Cited by 109Exercise and Physiological ResponsesCardiovascular and exercise physiologySports Performance and Training

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

Interleukin-6 and associated cytokine responses to an acute bout of high-intensity interval exercise: the effect of exercise intensity and volume

Open access

Cullen, Tom, Thomas, Andrew W., Webb, Richard, Hughes, Michael G.·2016·Applied Physiology, Nutrition, and Metabolism

DOI 10.1139/apnm-2015-0640

Open this paper in CoChat — free account Open PDF

Abstract

Acute increases in interleukin (IL)-6 following prolonged exercise are associated with the induction of a transient anti-inflammatory state (e.g., increases in IL-10) that is partly responsible for the health benefits of regular exercise. The purposes of this study were to investigate the IL-6–related inflammatory response to high-intensity interval exercise (HIIE) and to determine the impact of exercise intensity and volume on this response. Ten participants (5 males and 5 females) completed 3 exercise bouts of contrasting intensity and volume (LOW, MOD, and HIGH). The HIGH protocol was based upon standard HIIE protocols, while the MOD and LOW protocols were designed to enable a comparison of exercise intensity and volume with a fixed duration. Inflammatory cytokine concentrations were measured in plasma (IL-6, IL-10) and also determined the level of gene expression (IL-6, IL-10, and IL-4R) in peripheral blood. The plasma IL-6 response to exercise (reported as fold changes) was significantly greater in HIGH (2.70 ± 1.51) than LOW (1.40 ± 0.32) (P = 0.04) and was also positively correlated to the mean exercise oxygen uptake (r = 0.54, P < 0.01). However, there was no change in anti-inflammatory IL-10 or IL-4R responses in plasma or at the level of gene expression. HIIE caused a significant increase in IL-6 and was greater than that seen in low-intensity exercise of the same duration. The increases in IL-6 were relatively small in magnitude, and appear to have been insufficient to induce the acute systemic anti-inflammatory effects, which are evident following longer duration exercise.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1139/apnm-2015-0640

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100
Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575
The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Superior Cardiovascular Effect of Aerobic Interval Training Versus Moderate Continuous Training in Heart Failure Patients: A Randomized Study
Wisløff, U., Støylen, A., Loennechen, J. P., Bruvold, M., Rognmo, Ø., Haram, P. M., Tjønna, A. E., Helgerud, J., Slørdahl, S. A., Lee, S. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675041 · Cited by 1,996
Evidence for prescribing exercise as therapy in chronic disease
Pedersen, B. K., & Saltin, B. (2006) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00520.x · Cited by 1,384
Aerobic High-Intensity Intervals Improve V˙O2max More Than Moderate Training
HELGERUD, J., HØYDAL, K., WANG, E., KARLSEN, T., BERG, P., BJERKAAS, M., SIMONSEN, T., HELGESEN, C., HJORTH, N., BACH, R., et al. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180304570 · Cited by 1,332

Show all 41 references

Research works printed but not linked: 3

Abbasi A., 2013, Exerc. Immunol. Rev., 19, 8
Booth F.W., 2012, Compr. Physiol., 2, 1143, 10.1002/j.2040-4603.2012.tb00425.x · DOI · Paper page
Fischer C.P., 2006, Exerc. Immunol. Rev., 12, 6

