Maternal smoking during and after pregnancy and lung function in early adulthood: a prospective study
Open accessAbstract
BACKGROUND AND AIMS: There is a paucity of evidence about whether exposure to antenatal smoking impacts on offspring's lung function in early adulthood. This study aimed to examine whether (1) in utero exposure to maternal smoking is related to poorer respiratory functioning in early adulthood; (2) the impact of prenatal smoking is independent of postnatal maternal smoking; and (3) the link between prenatal smoking and a young adult's lung function is explained by the child's birth weight, smoking or history of asthma. METHODS: Data were from a 21-year follow-up of mothers and their children recruited into the Mater-University of Queensland Study of Pregnancy, a longitudinal prebirth cohort. The study is based on 2409 young adults (1185 males and 1224 females) who had prospective data available on respiratory function at 21 years and maternal smoking during and after pregnancy. A Spirobank G spirometer system was used to measure forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1)) and forced expiratory flow between 25% and 75% of FVC (FEF(25-75)). RESULTS: In utero exposure to maternal smoking was associated with a reduction in FEV(1) and FEF(25-75) in males (regression coefficient, -0.16; 95% CI, -0.30 to -0.02), after accounting for maternal smoking after pregnancy. At least part of the effect of in utero smoking on young adults' lung function was explained by the child's birth weight and subsequent asthma. CONCLUSIONS: Adverse effects of antenatal smoking on development of airway growth may persist into early adulthood. Gender differences noted in this longitudinal cohort need to be explored further.
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Men with prior in utero smoke exposure had significant reductions in FEV1 and midexpiratory flow.
“Hayatbakhsh and colleagues 51 also found that men with prior in utero smoke exposure had significant reductions in FEV 1 and midexpiratory flow.”
From Impact of Tobacco Smoke and Nicotine Exposure on Lung Development (2016) · cites this paper as [51]
Tobacco exposure during pregnancy reduces pulmonary function.
“Maternal smoking during pregnancy has adverse effects outside the central nervous system, most notably on lung development, causing lifelong decreases in pulmonary function.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [195]
Maternal smoking during pregnancy causes lifelong decreases in pulmonary function.
“Maternal smoking during pregnancy has adverse effects outside the central nervous system, most notably on lung development, causing lifelong decreases in pulmonary function.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [195]
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- Authors
- Hayatbakhsh, M. R., Sadasivam, S., Mamun, A. A., Najman, J. M., Williams, G. M., & O'Callaghan, M. J.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Hayatbakhsh, M R
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2009-06-11
- Volume
- 64
- Issue
- 9
- Pages
- 810-814
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2140382998
- Cited by
- 129
- References
- 34
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 9 · 2023: 9 · 2022: 8 · 2021: 9 · 2020: 21 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 11 · 2015: 4 · 2014: 8 · 2013: 3 · 2012: 8
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- University of Queensland
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- maternal smoking, prenatal smoking exposure, lung function, early adulthood, forced expiratory volume, forced vital capacity, birth weight, childhood asthma, airway growth, sex differences
- MeSH terms
- Asthma, Birth Weight, Epidemiologic Methods, Female, Humans, Lung Diseases, Male, Pregnancy, Prenatal Exposure Delayed Effects, Respiratory Function Tests, Smoking, Young Adult
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