jin, M., & Zang, B. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.11.004 · Cited by 49 · see citing works

Cell-derived microparticles and the lung

Nieri, D., Neri, T., Petrini, S., Vagaggini, B., Paggiaro, P., & Celi, A. (2016) · European Respiratory Review · doi:10.1183/16000617.0009-2016 · Cited by 49 · see citing works

Fibrinolytic therapy for refractory COVID‐19 acute respiratory distress syndrome: Scientific rationale and review

Barrett, C. D., Moore, H. B., Moore, E. E., McIntyre, R. C., Moore, P. K., Burke, J., Hua, F., Apgar, J. F., Talmor, D. S., Sauaia, A., et al. (2020) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12357 · Cited by 46 · see citing works

Pathophysiology and Management of Acute Respiratory Distress Syndrome in Children

Heidemann, S. M., Nair, A., Bulut, Y., & Sapru, A. (2017) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2017.06.004 · Cited by 47 · see citing works

PTX3 as a potential biomarker of acute lung injury: supporting evidence from animal experimentation

He, X., Han, B., Bai, X., Zhang, Y., Cypel, M., Mura, M., Keshavjee, S. H., & Liu, M. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1720-0 · Cited by 45 · see citing works

Fibrin formation by wounded bronchial epithelial cell layers in vitro is essential for normal epithelial repair and independent of plasma proteins

Perrio, M. J., Ewen, D., Trevethick, M. A., Salmon, G. P., & Shute, J. K. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02829.x · Cited by 45 · see citing works

Tumor-Derived Tissue Factor Aberrantly Activates Complement and Facilitates Lung Tumor Progression via Recruitment of Myeloid-Derived Suppressor Cells

Han, X., Zha, H., Yang, F., Guo, B., & Zhu, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010022 · Cited by 44 · see citing works

Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation

Bunch, C. M., Moore, E. E., Moore, H. B., Neal, M. D., Thomas, A. V., Zackariya, N., Zhao, J. C., Zackariya, S. K., Brenner, T. J., Berquist, M., et al. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.889999 · Cited by 42 · see citing works

Circulating microparticle levels are reduced in patients with ARDS

Shaver, C. M., Woods, J., Clune, J. K., Grove, B. S., Wickersham, N. E., McNeil, J. B., Shemancik, G., Ware, L. B., & Bastarache, J. A. (2017) · Critical Care · doi:10.1186/s13054-017-1700-7 · Cited by 41 · see citing works

A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome

Morris, P. E., Steingrub, J. S., Huang, B. Y., Tang, S., Liu, P. M., Rhode, P. R., & Wong, H. C. (2012) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-12-5 · Cited by 41 · see citing works

A review of pulmonary coagulopathy in acute lung injury, acute respiratory distress syndrome and pneumonia

Nieuwenhuizen, L., de Groot, P. G., Grutters, J. C., & Biesma, D. H. (2009) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2009.01238.x · Cited by 41 · see citing works

Growth Factors and Cytokines in Acute Lung Injury

Deng, J. C., & Standiford, T. J. (2010) · Comprehensive physiology · doi:10.1002/cphy.c090011 · Cited by 43 · see citing works

Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis via Targeting of Nuclear Factor-κB/Tissue Factor/Factor Xa Pathway in Melanoma B16F10 Cells

Zhao, Y., Zhang, D., Wang, S., Li, T., Wang, A., Chen, W., Zhu, Z., Zheng, S., Gao, X., & Lu, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056557 · Cited by 37 · see citing works

Sulfur mustard inhalation: mechanisms of injury, alteration of coagulation, and fibrinolytic therapy

White, C. W., Rancourt, R. C., & Veress, L. A. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13130 · Cited by 37 · see citing works

Molecular and Immune Biomarkers in Acute Respiratory Distress Syndrome: A Perspective From Members of the Pulmonary Pathology Society

Capelozzi, V. L., Allen, T. C., Beasley, M. B., Cagle, P. T., Guinee, D., Hariri, L. P., Husain, A. N., Jain, D., Lantuéjoul, S., Larsen, B. T., et al. (2017) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2017-0115-sa · Cited by 37 · see citing works

