Caffeine and exercise: metabolism and performance.

Graham, Terry E.; Rush, James W. E.; Soeren, Mary H. van

doi:10.1139/h94-010

Cited by 123Coffee research and impactsMuscle metabolism and nutritionExercise and Physiological Responses

Caffeine and exercise: metabolism and performance.

Graham, Terry E., Rush, James W. E., Soeren, Mary H. van·1994·Canadian Journal of Applied Physiology

DOI 10.1139/h94-010

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Abstract

Caffeine ingestion prior to prolonged exercise delays fatigue. However, the mechanisms involved are very unclear. Caffeine is associated with elevated plasma epinephrine but the metabolic impact of this is uncertain. Glycogen sparing occurs in active muscle, at least in the first few minutes, but studies have generally failed to demonstrate enhanced fat metabolism. The demethylation of caffeine by the hepatic cytochrome P-450 oxygenases begins within minutes and dimethylxanthines (especially paraxanthine) are generated. These compounds appear in the plasma within an hour of caffeine ingestion and may have effects on tissues that have been attributed to caffeine and/or epinephrine. While the most widely supported theory is that caffeine and other methylxanthines are adenosine receptor antagonists, this action alone cannot explain all of the observed responses. Nevertheless, habituation to and withdrawal from caffeine are associated with up and down regulation of adenosine receptors. One study demonstrated marked differences in the effects of caffeine on the plasma concentrations of epinephrine and dimethylxanthines between caffeine users and nonusers. Caffeine is clearly a very active drug that has many effects on humans including increasing exercise endurance. This can be associated with muscle glycogen sparing and elevated plasma epinephrine, but the underlying mechanisms are unknown.

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“7,8 Therefore, measurements of PWR can be used to noninvasively examine how the cardiovascular system may be impacted by an acute stressor.”
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Toxicological Evaluation of Weight Loss Patches: Review
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Self-citation
Acute and habitual caffeine ingestion and metabolic responses to steady-state exercise
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Self-citation
Effect of caffeine on metabolism, exercise endurance, and catecholamine responses after withdrawal
van Soeren, M. H., & Graham, T. E. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.4.1493 · Cited by 185 · see citing works
Self-citation
Caffeine and Sports Activity: A Review
Nehlig, A., & Debry, G. (1994) · International Journal of Sports Medicine · doi:10.1055/s-2007-1021049 · Cited by 140 · see citing works
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Authors: Graham, T. E., Rush, J. W. E., & Soeren, M. H. V.
Affiliations: University of Guelph (CA)
Venue: Canadian Journal of Applied Physiology
Publisher: Canadian Science Publishing
Published: 1994-06-01
Volume: 19
Issue: 2
Pages: 111-138
ISSN: 1066-7814 (ISSN-L)
DOI: 10.1139/h94-010
OpenAlex: W2092318720
Cited by: 123
References: 94
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 2
FWCI: 0.54
Type: journal article
Language: en
Open access: closed
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Canadian Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Guelph
Topics: Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: caffeine, exercise performance, fatigue, epinephrine, fat metabolism, dimethylxanthines, paraxanthine, adenosine receptor antagonism, caffeine withdrawal
MeSH terms: Caffeine, Catecholamines, Humans, Muscles, Physical Endurance, Exercise, Receptors, Purinergic P1

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Caffeine and exercise: metabolism and performance.

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