Cited by 516Plant nutrient uptake and metabolismIon Transport and Channel RegulationMetabolism, Diabetes, and Cancer

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Transport of Sugars

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Chen, Li-Qing, Cheung, Lily S., Feng, Liang, Tanner, Widmar, Frommer, Wolf B.·2015·Annual Review of Biochemistry

DOI 10.1146/annurev-biochem-060614-033904

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Abstract

Soluble sugars serve five main purposes in multicellular organisms: as sources of carbon skeletons, osmolytes, signals, and transient energy storage and as transport molecules. Most sugars are derived from photosynthetic organisms, particularly plants. In multicellular organisms, some cells specialize in providing sugars to other cells (e.g., intestinal and liver cells in animals, photosynthetic cells in plants), whereas others depend completely on an external supply (e.g., brain cells, roots and seeds). This cellular exchange of sugars requires transport proteins to mediate uptake or release from cells or subcellular compartments. Thus, not surprisingly, sugar transport is critical for plants, animals, and humans. At present, three classes of eukaryotic sugar transporters have been characterized, namely the glucose transporters (GLUTs), sodium-glucose symporters (SGLTs), and SWEETs. This review presents the history and state of the art of sugar transporter research, covering genetics, biochemistry, and physiology—from their identification and characterization to their structure, function, and physiology. In humans, understanding sugar transport has therapeutic importance (e.g., addressing diabetes or limiting access of cancer cells to sugars), and in plants, these transporters are critical for crop yield and pathogen susceptibility.

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See all 516

Authors: Chen, L.-Q., Cheung, L. S., Feng, L., Tanner, W., & Frommer, W. B.
Affiliations: Carnegie Institution for Science (US)
Stanford Medicine (US)
University of Regensburg (DE)
ORCID: Chen, Li-Qing
Cheung, Lily S.
Feng, Liang
Frommer, Wolf B.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2015-06-02
Volume: 84
Issue: 1
Pages: 865-894
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev-biochem-060614-033904
OpenAlex: W2116269912
Cited by: 507
References: 195
Citations by year: 2026: 33 · 2025: 64 · 2024: 64 · 2023: 56 · 2022: 68 · 2021: 51 · 2020: 36 · 2019: 37 · 2018: 30 · 2017: 39 · 2016: 19 · 2015: 10
FWCI: 3.39
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
Funders: National Science Foundation (1401855, 1258018)
U.S. Department of Energy (DE‐FG02‐, FG02-04ER15542, DEFG0204ER15542)
Bill and Melinda Gates Foundation (OPP1068450)
Alfred P. Sloan Foundation
Office of Science
Basic Energy Sciences (DE-FG02-04ER15542, DE-FG02)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: sugar transport, sugar transporters, glucose transporters, sodium-glucose cotransporter, sweets, sucrose transport, osmolytes, energy storage, diabetes mellitus, crop yield, pathogen susceptibility
MeSH terms: Animals, Biological Transport, Carbohydrates, Humans, Plants, Membrane Transport Proteins, Excitatory Amino Acid Transporter 2, Carbohydrate Metabolism, Plant Cells

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