Sorted by citations

Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927
Skeletal Muscle as Potential Central Link between Sarcopenia and Immune Senescence
Nelke, C., Dziewas, R., Minnerup, J., Meuth, S. G., & Ruck, T. (2019) · eBioMedicine · doi:10.1016/j.ebiom.2019.10.034 · Cited by 437
Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines
Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 271
IL‐6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance
Nash, D., Hughes, M. G., Butcher, L., Aicheler, R., Smith, P., Cullen, T., & Webb, R. (2023) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.14241 · Cited by 182
Self-citation
Inflammation and age-associated skeletal muscle deterioration (sarcopaenia)
Wang, J., Leung, K.-S., Chow, S. K.-H., & Cheung, W.-H. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.05.006 · Cited by 173
Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing
Tari, A. R., Walker, T. L., Huuha, A. M., Sando, S. B., & Wisløff, U. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00184-9 · Cited by 189
Exercise and cancer: from “healthy” to “therapeutic”?
Idorn, M., & Straten, P. T. (2017) · Cancer Immunology and Immunotherapy · doi:10.1007/s00262-017-1985-z · Cited by 147
The exercise IL-6 enigma in cancer
Orange, S. T., Leslie, J., Ross, M., Mann, D. A., & Wackerhage, H. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.08.001 · Cited by 158
Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression
Huang, Q., Wu, M., Wu, X., Zhang, Y., & Xia, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188761 · Cited by 124
Potential involvement of lactate and interleukin-6 in the appetite-regulatory hormonal response to an acute exercise bout
Islam, H., Townsend, L. K., McKie, G. L., Medeiros, P. J., Gurd, B. J., & Hazell, T. J. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00218.2017 · Cited by 100
Interleukin-10 responses from acute exercise in healthy subjects: A systematic review
Cabral‐Santos, C., de Lima Junior, E. A., Fernandes, I. M. D. C., Pinto, R. Z., Rosa‐Neto, J. C., Bishop, N. C., & Lira, F. S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27920 · Cited by 96
Short-Term High- and Moderate-Intensity Training Modifies Inflammatory and Metabolic Factors in Response to Acute Exercise
Lira, F. S., dos Santos, T., Caldeira, R. S., Inoue, D. S., Panissa, V. L. G., Cabral‐Santos, C., Campos, E. Z., Rodrigues, B., & Monteiro, P. A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00856 · Cited by 86
Acute high intensity interval exercise reduces colon cancer cell growth
Devin, J. L., Hill, M. M. C., Mourtzakis, M., Quadrilatero, J., Jenkins, D. G., & Skinner, T. L. (2019) · The Journal of Physiology · doi:10.1113/jp277648 · Cited by 82
Acute and Post-Exercise Physiological Responses to High-Intensity Interval Training in Endurance and Sprint Athletes.
Cipryan, L., Tschakert, G., & Hofmann, P. (2017) · Europe PMC (PubMed Central) · Cited by 62
Interpreting ‘anti‐inflammatory’ cytokine responses to exercise: focus on interleukin‐10
Islam, H., Neudorf, H., Mui, A. L., & Little, J. P. (2021) · The Journal of Physiology · doi:10.1113/jp281356 · Cited by 61
Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise – A systematic review and meta‐analysis
Ringleb, M., Javelle, F., Haunhorst, S., Bloch, W., Fennen, L., Baumgart, S., Drube, S., Reuken, P. A., Pletz, M. W., Wagner, H., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202301619r · Cited by 73
The effects of a single night of complete and partial sleep deprivation on physical and cognitive performance: A Bayesian analysis
Cullen, T., Thomas, G., Wadley, A. J., & Myers, T. (2019) · Journal of Sports Sciences · doi:10.1080/02640414.2019.1662539 · Cited by 52
Self-citation
The health benefits of passive heating and aerobic exercise: To what extent do the mechanisms overlap?
Cullen, T., Clarke, N. D., Hill, M. W., Menzies, C., Pugh, C. J. A., Steward, C. J., & Thake, D. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00608.2020 · Cited by 48
Self-citation
From Tissue to System: What Constitutes an Appropriate Response to Loading?
Gabbett, T. J., & Oetter, E. (2024) · Sports Medicine · doi:10.1007/s40279-024-02126-w · Cited by 48
