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Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes

Severson, David L·2004·Canadian Journal of Physiology and Pharmacology

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Abstract

Diabetic cardiomyopathy is defined as ventricular dysfunction of the diabetic heart in the absence of coronary artery disease. With the use of both in vivo and ex vivo techniques to assess cardiac phenotype, reduced contractile performance can be observed in experiments with mouse models of both type 1 (insulin-deficient) and type 2 (insulin-resistant) diabetes. Both systolic dysfunction (reduced left ventricular pressures and decreased cardiac output) and diastolic dysfunction (impaired relaxation) is observed in diabetic hearts, along with enhanced susceptibility to ischemic injury. Metabolism is also altered in diabetic mouse hearts: glucose utilization is reduced and fatty acid utilization is increased. The use of geneticallyengineered mice has provided a powerful experimental approach to test mechanisms that may be responsible for the deleterious effects of diabetes on cardiac function.Key words: cardiac function, cardiac metabolism, cardiac phenotype.

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See all 111

Authors: Severson, D. L.
Affiliations: University of Calgary (CA)
Corresponding author: Severson, David L
Venue: Canadian Journal of Physiology and Pharmacology
Publisher: Canadian Science Publishing
Published: 2004-10-01
Volume: 82
Issue: 10
Pages: 813-823
ISSN: 0008-4212 (ISSN-L)
1205-7541
DOI: 10.1139/y04-065
OpenAlex: W2107447005
Cited by: 111
References: 107
Citations by year: 2025: 1 · 2023: 2 · 2022: 7 · 2021: 3 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 11 · 2012: 4
FWCI: 1.16
Type: journal article
Language: en
Open access: closed
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Canadian Journal of Physiology and Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords: diabetic cardiomyopathy, type 1 diabetes, type 2 diabetes, mouse model, ventricular dysfunction, systolic dysfunction, diastolic dysfunction, myocardial ischemic injury, myocardial metabolism, glucose utilization, fatty acid utilization, genetically modified mice
MeSH terms: Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Disease Models, Animal, Humans, Cardiomyopathies, Mice

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Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes

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