NF-κB p65 Knock-down inhibits TF, PAI-1 and promotes activated protein C production in lipopolysaccharide-stimulated alveolar epithelial cells type II

Liu, Y., Wu, Y., Wang, Y., Cheng, Y., Yao, L., Liu, Y., Qian, H., Yang, H., & Shen, F. (2018) · Experimental Lung Research · doi:10.1080/01902148.2018.1505975 · Cited by 36 · see citing works

The Basic Science and Molecular Mechanisms of Lung Injury and Acute Respiratory Distress Syndrome

Aranda‐Valderrama, P., & Kaynar, A. M. (2017) · International Anesthesiology Clinics · doi:10.1097/aia.0000000000000177 · Cited by 35 · see citing works

Lung Epithelial Cell Transcriptional Regulation as a Factor in COVID-19–Associated Coagulopathies

FitzGerald, E. S., Chen, Y., Fitzgerald, K. A., & Jamieson, A. M. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0453oc · Cited by 35 · see citing works

Understanding the pathophysiology of typical acute respiratory distress syndrome and severe COVID-19

Ball, L., Silva, P. L., Giacobbe, D. R., Bassetti, M., Zubieta-Calleja, G. R., Rocco, P. R. M., & Pelosi, P. P. (2022) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2022.2057300 · Cited by 33 · see citing works

Pharmacological therapies for acute respiratory distress syndrome

Spieth, P. M., & Zhang, H. (2013) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000056 · Cited by 33 · see citing works

THE PROTHROMBOTIC STATE ASSOCIATED WITH SARS-COV-2 INFECTION: PATHOPHYSIOLOGICAL ASPECTS

Semeraro, N., & Colucci, M. (2021) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2021.045 · Cited by 33 · see citing works

Individualized predictions of early isolated distal deep vein thrombosis in patients with acute ischemic stroke: a retrospective study

Cheng, H.-R., Huang, G., Wu, Z., Wu, Y., Lin, G., Song, J., Liu, Y., Luan, X., Yuan, Z., Zhu, W., et al. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02088-y · Cited by 30 · see citing works

Analysis of cytotoxicity induced by proinflammatory cytokines in the human alveolar epithelial cell line A549

Muroya, M. (2012) · BioScience Trends · doi:10.5582/bst.2012.v6.2.70 · Cited by 29 · see citing works

Emodin improves alveolar hypercoagulation and inhibits pulmonary inflammation in LPS-provoked ARDS in mice via NF-κB inactivation

Liu, Y., Cheng, Y., Wu, Y., Zheng, X., Li, X., Yang, G., He, T., Li, S., & Shen, F. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107020 · Cited by 29 · see citing works

Anti-Human Tissue Factor Antibody Ameliorated Intestinal Ischemia Reperfusion-Induced Acute Lung Injury in Human Tissue Factor Knock-In Mice

He, X., Han, B., Mura, M., Li, L. Y., Cypel, M., Soderman, A. R., Picha, K. M., Yang, J., & Liu, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001527 · Cited by 28 · see citing works

Interferon-γ and tumor necrosis factor-α act synergistically to up-regulate tissue factor in alveolar epithelial cells

Bastarache, J. A., Sebag, S. C., Grove, B. S., & Ware, L. B. (2011) · Experimental Lung Research · doi:10.3109/01902148.2011.605512 · Cited by 26 · see citing works

A comprehensive overview of investigational elastase inhibitors for the treatment of acute respiratory distress syndrome

Matera, M. G., Rogliani, P., Ora, J., Calzetta, L., & Cazzola, M. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2263366 · Cited by 24 · see citing works

Tissue Factor Signals Airway Epithelial Basal Cell Survival via Coagulation and Protease-Activated Receptor Isoforms 1 and 2

Ahmad, S., Ahmad, A. M., Rancourt, R. C., Neeves, K. B., Loader, J. E., Hendry‐Hofer, T. B., Paola, J. D., Reynolds, S. D., & White, C. W. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0189oc · Cited by 24 · see citing works