Age and Sport Intensity-Dependent Changes in Cytokines and Telomere Length in Elite Athletes
Sellami, M., Almuraikhy, S., Al-Jaber, H., Al-Amri, H. S., Al-Mansoori, L., Mazloum, N. A., Donati, F., Botrè, F., & Elrayess, M. A. (2021) · Antioxidants · doi:10.3390/antiox10071035 · Cited by 40
The Therapeutic Potential of Anti-Inflammatory Exerkines in the Treatment of Atherosclerosis
Yu, M., Tsai, S., & Kuo, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061260 · Cited by 39
The effects of combined probiotic ingestion and circuit training on muscular strength and power and cytokine responses in young males
Ibrahim, N. S., Muhamad, A. S., Ooi, F. K., Meor-Osman, J., & Chen, C. K. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0464 · Cited by 38
Acute high-intensity interval exercise induces comparable levels of circulating cell-free DNA and Interleukin-6 in obese and normal-weight individuals
Ferrandi, P. J., Fico, B. G., WHITEHURST, M. A., Zourdos, M. C., Bao, F., Dodge, K. M., Rodriguez, A. L., Pena, G. S., & Huang, C. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.04.007 · Cited by 39
Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
Zhou, N., Gong, L., Zhang, E., & Wang, X. (2024) · PeerJ · doi:10.7717/peerj.17267 · Cited by 35
Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment
Boukelia, B., Gomes, E. C., & Florida-James, G. D. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3402143 · Cited by 26
The exercise-induced inflammatory response in inflammatory bowel disease: A systematic review and meta-analysis
Baker, K. A., Miller, T. D., Marino, F. E., & Hartmann, T. E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262534 · Cited by 28
One week of magnesium supplementation lowers IL-6, muscle soreness and increases post-exercise blood glucose in response to downhill running
Steward, C. J., Zhou, Y., Keane, G., Cook, M. D., Liu, Y., & Cullen, T. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04238-y · Cited by 26
Self-citation
ANGPTL4, IL-6 and TNF-α as regulators of lipid metabolism during a marathon run
Górecka, M., Krzeminski, K., Mikulski, T., & Ziemba, A. W. (2022) · Scientific Reports · doi:10.1038/s41598-022-17439-x · Cited by 24
Effect of high-intensity interval training on clinical and laboratory parameters of adolescents with attention deficit hyperactivity disorder
Soori, R., Goodarzvand, F., Akbarnejad, A., Effatpanah, M., Ramezankhani, A., Teixeira, A. L., & Ghram, A. (2020) · Science & Sports · doi:10.1016/j.scispo.2019.08.002 · Cited by 22
Can Exercise Counteract Cancer Cachexia? A Systematic Literature Review and Meta-Analysis
Niels, T., Tomanek, A., Freitag, N., & Schumann, M. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420940414 · Cited by 21
Aerobic Training Efficacy in Inflammation, Neurotrophins, and Function in Chronic Stroke Persons: A Randomized Controlled Trial Protocol
Oliveira, D. M. G., Aguiar, L. T., Limones, M. V. D. O., Gomes, A. G., da Silva, L. C., Faria, C. D. C. D. M., & Scalzo, P. L. (2018) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2018.10.016 · Cited by 20
Cytokine responses to repeated, prolonged walking in lean versus overweight/obese individuals
Verheggen, R. J. H. M., Eijsvogels, T. M. H., Catoire, M., Terink, R., Ramakers, R. E. F. S., Bongers, C. C. W. G., Mensink, M., Hermus, A. R., Thijssen, D. H. J., & Hopman, M. T. E. (2018) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2018.07.019 · Cited by 18
Preliminary evidence that age and sex affect exercise-induced hTERT expression
Cluckey, T. G., Nieto, N. C., Rodoni, B. M., & Traustadóttir, T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.003 · Cited by 16
Acute effects of aerobic intensities on the cytokine response in women with mild multiple sclerosis
Berkowitz, S. H., Achiron, A., Gurevich, M., Sonis, P., & Kalron, A. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.03.025 · Cited by 17
Vascular Inflammation as a Therapeutic Target in COVID-19 “Long Haulers”: HIITing the Spot?
Christensen, R. H., & Berg, R. M. G. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.643626 · Cited by 16
Comparison of the inflammatory and stress response between sprint interval swimming and running
