Effects of high-protein intake on bone turnover in long-term bed rest in women
Open accessAbstract
Bed rest (BR) causes bone loss, even in otherwise healthy subjects. Several studies suggest that ambulatory subjects may benefit from high-protein intake to stimulate protein synthesis and to maintain muscle mass. However, increasing protein intake above the recommended daily intake without adequate calcium and potassium intake may increase bone resorption. We hypothesized that a regimen of high-protein intake (HiPROT), applied in an isocaloric manner during BR, with calcium and potassium intake meeting recommended values, would prevent any effect of BR on bone turnover. After a 20-day ambulatory adaptation to a controlled environment, 16 women participated in a 60-day, 6° head-down-tilt (HDT) BR and were assigned randomly to 1 of 2 groups. Control (CON) subjects (n = 8) received 1 g/(kg body mass·day)−1 dietary protein. HiPROT subjects (n = 8) received 1.45 g protein/(kg body mass·day)−1 plus an additional 0.72 g branched-chain amino acids per day during BR. All subjects received an individually tailored diet (before HDTBR: 1888 ± 98 kcal/day; during HDTBR: 1604 ± 125 kcal/day; after HDTBR: 1900 ± 262 kcal/day), with the CON group’s diet being higher in fat and carbohydrate intake. High-protein intake exacerbated the BR-induced increase in bone resorption marker C-telopeptide (>30%) (p < 0.001) by the end of BR. Bone formation markers were unaffected by BR and high-protein intake. We conclude that high-protein intake in BR might increase bone loss. Further long-duration studies are mandatory to show how the positive effect of protein on muscle mass can be maintained without the risk of reducing bone mineral density.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
High intakes of dietary protein, iron, and sodium are detrimental to bone.
“Conversely, high intakes of dietary protein87,88, iron89 and sodium90 are detrimental to bone.”
From Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars (2020) · cites this paper as [87]
The Results (page not available in our copy) report greater bone-resorption markers in the high-protein group during bed rest. But the Discussion says a comparable increase was not found under ambulatory conditions, so the source does not support the unqualified claim that high protein intake is detrimental to bone generally. Iron and sodium have separate citations in the citing sentence and are not attributed to this source. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1992) · Applied Ergonomics · doi:10.1016/0003-6870(92)90338-v · Cited by 7,153 · see citing works
Dietary Reference Intakes for Calcium and Vitamin D
(2018) · American Academy of Pediatrics eBooks · doi:10.1542/9781610021494-part06-dietary_reference_int · Cited by 2,712 · see citing works
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · cited 1× · see citing works
“To overcome reduction in muscle protein synthesis increasing daily protein intake to levels about 1.0-1.2 (moderately high) (Bauer et al. 2013) and 1.2-1.5 g/kg BM/d (high) or between 15 and 20% of the daily energy intake (Deutz et al. 2014; Wolfe et al. 2008) are recommended for older people.”
BackgroundInfluentialSelf-citationDeutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738 · see citing works
Self-citationCortical and Trabecular Bone Mineral Loss From the Spine and Hip in Long-Duration Spaceflight
Lang, T., LeBlanc, A., Evans, H., Lu, Y., Genant, H., & Yu, A. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040307 · Cited by 828 · see citing works
Vico, L., Collet, P., Guignandon, A., Lafage-Proust, M.-H., Thomas, T., Rehailia, M., & Alexandre, C. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02217-0 · Cited by 821 · see citing works
Potential Renal Acid Load of Foods and its Influence on Urine pH
Remer, T., & Manz, F. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00219-7 · Cited by 742 · see citing works
Dose-Response Relationships Between Energy Availability and Bone Turnover in Young Exercising Women
Ihle, R., & Loucks, A. B. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040410 · Cited by 523 · see citing works
Protecting muscle mass and function in older adults during bed rest
English, K. L., & Paddon-Jones, D. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328333aa66 · Cited by 477 · see citing works
Optimal protein intake in the elderly
Wolfe, R. R., Miller, S. L., & Miller, K. B. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.008 · Cited by 456 · see citing works
