The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
The Cryptochromes: Blue Light Photoreceptors in Plants and Animals
Abstract
Cryptochromes are flavoprotein photoreceptors first identified in Arabidopsis thaliana, where they play key roles in growth and development. Subsequently identified in prokaryotes, archaea, and many eukaryotes, cryptochromes function in the animal circadian clock and are proposed as magnetoreceptors in migratory birds. Cryptochromes are closely structurally related to photolyases, evolutionarily ancient flavoproteins that catalyze light-dependent DNA repair. Here, we review the structural, photochemical, and molecular properties of cry-DASH, plant, and animal cryptochromes in relation to biological signaling mechanisms and uncover common features that may contribute to better understanding the function of cryptochromes in diverse systems including in man.
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In the citing paper
“In the coral Acropora millepora, three types of Crys were identified (24): Ami-Cry1 has closest homology to tr-Crys, Ami-Cry2 is positioned in the group of the 6-4 photolyases, while the third molecule, Ami-CryDash, is related to another ancient group of Crys that has been dubbed “cry-Drosophila, Arabidopsis, Synechocystis, Homo” (Cry-DASH) due to its broad evolutionary conservation (32).”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [32]
In the citing paper
“Molecular phylogenetic analyses show that Crys form multiple, evolutionarily conserved subgroups (32–34).”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [32]
In the citing paper
“Crys are flavoproteins involved in cellular signaling, which are anciently related to photolyases, UV-responsive DNA repair enzymes (32).”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [32]
Citations
Cites
Molecular components of the mammalian circadian clock
Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,725
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
Sancar, A. (2003) · Chemical Reviews · doi:10.1021/cr0204348 · Cited by 1,317
HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor
Ahmad, M., & Cashmore, A. R. (1993) · Nature · doi:10.1038/366162a0 · Cited by 1,279
Self-citationA Model for Photoreceptor-Based Magnetoreception in Birds
Ritz, T., Adem, S., & Schulten, K. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76629-x · Cited by 1,176
Self-citationRegulation and Identity of Florigen: FLOWERING LOCUS T Moves Center Stage
Turck, F., Fornara, F., & Coupland, G. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092755 · Cited by 1,053
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81638-4 · Cited by 968
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Post-translational modifications regulate the ticking of the circadian clock
Gallego, M., & Virshup, D. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2106 · Cited by 881
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
Lucas, R. J., Hattar, S. S., Takao, M., Berson, D. M., Foster, F., & Yau, K. (2003) · Science · doi:10.1126/science.1077293 · Cited by 835
Cited by
Sorted by citations
The Radical-Pair Mechanism of Magnetoreception
Hore, P. J., & Mouritsen, H. (2016) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-032116-094545 · Cited by 813
Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder
Patke, A., Murphy, P. J., Onat, O. E., Krieger, A. C., Özçelik, T., Campbell, S. S., & Young, M. W. (2017) · Cell · doi:10.1016/j.cell.2017.03.027 · Cited by 381
Plant Flavoprotein Photoreceptors
Christie, J. M., Blackwood, L., Petersen, J., & Sullivan, S. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcu196 · Cited by 294
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket
Xing, W., Busino, L., Hinds, T. R., Marionni, S. T., Saifee, N. H., Bush, M. F., Pagano, M., & Zheng, N. (2013) · Nature · doi:10.1038/nature11964 · Cited by 234
Metadata
- Authors
- Chaves, I., Pokorny, R., Byrdin, M., Hoang, N., Ritz, T., Brettel, K., Essen, L.-O., van der Horst, G. T. J., Batschauer, A., & Ahmad, M.
- Affiliations
- Erasmus MC (NL)
- Philipps University of Marburg (DE)
- Centre National de la Recherche Scientifique (FR)
- Université Pierre-et-Marie-Curie (FR)
- University of California, Irvine (US)
- Department of Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands;,
- Pennsylvania State University (US)
- ORCID
- Venue
- Annual Review of Plant Biology
- Publisher
- Annual Reviews
- Published
- 2011-06-02
- Volume
- 62
- Issue
- 1
- Pages
- 335-364
- ISSN
- 1543-5008 (ISSN-L)
- 1545-2123
- OpenAlex
- W2117719962
- Cited by
- 845
- References
- 140
- Citations by year
- 2026: 44 · 2025: 45 · 2024: 35 · 2023: 59 · 2022: 74 · 2021: 54 · 2020: 65 · 2019: 59 · 2018: 66 · 2017: 71 · 2016: 57 · 2015: 59 · 2014: 70 · 2013: 41 · 2012: 37
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Plant Biology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- cryptochrome, blue-light photoreceptor, flavoprotein, photolyase, circadian clock, magnetoreception, bird migration, Arabidopsis thaliana, plant development, photochemistry, flavin cofactor, DNA repair
- MeSH terms
- Adenosine Triphosphate, Animals, Deoxyribodipyrimidine Photo-Lyase, DNA Repair, Homing Behavior, Insecta, Magnetics, Oxidation-Reduction, Phosphorylation, Plants, Mice, Light Signal Transduction, Cryptochromes
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