Casuso, R. A., Aragón‐Vela, J., Huertas, J. R., Ruiz‐Ariza, A., & López, E. J. M. (2017) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13046 · Cited by 15
Direct assessment of leukocyte signalling and cytokine secretion reveals exercise intensity‐dependent reductions in anti‐inflammatory cytokine action
Islam, H., Tsai, S., Figueiredo, C., Jackson, G. S., Marcotte‐Chénard, A., Bosak, J., Moreno‐Cabañas, A., Lira, F. S., & Little, J. P. (2024) · The Journal of Physiology · doi:10.1113/jp286228 · Cited by 13
Human hair follicle transcriptome profiling: a minimally invasive tool to assess molecular adaptations upon low‐volume, high‐intensity interval training
Zhang, J., Wallace, S. J., Shiu, M. Y., Smith, I., Rhind, S. G., & Langlois, V. S. (2017) · Physiological Reports · doi:10.14814/phy2.13534 · Cited by 13
Association of Accelerometer‐Derived Physical Activity Pattern With the Risks of All‐Cause, Cardiovascular Disease, and Cancer Death
Liao, D., Li, H., Chen, H., Lai, S., Tang, X., Qiu, C., Du, L., Huang, H.-X., Xiong, Z., Kuang, L., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039225 · Cited by 15
Peri-operative patient optimization for oesophageal cancer surgery – From prehabilitation to enhanced recovery
Zylstra, J., Boshier, P. R., Whyte, G. P., Low, D. E., & Davies, A. (2018) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2018.11.006 · Cited by 12
Exercise, Exerkines, and Sarcopenia
Chung, H. S., & Choi, K. M. (2026) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0972 · Cited by 12
Effect of an acute exercise on early responses of iron and iron regulatory proteins in young female basketball players
Cichoń-Woźniak, J., Ostapiuk–Karolczuk, J., Cieślicka, M., Dziewiecka, H., Marcinkiewicz, A., Tafil‐Klawe, M., Basta, P., Maciejewski, D., & Skarpańska-Stejnborn, A. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00465-7 · Cited by 13
Post exercise hot water immersion and hot water immersion in isolation enhance vascular, blood marker, and perceptual responses when compared to exercise alone
Steward, C. J., Hill, M. W., Menzies, C., Bailey, S. J., Rahman, M., Thake, D., Pugh, C. J. A., & Cullen, T. (2024) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14600 · Cited by 10
Self-citation
Decompression Illness After Technical Diving Session in Mediterranean Sea: Oxidative Stress, Inflammation, and HBO Therapy
Mrakic‐Sposta, S., Brizzolari, A., Vezzoli, A., Graci, C., Cimmino, A., Giacon, T. A., Dellanoce, C., Barassi, A., Sesana, G., & Bosco, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111367 · Cited by 10
Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking
Soares, V., de Avelar, I. S., Venâncio, P. E. M., Pires-Oliveira, D. A. D. A., Silva, P. H. D. A., Borges, A. R., Fonseca, G. P. E. F., & Noll, M. A. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s281113 · Cited by 13
Interleukins in adipose tissue: Keeping the balance
Antuna-Puente, B., Fellahi, S., McAvoy, C., Fève, B., & Bastard, J. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111531 · Cited by 11
Resistance Exercise in a Hot Environment Alters Serum Markers in Untrained Males
Eskandari, A., Fashi, M., Saeidi, A., Boullosa, D. A., Laher, I., Abderrahman, A. B., Jabbour, G., & Zouhal, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00597 · Cited by 9
Caffeine Augments the Lactate and Interleukin-6 Response to Moderate-Intensity Exercise
Abbotts, K. S. S., Ewell, T. R., Bomar, M. C., Butterklee, H. M., & Bell, C. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003121 · Cited by 13
Immunoinflammatory Response to Acute Noise Stress in Male Rats Adapted with Different Exercise Training
Farahbakht, E., AL-Sinani, Y., Safari, M., Hofmeister, M., Rezaie, R., Sharifabadi, A., & Jahromi, M. K. (2023) · Noise and Health · doi:10.4103/nah.nah_23_23 · Cited by 8
Clinical safety and hemodynamic, cardiac autonomic and inflammatory responses to a single session of inspiratory muscle training in obstructive sleep apnea
Ferreira, S. T. B. P., Brasileiro-Santos, M. D. S., Teixeira, J. B., Rabello, M. C. D. S., de Lorena, V. M. B., Farah, B. Q., Silva, T. N. S., & de Lima, A. M. J. (2021) · Sleep And Breathing · doi:10.1007/s11325-021-02364-6 · Cited by 8
The Benefits of Exercise Effect on Cancer: A Review
