Cited by 256Nerve injury and regenerationPhysical Activity and HealthExercise and Physiological Responses

The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.

Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions

Open access

Walsh, Jeremy J., Tschakovsky, Michael E.·2018·Applied Physiology Nutrition and Metabolism

DOI 10.1139/apnm-2018-0192

Open this paper in CoChat — free account Open PDF

Abstract

Engagement in regular bouts of exercise confers numerous positive effects on brain health across the lifespan. Acute bouts of exercise transiently improve cognitive function, while long-term exercise training stimulates brain plasticity, improves brain function, and helps to stave off neurological disease. The action of brain-derived neurotrophic factor (BDNF) is a candidate mechanism underlying these exercise-induced benefits and is the subject of considerable attention in the exercise-brain health literature. It is well established that acute exercise increases circulating levels of BDNF and numerous studies have sought to characterize this response for the purpose of improving brain health. Despite the interest in BDNF responses to exercise, little focus has been given to understanding the sources and mechanisms that underlie this response for the purpose of deliberately increasing circulating levels of BDNF. Here we review evidence to support that exploiting these mechanisms of BDNF release can help to optimize brain plasticity outcomes via exercise interventions, which could be especially relevant in the context of multimodal training (i.e., exercise and cognitive stimulation). Therefore, the purpose of this paper is to review the candidate sources of BDNF during exercise and the mechanisms of release. As well, we discuss strategies for maximizing BDNF responses to exercise, and propose novel research directions for advancing our understanding of these mechanisms.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1139/apnm-2018-0192

Cites

84 of 84 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060
The effects of acute exercise on cognitive performance: a meta-analysis
Chang, Y. K., Labban, J. D., Gapin, J. I., & Etnier, J. L. (2012) · Brain Research · doi:10.1016/j.brainres.2012.02.068 · Cited by 1,930
Purification of a new neurotrophic factor from mammalian brain.
Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822
Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials
Smith, P. J., Blumenthal, J. A., Hoffman, B. M., Cooper, H., Strauman, T. A., Welsh-Bohmer, K., Browndyke, J. N., & Sherwood, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d14633 · Cited by 1,714
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353
Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?
Kerschensteiner, M., Gallmeier, E., Behrens, L., Vargas-Leal, V., Misgeld, T., Klinkert, W. E. F., Kolbeck, R., Hoppe, E., Oropeza-Wekerle, R. L., Bartke, I., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.865 · Cited by 1,019

