Impaired handgrip exercise-induced brachial artery flow-mediated dilation in young obese males
Open accessAbstract
Flow mediated dilation (FMD) stimulated by different shear stress stimulus profiles may recruit distinct transduction mechanisms, and provide distinct information regarding endothelial function. The purpose of this study was to determine whether obesity influences brachial artery FMD differently depending on the shear stress profile used for FMD assessment. The FMD response to a brief, intermediate, and sustained shear stress profile was assessed in obese (n = 9) and lean (n = 19) young men as follows: brief stimulus, standard reactive hyperemia (RH) following a 5 min forearm occlusion (5 min RH); intermediate stimulus, RH following a 15 min forearm occlusion (15 min RH); sustained stimulus, 10 min of handgrip exercise (HGEX). Brachial artery diameter and mean shear stress were assessed using echo and Doppler ultrasound, respectively, during each FMD test. There was no group difference in HGEX shear stress (p = 0.390); however, the obese group had a lower HGEX-FMD (5.2 ± 3.0% versus 11.5 ± 4.4%, p < 0.001). There was no group difference in 5 min RH-FMD (p = 0.466) or 15 min RH-FMD (p = 0.181); however, the shear stress stimulus was larger in the obese group. After normalization to the stimulus the 15 min RH-FMD (p = 0.002), but not the 5 min RH-FMD (p = 0.118) was lower in the obese group. These data suggest that obesity may have a more pronounced impact on the endothelium’s ability to respond to prolonged increases in shear stress.
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Early risks for CVD have been observed in young individuals with disease states that elevate inflammation, such as obesity and diabetes.
“Early risks for CVD have been observed in young individuals with disease states that elevate inflammation (e.g., obesity, diabetes) (22, 23), thus if mild OIL poses an impairment to cardiovascular health, this might present itself among young and healthy individuals.”
From Oral inflammatory load predicts vascular function in a young adult population: a pilot study (2023) · cites this paper as [22]
The Discussion reports impaired flow-mediated dilation and lower vascular health in young men with obesity, supporting early signs of cardiovascular risk. The Limitations state that inflammation was not measured, and the study did not examine diabetes; the Discussion also says links to clinical outcomes remain undetermined. No page numbers are available in our copy. (LLM, conf=0.88)
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Sustained Shear Stress Reveals Agreement between Flow-Mediated Dilation and Flow-Mediated Slowing
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- Authors
- Slattery, D. J., Stuckless, T. J. R., King, T. J., & Pyke, K. E.
- Affiliations
- Queen's University (CA)
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2016-05
- Volume
- 41
- Issue
- 5
- Pages
- 528-537
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2278847188
- Semantic Scholar
- 2008a5dcd5583a26c104aadf019c7a64d6f4158e
- Cited by
- 22
- References
- 52
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 3
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Applied Physiology Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (acceptedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Ontario Ministry of Research and Innovation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- obesity, endothelial function, flow-mediated dilation, brachial artery, handgrip exercise, shear stress, reactive hyperemia, forearm occlusion, young men
- MeSH terms
- Adolescent, Adult, Blood Flow Velocity, Blood Pressure, Brachial Artery, Dilatation, Forearm, Heart Rate, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Obesity, Stress, Mechanical, Triglycerides, Ultrasonography, Hand Strength, Waist Circumference, Young Adult
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