Frid, A. H., Nilsson, M., Holst, J. J., & Björck, I. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.1.69 · Cited by 387 · see citing works
Zerwekh, J. E., Ruml, L. A., Gottschalk, F., & Pak, C. Y. C. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.10.1594 · Cited by 373 · see citing works
Smith, S. M., Heer, M. A., Shackelford, L. C., Sibonga, J. D., Ploutz-Snyder, L., & Zwart, S. R. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1647 · Cited by 351 · see citing works
Self-citationExtracellular pH Regulates Bone Cell Function , ,
Arnett, T. R. (2008) · Journal of Nutrition · doi:10.1093/jn/138.2.415s · Cited by 349 · see citing works
(2007) · PubMed · Cited by 337 · see citing works
Frid, A. H., Nilsson, M., Holst, J. J., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.69 · Cited by 324 · see citing works
Dietary Protein: An Essential Nutrient For Bone Health
Bonjour, J. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719501 · Cited by 295 · see citing works
The Impact of Dietary Protein on Calcium Absorption and Kinetic Measures of Bone Turnover in Women
Kerstetter, J. E., O'Brien, K. O., Caseria, D. M., Wall, D. E., & Insogna, K. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0179 · Cited by 290 · see citing works
Diet Acids and Alkalis Influence Calcium Retention in Bone
Buclin, T., Cosma, M., Appenzeller, M., Jacquet, A. F., Decosterd, L. A., Biollaz, J., & Burckhardt, P. (2001) · Osteoporosis International · doi:10.1007/s001980170095 · Cited by 223 · see citing works
Resistance exercise maintains skeletal muscle protein synthesis during bed rest
Ferrando, A. A., Tipton, K. D., Bamman, M. M., & Wolfe, R. R. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.3.807 · Cited by 221 · see citing works
Dietary protein, calcium metabolism, and skeletal homeostasis revisited
Kerstetter, J. E., O'Brien, K. O., & Insogna, K. L. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.584s · Cited by 218 · see citing works
Alexy, U., Remer, T., Manz, F., Neu, C. M., & Schöenau, E. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1107 · Cited by 214 · see citing works
Low Protein Intake: The Impact on Calcium and Bone Homeostasis in Humans
Kerstetter, J. E., O'Brien, K. O., & Insogna, K. L. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.3.855s · Cited by 212 · see citing works
High dietary protein intake, reducing or eliciting insulin resistance?
Rietman, A., Schwarz, J., Tomé, D., Kok, F. J., & Mensink, M. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.123 · Cited by 202 · see citing works
Macdonald, H. M., New, S. A., Fraser, W. D., Campbell, M., & Reid, D. M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.4.923 · Cited by 186 · see citing works
Jehle, S., Zanetti, A., Muser, J., Hulter, H. N., & Krapf, R. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006030233 · Cited by 172 · see citing works
Leucine partially protects muscle mass and function during bed rest in middle-aged adults
English, K. L., Mettler, J. A., Ellison, J. B., Mamerow, M. M., Arentson-Lantz, E., Pattarini, J. M., Ploutz-Snyder, R., Sheffield-Moore, M., & Paddon-Jones, D. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.112359 · Cited by 162 · cited 3× · see citing works
“Given that a positive effect such as maintaining muscle mass by maintaining muscle protein synthesis (English et al. 2016; Moore 2014) would be very beneficial in inactivity such as BR, increased protein intake might still increase bone Page 5 of 40”
BackgroundResultCollagen Cross-Link Excretion during Space Flight and Bed Rest1
Smith, S. M., Nillen, J. L., LeBlanc, A., Lipton, A., Demers, L. M., Lane, H. W., & Leach, C. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5169 · Cited by 160 · see citing works
Self-citationWall, B. T., Dirks, M. L., Snijders, T., van Dijk, J., Fritsch, M., Verdijk, L. B., & van Loon, L. J. C. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00227.2015 · Cited by 160 · see citing works
Dietary Animal and Plant Protein and Human Bone Health: A Whole Foods Approach
Massey (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.862s · Cited by 145 · see citing works
Short‐term bed rest impairs amino acid‐induced protein anabolism in humans
Biolo, G., Ciocchi, B., Lebenstedt, M., Barazzoni, R., Zanetti, M., Platen, P., Heer, M. A., & Guarnieri, G. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.066365 · Cited by 145 · see citing works
