Cited by 256Nerve injury and regenerationPhysical Activity and HealthExercise and Physiological Responses

The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.

Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions

Open access

Walsh, Jeremy J., Tschakovsky, Michael E.·2018·Applied Physiology Nutrition and Metabolism

DOI 10.1139/apnm-2018-0192

Open this paper in CoChat — free account Open PDF

Abstract

Engagement in regular bouts of exercise confers numerous positive effects on brain health across the lifespan. Acute bouts of exercise transiently improve cognitive function, while long-term exercise training stimulates brain plasticity, improves brain function, and helps to stave off neurological disease. The action of brain-derived neurotrophic factor (BDNF) is a candidate mechanism underlying these exercise-induced benefits and is the subject of considerable attention in the exercise-brain health literature. It is well established that acute exercise increases circulating levels of BDNF and numerous studies have sought to characterize this response for the purpose of improving brain health. Despite the interest in BDNF responses to exercise, little focus has been given to understanding the sources and mechanisms that underlie this response for the purpose of deliberately increasing circulating levels of BDNF. Here we review evidence to support that exploiting these mechanisms of BDNF release can help to optimize brain plasticity outcomes via exercise interventions, which could be especially relevant in the context of multimodal training (i.e., exercise and cognitive stimulation). Therefore, the purpose of this paper is to review the candidate sources of BDNF during exercise and the mechanisms of release. As well, we discuss strategies for maximizing BDNF responses to exercise, and propose novel research directions for advancing our understanding of these mechanisms.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1139/apnm-2018-0192

Cites

84 of 84 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060
The effects of acute exercise on cognitive performance: a meta-analysis
Chang, Y. K., Labban, J. D., Gapin, J. I., & Etnier, J. L. (2012) · Brain Research · doi:10.1016/j.brainres.2012.02.068 · Cited by 1,930
Purification of a new neurotrophic factor from mammalian brain.
Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822
Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials
Smith, P. J., Blumenthal, J. A., Hoffman, B. M., Cooper, H., Strauman, T. A., Welsh-Bohmer, K., Browndyke, J. N., & Sherwood, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d14633 · Cited by 1,714
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353
Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?
Kerschensteiner, M., Gallmeier, E., Behrens, L., Vargas-Leal, V., Misgeld, T., Klinkert, W. E. F., Kolbeck, R., Hoppe, E., Oropeza-Wekerle, R. L., Bartke, I., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.865 · Cited by 1,019