Show all 84 references

Research works printed but not linked: 1

Caspersen C.J., 1985, Publ. Health Rep., 100, 126

Sorted by citations

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504
Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage
Walsh, E., Smith, L. M., Northey, J. M., Rattray, B., & Cherbuin, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101044 · Cited by 175
A Systematic Review on the Cognitive Benefits and Neurophysiological Correlates of Exergaming in Healthy Older Adults
Stojan, R., & Voelcker‐Rehage, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050734 · Cited by 163
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis.
Zhang, M., Jia, J., Yang, Y., Zhang, L., & Wang, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102116 · Cited by 157
Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms
Chen, C., & Nakagawa, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101868 · Cited by 178
Exercise mimetics: harnessing the therapeutic effects of physical activity
Gubert, C., & Hannan, A. J. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00217-1 · Cited by 157
Are the neuroprotective effects of exercise training systemically mediated?
Tari, A. R., Norevik, C. S., Scrimgeour, N. R., Kobro‐Flatmoen, A., Storm‐Mathisen, J., Bergersen, L. H., Wrann, C. D., Selbæk, G., Kivipelto, M., Moreira, J. B. N., et al. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.02.003 · Cited by 124
The effects of high-intensity interval training, Nordic walking and moderate-to-vigorous intensity continuous training on functional capacity, depression and quality of life in patients with coronary artery disease enrolled in cardiac rehabilitation: A randomized controlled trial (CRX study)
Reed, J. L., Terada, T., Cotie, L. M., Tulloch, H. E., Leenen, F. H. H., Mistura, M., Hans, H., Wang, H., Vidal‐Almela, S., Reid, R. D., et al. (2021) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2021.07.002 · Cited by 116
Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer’s disease risk
Baranowski, B. J., Marko, D. M., Fenech, R. K., Yang, A. J. T., & MacPherson, R. E. K. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0910 · Cited by 114
Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience
Nowacka-Chmielewska, M. M., Grabowska, K., Grabowski, M., Meybohm, P., Burek, M., & Małecki, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113348 · Cited by 120
Immediate effect of high-intensity exercise on brain-derived neurotrophic factor in healthy young adults: A systematic review and meta-analysis
Fernández‐Rodríguez, R., Álvarez‐Bueno, C., Martínez-Ortega, I. A., Martínez‐Vizcaíno, V., Mesas, A. E., & Notario‐Pacheco, B. (2021) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2021.08.004 · Cited by 102
Effect of 9 weeks continuous vs. interval aerobic training on plasma BDNF levels, aerobic fitness, cognitive capacity and quality of life among seniors with mild to moderate Alzheimer’s disease: a randomized controlled trial
Enette, L., Vogel, T., Merle, S., Valard-Guiguet, A.-G., Ozier-Lafontaine, N., Nevière, R., Leuly-Joncart, C., Fanon, J. L., & Lang, P. O. (2020) · European Review of Aging and Physical Activity · doi:10.1186/s11556-019-0234-1 · Cited by 101
Physical Exercise-Induced Myokines in Neurodegenerative Diseases
Lee, B., Shin, M., Park, Y., Won, S.-Y., & Cho, K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115795 · Cited by 79
Acute increases in brain-derived neurotrophic factor in plasma following physical exercise relates to subsequent learning in older adults
Nilsson, J., Ekblom, Ö. B., Ekblom, M., Lebedev, A. V., Tarassova, O., Moberg, M., & Lövdén, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-60124-0 · Cited by 92
Mechanisms of the Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor Expression in Alzheimer’s Disease
Jaberi, S., & Fahnestock, M. L. (2023) · Biomolecules · doi:10.3390/biom13111577 · Cited by 78
The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review
Ribeiro, D., Petrigna, L., Pereira, F. C., Muscella, A., Bianco, A., & Tavares, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168814 · Cited by 83