Self-citationDietary protein and calcium interact to influence calcium retention: a controlled feeding study
Hunt, J. R., Johnson, L. K., & Roughead, Z. F. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27238 · Cited by 142 · see citing works
New, S. A., Macdonald, H. M., Campbell, M., Martin, J. C., Garton, M. J., Robins, S. P., & Reid, D. M. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.1.131 · Cited by 140 · see citing works
Calorie restriction accelerates the catabolism of lean body mass during 2 wk of bed rest
Biolo, G., Ciocchi, B., Stulle, M., Bosutti, A., Barazzoni, R., Zanetti, M., Antonione, R., Lebenstedt, M., Platen, P., Heer, M. A., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.366 · Cited by 139 · see citing works
Self-citationTrudel, G., Payne, M. W. C., Mädler, B., Ramachandran, N., Lecompte, M., Wade, C. E., Biolo, G., Blanc, S., Hughson, R. L., Bear, L. A., et al. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91530.2008 · Cited by 134 · see citing works
Self-citationChanges in Bone Turnover in Young Women Consuming Different Levels of Dietary Protein1
Kerstetter, J. E., Mitnick, M., Gundberg, C. M., Caseria, D. M., Ellison, A. F., Carpenter, T. O., & Insogna, K. L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5552 · Cited by 131 · see citing works
Bourrin, S., Ammann, P., Bonjour, J., & Rizzoli, R. (2000) · Endocrinology · doi:10.1210/endo.141.9.7633 · Cited by 130 · see citing works
Interaction of Dietary Calcium and Protein in Bone Health in Humans
Dawson‐Hughes, B. (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.852s · Cited by 128 · see citing works
Kerstetter, J., Caseria, D. M., Mitnick, M., Ellison, A., Gay, L. A., Liskov, T. A. P., Carpenter, T. O., & Insogna, K. L. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.5.1188 · Cited by 122 · see citing works
Meta-Analysis of the Effect of the Acid-Ash Hypothesis of Osteoporosis on Calcium Balance
Fenton, T. R., Lyon, A. W., Eliasziw, M., Tough, S., & Hanley, D. A. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090515 · Cited by 119 · see citing works
Friedlander, A. L., Butterfield, G. E., Moynihan, S., Grillo, J., Pollack, M., Holloway, L., Friedman, L., Yesavage, J. A., Matthias, D., Lee, S., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7377 · Cited by 118 · see citing works
Fenton, T. R., Tough, S., Lyon, A. W., Eliasziw, M., & Hanley, D. A. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-41 · Cited by 116 · see citing works
Sahni, S., Cupples, L. A., McLean, R. R., Tucker, K. L., Broe, K. E., Kiel, D. P., & Hannan, M. T. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.194 · Cited by 112 · see citing works
Calcium absorption, endogenous excretion, and endocrine changes during and after long-term bed rest
LeBlanc, A., Schneider, V. B., Spector, E. R., Evans, H., Rowe, R., Lane, H. W., Demers, L., & Lipton, A. (1995) · Bone · doi:10.1016/s8756-3282(95)80193-6 · Cited by 106 · see citing works
Thorpe, M. P., Jacobson, E. H., Layman, D. K., He, X., Kris‐Etherton, P. M., & Evans, E. M. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.1096 · Cited by 104 · see citing works
Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial
Baecker, N., Tomic, A., Mika, C., Gotzmann, A., Platen, P., Gerzer, R., & Heer, M. A. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00264.2003 · Cited by 103 · see citing works
Self-citationAlibegovic, A. C., Højbjerre, L., Sonne, M. P., van Hall, G., Stallknecht, B., Dela, F., & Vaag, A. (2009) · Diabetes · doi:10.2337/db09-0369 · Cited by 103 · see citing works
Men and Women in Space: Bone Loss and Kidney Stone Risk After Long-Duration Spaceflight
Smith, S. M., Zwart, S. R., Heer, M., Hudson, E. K., Shackelford, L., & Morgan, J. L. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2185 · Cited by 102 · see citing works
Self-citationAltered biochemical markers of bone turnover in humans during 120 days of bed rest
Inoue, M., Tanaka, H., Moriwake, T., Oka, M., Sekiguchi, C., & Seino, Y. (2000) · Bone · doi:10.1016/s8756-3282(99)00282-3 · Cited by 102 · see citing works
Bowen, J., Noakes, M., & Clifton, P. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.3.568 · Cited by 97 · see citing works
Zhu, K., Meng, X., Kerr, D. A., Devine, A., Solah, V. A., Binns, C. W., & Prince, R. L. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.429 · Cited by 97 · see citing works
Effects of 1-week head-down tilt bed rest on bone formation and the calcium endocrine system.