Biological therapies in the acute respiratory distress syndrome

Boyle, A. J., McNamee, J. J., & McAuley, D. F. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.905536 · Cited by 23 · see citing works

Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis

José, R. J. P., Williams, A. E., Manuel, A. R., Brown, J., & Chambers, R. C. (2020) · European Respiratory Review · doi:10.1183/16000617.0240-2020 · Cited by 23 · see citing works

BAY11‑7082 inhibits the expression of tissue factor and plasminogen activator inhibitor‑1 in type‑II alveolar epithelial cells following TNF‑α stimulation via the NF‑κB pathway

Cheng, Y., Liu, Y., Qian, H., Yang, H., Wang, Y., Wu, Y., & Shen, F. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9608 · Cited by 23 · see citing works

Induction of Tissue Factor by Urokinase in Lung Epithelial Cells and in the Lungs

Shetty, S., Bhandary, Y. P., Shetty, S. K., Velusamy, T., Shetty, P. K., Bdeir, K. H., Gyetko, M. R., Cines, D. B., Idell, S., Neuenschwander, P. F., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200901-0015oc · Cited by 22 · see citing works

The Contribution of the Urokinase Plasminogen Activator and the Urokinase Receptor to Pleural and Parenchymal Lung Injury and Repair: A Narrative Review

Tucker, T. A., & Idell, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031437 · Cited by 19 · see citing works

Single immunoglobulin IL-1 receptor-related protein attenuates the lipopolysaccharide-induced inflammatory response in A549 cells

Tian, F., Yun-feng, N., Jinbo, Z., Zhipei, Z., Huizhong, Z., Liu, L., Jiang, T., & Wang, Y. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.11.022 · Cited by 19 · see citing works

Unpuzzling COVID-19 Prothrombotic State: Are Preexisting Thrombophilic Risk Profiles Responsible for Heterogenous Thrombotic Events?

Burlacu, A., Genovesi, S., Popa, I. V., & Crișan-Dabija, R. A. (2020) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029620952884 · Cited by 19 · see citing works

Deep vein thrombosis in acute respiratory distress syndrome caused by bacterial pneumonia

Cui, N., Mi, S., Jiang, C., Sun, W., Mao, W., Zhang, L., & Feng, X. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01632-1 · Cited by 18 · see citing works

Epithelial and Erythrocyte Microvesicles From Bronchoalveolar Lavage Fluid Are Elevated and Associated With Outcome in Chronic Lung Allograft Dysfunction

Harms, A., Fuehner, T., Warnecke, G., Haverich, A., Gottlieb, J., & Trummer, A. (2015) · Transplantation · doi:10.1097/tp.0000000000000881 · Cited by 18 · see citing works

Markers of Inflammation and Coagulation May Be Modulated by Enteral Feeding Strategy

Bastarache, J. A., Ware, L. B., Girard, T. D., Wheeler, A. P., & Rice, T. W. (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111433054 · Cited by 18 · see citing works

Pulmonary disorders, including vocal cord dysfunction

Greenberger, P. A., & Grammer, L. C. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.020 · Cited by 18 · see citing works

Intestinal Epithelium is More Susceptible to Cytopathic Injury and Altered Permeability than the Lung Epithelium in the Context of Acute Sepsis

Julian, M., Bao, S.-Y., Knoell, D., Fahy, R. J., Shao, G., & Crouser, E. (2011) · International journal of experimental pathology (Print) · doi:10.1111/j.1365-2613.2011.00783.x · Cited by 16 · see citing works

Mechanical Stretch Inhibits Lipopolysaccharide-induced Keratinocyte-derived Chemokine and Tissue Factor Expression While Increasing Procoagulant Activity in Murine Lung Epithelial Cells

Sebag, S. C., Bastarache, J. A., & Ware, L. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.403220 · Cited by 17 · see citing works

Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis

Machado, G.-B., OLIVEIRA, A. V. D., Saliba, A. M., de Lima, C. D. M., Suassuna, J. H. R., & Plotkowski, M. C. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-104 · Cited by 17 · see citing works

Emerging targets for treating sulfur mustard–induced injuries

Ahmad, S., & Ahmad, A. M. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13095 · Cited by 17 · see citing works

Síndrome de distrés respiratorio agudo: revisión a propósito de la definición de Berlín

Cabezón, N. D. L., Castro, I. S., Uriarte, U. X. B., Casanova, M. P. R., Jm, G. P., & Celorrio, L. A. (2014) · Revista Española de Anestesiología y Reanimación · doi:10.1016/j.redar.2014.02.007 · Cited by 17 · see citing works

IKKβ regulates the expression of coagulation and fibrinolysis factors through the NF‑κB canonical pathway in LPS‑stimulated alveolar epithelial cells type II

Liu, Y., Wang, Y., Wu, Y., Cheng, Y., Qian, H., Yang, H., & Shen, F. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7928 · Cited by 16 · see citing works

Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury

Shaver, C. M., Grove, B. S., Clune, J. K., Mackman, N., Ware, L. B., & Bastarache, J. A. (2016) · Scientific Reports · doi:10.1038/srep22249 · Cited by 16 · see citing works

Growth Factors and Cytokines in Acute Lung Injury

Deng, J. C., & Standiford, T. J. (2011) · Comprehensive physiology · doi:10.1002/j.2040-4603.2011.tb00315.x · Cited by 15 · see citing works

Coagulation System Activation for Targeting of COVID-19: Insights into Anticoagulants, Vaccine-Loaded Nanoparticles, and Hypercoagulability in COVID-19 Vaccines

Abdel‐Bakky, M. S., Amin, E., Ewees, M. G., Mahmoud, N. I., Mohammed, H. A., Altowayan, W. M., & Abdellatif, A. A. H. (2022) · Viruses · doi:10.3390/v14020228 · Cited by 14 · see citing works

Tissue factor promotes airway pathological features through epithelial-mesenchymal transition of bronchial epithelial cells in mice with house dust mite-induced asthma

Zhao, J., Jiang, T., Li, P., Dai, L., Shi, G., Jing, X., Gao, S., Jia, L., Wu, S., Wang, Y., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107690 · Cited by 13 · see citing works

Pharmacological management of adult patients with acute respiratory distress syndrome

Matera, M. G., Rogliani, P., Bianco, A., & Cazzola, M. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1801636 · Cited by 13 · see citing works

Epithelial-Cell-Derived Extracellular Vesicles in Pathophysiology of Epithelial Injury and Repair in Chronic Rhinosinusitis: Connecting Immunology in Research Lab to Biomarkers in Clinics

Takahashi, T., & Schleimer, R. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111709 · Cited by 12 · see citing works

Sulfated Extracellular Matrix Modulates Differentiation of Human Alveolar Type II Cells In Vitro

Apparao, K. B. C., Newman, D. R., Zhang, H., Khosla, J., & Sannes, P. L. (2012) · Proceedings of the American Thoracic Society

Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity

Bastarache, J. A., Wang, L., Wang, Z., Albertine, K. H., Matthay, M. A., & Ware, L. B. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00372.2007 · Cited by 56 · see citing works

Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome

Bastarache, J. A., Fremont, R. D., Kropski, J. A., Bossert, F. R., & Ware, L. B. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00214.2009 · Cited by 153 · see citing works

Tissue Factor Procoagulant Expression by Rat Alveolar Epithelial Cells

Gross, T. J., Simon, R. H., & Sitrin, R. G. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.4.397 · Cited by 49 · see citing works

Regulation of Alveolar Procoagulant Activity and Permeability in Direct Acute Lung Injury by Lung Epithelial Tissue Factor

Shaver, C. M., Grove, B. S., Putz, N. D., Clune, J. K., Lawson, W. E., Carnahan, R. H., Mackman, N., Ware, L. B., & Bastarache, J. A. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0179oc · Cited by 49 · see citing works