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The discovery of proteases and intramembrane proteolysis

Paschkowsky, Sandra, Hsiao, Jacqueline Melissa, Young, Jason C., Munter, Lisa Marie·2019·Biochemistry and Cell Biology
DOI 10.1139/bcb-2018-0186
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Abstract

Proteases carry out a wide variety of physiological functions. This review presents a brief history of protease research, starting with the original discovery of pepsin in 1836. Following the path of time, we revisit how proteases were originally classified based on their catalytic mechanism and how chemical and crystallographic studies unravelled the mechanism of serine proteases. Ongoing research on proteases addresses their biological roles, small molecule inhibitors for therapeutic uses, and protein engineering to modify their activities. The discovery of intramembrane proteases is more recent, beginning with the discovery of site-2 protease in 1997. Since then, different mechanistic classes of intramembrane proteases have been characterized, and many of these act in regulated intramembrane proteolysis in signaling pathways. Furthermore, the rhomboid intramembrane proteases were discovered by genetic and biochemical experiments in Drosophila and then in human cells. Research on the intramembrane proteases is expanding, as their biological importance is recognized.

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  • α-secretase cleavage of APP is performed by ADAMs of the metzincin superfamily, constitutively by ADAM10 or in a regulated manner by ADAM17/TACE.

    “This is performed by a disintegrin and metalloproteinases (ADAMs) of the metzincin superfamily of metalloproteinases (Rivera et al., 2010; Paschkowsky et al., 2019), in a constitutive (ADAM10) or regulated manner (ADAM17; also known as TACE for TNF-α converting enzyme) (Lammich et al., 1999; Jorissen et al., 2010; Kuhn et al., 2010).”

    From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Paschkowsky et al., 2019

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Metadata

Authors
Paschkowsky, S., Hsiao, J. M., Young, J. C., & Munter, L. M.
Affiliations
  • Department of Pharmacology & Therapeutics, McGill University, Bellini Life Sciences Complex, 3649 Promenade Sir William Osler, Montreal, QC H3G 0B1, Canada.
  • Department of Biochemistry, McGill University, McIntyre Building, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada.
Venue
Biochemistry and Cell Biology
Publisher
Canadian Science Publishing
Published
2019-06
Volume
97
Issue
3
Pages
265-269
ISSN
  • 0829-8211
  • 1208-6002
DOI
10.1139/bcb-2018-0186
Cited by
14
References
4
Language
en
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)

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