Show all 84 references

Research works printed but not linked: 1

Caspersen C.J., 1985, Publ. Health Rep., 100, 126

Sorted by citations

Items 101–200 of 256

Acute effect of combined exercise with aerobic and resistance exercises on executive function
Chen, Y.-C., Li, R., Chen, F., Wu, C., Chen, C., Chang, C.-C., & Chang, Y. (2023) · PeerJ · doi:10.7717/peerj.15768 · Cited by 13
Evaluating the impact of aerobic and resistance green exercises on the fitness, aerobic and intrinsic capacity of older individuals
Ayaz, E. Y., Dinçer, B., Mete, E., Benli, R. K., Cinbaz, G., Karacan, E., Cankül, A., & Mesçi, B. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105281 · Cited by 13
Habit Formation and the Effect of Repeated Stress Exposures on Cognitive Flexibility Learning in Horses
Henshall, C., Randle, H., Francis, N., & Freire, R. (2022) · Animals · doi:10.3390/ani12202818 · Cited by 15
Essential amino acid supplements ingestion has a positive effect on executive function after moderate-intensity aerobic exercise
Dora, K., Tsukamoto, H., Suga, T., Tomoo, K., Suzuki, A., Adachi, Y., Takeshita, M., KATO, Y. O., Kawasaki, M., Sato, W., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-49781-z · Cited by 13
A review of exercise interventions for reducing anxiety symptoms: Insights and implications
Ewuzie, Z. D. D., Ezeano, C., & Aderinto, N. (2024) · Medicine · doi:10.1097/md.0000000000040084 · Cited by 16
Evidence of the Long-Term Protective Effect of Moderate-Intensity Physical Activity on Cognitive Function in Middle-Aged and Elderly Individuals: A Predictive Analysis of Longitudinal Studies
Hao, Z., Zhang, X., & Wang, Y. (2024) · Life · doi:10.3390/life14101343 · Cited by 12
The Role of Myokines in Liver Diseases
Nishikawa, H., Kim, S. K., & Asai, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031043 · Cited by 12
Effects of exercise on BDNF-TrkB signaling in the paraventricular nucleus and rostral ventrolateral medulla in rats post myocardial infarction
Lee, H. W., Ahmad, M., Wang, H., & Leenen, F. H. H. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102058 · Cited by 12
Acute effects of ambient nitrogen dioxide exposure on serum biomarkers of nervous system damage in healthy older adults
Song, J., Qu, R., Sun, B., Wang, Y., Chen, R., Kan, H., An, Z., Wu, H., Li, J., Jiang, J., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114423 · Cited by 12
Sedentary patterns are associated with BDNF in patients with type 2 diabetes mellitus
Júdice, P. B., Magalhães, J. P., Hetherington‐Rauth, M., Correia, I. R., & Sardinha, L. B. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04568-2 · Cited by 12
Serum Levels of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Elite Athletes: Potential Markers of the Use of Transcranial Direct Current Stimulation in Sport
Donati, F., Sian, V., Biasini, G. M., de la Torre, X., Folchitto, F., & Botrè, F. (2021) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2021.619573 · Cited by 14
Benefits of Higher Cardiovascular and Motor Coordinative Fitness on Driving Behavior Are Mediated by Cognitive Functioning: A Path Analysis
Stojan, R., Kaushal, N., Bock, O. L., Hudl, N., & Voelcker‐Rehage, C. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.686499 · Cited by 11
Chronic running‐wheel exercise from adolescence leads to increased anxiety and depression‐like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype
Jaehne, E. J., Kent, J. N., Lam, N., Schonfeld, L., Spiers, J. G., Begni, V., Rosa, F. D., Riva, M. A., & van den Buuse, M. (2022) · Developmental Psychobiology · doi:10.1002/dev.22347 · Cited by 12
Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons
Li, J., Zhou, Z., Wu, Y., Zhao, J., Duan, H.-K., Peng, Y., Wang, X., Fan, Z., Yin, L., Li, M., et al. (2024) · Theranostics · doi:10.7150/thno.101422 · Cited by 15
The effects of endurance exercise combined with high-temperature head-out water immersion on serum concentration of brain-derived neurotrophic factor in healthy young men
Ohko, H., Umemoto, Y., Sakurai, Y., Araki, S., Kojima, D., Kamijo, Y., Murai, K., Yasuoka, Y., & Tajima, F. (2021) · International Journal of Hyperthermia · doi:10.1080/02656736.2021.1922761 · Cited by 11
Brain-derived neurotrophic factor and physical activity: A review
Владимировна, С. Н. (2022) · Comprehensive Child Studies · doi:10.33910/2687-0223-2022-4-2-124-133 · Cited by 11
The comprehensive impact of exercise interventions on cognitive function and quality of life in alzheimer’s disease patients: a systematic review and meta-analysis
Li, P., He, Y., & He, M. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06454-y · Cited by 11
Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating
Ogawa, T., Hoekstra, S. P., Kamijo, Y., Goosey-Tolfrey, V. L., Walsh, J. J., Tajima, F., & Leicht, C. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260775 · Cited by 11
Self-citation
Neurophysiological Markers for Monitoring Exercise and Recovery Cycles in Endurance Sports
Reichel, T., Hacker, S., Palmowski, J., Boßlau, T. K., Frech, T., Tirekoglou, P., Weyh, C., Bothur, E., Samel, S., Walscheid, R., et al. (2022) · Journal of Sports Science and Medicine · doi:10.52082/jssm.2022.446 · Cited by 11
Effects of traditional Chinese exercises on brain-derived neurotrophic factor in middle-aged and older adults: A systematic review and meta-analysis of randomized controlled trials
Gan, J., He, J., Zhou, K., Shang, Z., Dong, G., Bao, D., & Zhou, J. (2024) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2024.12.004 · Cited by 11
Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet
Maroofi, A., Rouch, A. B., Naderi, N., & Damirchi, A. (2022) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2022.101022 · Cited by 10
Effects of hemp seed alone and combined with aerobic exercise on metabolic parameters, oxidative stress, and neurotrophic factors in young sedentary men
Mohammadrezaei, A., Kavakeb, A., Farhangi, M. A., & Abbasi, M. M. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14417 · Cited by 11
Combined Training Improves Executive Functions Without Changing Brain-Derived Neurotrophic Factor Levels of Middle-Aged and Older Adults with Type 2 Diabetes
Silveira-Rodrigues, J. G., Nogueira, N. G. D. H. M., Faria, L. O., Pereira, D. S., & Soares, D. D. (2023) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-2069-4050 · Cited by 10
Blood and MRI biomarkers of mild traumatic brain injury in non-concussed collegiate football players
Cho, E., Granger, J., Theall, B. M., Lemoine, N. P., Calvert, D. D., Marucci, J., Mullenix, S., O’Neal, H. R., Jacome, T. H., Irving, B. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-023-51067-3 · Cited by 10
Association of plasma BDNF and MMP-9 levels with mild cognitive impairment: a matched case-control study
Zhang, T., Si, H., Liao, J., & Ma, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-81895-w · Cited by 9
Sixteen Weeks of Aerobic Exercise does not Alter Resting-state Connectivity of the Precuneus in Patients with Alzheimer’s Disease
Musaeus, C. S., Johansen, L. B., Hasselbalch, S. G., Beyer, N., Høgh, P., Siebner, H. R., & Frederiksen, K. S. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220304091241 · Cited by 9
Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke
Saleh, R. O., Majeed, A. A., Margiana, R., Alkadir, O. K. A., Almalki, S. G., Ghildiyal, P., Samusenkov, V. O., Jabber, N. K., Mustafa, Y. F., & Elawady, A. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3957 · Cited by 9
The effect of functional training on level of brain-derived neurotrophic factor and functional performance in women with obesity
Alizadeh, M., & Dehghanizade, J. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113798 · Cited by 8
Are COMT Val158Met (rs4680), DRD2 TaqIA (rs1800497), and BDNF Val66Met (rs6265) polymorphisms associated with executive functions performance at rest and during physical exercise?
Frois, T., Faria, L. O., de Souza, R. P., Cunha, A. E. D. S., Nogueira, N. G. D. H. M., Lim, V. T., Fortes, L. D. S., de Miranda, D. M., Bertollo, M., & Albuquerque, M. R. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113973 · Cited by 10
Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer’s Disease
Venkatraman, V. K., Steward, C. E., Cox, K. L., Ellis, K. A., Phal, P. M., Sharman, M. J., Villemagne, V. L., Lai, M. M. Y., Cyarto, E., Ames, D. J., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00115 · Cited by 9
Impact of High-Intensity Exercise on BDNF Levels and Its Implications in High-Performance Sport: A Systematic Review
Moreno-Infantes, F., Díaz-Quesada, G., Radesca, K., Muñoz-Andradas, G., & Domínguez-Balmaseda, D. (2024) · Physiologia · doi:10.3390/physiologia4040027 · Cited by 9
The Impact of Physical Activity on Depression Treatment: A Literature Review
Sieniawska, D., Sieniawska, J., & Proszowska, P. (2024) · Quality in Sport · doi:10.12775/qs.2024.16.52858 · Cited by 9
Changes in brain-derived neurotropic factor following aerobic exercise
Curtis, R., Blades, A., Moris, J. M., & Koh, Y. (2024) · Sport Sciences for Health · doi:10.1007/s11332-024-01244-2 · Cited by 11
Effects of acute aerobic exercise on brain-derived neurotrophic factor level in rheumatoid arthritis patients
Yentür, S. B., Ercan, Z., Deniz, G., Karataş, A., Gür, M., Alkan, G., & Koca, S. S. (2023) · Archives of Rheumatology · doi:10.46497/archrheumatol.2023.9599 · Cited by 8
Decreased Serum Brain-Derived Neurotrophic Factor Concentrations 72 Hours Following Marathon Running
Roeh, A., Holdenrieder, S., Schoenfeld, J., Haeckert, J., Halle, M., Falkai, P., Scherr, J., & Hasan, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.668454 · Cited by 8
The Effect of Aerobic or Strength Training in Elderly with Cognitive Decline: The Fit4Alz Project
Silva, A. F., Clemente, F. M., Roriz, M. S., Azevedo, J. A., Jovanovic, O., Adamovic, M., Bozic, A., & Silva, R. (2025) · Journal of Sports Science and Medicine · doi:10.52082/jssm.2025.172 · Cited by 11
The benefits of rehabilitation exercise in improving chronic traumatic encephalopathy: recent advances and future perspectives
Huang, Y., Wu, Z., Lin, S., & Chen, X. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00728-0 · Cited by 7
The Relationship between Physical Fitness and Cognitive Functions in Older People: A Systematic Review
Tinôco, M. A., Nascimento, M. D. M., Marques, A., Gouveia, É. R., Miguel, S., Santos, F., & Ihle, A. (2023) · Sustainability · doi:10.3390/su152316314 · Cited by 13
Association between dietary intake of vitamin D and risk of depression, anxiety, and sleep disorders among physically active adults: a cross-sectional study
Arabshahi, V., Khoddami, M., Milajerdi, M., Moabedi, M., & Milajerdi, A. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1339152 · Cited by 10
APP processing: a biochemical competition influenced by exercise-induced signaling mediators?
Marko, D. M., & MacPherson, R. E. K. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00297.2021 · Cited by 7
Acute effects of two different work-to-rest ratio of high-intensity interval training on brain-derived neurotrophic factor in untrained young men
Zhao, K., Hu, Z., Wang, T., Tian, L., Wang, M., Liu, R., Zuo, C., & Jihua, W. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.988773 · Cited by 9
Physical and Cognitive Activities: Interaction and Mechanisms of Influence
Kabachkova, A. V., Zakharova, A. N., Krivoshchekov, S. G., & Капилевич, Л. В. (2022) · Human Physiology · doi:10.1134/s0362119722600199 · Cited by 7
Toward a Comprehensive Professional Philosophy in Performance and Well-Being Psychology: Integrating Functional Contextualism and Relational Frame Theory for Esports and Other High-Performance Environments
Horne, G., & Swettenham, L. D. (2024) · Journal of Electronic Gaming and Esports · doi:10.1123/jege.2024-0017 · Cited by 10
Protocol for a randomized controlled trial: exercise-priming of CBT for depression (the CBT+ trial)
Meyer, J. D., Kelly, S. J. E., Gidley, J. M., Lansing, J. E., Smith, S. L., Churchill, S. L., Thomas, E. B. K., Goldberg, S. B., Abercrombie, H. C., Murray, T. A., et al. (2024) · Trials · doi:10.1186/s13063-024-08495-x · Cited by 6
BDNF and proBDNF serum levels during antidepressant treatment in adolescent girls with a first-lifetime episode of depression: A prospective case-controlled study
Zwolińska, W., Bilska, K., Skibińska, M., Pytlińska, N., Słopień, A., & Dmitrzak‐Węglarz, M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.02.038 · Cited by 6
Ejercicio y algunos mecanismos moleculares que subyacen a una mejora del desempeño en tareas cognitivas
Herrera, B. M. (2020) · Revista Iberoamericana de Ciencias de la Actividad Física y el Deporte · doi:10.24310/riccafd.2020.v9i1.8303 · Cited by 6
An 18-hole round of golf acutely elevates serum interleukin-6 and brain-derived neurotrophic factor concentration - a pilot study
Yasuoka, Y., Nakamura, T., Umemoto, Y., Kinoshita, T., Hoekstra, S. P., Hoshiai, K., Ohko, H., Abo, M., & Tajima, F. (2022) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.11.1 · Cited by 6
The impact of early-life exercise on CREB-signaling pathway and hippocampus neuroplasticity in diabetic adult male rats; the study of developmental model
Khaledi, N., Jeddi, S., Abbasi, S., Eftekharzadeh, M., Khodadadi, H., Namdari, M., & Tuplin, E. W. N. (2024) · Neurological Research · doi:10.1080/01616412.2024.2359265 · Cited by 6
BDNF and Its Multirole Function in Neurogenesis, Synaptic Transmission and Neurodegenerative Diseases
Huang, Y., Wang, Y., Gao, Y., Liu, Q., Ye, F.-F., Guo, B., Wu, Y.-C., & Xue, L. (2020) · Nano LIFE · doi:10.1142/s1793984420400073 · Cited by 6
Applying the understanding of central sensitization in practice
Wallden, M., & Nijs, J. (2021) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2021.04.004 · Cited by 6
Acute effects of physical activity patterns on plasma cortisol and brain-derived neurotrophic factor in relation to corticospinal excitability
Ekblom, M., Bojsen‐Møller, E., Blom, V., Tarassova, O., Moberg, M., Pontén, M., Wang, R., & Ekblom, Ö. B. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113926 · Cited by 6
Exercise as elixir to combat cardiovascular ageing
Feng, Z., Yuan, X., Yi, W., Gao, F., Sun, Y., & Zhang, X. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102848 · Cited by 7
The relationship between the brain-derived neurotrophic factor and neurocognitive response to physical exercise in individuals with schizophrenia
Bang-Kittilsen, G., Egeland, J., Ueland, T., Andersen, E., Bigseth, T. T., Holmen, T. L., Mordal, J., Holst, R., & Engh, J. A. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106356 · Cited by 5
Psychotomimetic compensation versus sensitization
Brouwer, A., Carhart-Harris, R. L., & Raison, C. L. (2024) · Pharmacology Research & Perspectives · doi:10.1002/prp2.1217 · Cited by 7
Neuroplasticity. How regular physical activity influences the brain’s structure and function
Dołęga, J., Papież, Ł. S., Mól, P., Maciejczyk, T., Sieńko, A., Łabuś, M., Zabawa, B., Hudzińska, P., Krzykawski, K., & Sadowski, J. (2024) · Quality in Sport · doi:10.12775/qs.2024.34.56026 · Cited by 11
Exercise and hypoxia independently stimulate platelet liberation of brain‐derived neurotrophic factor and platelet factor 4
Thomas, K. N., Caldwell, H. G., MacLeod, D. B., Abraham, W. C., Carr, J. M. J. R., Gasho, C., Brewster, L. M., Bruce, C. D., Monteleone, J. A., Duffy, J. S., et al. (2025) · The Journal of Physiology · doi:10.1113/jp289261 · Cited by 5
Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults
Assi, M. J., Poursalehi, D., Tirani, S. A., Shahdadian, F., Hajhashemy, Z., Mokhtari, E., Mohammadi, S., & Saneei, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-43855-8 · Cited by 5
Safety and effectiveness of acute intermittent hypoxia during a single treatment at different hypoxic severities
Smith, C. M., & Salmon, O. F. (2024) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2024.104358 · Cited by 4
Vital Role of Visceral Adipose Tissue in Maintaining Cognitive Functions
Shirafuji, R., Amagase, Y., Goto, A., & Takei, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146597 · Cited by 5
Home‐Based High‐Intensity Interval Training for People With Parkinson's: A Randomized, Controlled, Feasibility Trial
Harpham, C., Gunn, H., Marsden, J. F., Bescós, R., Murgatroyd, C., & Connolly, L. J. (2025) · Health Science Reports · doi:10.1002/hsr2.71024 · Cited by 4
Resistance Training Improves Cognitive Function and Depression Without Changing BDNF Levels in People Living with HIV: a Randomized Controlled Clinical Trial
de Souza, D. C., Marchini, K. B., Nunhes, P. M., Domingues, W. J. R., Bertolini, D. A., Oliveira, V., Mazzardo, O., & Avelar, A. (2025) · AIDS and Behavior · doi:10.1007/s10461-025-04824-6 · Cited by 5
Neurogenesis markers in brain aging and their serotonergic modulation by physical exercise: A narrative review
Silva, J. D. N., Rodrigues, B. A., & Kawamoto, E. M. (2025) · NeuroMarkers. · doi:10.1016/j.neumar.2025.100110 · Cited by 4
The Effect of Physical Activity on Neurotrophin Concentrations and Cognitive Control in Patients With a Depressive Episode
Jasińska-Mikołajczyk, A., Drews, K., Domaszewska, K., Kolasa, G., Konofalska, M., Jowik, K., Skibińska, M., & Rybakowski, F. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.777394 · Cited by 4
Effect of high-intensity exercise on endoplasmic reticulum stress and proinflammatory cytokine levels
Korkmaz, K., Düzova, H., Taşlıdere, A. Ç., Koç, A., Karaca, Z. M., & Durmuş, K. (2023) · Science & Sports · doi:10.1016/j.scispo.2022.04.009 · Cited by 4
Higher Protein Intake does not Modulate Resistance Training–Induced Changes in Myokines and Cognitive Function in Middle-Aged Adults
Kim, J., McKenna, C. F., Askow, A. T., Salvador, A. F., Scaroni, S. E., Cerna, J., Cannavale, C. N., Paluska, S. A., Lisio, M. D., Petruzzello, S. J., et al. (2024) · Journal of Cognitive Enhancement · doi:10.1007/s41465-024-00285-2 · Cited by 4
PRP and other techniques for restoring function across peripheral nerve gaps
Kuffler, D. P. (2024) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2024.100131 · Cited by 6
Brain-Derived Neurotrophic Factor and Psychophysiological Response in Youth Badminton Athletes During the Season
Santos, A. M. S., Jiménez‐Maldonado, A., de Sousa, A. V. M., Brito, S. O. S., de Moura, R. C., Figueiredo, C., Monteiro, P. A., Neves, L. M., Júnior, I. F. F., dos Santos, M. A. P., et al. (2021) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2020-0911 · Cited by 4
Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review
Wing, D., Roelands, B., Snyder, A. Z., Yingling, M. D., Araque, M., Shimony, J. S., Klaus, F., Orav, G., Godino, J., MEEUSEN, R. R., et al. (2025) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2025.07.008 · Cited by 3
High-Velocity, Accentuated Eccentric, or Maximal Elastic Band Resistance Training? Effects of Resistance Training Modalities on Bone Health, Isokinetic Strength, and Systemic Biomarkers in Sedentary Older Adults: A Comparative Study
Saez-Berlanga, Á., Gené‐Morales, J., Teixeira, A. M., Castuera, R. J., Gené‐Sampedro, A., Juesas, Á., Gargallo, P., Caballero, O., Garrido, J. F., Alix‐Fages, C., et al. (2025) · Healthcare · doi:10.3390/healthcare13233129 · Cited by 4
Exercise-Induced Changes in Brain-Derived Neurotrophic Factor in Neurodegenerative Diseases: A Bayesian Network Meta-Analysis
Tang, Z., Yin, M., Xu, K., Zheng, H., Yan, H., Zhao, Z., & Liu, Q. (2025) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887251409415 · Cited by 3
The role of neurotrophic growth factors in the pathophysiology of bronchial asthma associated with obesity
Kytikovа, O. Y., Novgorodtseva, T. P., Antonyuk, M. V., & Gvozdenko, T. A. (2021) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2021-1-158-167 · Cited by 4
Whole body hypoxic preconditioning-mediated multiorgan protection in db/db mice via nitric oxide-BDNF-GSK-3β-Nrf2 signaling pathway
Li, Y., Huang, Y. L., Cheng, X., He, Y., & Hu, X. Y. (2021) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2021.25.4.281 · Cited by 3
Assessment of serum BDNF levels in complex rehabilitation of patients with ischemic stroke using traditional approaches to the restoration of motor functions
Дмитриевич, К. С., Koroleva, E. S., Brazovskaya, N. G., Zaytsev, A. A., Ivanova, S. А., & Alifirova, V. M. (2021) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2021-3-38-45 · Cited by 3
High blood levels of brain-derived neurotrophic factor (BDNF) mRNA in early psychosis are associated with inflammatory markers
Moreno, I., Stojanovic‐Pérez, A., Bulduk, B. K., Sánchez‐Gistau, V., Algora, M. J., Ortega, L., Muntané, G., Vilella, E., Labad, J., & Martorell, L. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.07.003 · Cited by 4
Effects of 12 weeks of inspiratory muscle training and whole body vibration on the inflammatory profile, BDNF and muscular system in pre-frail elderly women: A randomized controlled trial
de Souza, H. C. M., Pessoa, M. F., Clemente, R. D. S., da Silva, A. V., Cardoso, P. R. G., Fernandes, J., & de Andrade, A. D. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105421 · Cited by 3
Brain derived neurotrophic factor and secreted amyloid precursor protein‐α response to moderate and high intensity exercise
Spencer, F. S. E., Elsworthy, R. J., Breen, L., Bishop, J. R. B., Lucas, S. J. E., & Aldred, S. (2025) · Physiological Reports · doi:10.14814/phy2.70366 · Cited by 4
Vitamin D and exercise in obesity: a neurovascular–muscle axis
Zheng, X., & Zhang, C. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1750915 · Cited by 3
Effect of pedaling cadence on serum levels of brain-derived neurotrophic factor during ergometric exercise in healthy adults
Miyamoto, T., Nishiwaki, E., Uho, T., Mizutani, R., Miyamae, N., & Yamada, E. (2021) · Sport Sciences for Health · doi:10.1007/s11332-020-00706-7 · Cited by 3
Acute caffeine intake in humans reduces post exercise performance in learning and memory
Berg, J., Cooper, J., Salonikas, C., Seyedsadjadi, N., & Grant, R. (2021) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2775 · Cited by 3
The effect of rehabilitation with sensory glove and virtual reality on concentration of brain-derived neurotrophic factor and event related potential P300 in the early rehabilitation period after ischemic stroke
Петрова, Л. В., Kostenko, E. G., Martynov, M. Y., Pogonchenkova, I. V., & Kopasheva, V. D. (2023) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202312312275 · Cited by 3
Utilizing Entropy of Cadence to Optimize Cycling Rehabilitation in Individuals With Parkinson’s Disease
Kim, Y., Smith, B. E., Shigo, L. M., Shaikh, A. G., Loparo, K. A., & Ridgel, A. L. (2024) · Neurorehabilitation and neural repair · doi:10.1177/15459683241268556 · Cited by 3
Increased Salivary BDNF and Improved Fundamental Motor Skills in Children Following a 3-Month Integrated Neuromuscular Training in Primary School
Vasileva, F., Font‐Lladó, R., Carreras‐Badosa, G., López‐Ros, V., Ferrusola-Pastrana, A., López‐Bermejo, A., & Prats‐Puig, A. (2024) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk9030154 · Cited by 3
Preliminary results of the cross-sectional associations of sedentary behavior and physical activity with serum brain-derived neurotrophic factor in adults with coronary heart disease
Ullrich, A., Wenzel, K., Bahls, M., Voigt, L., Könemann, S., Dörr, M., Wurm, S., & Ulbricht, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-23706-8 · Cited by 3
The Impact of Dual-Task Training Versus Single-Task Training on Cognitive and Physical Function in Neurologically Impaired Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Abidin, N. Z., Mansor, N. S., Yusof, H. A., Hamid, A. I. A., & Isa, S. M. (2026) · Perceptual and Motor Skills · doi:10.1177/00315125261425126 · Cited by 2
BDNF/TrkB Signaling in the Brain–Kidney Axis Under Functional Stress
Beknazarova, A., Kuvaeva, V., Baltin, M. E., Mutig, K., & Bobylev, A. G. (2026) · Biology · doi:10.3390/biology15090696 · Cited by 2
Acute submaximal exercise does not impact aspects of cognition and BDNF in people with spinal cord injury: A pilot study
Nhan, K., Todd, K. R., Jackson, G. S., van der Scheer, J. W., Dix, G. U., Ginis, K. A. M., Little, J. P., & Walsh, J. J. (2022) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2022.983345 · Cited by 2
Self-citation
Physical Exercise, Sleep, and the Brain
Brewer‐Smyth, K. (2022) · Springer eBooks · doi:10.1007/978-3-031-08801-8_13 · Cited by 2
Dietary intake of methyl donor nutrients in relation to metabolic health status, serum levels of brain-derived neurotrophic factor and adropin
