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Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes

Severson, David L·2004·Canadian Journal of Physiology and Pharmacology

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Abstract

Diabetic cardiomyopathy is defined as ventricular dysfunction of the diabetic heart in the absence of coronary artery disease. With the use of both in vivo and ex vivo techniques to assess cardiac phenotype, reduced contractile performance can be observed in experiments with mouse models of both type 1 (insulin-deficient) and type 2 (insulin-resistant) diabetes. Both systolic dysfunction (reduced left ventricular pressures and decreased cardiac output) and diastolic dysfunction (impaired relaxation) is observed in diabetic hearts, along with enhanced susceptibility to ischemic injury. Metabolism is also altered in diabetic mouse hearts: glucose utilization is reduced and fatty acid utilization is increased. The use of geneticallyengineered mice has provided a powerful experimental approach to test mechanisms that may be responsible for the deleterious effects of diabetes on cardiac function.Key words: cardiac function, cardiac metabolism, cardiac phenotype.

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Haffner, S. M., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390404 · Cited by 7,000
Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association
Grundy, S. M., Benjamin, I. J., Burke, G. L., Chait, A., Eckel, R. H., Howard, B. V., Mitch, W., Smith, S. C., & Sowers, J. R. (1999) · Circulation · doi:10.1161/01.cir.100.10.1134 · Cited by 2,698
Lipotoxicity: when tissues overeat
Schaffer, J. E. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00008 · Cited by 933
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A. D., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14080 · Cited by 887
Lipotoxic diseases
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214080 · Cited by 765
A novel mouse model of lipotoxic cardiomyopathy
Chiu, H.-C., Kovács, A., Ford, D. A., Hsu, F., Garcia, R. A., Herrero, P., Saffitz, J. E., & Schaffer, J. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10947 · Cited by 762
Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.
Inoguchi, T., Battan, R., Handler, E., Sportsman, J. R., Heath, W., & King, G. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.11059 · Cited by 739
Evidence for Cardiomyopathy in Familial Diabetes Mellitus
Regan, T. J., Lyons, M. M., Ahmed, S. S., Levinson, G. E., Oldewurtel, H. A., Ahmad, M., & Haider, B. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108843 · Cited by 728
Effect of Vanadate on Elevated Blood Glucose and Depressed Cardiac Performance of Diabetic Rats
Heyliger, C. E., Tahiliani, A. G., & McNeill, J. H. (1985) · Science · doi:10.1126/science.3156405 · Cited by 711

Flagged first, then by citations

Show all 107 references

Research works printed but not linked: 19

Aasum E., 2002, Am. J. Physiol., 283, H949
Belke D., 2000, Am. J. Physiol., 279, E1104
Choi K., 2002, Am. J. Physiol., 283, H1398
Christensen G., 1997, Am. J. Physiol., 272, H2513
De Windt L., 2001, Am. J. Physiol., 280, H2572
Georgakopoulos D., 2003, Methods Mol. Biol., 219, 233
Giacomelli F., 1979, Lab. Investig., 40, 460
Hribal M., 2002, Am. J. Physiol., 282, E977
Khairallah M., 2004, Am. J. Physiol., 286, H1461
Naumova A., 2003, Am. J. Physiol., 285, H1976
Neitzel A., 2003, Am. J. Physiol., 284, E357
Roth D., 2002, Am. J. Physiol., 282, H2134
Semeniuk L., 2002, Am. J. Physiol., 283, H976
Suarez J., 2004, Am. J. Physiol., 286, H68
Tomlinson K., 1992, Pharmacol. Rev., 44, 103
Vadlamudi R., 1983, Am. J. Physiol., 244, H844
Xiang H., 1991, Am. J. Physiol., 260, H557
Yang X.-P., 1999, Am. J. Physiol., 277, H1967
Yu Z., 1994, Am. J. Physiol., 266, H2982

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Niu, Y., & Evans, R. D. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173542 · Cited by 11
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Authors: Severson, D. L.
Affiliations: University of Calgary (CA)
Corresponding author: Severson, David L
Venue: Canadian Journal of Physiology and Pharmacology
Publisher: Canadian Science Publishing
Published: 2004-10-01
Volume: 82
Issue: 10
Pages: 813-823
ISSN: 0008-4212 (ISSN-L)
1205-7541
DOI: 10.1139/y04-065
OpenAlex: W2107447005
Cited by: 111
References: 107
Citations by year: 2025: 1 · 2023: 2 · 2022: 7 · 2021: 3 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 11 · 2012: 4
FWCI: 1.16
Type: journal article
Language: en
Open access: closed
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Canadian Journal of Physiology and Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords: diabetic cardiomyopathy, type 1 diabetes, type 2 diabetes, mouse model, ventricular dysfunction, systolic dysfunction, diastolic dysfunction, myocardial ischemic injury, myocardial metabolism, glucose utilization, fatty acid utilization, genetically modified mice
MeSH terms: Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Disease Models, Animal, Humans, Cardiomyopathies, Mice

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Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes

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