Arnaud, S. B., Sherrard, D. J., Maloney, N. A., Whalen, R. T., & Fung, P. (1992) · PubMed · Cited by 96 · see citing works
Keeping Older Muscle “Young” through Dietary Protein and Physical Activity
Moore, D. R. (2014) · Advances in Nutrition · doi:10.3945/an.113.005405 · Cited by 92 · see citing works
Armbrecht, G., Belavý, D. L., Backström, M., Beller, G., Alexandre, C., Rizzoli, R., & Felsenberg, D. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.482 · Cited by 91 · see citing works
Smith, S. M., Zwart, S. R., Heer, M. A., Lee, S. M. C., Baecker, N., Meuche, S., Macias, B. R., Shackelford, L. C., Schneider, S. M., & Hargens, A. R. (2008) · Bone · doi:10.1016/j.bone.2007.11.015 · Cited by 86 · see citing works
Self-citationDietary protein and skeletal health: a review of recent human research
Kerstetter, J. E., Kenny, A. M., & Insogna, K. L. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283419441 · Cited by 84 · see citing works
Biochemical parameters of bone turnover during ten days of bed rest and subsequent mobilization
van der Wiel, H. E., Lips, P. T. A. M., Nauta, J. J. P., Netelenbos, J. C., & Hazenberg, G. J. (1991) · Bone and Mineral · doi:10.1016/0169-6009(91)90079-f · Cited by 83 · see citing works
Amino acid supplementation alters bone metabolism during simulated weightlessness
Zwart, S. R., Davis-Street, J. E., Paddon-Jones, D., Ferrando, A. A., Wolfe, R. R., & Smith, S. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01406.2004 · Cited by 80 · see citing works
Self-citationThe dietary protein, IGF-I, skeletal health axis
Bonjour, J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0003 · Cited by 77 · see citing works
Zwart, S. R., Hargens, A. R., & Smith, S. M. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.1058 · Cited by 73 · see citing works
Self-citationThe Balance of Bone Health: Tipping the Scales in Favor of Potassium-Rich, Bicarbonate-Rich Foods
Lanham-New, S. A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.1.172s · Cited by 72 · see citing works
Guinet, P., Schneider, S. M., Macias, B. R., Watenpaugh, D. E., Hughson, R. L., Traon, A. P., Bansard, J., & Hargens, A. R. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1009-6 · Cited by 71 · see citing works
Changes in bone turnover markers during 14-day 6� head-down bed rest
Kim, H., Iwasaki, K., Miyake, T., Shiozawa, T. Y., Nozaki, S., & Yajima, K. (2003) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-003-0426-6 · Cited by 71 · see citing works
Dietary protein and bone health: harmonizing conflicting theories
Thorpe, M. P., & Evans, E. M. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00379.x · Cited by 60 · see citing works
Beller, G., Belavý, D. L., Sun, L., Armbrecht, G., Alexandre, C., & Felsenberg, D. (2011) · Bone · doi:10.1016/j.bone.2011.06.021 · Cited by 60 · see citing works
Schneider, S. M., Lee, S. M. C., Macias, B. R., Watenpaugh, D. E., & Hargens, A. R. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181aa04e5 · Cited by 52 · see citing works
Thorpe, M. P., Mojtahedi, M. C., Chapman‐Novakofski, K., McAuley, E., & Evans, E. M. (2008) · Journal of Nutrition · doi:10.1093/jn/138.1.80 · Cited by 51 · see citing works
Kraut, J. A., & Coburn, J. W. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302510 · Cited by 49 · see citing works
Postgraduate Symposium Positive influence of nutritional alkalinity on bone health