Dynamic cerebral autoregulation across the cardiac cycle during 8 hr of recovery from acute exercise
Burma, J. S., Copeland, P. V., Macaulay, A., Khatra, O., Wright, A. D., & Smirl, J. D. (2020) · Physiological Reports · doi:10.14814/phy2.14367 · Cited by 69
β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure
Cannavò, A., Jun, S., Rengo, G., Marzano, F., Agrimi, J., Liccardo, D., Elia, A., Keceli, G., Altobelli, G. G., Marcucci, L., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.321583 · Cited by 65
The effect of physical exercise on circulating brain‐derived neurotrophic factor in healthy subjects: A meta‐analysis of randomized controlled trials
Wang, Y., Zhou, H., Luo, Q., & Cui, S. (2022) · Brain and Behavior · doi:10.1002/brb3.2544 · Cited by 73
BDNF corrects NLRP3 inflammasome-induced pyroptosis and glucose metabolism reprogramming through KLF2/HK1 pathway in vascular endothelial cells
Jin, H. L., Zhu, Y., Wang, X.-D., Luo, E., Li, Y., Wang, B.-L., & Chen, Y. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109843 · Cited by 62
The Impact of Motor-Cognitive Dual-Task Training on Physical and Cognitive Functions in Parkinson’s Disease
Xiao, Y., Yang, T., & Shang, H. (2023) · Brain Sciences · doi:10.3390/brainsci13030437 · Cited by 71
Antidepressant Drugs and Physical Activity: A Possible Synergism in the Treatment of Major Depression?
Guerrera, C. S., Furneri, G., Grasso, M., Caruso, G., Castellano, S., Drago, F., Nuovo, S. D., & Caraci, F. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00857 · Cited by 66
Short‐term ketone monoester supplementation improves cerebral blood flow and cognition in obesity: A randomized cross‐over trial
Walsh, J. J., Caldwell, H. G., Neudorf, H., Ainslie, P. N., & Little, J. P. (2021) · The Journal of Physiology · doi:10.1113/jp281988 · Cited by 57
Self-citation
A Systematic Review of the Impact of Physical Exercise-Induced Increased Resting Cerebral Blood Flow on Cognitive Functions
Renke, M. B., Marcinkowska, A. B., Kujach, S., & Winklewski, P. J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.803332 · Cited by 50
Physical exercise and seizure activity
Arida, R. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165979 · Cited by 48
Fasting for 20 h does not affect exercise‐induced increases in circulating BDNF in humans
Gibbons, T. D., Cotter, J. D., Ainslie, P. N., Abraham, W. C., Mockett, B. G., Campbell, H. A., Jones, E. M. W., Jenkins, E. J., & Thomas, K. N. (2023) · The Journal of Physiology · doi:10.1113/jp283582 · Cited by 49
Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention
Lu, X., Chen, Y., Shi, Y., Shi, Y., Su, X., Chen, P., Wu, D., & Shi, H. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112685 · Cited by 50
Effects of physical exercise on Irisin and BDNF concentrations, and their relationship with cardiometabolic and mental health of individuals with Metabolic Syndrome: A Systematic Review
Parra, W. A. V., & Moscoso-Loaiza, L. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112640 · Cited by 58
Effectiveness of high‐intensity interval training on peripheral brain‐derived neurotrophic factor in adults: A systematic review and network meta‐analysis
Rodríguez‐Gutiérrez, E., Torres‐Costoso, A., Saz‐Lara, A., Bizzozero‐Peroni, B., Guzmán‐Pavón, M. J., Sánchez‐López, M., & Martínez‐Vizcaíno, V. (2024) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.14496 · Cited by 42
Motor-cognitive Approach and Aerobic Training: A Synergism for Rehabilitative Intervention in Parkinson’s Disease
Ferrazzoli, D., Ortelli, P., Cucca, A., Bakdounes, L., Canesi, M., & Volpe, D. (2020) · Neurodegenerative Disease Management · doi:10.2217/nmt-2019-0025 · Cited by 42
Aerobic exercise in the treatment of PTSD: An examination of preclinical and clinical laboratory findings, potential mechanisms, clinical implications, and future directions
Crombie, K. M., Adams, T. G., Dunsmoor, J. E., Greenwood, B. N., Smits, J. A. J., Nemeroff, C. B., & Cisler, J. M. (2023) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2023.102680 · Cited by 42