Lee, N. (2020) · Exercise Science · doi:10.15857/ksep.2020.29.1.4 · Cited by 8
Acute effects of high-intensity interval training on cognition and retinal microcirculation in experienced amateur boxers
Solianik, R., Bružas, V., Mockus, P., Vadopalas, K., & Streckis, V. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.20.11352-5 · Cited by 8
Physical activity and exercise as an essential medical strategy for the COVID-19 pandemic and beyond
Seman, S., Dražilov, S. S., Ilić, V., Tesic, M. B., Stojiljković, S., Arena, R. A., & Popović, D. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211028543 · Cited by 8
Interleukin-6, undercarboxylated osteocalcin, and brain-derived neurotrophic factor responses to single and repeated sessions of high-intensity interval exercise
Aktitiz, S., ATAKAN, M. M., Turnagöl, H. H., & Koşar, Ş. N. (2022) · Peptides · doi:10.1016/j.peptides.2022.170864 · Cited by 8
Acute resistance exercise-induced changes in IL-6, IL-10, and IL-1ra in healthy adults: a systematic review and meta-analysisPreprint
Ringleb, M., Javelle, F., Haunhorst, S., Bloch, W., Fennen, L., Baumgart, S., Drube, S., Reuken, P. A., Pletz, M. W., Wagner, H., et al. (2023) · medRxiv · doi:10.1101/2023.05.10.23289790 · Cited by 8
Low-intensity physical activity may protect pregnant women against spontaneous preterm labour: a prospective case-control study
Steckle, V., Shynlova, O. P., Lye, S. J., & Bocking, A. D. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0911 · Cited by 7
The impact of different gas mixtures on inflammatory responses in advanced recreational divers
Rocco, M., Maggi, L., Loffredo, C., Pelli, M., di Benedetto, P., Fiorelli, S., Simmaco, M., & Blasi, R. A. D. (2021) · Diving and Hyperbaric Medicine Journal · doi:10.28920/dhm51.2.140-146 · Cited by 7
What is the optimal type and dose of physical activity for colorectal cancer prevention?
Orange, S. T. (2023) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2023.101841 · Cited by 17
The molecular mechanisms of exercise in cancer prevention and management
Chen, J., Yang, L., Li, W., & Liu, Q. (2025) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000989 · Cited by 10
The Effect of Moderate-Intensity Physical Exercise on Some Serum Inflammation Markers and the Immune System in Rats Fed Intermittent Fasting with a High-Fat Diet
GÜNBATAR, N., Bulduk, B., Bezgin, S., Oto, G., Bayıroğlu, F., & Bulduk, M. (2023) · Medicina · doi:10.3390/medicina59091687 · Cited by 6
Factors that influence the neurobiological effects of exercise likely extend beyond age and intensity in people with major depression
Schuch, F. B., Deslandes, A. C., Stubbs, B., Gosmann, N. P., da Silva, C. T. B., & Fleck, M. P. D. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.004 · Cited by 6
Expression of ABC transporter and scavenger receptor mRNAs in PBMCs in 100‐km ultramarathon runners
Juan, C., Li, L., Hou, S., Liu, P., Kao, W., Chiu, Y., & How, C. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13365 · Cited by 6
Level of physical activity and gene expression of IL-10 and TNF-α in children and adolescents with Type 1 diabetes
Haber, J. F. D. S., Chagas, E. F. B., Barbalho, S. M., Sgarbi, J. A., Haber, R. S. D. A., de Lábio, R. W., & Payão, S. L. M. (2021) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2021.108104 · Cited by 6
Vascular, inflammatory and perceptual responses to hot water immersion: Impacts of water depth and temperature in young healthy adults
Menzies, C., Clarke, N. D., Steward, C. J., Thake, D., Pugh, C. J. A., & Cullen, T. (2025) · Experimental Physiology · doi:10.1113/ep092761 · Cited by 5
Self-citation
“Immunopause” no more: exercise to counter immunosenescence in aging
Sun, C., Li, J., Xu, H., Du, J., Muthusamy, P., Liu, K., Song, W., & Zhang, L. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00549-1 · Cited by 6
Effects of high-intensity interval training (HIIT) and maximum fat oxidation intensity training (MFOIT) on body composition, inflammation in overweight and obese adults
Lin, W. W., Su, H., Lan, X. Y., Ni, Q. Y., Wang, X. Y., Cui, K. Y., & Zhang, L. (2024) · Science & Sports · doi:10.1016/j.scispo.2023.09.002 · Cited by 5
Why you should not skip tailored exercise interventions when using incretin mimetics for weight loss
Gross, K., & Brinkmann, C. K. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1449653 · Cited by 5
Establishing the optimum use of high-intensity interval training in heart failure: current status and future directions
Moneghetti, K. J., Carrick‐Ranson, G., & Howden, E. J. (2023) · Current Opinion in Physiology · doi:10.1016/j.cophys.2023.100669 · Cited by 5
Acute inflammatory responses to high-intensity functional training programming: An observational study
Kliszczewicz, B. M., Markert, C. D., Bechke, E. E., Williamson, C. M., Clemons, K. N., Snarr, R. L., & Mckenzie, M. J. (2019) · Journal of Human Sport and Exercise · doi:10.14198/jhse.2019.144.18 · Cited by 5
The Effect of Exercise and Psychological Stress on Anti- and Proinflammatory Cytokines
Hasanli, S., Hojjati, S., & Jahromi, M. K. (2020) · NeuroImmunoModulation · doi:10.1159/000512814 · Cited by 5
Effectiveness of Non-pharmacological interventions on pain and fatigue management in cancer survivors: A systematic review and meta-analysis study
Hadoush, H., Almhasis, R., Kassab, M. I., Almasri, N. A., & Al-Wardat, M. S. (2025) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2025.05.046 · Cited by 4
The Immune System and Inflammation in Type 2 Diabetes
García-Macedo, R., & Fortis, M. D. L. Á. (2023) · Springer eBooks · doi:10.1007/978-3-031-25519-9_12 · Cited by 6
Evaluation of Plasma Levels of Interleukin 6 and Iron Status of Volleyball Players in a Nigerian University
Obeagu, E. I., Anierobi, C. C., Eze, G. C., Chukwueze, C. M., Makonyonga, R. D., Amadi, N. M., & Hassan, R. (2022) · Journal of Advances in Medical and Pharmaceutical Sciences · doi:10.9734/jamps/2022/v24i630307 · Cited by 4
Exercise-induced stress pathways: Crosstalk between AMPK, HSPs, and inflammation
Xiang, L., & Su, Z. (2025) · Journal of Investigative Medicine · doi:10.1177/10815589251366914 · Cited by 3
Exercise modulates redox homeostasis in cardiovascular and metabolic diseases: from bench to clinic
Wang, J., Zhang, J., Zhang, H., Yu, F., Tian, Z., & Jia, D. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03131-1 · Cited by 4
Serum levels of interleukin-6 (IL-6), IL-10, and lactate in response to combat physical fitness test
Bazgir, B., Delpasand, A., & Shirvani, H. (2019) · Sport Sciences for Health · doi:10.1007/s11332-019-00567-9 · Cited by 3
Effect of Different Exercise Modalities on Inflammatory Markers in Individuals with Depressive Disorder: A Systematic Review and Meta-Analysis
Song, J., Zhang, J., Wang, X., Liang, J., & Li, Y. (2025) · Life · doi:10.3390/life15091452 · Cited by 6
Respostas inflamatórias agudas ao exercício de alta intensidade versus exercício de intensidade moderada em homens jovens: uma revisão sistemática
Nogueira, C. J., da Silva, J. K. R. M., Dias, V. M., Brandão, P. P., & Dantas, E. H. M. (2022) · Revista Brasileira de Fisiologia do Exercício · doi:10.33233/rbfex.v21i1.5096 · Cited by 2
Effects of Resistance Exercise Intensity on Cytokine and Chemokine Gene Expression in Atopic Dermatitis Mouse Model
Choi, E., & So, W.-Y. (2018) · Journal of Men s Health · doi:10.22374/1875-6859.14.2.3 · Cited by 2
Health Assessment in Adolescents Transitioning from High School to University Based on Their Hematological Parameters
Rakhmanov, R. S., Bogomolova, E. S., Tarasov, A. V., & Nepryakhin, D. V. (2022) · ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT · doi:10.35627/2219-5238/2022-30-8-44-50 · Cited by 2
Acute and Recovery Effects of Aerobic Exercise on Serum Interleukin-6 in Adult Male Smokers
Hoseini, M. A. S., Eizadi, M., & Zarea, K. (2018) · Jundishapur Journal of Chronic Disease Care · doi:10.5812/jjcdc.63837 · Cited by 1
No immediate change in systemic cytokines following an eccentric muscle training session in people with multiple sclerosis
Alt, Y., Wochatz, M., Schraplau, A., Engel, T., Sharon, H., Gurevich, M., Menascu, S., Mayer, F. O., & Kalron, A. (2024) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864241266113 · Cited by 1
Physical exercise and sarcopenia in older people: an OrtoMed position paper
