The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes
Abstract
Diabetic cardiomyopathy is defined as ventricular dysfunction of the diabetic heart in the absence of coronary artery disease. With the use of both in vivo and ex vivo techniques to assess cardiac phenotype, reduced contractile performance can be observed in experiments with mouse models of both type 1 (insulin-deficient) and type 2 (insulin-resistant) diabetes. Both systolic dysfunction (reduced left ventricular pressures and decreased cardiac output) and diastolic dysfunction (impaired relaxation) is observed in diabetic hearts, along with enhanced susceptibility to ischemic injury. Metabolism is also altered in diabetic mouse hearts: glucose utilization is reduced and fatty acid utilization is increased. The use of geneticallyengineered mice has provided a powerful experimental approach to test mechanisms that may be responsible for the deleterious effects of diabetes on cardiac function.Key words: cardiac function, cardiac metabolism, cardiac phenotype.
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“It has long been known that diabetes is associated with shifts in myocardial substrate utilization characterized by an increase in FA utilization and a decrease in glucose utilization (37, 315).”
From Cardiac remodeling in obesity (2008) · cites this paper as [315]
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Cites
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Items 101–111 of 111
Expresión diferencial de proteínas cardiacas en ratas diabéticas tipo Sprague-Dawley
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Metadata
- Authors
- Severson, D. L.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Severson, David L
- Venue
- Canadian Journal of Physiology and Pharmacology
- Publisher
- Canadian Science Publishing
- Published
- 2004-10-01
- Volume
- 82
- Issue
- 10
- Pages
- 813-823
- ISSN
- 0008-4212 (ISSN-L)
- 1205-7541
- OpenAlex
- W2107447005
- Cited by
- 111
- References
- 107
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 7 · 2021: 3 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 11 · 2012: 4
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Physiology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- diabetic cardiomyopathy, type 1 diabetes, type 2 diabetes, mouse model, ventricular dysfunction, systolic dysfunction, diastolic dysfunction, myocardial ischemic injury, myocardial metabolism, glucose utilization, fatty acid utilization, genetically modified mice
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Disease Models, Animal, Humans, Cardiomyopathies, Mice
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