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Cited by 61Cellular transport and secretionEndoplasmic Reticulum Stress and DiseaseHeat shock proteins research

The function, structure, and origins of the ER membrane protein complex

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Hegde, Ramanujan S.·2022·Annual Review of Biochemistry
DOI 10.1146/annurev-biochem-032620-104553
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Abstract

The endoplasmic reticulum (ER) is the site of membrane protein insertion, folding, and assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical studies have implicated an abundant factor termed the ER membrane protein complex (EMC) in several aspects of membrane protein biogenesis. This large nine-protein complex is built around a deeply conserved core formed by the EMC3–EMC6 subcomplex. EMC3 belongs to the universally conserved Oxa1 superfamily of membrane protein transporters, whereas EMC6 is an ancient, widely conserved obligate partner. EMC has an established role in the insertion of transmembrane domains (TMDs) and less understood roles during the later steps of membrane protein folding and assembly. Several recent structures suggest hypotheses about the mechanism(s) of TMD insertion by EMC, with various biochemical and proteomics studies beginning to reveal the range of EMC's membrane protein substrates.

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Cited by

Sorted by citations

Authors
Hegde, R. S.
Affiliations
MRC Laboratory of Molecular Biology (GB)
Corresponding author
Hegde, Ramanujan S.
ORCID
Hegde, Ramanujan S.
Venue
Annual Review of Biochemistry
Publisher
Annual Reviews
Published
2022-06-21
Volume
91
Issue
1
Pages
651-678
ISSN
  • 0066-4154 (ISSN-L)
  • 1545-4509
DOI
10.1146/annurev-biochem-032620-104553
OpenAlex
W4220763104
Cited by
61
References
6
Citations by year
2026: 13 · 2025: 14 · 2024: 14 · 2023: 17 · 2022: 3
FWCI
1.73
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council (MC_ UP_A022_1007)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords
electromagnetic compatibility, membrane protein biogenesis, membrane protein folding, protein assembly, endoplasmic reticulum, protein complex structure, protein complex evolution
MeSH terms
Protein Domains, Endoplasmic Reticulum, Membrane Proteins, Protein Biosynthesis, Protein Folding

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