The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
Transport of Sugars
Open accessAbstract
Soluble sugars serve five main purposes in multicellular organisms: as sources of carbon skeletons, osmolytes, signals, and transient energy storage and as transport molecules. Most sugars are derived from photosynthetic organisms, particularly plants. In multicellular organisms, some cells specialize in providing sugars to other cells (e.g., intestinal and liver cells in animals, photosynthetic cells in plants), whereas others depend completely on an external supply (e.g., brain cells, roots and seeds). This cellular exchange of sugars requires transport proteins to mediate uptake or release from cells or subcellular compartments. Thus, not surprisingly, sugar transport is critical for plants, animals, and humans. At present, three classes of eukaryotic sugar transporters have been characterized, namely the glucose transporters (GLUTs), sodium-glucose symporters (SGLTs), and SWEETs. This review presents the history and state of the art of sugar transporter research, covering genetics, biochemistry, and physiology—from their identification and characterization to their structure, function, and physiology. In humans, understanding sugar transport has therapeutic importance (e.g., addressing diabetes or limiting access of cancer cells to sugars), and in plants, these transporters are critical for crop yield and pathogen susceptibility.
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“researchers asserted that besides its role in glucose reabsorption, SGLT may exhibit other distinct functions in CNS.13–15”
From Dapagliflozin Activates Neurons in the Central Nervous System and Regulates Cardiovascular Activity by Inhibiting SGLT-2 in Mice (2020) · cites this paper as [15]
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Cited by
Sorted by citations
Feed Your Friends: Do Plant Exudates Shape the Root Microbiome?
Sasse, J., Martinoia, E., & Northen, T. R. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2017.09.003 · Cited by 2,246
SWEETs, transporters for intracellular and intercellular sugar translocation
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“Nevertheless, in addition to GLUT4, other non-classical GLUTs such as GLUT12 may also play roles in fine-tuning glucose uptake and substrate metabolism in insulin-sensitive tissues in response to different physiological cues and/or increased energy demand (Fig.”
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Metadata
- Authors
- Chen, L.-Q., Cheung, L. S., Feng, L., Tanner, W., & Frommer, W. B.
- Affiliations
- Carnegie Institution for Science (US)
- Stanford Medicine (US)
- University of Regensburg (DE)
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2015-06-02
- Volume
- 84
- Issue
- 1
- Pages
- 865-894
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2116269912
- Cited by
- 507
- References
- 195
- Citations by year
- 2026: 33 · 2025: 64 · 2024: 64 · 2023: 56 · 2022: 68 · 2021: 51 · 2020: 36 · 2019: 37 · 2018: 30 · 2017: 39 · 2016: 19 · 2015: 10
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Funders
- National Science Foundation (1401855, 1258018)
- U.S. Department of Energy (DE‐FG02‐, FG02-04ER15542, DEFG0204ER15542)
- Bill and Melinda Gates Foundation (OPP1068450)
- Alfred P. Sloan Foundation
- Office of Science
- Basic Energy Sciences (DE-FG02-04ER15542, DE-FG02)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- sugar transport, sugar transporters, glucose transporters, sodium-glucose cotransporter, sweets, sucrose transport, osmolytes, energy storage, diabetes mellitus, crop yield, pathogen susceptibility
- MeSH terms
- Animals, Biological Transport, Carbohydrates, Humans, Plants, Membrane Transport Proteins, Excitatory Amino Acid Transporter 2, Carbohydrate Metabolism, Plant Cells
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