Moretti, A., Tomaino, F., Paoletta, M., Liguori, S., Migliaccio, S., Iorio, A. D., Pellegrino, R., Donnarumma, D., Nunzio, D. D., Toro, G., et al. (2025) · International Journal of Bone Fragility · doi:10.57582/ijbf.240403.080 · Cited by 1
Cytokine response to resistance exercise in children with excess adiposity and Prader‐Willi syndrome
Vuong, V., Haqq, A. M., & Rubin, D. A. (2025) · Physiological Reports · doi:10.14814/phy2.70327 · Cited by 1
A short bout of exercise impacts TH2 inflammation of patients with obesity and well-controlled asthma
Cortés-Telles, A., Chávez‐Galán, L., Ocaña‐Guzmán, R., & Sada‐Ovalle, I. (2025) · Annals of Thoracic Medicine · doi:10.4103/atm.atm_303_24 · Cited by 1
Chronobiological effects of morning and evening exercise on biochemical responses in elite boxers
Ozan, M., Öztaşyonar, Y., Buzdağlı, Y., Baygutalp, N. K., Öget, F., Yüce, N., Kacı, F. N., Savaş, A., & Baygutalp, F. (2025) · Chronobiology International · doi:10.1080/07420528.2025.2556835 · Cited by 1
Exercise modalities and dosages on glycated haemoglobin and exerkines in type 2 diabetes: a systematic review with pairwise, network, and dose-response meta-analyses
Liang, L.-B., Zhao, Z.-H., Li, W.-X., Wang, S., Shen, Q., Wu, C.-Q., & Li, K.-P. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03236-7 · Cited by 1
Physical exercises as an effective adjuvant therapy of IBD in remission (review)
Kostyukevich, S. V., & Бакулин, И. Г. (2024) · Koloproktologia · doi:10.33878/2073-7556-2024-23-1-152-161 · Cited by 1
Right Ventricular Function Improves After Bench Press: A Speckle Tracking Echocardiography Study
Martínez-Lechuga, M. B., Hidalgo-Martín, J., & Ruiz-Bailén, M. (2025) · Medicina · doi:10.3390/medicina61081469 · Cited by 1
The Differential Impact Of High-Intensity Swimming Exercise and Inflammatory Bowel Disease On IL-1b, TNF-a, and COX-2 Gene Expression in the Small Intestine and Colon in Mice
Choi, E., & So, W.-Y. (2018) · Journal of Men s Health · doi:10.22374/1875-6859.14.2.4 · Cited by 1
Lower Level of Interleukin-6 and Hepcidin Found in Lower Density of Physical Exercise among Athlete During Pandemic of Covid-19
Purwani, D., Sulistiawati, S., & Purwanto, B. (2021) · Folia Medica Indonesiana · doi:10.20473/fmi.v57i2.23590 · Cited by 1
Relationship of inflammatory response and mood to high-intensity interval exercise
Kemp, R. N., Loh, R., Howe, C. C. F., & Moir, H. J. (2018) · Translational Sports Medicine · doi:10.1002/tsm2.50
تأثیر تدریبات التحمل على بعض مؤشرات الإلتهابات والإجهاد التأکسدی خلال فترة الإعداد الخاص لدى متسابقی 800 م جری
الجاکى, م. ح. م. ف. (2020) · المجلة العلمیة للتربیة البدنیة وعلوم الریاضة جامعة حلوان · doi:10.21608/jsbsh.2020.28438.1141
Evaluation of the cytokines response in the organism of cursors of the higher education institution at adaptation to the conditions of education
Rakhmanov, R. S., Bogomolova, E. S., Tarasov, A. V., & Nepryakhin, D. V. (2020) · Hygiene and Sanitation · doi:10.33029/0016-9900-2020-99-5-483-487
Cancer Rehabilitation or Physical Exercise Effect on Immune Function
Morishita, S., Fu, J. B., & Tsubaki, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_354-1
Efeitos do treinamento físico aeróbio concomitante a restrição calórica no perfil de miocinas.
Aquino‐Junior, J. C. J. (2021) · doi:10.11606/t.42.2021.tde-15122022-165457
High-Intensity Interval Training Protocols Variation Response to Immune Parameters and Cardiovascular Risk Factors: A Scoping Review
Zaid, N. S. N., Muhamad, A. S., Jawis, M. N., Ooi, F. K., Mohamed, M., Mohamud, R., & Jusoh, N. B. (2023) · Lecture notes in bioengineering · doi:10.1007/978-981-99-2162-1_9
The protective effect of endurance running against the pro-invasive effects of ageing in breast cancer cells and mesenchymal stem cells in vitro
Brown, M.-J., Nickels, M., Akam, E. C., & Morris, M. A. (2023) · In vitro models · doi:10.1007/s44164-023-00055-y
Effects of Extreme Physical and Mental Load on Circulating Exerkines in Professional Athletes
Ligetvári, R. (2024) · Pesci Egyetemi Archivum (University of Pécs) · doi:10.15170/pte.2024.013
Serum Interleukin-6 seems to be comparable in patients with type 2 diabetes and those with impaired fasting glucose
Hashim, R. D., Al-Sharifi, N. A. N., Nathir, I., & Aljubori, A. (2024) · Gaceta Médica Boliviana · doi:10.47993/gmb.v47i2.902

Authors: Cullen, T., Thomas, A. W., Webb, R., & Hughes, M. G.
Affiliations: University of Worcester (GB)
Cardiff Metropolitan University (GB)
ORCID: Cullen, Tom
Hughes, Michael G.
Venue: Applied Physiology, Nutrition, and Metabolism
Publisher: Canadian Science Publishing
Published: 2016-08
Volume: 41
Issue: 8
Pages: 803-808
ISSN: 1715-5312 (ISSN-L)
1715-5320
DOI: 10.1139/apnm-2015-0640
OpenAlex: W2297029629
Cited by: 109
References: 41
Citations by year: 2026: 9 · 2025: 15 · 2024: 12 · 2023: 10 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 7 · 2018: 10 · 2017: 11
FWCI: 9.98
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Applied Physiology Nutrition and Metabolism (publishedVersion)
PubMed (publishedVersion)
TSpace (University of Toronto) (acceptedVersion)
Worcester Research and Publications (University of Worcester) (acceptedVersion)
Figshare (submittedVersion, cc-by)
Repository@Hull (Worktribe) (University of Hull) (submittedVersion)
Pure (Coventry University) (submittedVersion)
Cardiff Metropolitan Research Repository (Cardiff Metropolitan University) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: interleukin-6, IL-10, interleukin-4 receptor, high-intensity interval exercise, acute exercise, exercise intensity, exercise volume, inflammatory cytokines, anti-inflammatory response, exercise oxygen consumption, gene expression, plasma cytokines
MeSH terms: High-Intensity Interval Training, Adult, Diet, Female, Gene Expression Regulation, Humans, Male, Oxygen Consumption, RNA, Messenger, Exercise, Interleukin-6, Linear Models, Interleukin-10, Receptors, Interleukin-6, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukin-6 and associated cytokine responses to an acute bout of high-intensity interval exercise: the effect of exercise intensity and volume

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks