The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.
Acid and neutral sphingomyelinases: roles and mechanisms of regulation
Abstract
Ceramide, an emerging bioactive lipid and second messenger, is mainly generated by hydrolysis of sphingomyelin through the action of sphingomyelinases. At least two sphingomyelinases, neutral and acid sphingo myelinases, are activated in response to many extracellular stimuli. Despite extensive studies, the precise cellular function of each of these sphingomyelinases in sphingomyelin turnover and in the regulation of ceramide-mediated responses is not well understood. Therefore, it is essential to elucidate the factors and mechanisms that control the activation of acid and neutral sphingomyelinases to understand their the roles in cell regulation. This review will focus on the molecular mechanisms that regulate these enzymes in vivo and in vitro, especially the roles of oxidants (glu ta thi one, peroxide, nitric oxide), proteins (saposin, caveolin 1, caspases), and lipids (diacylglycerol, arachidonic acid, and ceramide).Key words: sphingomyelinase, ceramide, apoptosis, Niemann-Pick disease, FAN (factor associated with N-SMase activation).
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Self-citationFunctions of Ceramide in Coordinating Cellular Responses to Stress
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Self-citationTumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
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Bioactive sphingolipids: metabolism and function
Bartke, N., & Hannun, Y. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800080-jlr200 · Cited by 683
Self-citationArachidonic acid: Physiological roles and potential health benefits – A review
Tallima, H., & El Ridi, R. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2017.11.004 · Cited by 671
The sphingolipid salvage pathway in ceramide metabolism and signaling
Kitatani, K., Idkowiak-Baldys, J., & Hannun, Y. A. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.006 · Cited by 632
Self-citationAcid sphingomyelinase activity triggers microparticle release from glial cells
Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., Saglietti, L., Schuchman, E. H., Furlan, R., Clementi, E., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.45 · Cited by 615
Adibhatla, R. M., & Hatcher, J. F. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2668 · Cited by 480
Metadata
- Authors
- Marchesini, N., & Hannun, Y. A.
- Venue
- Biochemistry and Cell Biology
- Publisher
- Canadian Science Publishing
- Published
- 2004-02-01
- Volume
- 82
- Issue
- 1
- Pages
- 27-44
- ISSN
- 0829-8211 (ISSN-L)
- 1208-6002
- OpenAlex
- W2101828725
- Cited by
- 339
- References
- 182
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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