Wynn, E., Krieg, M., Lanham-New, S. A., et al. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s002966510999173x · Cited by 39 · see citing works
Protecting Skeletal Muscle with Protein and Amino Acid during Periods of Disuse
Galvan, E., Arentson‐Lantz, E. J., Lamon, S., & Paddon‐Jones, D. (2016) · Nutrients · doi:10.3390/nu8070404 · Cited by 38 · see citing works
Dietary Protein's and Dietary Acid Load's Influence on Bone Health
Remer, T., Krupp, D., & Shi, L. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.627519 · Cited by 36 · see citing works
Cao, J., Pasiakos, S. M., Margolis, L. M., Sauter, E. R., Whigham, L. D., McClung, J. P., Young, A., & Combs, G. F. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.073809 · Cited by 32 · see citing works
Edgell, H., Zuj, K. A., Greaves, D. K., Shoemaker, J. K., Custaud, M.-A., Kerbeci, P., Arbeille, P., & Hughson, R. L. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00187.2007 · Cited by 30 · see citing works
Whey Protein Ingestion Enhances Postprandial Anabolism during Short-Term Bed Rest in Young Men
Antonione, R., Caliandro, E., Zorat, F., Guarnieri, G., Heer, M. A., & Biolo, G. (2008) · Journal of Nutrition · doi:10.3945/jn.108.086462 · Cited by 28 · see citing works
Self-citationArbeille, P., Kerbeci, P., Mattar, L., Shoemaker, J. K., & Hughson, R. L. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01021.2007 · Cited by 26 · see citing works
Protein quality affects bone status during moderate protein restriction in growing mice
Rouy, E., Vico, L., Laroche, N., Benoit, V., Rousseau, B., Blachier, F., Tomé, D., & Blais, A. (2013) · Bone · doi:10.1016/j.bone.2013.10.013 · Cited by 24 · see citing works
The acid–ash hypothesis revisited: a reassessment of the impact of dietary acidity on bone
Nicoll, R., & Howard, J. M. (2014) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-014-0571-0 · Cited by 24 · see citing works
Baecker, N., Frings-Meuthen, P., Smith, S. M., & Heer, M. (2010) · Nutrition · doi:10.1016/j.nut.2009.06.006 · Cited by 22 · see citing works
Self-citationSex‐specific responses of bone metabolism and renal stone risk during bed rest
Morgan, J. L. L., Heer, M. A., Hargens, A. R., Macias, B. R., Hudson, E. K., Shackelford, L. C., Zwart, S. R., & Smith, S. M. (2014) · Physiological Reports · doi:10.14814/phy2.12119 · Cited by 19 · see citing works
Self-citationAmmann, P., Bonjour, J. ‐., & Rizzoli, R. (2000) · PubMed · Cited by 18 · see citing works
Hodges, G. J., Mattar, L., Zuj, K. A., Greaves, D. K., Arbeille, P., Hughson, R. L., & Shoemaker, J. K. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2010.054254 · Cited by 16 · see citing works
Immobilization Hypercalcemia in the Elderly
Wick, J. Y. (2007) · The Consultant Pharmacist · doi:10.4140/tcp.n.2007.892 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 13
- [5]5. Arbeille,P., Kerbeci,P., Greaves,D., Schneider,S., Hargens,A. & Hughson,R. 2007. Arterial and venous response to Tilt with LBNP test after a 60 day HDT bedrest (WISE study). J. Gravit. Physiol 14: 47-48. PMID:18372693.
- [13]13. Beavers,K.R., Greaves,D.K., Arbeille,P. & Hughson,R.L. 2007. WISE-2005: orthostatic tolerance is poorly predicted by acute changes in cardiovascular variables. J. Gravit. Physiol. 14: 63-64. PMID:18372701.
- [17]17. Biolo,G., Maggi,S.P., Williams,B.D., Tipton,K.D. & Wolfe,R.R. 1995. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am. J. Physiol. 268: E514-E520. PMID:7900797.
- [32]32. Ferrando,A.A., Lane,H.W., Stuart,C.A., Davis-Street,J. & Wolfe,R.R. 1996. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am. J. Physiol. 270: E627- E633. PMID:8928769.
- [34]34. Food and Nutrition Board & Institute of Medicine 2005. Protein and Amino Acids. In: Dietary Reference Intakes for Energy, Carbohydrate, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients), pp. 589-768.
- [35]35. Washington D.C.: National Academies Press.
- [38]38. Gagne,N., Fischer,D., Greaves,D.K. & Hughson,R.L. 2007. WISE-2005: developing a non- invasive method to monitor cardiovascular deconditioning. J. Gravit. Physiol. 14: 137-138. PMID:18372737.
- [47]47. Institute of Medicine 2002. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington DC: National Academies Press.
- [48]48. Institute of Medicine 2004. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington DC: National Academies Press.
- [51]51. Kerbeci,P., Shoemaker,K., Hughson,R., Roncin,A. & Arbeille,P. 2007. Tibial and gastrocnemian vein response to LBNP after a 60 day bedrest with and without counter- measures (WISE study). J. Gravit. Physiol 14: 57-58. PMID:18372698.
- [68]68. Murray,T.M. 1996. Prevention and management of osteoporosis: consensus statements from the Scientific Advisory Board of the Osteoporosis Society of Canada. 4. Calcium nutrition and osteoporosis. Can. Med. Assoc. J. 155: 935-939. PMID:8837545.
- [92]92. Yanagibori,R., Suzuki,Y., Kawakubo,K., Kondo,K., Iwamoto,T., Itakura,H., Makita,Y., Sekiguchi,C., Gunji,A. & Kondou,K. 1997. The effects of 20 days bed rest on serum lipids and lipoprotein concentrations in healthy young subjects. J. Gravit. Physiol. 4: S82-S90. PMID:11541183.
- [95]95. Zuj,K.A., Greaves,D.K. & Hughson,R.L. 2007. WISE-2005: reduced cerebral blood flow velocity with nitroglycerin--comparison with common carotid artery blood flow. J. Gravit. Physiol. 14: 65-66. PMID:18372702.
Cited by
Sorted by citations
Patel, Z. S., Brunstetter, T. J., Tarver, W. J., Whitmire, A. M., Zwart, S. R., Smith, S. M., & Huff, J. L. (2020) · npj Microgravity · doi:10.1038/s41526-020-00124-6 · Cited by 373 · see citing works
Self-citationSkeletal changes during and after spaceflight
Vico, L., & Hargens, A. (2018) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2018.37 · Cited by 236 · see citing works
Dietary acid load and bone turnover during long-duration spaceflight and bed rest
Zwart, S. R., Rice, B. L., Dlouhy, H., Shackelford, L. C., Heer, M., Koslovsky, M. D., & Smith, S. M. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy029 · Cited by 42 · see citing works
Self-citation
- Authors
- Heer, M., Baecker, N., Frings-Meuthen, P., Graf, S., Zwart, S. R., Biolo, G., & Smith, S. M.
- Affiliations
- University of Bonn (DE)
- German Aerospace Center (DLR), Institute of Aerospace Medicine, 51147 Cologne, Germany.
- The University of Texas Medical Branch at Galveston (US)
- University of Trieste (IT)
- National Aeronautics and Space Administration (US)
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2017-05
- Volume
- 42
- Issue
- 5
- Pages
- 537-546
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2574501305
- Cited by
- 24
- References
- 82
- Citations by year
- 2026: 1 · 2025: 5 · 2023: 4 · 2022: 3 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 2
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Applied Physiology, Nutrition, and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (acceptedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion, other-oa)
- elib (German Aerospace Center) (submittedVersion)
- Funders
- National Aeronautics and Space Administration
- Centre National d’Etudes Spatiales
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- high-protein diet, bed rest, bone turnover, bone resorption, bone loss, head-down tilt, women, branched-chain amino acids, C-terminal telopeptide, bone formation markers, calcium intake, potassium intake, isocaloric diet, microgravity
- MeSH terms
- Adult, Bed Rest, Body Composition, Bone Resorption, Diet, Dietary Proteins, Female, Humans, Bone Density, Space Simulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
