Interleukin-10 responses from acute exercise in healthy subjects: A systematic review
Open accessAbstract
PURPOSE: Interleukin 10 (IL-10) is a cytokine that plays a critical role with potent anti-inflammatory properties when produced during exercise, limiting host immune response to pathogens and preventing tissue damage. The purpose of this systematic review was to assess the response of IL-10 after acute exercise session in healthy adults. METHODS: Databases of Ovid Medline (1978-2016), CINAHL (1998-2016), EMBASE (2003-2016), SportDiscus (1990-2016), and Web of Science library (1990-2016) were carefully screened. Clinical trials comparing exercise types in healthy individuals were included for pooled analysis. The trials of exercise were methodologically appraised by PEDro Scale. RESULTS: Twelve randomized controlled and crossover trials containing 176 individuals were identified for inclusion. The Kruskal-Wallis test showed no significant differences between type of exercise and the corresponding values in IL-10 [X2(4) = 2.878; p = 0.449]. The duration of exercise was significantly correlated with increase in IL-10 changes (Pearson's r = 1.00, 95%CI: 0.015-0.042, p < 0.0001) indicating that 48% of the variation in IL-10 levels can be explained by the duration of the exercise performed. In addition, despite a linear increase, we did not find a significant correlation with the intensity of exercise and IL-10 changes (Pearson's r = 0.218, 95%CI: -0.554-0.042, p < 0.035). CONCLUSION: Overall, the duration of the exercise is the single most important factor determining the magnitude of the exercise-induced increase of plasma IL-10.
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In healthy individuals subjected to aerobic exercise interventions, systematic reviews and meta-analyses have found decreased circulating levels of TNF-α, IL-6, and CRP, as well as increased levels of the anti-inflammatory cytokine IL-10.
“In healthy individuals subjected to aerobic exercise interventions, systematic reviews and meta-analyses have found decreased circulating levels of TNF-α, IL-6, and CRP [249], as well as increased levels of the anti-inflammatory cytokine IL-10 [250].”
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- Authors
- Cabral‐Santos, C., de Lima Junior, E. A., Fernandes, I. M. D. C., Pinto, R. Z., Rosa‐Neto, J. C., Bishop, N. C., & Lira, F. S.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Immunometabolism Research Group, Department of Cell and Developmental Biology University of São Paulo Butantã São Paulo Brazil
- Universidade Federal de Minas Gerais (BR)
- School of Sport, Exercise, and Health Sciences and National Centre for Sport and Exercise Medicine, Loughborough University Loughborough United Kingdom
- Corresponding author
- Lira, Fábio Santos
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2018-12-07
- Volume
- 234
- Issue
- 7
- Pages
- 9956-9965
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2905098449
- Cited by
- 96
- References
- 36
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 14 · 2023: 17 · 2022: 14 · 2021: 14 · 2020: 9 · 2019: 5
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Loughborough University Institutional Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- Loughborough University Research Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2015/17068‐2, 2016/1409‐8, 2016/16712‐8, 2015/26148‐0)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- IL-10, acute exercise, anti-inflammatory response, exercise duration, exercise intensity, plasma cytokines, exercise type, healthy adults
- MeSH terms
- Adult, Female, Humans, Inflammation, Male, Time Factors, Biomarkers, Exercise, Up-Regulation, Randomized Controlled Trials as Topic, Interleukin-10, Young Adult
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