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Cited by 444

The DOI matches its OpenAlex record; 81 of the 81 references it cites were found in a registry or an index.

Advances in the osteoblast lineage

Jane E. Aubin·1998·Biochemistry and Cell Biology
DOI 10.1139/bcb-76-6-899
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Abstract

Osteoblasts are the skeletal cells responsible for synthesis, deposition and mineralization of the extracellular matrix of bone. By mechanisms that are only beginning to be understood, stem and primitive osteoprogenitors and related mesenchymal precursors arise in the embryo and at least some appear to persist in the adult organism, where they contribute to replacement of osteoblasts in bone turnover and in fracture healing. In this review, we describe the morphological, molecular, and biochemical criteria by which osteoblasts are defined and cell culture approaches that have helped to clarify transitional stages in osteoblast differentiation. Current understanding of differential expression of osteoblast-associated genes during osteoprogenitor proliferation and differentiation to mature matrix synthesizing osteoblasts is summarized. Evidence is provided to support the hypothesis that the mature osteoblast phenotype is heterogeneous with subpopulations of osteoblasts expressing only subsets of the known osteoblast markers. Throughout this paper, outstanding uncertainties and areas for future investigation are also identified.

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Citations

Cites

Show all 81 references

Research works printed but not linked: 34

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Metadata

Authors
Aubin, J. E.
Venue
Biochemistry and Cell Biology
Publisher
Canadian Science Publishing
Published
1998-12-01
Volume
76
Issue
6
Pages
899-910
ISSN
  • 0829-8211 (ISSN-L)
  • 1208-6002
DOI
10.1139/bcb-76-6-899
OpenAlex
W2105646619
Cited by
444
References
81
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)

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Aubin, J. E. (1998). Advances in the osteoblast lineage. Biochemistry and Cell Biology. https://doi.org/10.1139/bcb-76-6-899

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