Physical activity and neurotrophic factors as potential drivers of neuroplasticity in Parkinson’s Disease: A systematic review and meta-analysis
Rotondo, R., Proietti, S., Marzia Perluigi, A., Padua, E., Stocchi, F., Fini, M., Stocchi, V., Volpe, D., & Pandis, M. F. D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102089 · Cited by 44
Peripheral BDNF Response to Physical and Cognitive Exercise and Its Association With Cardiorespiratory Fitness in Healthy Older Adults
Tarassova, O., Ekblom, M., Moberg, M., Lövdén, M., & Nilsson, J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01080 · Cited by 46
Resistance training‐induced adaptations in the neuromuscular system: Physiological mechanisms and implications for human performance
Lecce, E., Amoruso, P., Felici, F., & Bazzucchi, I. (2025) · The Journal of Physiology · doi:10.1113/jp289716 · Cited by 56
Examination of BDNF Treatment on BACE1 Activity and Acute Exercise on Brain BDNF Signaling
Baranowski, B. J., Hayward, G. C., Marko, D. M., & MacPherson, R. E. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.665867 · Cited by 41
Results From the WAGR Syndrome Patient Registry: Characterization of WAGR Spectrum and Recommendations for Care Management
Duffy, K. A., Trout, K. L., Gunckle, J. M., Krantz, S. M., Morris, J., & Kalish, J. M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.733018 · Cited by 41
The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis
Kraemer, R. R., & Kraemer, B. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1202349 · Cited by 43
Comparison of the effects of open- and closed-skill exercise on cognition and peripheral proteins: A cross-sectional study
Gökçe, E., Güneş, E., Arı, F., Hayme, S., & Nalçacı, E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251907 · Cited by 45
Cognitive impairment in adolescent and young adult cancer patients: Pre‐treatment findings of a longitudinal study
Chan, A., Cheng, I., Wang, C., Tan, C. J., Toh, Y. L., Ng, D. Q., Koh, Y. Q., Zhou, H., Foo, K. M., Chan, R. J., et al. (2022) · Cancer Medicine · doi:10.1002/cam4.5295 · Cited by 37
Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions
Oyovwi, M. O., Ogenma, U. T., & Onyenwenyi, A. O. C. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10248-1 · Cited by 41
Comparison of the central human and mouse platelet signaling cascade by systems biological analysis
Balkenhol, J., Kaltdorf, K. V., Mammadova‐Bach, E., Braun, A., Nieswandt, B., Dittrich, M. T., & Dandekar, T. (2020) · BMC Genomics · doi:10.1186/s12864-020-07215-4 · Cited by 34
Does brain-derived neurotrophic factor mediate the effects of exercise on memory?
Loprinzi, P. D. (2019) · The Physician and Sportsmedicine · doi:10.1080/00913847.2019.1610255 · Cited by 33
Status of precision medicine approaches to traumatic brain injury
Reddi, S., Thakker‐Varia, S., Alder, J., & Giarratana, A. O. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335824 · Cited by 33
CCRT and aerobic exercise: a randomised controlled study of processing speed, cognitive flexibility, and serum BDNF expression in schizophrenia
Dai, Y., Ding, H., Lu, X., Wu, X., Xu, C., Jiang, T., Liang, M., Xia, Z., Song, C., Shen, H., et al. (2022) · Schizophrenia · doi:10.1038/s41537-022-00297-x · Cited by 38
Exercise training and BDNF injections alter amyloid precursor protein (APP) processing enzymes and improve cognition
Baranowski, B. J., Mohammad, A., Finch, M. S., Brown, A. D. H., Dhaliwal, R., Marko, D. M., LeBlanc, P. J., McCormick, C. M., Fajardo, V. A., & MacPherson, R. E. K. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00114.2023 · Cited by 36
Positive effects of physical activity in autism spectrum disorder: how influences behavior, metabolic disorder and gut microbiota
Ranieri, A., Mennitti, C., Falcone, N., La Monica, I., Di Iorio, M. R., Tripodi, L., Gentile, A., Vitale, M., Pero, R., Pastore, L., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1238797 · Cited by 32
Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial
Walsh, J. J., D’Angiulli, A., Cameron, J. D., Sigal, R. J., Kenny, G. P., Holčı́k, M., Doucette, S. P., Alberga, A. S., Prud’homme, D., Hadjiyannakis, S., et al. (2018) · Neural Plasticity · doi:10.1155/2018/7169583 · Cited by 31