Poursalehi, D., Lotfi, K., Shahdadian, F., Hajhashemy, Z., Rouhani, P., & Saneei, P. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.04.031 · Cited by 2
Aerobic exercise improves cognitive flexibility and modulates regional volume changes in a rat model of autism
Sivayokan, B., King, C., Mali, I., Payne, M. M., Strating, H., Warnes, E., Bossmann, S. H., & Plakke, B. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115136 · Cited by 2
Development and Validation of the Communities Geriatric Mild Cognitive Impairment Risk Calculator (CGMCI-Risk)
Chen, J., Fang, Q., Yang, K., Pan, J., Zhou, L., Xu, Q., & Shen, Y. (2024) · Healthcare · doi:10.3390/healthcare12202015 · Cited by 2
Molecular biomarkers of dysphagia targeted exercise induced neuroplasticity: A review of mechanistic processes and preliminary data on detraining effects
Krishnamurthy, R., Krishnamoorthy, C., Dietsch, A. M., & Natarajan, S. K. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149287 · Cited by 2
Understanding the neurobiological mechanisms of LPS‑induced memory impairment
Golkar, A., Dalfardi, M., Hedayati‐Moghadam, M., Askarpour, H., Hosseini, M., & Baghcheghi, Y. (2025) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2024-2629 · Cited by 4
Lactate infusion increases circulating pro-brain-derived neurotrophic factor levels in humans
Röja, J., Ameller, N. F., Grip, J., Apró, W., & Moberg, M. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1644843 · Cited by 3
The gut microbiome
Houghton, C. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00014-8 · Cited by 3
Effects of Exercise on Memory Interference in Neuropsychiatric Disorders
Crawford, L. K., & Loprinzi, P. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1792-1_29 · Cited by 2
Healthy Ageing in the Clinical Setting: Current Concepts and Future Prospects
Kyriazis, M. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-52663-4_29 · Cited by 3
Physical Exercise as a Strategy to Reduce Seizure Susceptibility
Arida, R. M. (2023) · Springer eBooks · doi:10.1007/978-3-031-36526-3_21 · Cited by 1
Changes in Physical Fitness, Muscle Damage and Cognitive Function in Elite Rugby Players over a Season
Karamti, H. M., Zouhal, H., Bousselmi, M., Darragi, M., Khannous, H., Hmid, A. B., Zamali, I., Ahmed, M. B., Laher, I., Granacher, U., et al. (2024) · Sports · doi:10.3390/sports12080223 · Cited by 1
Effectiveness of exercise interventions, alone or in combination with dietary modifications, on working memory in overweight and obese individuals: A systematic review
Cristi‐Montero, C., Barriga, V., Peña‐Jorquera, H., Martínez‐Flores, R., Espinoza‐Puelles, J. P., Olivares, L. A. F., Mendias, E. Q., & del Castillo, L. A. E. (2024) · European Journal of Sport Science · doi:10.1002/ejsc.12124 · Cited by 1
Can heat stress augment the cerebrovascular and neurotrophic benefits of exercise?
Leaney, S. F., Killick, J. A., Connor, K. E., & Tommasini, E. (2025) · The Journal of Physiology · doi:10.1113/jp289184 · Cited by 1

Authors: Walsh, J. J., & Tschakovsky, M. E.
Affiliations: Children's Hospital of Eastern Ontario (CA)
Queen's University (CA)
ORCID: Walsh, Jeremy J.
Tschakovsky, Michael E.
Venue: Applied Physiology Nutrition and Metabolism
Publisher: Canadian Science Publishing
Published: 2018-11
Volume: 43
Issue: 11
Pages: 1095-1104
ISSN: 1715-5312 (ISSN-L)
1715-5320
DOI: 10.1139/apnm-2018-0192
OpenAlex: W2803921770
Cited by: 256
References: 84
Citations by year: 2026: 28 · 2025: 39 · 2024: 43 · 2023: 38 · 2022: 44 · 2021: 33 · 2020: 22 · 2019: 5 · 2018: 3
FWCI: 2.04
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Applied Physiology Nutrition and Metabolism (publishedVersion)
PubMed (publishedVersion)
TSpace (University of Toronto) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: brain-derived neurotrophic factor, BDNF release, physical activity, neuroplasticity, exercise intervention, multimodal training, cognitive stimulation, acute exercise, neurodegenerative disease prevention
MeSH terms: Humans, Neuronal Plasticity, Exercise, Brain-Derived Neurotrophic Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks