The DOI matches its Crossref record; 249 of the 249 references it cites were found in a registry or an index.
Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure
Open accessAbstract
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing.
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1 retracted
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Cited by
A large-scale binding and functional map of human RNA-binding proteins
Van Nostrand, E. L., Freese, P., Pratt, G. A., Wang, X., Wei, X., Xiao, R., Blue, S. M., Chen, J.-Y., Cody, N. A. L., Dominguez, D., et al. (2020) · Nature · doi:10.1038/s41586-020-2077-3 · Cited by 1,317
Alternative polyadenylation of mRNA precursors
Tian, B., & Manley, J. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.116 · Cited by 1,179
Melamed, Z., López-Erauskin, J., Baughn, M. W., Zhang, O., Drenner, K., Sun, Y., Freyermuth, F., McMahon, M. A., Beccari, M. S., Artates, J. W., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0293-z · Cited by 635
Is H3K4me3 instructive for transcription activation?
Howe, F. S., Fischl, H., Murray, S. C., & Mellor, J. (2017) · BioEssays · doi:10.1002/bies.201600095 · Cited by 513
Alternative splicing as a source of phenotypic diversity
Wright, C. J., Smith, C. W. J., & Jiggins, C. D. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00514-4 · Cited by 454
Metadata
- Authors
- Naftelberg, S., Schor, I. E., Ast, G., & Kornblihtt, A. R.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2015-06-02
- Volume
- 84
- Issue
- 1
- Pages
- 165-198
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2105037453
- Cited by
- 448
- References
- 249
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Naftelberg, S., Schor, I. E., Ast, G., & Kornblihtt, A. R. (2015). Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-060614-034242
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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