Self-citation
Physical Exercise and Brain-Derived Neurotrophic Factor Concentration in Children and Adolescents: A Systematic Review With Meta-Analysis
de Menezes-Junior, F. J., de Jesus, Í. C., Brand, C., Mota, J. A. P. S., & Leite, N. (2021) · Pediatric Exercise Science · doi:10.1123/pes.2020-0207 · Cited by 35
Sensorimotor Rehabilitation Promotes Vestibular Compensation in a Rodent Model of Acute Peripheral Vestibulopathy by Promoting Microgliogenesis in the Deafferented Vestibular Nuclei
Marouane, E., Mahmoudi, N. E., Rastoldo, G., Péricat, D., Watabe, I., Lapôtre, A., Tonetto, A., Xavier, F., Dumas, O., Chabbert, C., et al. (2021) · Cells · doi:10.3390/cells10123377 · Cited by 31
Association of plasma brain-derived neurotrophic factor levels and frailty in community-dwelling older adults
Roh, E., Hwang, S. Y., Song, E., Park, M., Yoo, H. J., Baik, S. H., Kim, M., Won, C. W., & Choi, K. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-19706-3 · Cited by 32
Changes of brain-derived neurotrophic factor (BDNF) levels after different exercise protocols: a systematic review of clinical studies in Parkinson’s disease
Paterno, A., Polsinelli, G., & Federico, B. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1352305 · Cited by 30
Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials
Gholami, F., Mesrābādi, J., Iranpour, M., & Donyaei, A. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112658 · Cited by 38
Evidence of brain-derived neurotrophic factor in ameliorating cancer-related cognitive impairment: A systematic review of human studies
Ng, D. Q., Chan, D., Agrawal, P., Zhao, W., Xu, X., Acharya, M. M., & Chan, A. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103748 · Cited by 31
BDNF, endurance activity, and mechanisms underlying the evolution of hominin brains
Hill, T., & Polk, J. D. (2018) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23762 · Cited by 33
The BDNF-Increasing Allele is Associated With Increased Proportion of Fast-Twitch Muscle Fibers, Handgrip Strength, and Power Athlete Status
Guilherme, J. P. L. F., Semenova, E. A., Borisov, O., Kostryukova, E., Vepkhvadze, T. F., Lysenko, E. A., Andryushchenko, O. N., Andryushchenko, L. B., Lednev, E. M., Larin, A. K., et al. (2020) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003756 · Cited by 29
Efficacy of Whole-Body Vibration Training on Brain-Derived Neurotrophic Factor, Clinical and Functional Outcomes, and Quality of Life in Women with Fibromyalgia Syndrome: A Randomized Controlled Trial
Ribeiro, V. G. C., Lacerda, A. C. R., dos Santos, J. M., Coelho-Oliveira, A. C., da Fonseca, S. F., Prates, A. C. N., Flor, J., Garcia, B. C. C., Tossige-Gomes, R., Leite, H. R., et al. (2021) · Journal of Healthcare Engineering · doi:10.1155/2021/7593802 · Cited by 28
The Challenge of Long COVID-19 Management: From Disease Molecular Hallmarks to the Proposal of Exercise as Therapy
Scurati, R., Papini, N., Giussani, P., Alberti, G., & Tringali, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012311 · Cited by 30
Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer’s Disease
Piancatelli, D., Aureli, A., Sebastiani, P., Colanardi, A., Beato, T. D., Cane, L. D., Sucapane, P., Marini, C., & Loreto, S. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314599 · Cited by 29
Effects of voluntary, and forced exercises on neurotrophic factors and cognitive function in animal models of Parkinson's disease
Rafie, F., Rajizadeh, M. A., Shahbazi, M., Pourranjbar, M., Nekouei, A. H., Sheibani, V., & Peterson, D. S. (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102357 · Cited by 26
Training Willpower: Reducing Costs and Valuing Effort
Audiffren, M. F., André, N., & Baumeister, R. F. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.699817 · Cited by 31
Brain-derived neurotrophic factor as a biomarker in cancer-related cognitive impairment among adolescent and young adult cancer patients
Ng, D. Q., Cheng, I., Wang, C., Tan, C. J., Toh, Y. L., Koh, Y. Q., Ke, Y., Foo, K. M., Chan, R. J., Ho, H. K., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-43581-1 · Cited by 26
The Effect of Exogenous Ketone Monoester Ingestion on Plasma BDNF During an Oral Glucose Tolerance Test
Walsh, J. J., Myette‐Côté, É., & Little, J. P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01094 · Cited by 25
Self-citation
Ageing, Cognitive Decline, and Effects of Physical Exercise: Complexities, and Considerations from Animal Models
Caruso, M. G., Nicolas, S., Lucassen, P. J., Mul, J. D., O’Leary, O. F., & Nolan, Y. M. (2024) · Brain Plasticity · doi:10.3233/bpl-230157 · Cited by 25
Activation of BDNF-TrkB-PI3K-AKT signaling pathway by Tong-Qiao-Huo-Xue Decoction facilitates nerve regeneration and mitigates cerebral ischemia-reperfusion injury
Peng, Y., Sun, H., Xu, F., Ye, H., Wang, Y., Zhou, X., Chang, D., Wang, N., & Huang, P. C. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156966 · Cited by 27
Beyond FITT: addressing density in understanding the dose–response relationships of physical activity with health—an example based on brain health
Herold, F., Zou, L., Theobald, P., Manser, P., Falck, R. S., Yu, Q., Liu-Ambrose, T. Y. L., Hillman, C. H., Kramer, A. F., Erickson, K. I., et al. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-05858-3 · Cited by 40
Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise
Wang, D., Lin, H., Lee, Y.-J., Yu, H.-F., Wu, S.-R., & Qamar, M. U. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113867 · Cited by 25
Effects of Nordic walking in Alzheimer’s disease: A single-blind randomized controlled clinical trial
Angiolillo, A., Leccese, D., Ciccotelli, S., Cesare, G. D., D’Elia, K., Aurisano, N., Matrone, C., Dentizzi, C., & Costanzo, A. D. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15865 · Cited by 28
Effects of multicomponent training and HMB supplementation on disability, cognitive and physical function in institutionalized older adults aged over 70 years: a cluster-randomized controlled trial
Gutiérrez-Reguero, H., Buendía-Romero, Á., Franco-López, F., Martínez-Cava, A., Hernández-Belmonte, A., Courel-Ibáñez, J., Ara, I., Alcazar, J., & Pallarés, J. G. (2024) · The Journal of nutrition, health and aging · doi:10.1016/j.jnha.2024.100208 · Cited by 22
Influence of High-Intensity Interval Training on Neuroplasticity Markers in Post-Stroke Patients: Systematic Review
Montero-Almagro, G., Utrera, C. B., Geribaldi‐Doldán, N., Nunez‐Abades, P., Castro, C., & Rodríguez‐Blanco, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13071985 · Cited by 27
Exercise prevents the impairment of learning and memory in prenatally phthalate-exposed male rats by improving the expression of plasticity-related proteins
Sun, G., Lee, Y.-J., Lee, Y., Yu, H.-F., & Wang, D. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113444 · Cited by 23
Brain-Derived Neurotrophic Factor Mitigates the Association Between Platelet Dysfunction and Cognitive Impairment
Bélanger, J.-C., Bouchard, V., Blanc, J. L., Starnino, L., Welman, M., Chabot-Blanchet, M., Busseuil, D., Chertkow, H. M., D’Antono, B., & Lordkipanidzé, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.739045 · Cited by 20
The Impact of Exercise and Virtual Reality Executive Function Training on Cognition Among Heavy Drinking Veterans With Traumatic Brain Injury: A Pilot Feasibility Study
Pennington, D., Reavis, J. V., Cano, M. T., Walker, E., & Batki, S. L. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.802711 · Cited by 25
Effects of Aerobic Exercise on Cognitive Function in Women With Methamphetamine Dependence in a Detoxification Program in Tianjin, China: A Randomized Controlled Trial
Liu, J., Chen, C. H. E. N., Liu, M., & Zhuang, S. (2021) · Journal of Nursing Research · doi:10.1097/jnr.0000000000000440 · Cited by 22
The effect of stress and exercise on the learning performance of horses
Henshall, C., Randle, H., Francis, N., & Freire, R. (2022) · Scientific Reports · doi:10.1038/s41598-021-03582-4 · Cited by 27
Effect of exercise training on the FNDC5/BDNF pathway in spontaneously hypertensive rats
Wang, T., Maltez, M. T., Lee, H. W., Ahmad, M., Wang, H., & Leenen, F. H. H. (2019) · Physiological Reports · doi:10.14814/phy2.14323 · Cited by 22
Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial
Castells-Sánchez, A., Roig-Coll, F., Dacosta‐Aguayo, R., Lamonja-Vicente, N., Torán‐Monserrat, P., Pera, G., García‐Molina, A., Tormos, J. M., Montero-Alía, P., Heras, A., et al. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.854175 · Cited by 20
Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond
Jia, Y., Yao, Y., Zhuo, L., Chen, X., Yan, C., Ji, Y., Tao, J., & Zhu, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.862078 · Cited by 21
Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals
Ceylan, H. İ., Öztürk, M. E., Öztürk, D., Silva, A. F., Albayrak, M., Saygın, Ö., Eken, Ö., Clemente, F. M., & Nobarı, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-34278-6 · Cited by 18
Effects of exercise of different intensities on withdrawal symptoms among people with substance use disorder: a systematic review and meta-analysis
Li, H., Su, W., Cai, J., Zhao, L., & Li, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1126777 · Cited by 21
Time-course effects of functional fitness sessions performed at different intensities on the metabolic, hormonal, and BDNF responses in trained men
Tibana, R. A., Neto, I. V. D. S., de Sousa, N. M. F., dos Santos, W. M., Prestes, J., Neto, J. H. F., Dominski, F. H., Kennedy, M. D., & Voltarelli, F. A. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00412-6 · Cited by 19
The Effect of High-Intensity Interval Training (HIIT) on Brain-Derived Neurotrophic Factor Levels (BNDF): A Systematic Review
Mielniczek, M., & Aune, T. K. (2024) · Brain Sciences · doi:10.3390/brainsci15010034 · Cited by 17
Exercise as Modulator of Brain-Derived Neurotrophic Factor (BDNF) in Children: A Systematic Review of Randomized Controlled Trials
Rico-González, M., González-Devesa, D., Gómez‐Carmona, C. D., & Moreno-Villanueva, A. (2025) · Life · doi:10.3390/life15071147 · Cited by 28
Associations of Brain-Derived Neurotropic Factor rs6265 Gene Polymorphism with Personality Dimensions among Athletes
Humińska‐Lisowska, K., Chmielowiec, J., Chmielowiec, K., Niewczas, M., Lachowicz, M., Cięszczyk, P., Masiak, J., Strońska-Pluta, A., Michałowska‐Sawczyn, M., Maculewicz, E., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159732 · Cited by 17
Acute bouts of aerobic and resistance exercise similarly alter inhibitory control and response time while inversely modifying plasma BDNF concentrations in middle-aged and older adults with type 2 diabetes
Silveira-Rodrigues, J. G., Campos, B. T., de Lima, A. T., Ogando, P. H. M., Gomes, C. B., Gomes, P. F., Aleixo, I. M. S., & Soares, D. D. (2023) · Experimental Brain Research · doi:10.1007/s00221-023-06588-8 · Cited by 18
Effects of Strength Training on BDNF in Healthy Young Adults
Babiarz, M., Laskowski, R., & Grzywacz, T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192113795 · Cited by 20
The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing
Sun, Q., Liu, Z., Xie, C., Hu, L., Li, H., Ge, Y., Lin, L., & Tang, B. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.113102 · Cited by 17
The interaction of BDNF with estrogen in the development of hypertension and obesity, particularly during menopause
Zhang, Z., He, Z., Pan, J., Yuan, M., Lang, Y., Wei, X., & Zhang, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1384159 · Cited by 19
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management
Ratne, N., Jari, S., Tadas, M., Katariya, R., Kale, M. B., Kotagale, N. R., Madia, D., Umekar, M. J., & Taksande, B. G. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102687 · Cited by 17
Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome
Zhang, Y., Chen, D., Wang, D., Wang, L., Weng, Y., Wang, H., Wu, X., & Wang, Y. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195584 · Cited by 15
Diet and physical activity influence the composition of gut microbiota, benefit on Alzheimer’s disease
Zhou, J., Tang, M., Li, W., Fang, R., Tang, C., & Wang, Q. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250049 · Cited by 16
Electrical stimulation: a potential alternative to positively impact cerebral health?
Descollonges, M., Chaney, R., Garnier, P. E., Prigent‐Tessier, A., Brugniaux, J. V., & Deley, G. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1464326 · Cited by 15
The impact of physical fitness, social life, and cognitive functions on work ability in middle-aged and older adults
Rieker, J. A., Gajewski, P. D., Avilés, J. M. R., Ballesteros, S., Golka, K., Hengstler, J. G., Wascher, E., & Getzmann, S. (2022) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-022-01943-8 · Cited by 19
Elevations in serum brain-derived neurotrophic factor following occupational heat stress are not influenced by age or common chronic disease
Goulet, N., McCormick, J. J., King, K. E., Notley, S. R., Goldfield, G. S., Fujii, N., Amano, T., & Kenny, G. P. (2023) · Temperature · doi:10.1080/23328940.2023.2176107 · Cited by 14
Low lean mass and cognitive performance: data from the National Health and Nutrition Examination Surveys
Geng, J., Deng, L., Qiu, S., Bian, H., Cai, B., Li, Y., Li, J., Qin, Z., Yang, Q., Dong, B., et al. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01835-w · Cited by 14
Exercise intensity and sex alter neurometabolic, transcriptional, and functional recovery following traumatic brain injury
White, B. A., Ivey, J. T., Velazquez-Cruz, R., Oliverio, R., Whitehead, B. J., Pinti, M. V., Hollander, J. M., Ma, L., Hu, G., Weil, Z. M., et al. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114483 · Cited by 13
Adolescent treadmill exercise enhances hippocampal brain-derived neurotrophic factor (BDNF) expression and improves cognition in autism-modeled rats
King, C., Rogers, L. G., Jansen, J., Sivayokan, B., Neyhard, J., Warnes, E., Hall, S. E., & Plakke, B. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114638 · Cited by 16
Arterial–venous differences of brain‐derived neurotrophic factor isoforms across the brain and muscle after exercise at different intensities
Tarassova, O., Jiang, Y., Wallin, H., Jensen‐Urstad, M., Drca, N., Röja, J., Pontén, M., Katz, A., Nilsson, J., Ekblom, M., et al. (2025) · The Journal of Physiology · doi:10.1113/jp288409 · Cited by 13
Effect of non‐invasive brain stimulation on behavior and serum brain‐derived neurotrophic factor and insulin‐like growth factor‐1 levels in autistic patients
Robinson‐Agramonte, M. D. L. Á., Michalski, B., Fernández, L. G., Vidal-Martínez, B., Cuesta, H. V., Rizo, C. M., & Fahnestock, M. L. (2021) · Drug Development Research · doi:10.1002/ddr.21808 · Cited by 16
Effects of Leisure-Time Physical Activity on Cognitive Reserve Biomarkers and Leisure Motivation in the Pre-Diabetes Elderly
Kim, B.-R., & Lim, S. (2022) · Healthcare · doi:10.3390/healthcare10040737 · Cited by 14
Sedentary time play a moderator role in the relationship between physical fitness and brain-derived neurotrophic factor in children: A pilot study
Fochesatto, C. F., Brand, C., Menezes, F., Cristi‐Montero, C., Gaya, A. C. A., Leite, N., & Gaya, A. R. (2022) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2022.11.004 · Cited by 18

Authors: Walsh, J. J., & Tschakovsky, M. E.
Affiliations: Children's Hospital of Eastern Ontario (CA)
Queen's University (CA)
ORCID: Walsh, Jeremy J.
Tschakovsky, Michael E.
Venue: Applied Physiology Nutrition and Metabolism
Publisher: Canadian Science Publishing
Published: 2018-11
Volume: 43
Issue: 11
Pages: 1095-1104
ISSN: 1715-5312 (ISSN-L)
1715-5320
DOI: 10.1139/apnm-2018-0192
OpenAlex: W2803921770
Cited by: 256
References: 84
Citations by year: 2026: 28 · 2025: 39 · 2024: 43 · 2023: 38 · 2022: 44 · 2021: 33 · 2020: 22 · 2019: 5 · 2018: 3
FWCI: 2.04
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Applied Physiology Nutrition and Metabolism (publishedVersion)
PubMed (publishedVersion)
TSpace (University of Toronto) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: brain-derived neurotrophic factor, BDNF release, physical activity, neuroplasticity, exercise intervention, multimodal training, cognitive stimulation, acute exercise, neurodegenerative disease prevention
MeSH terms: Humans, Neuronal Plasticity, Exercise, Brain-Derived Neurotrophic Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks