Signaling Networks Determining Life Span

The Hallmarks of Aging

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Aging: a theory based on free radical and radiation chemistry

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The serial cultivation of human diploid cell strains

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Telomeres shorten during ageing of human fibroblasts

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mTOR: from growth signal integration to cancer, diabetes and ageing

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

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ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

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The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore

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New insights into protein–protein interaction modulators in drug discovery and therapeutic advance

Nada, H., Choi, Y., Kim, S.-D., Jeong, K. S., Meanwell, N. A., & Lee, K. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02036-3 · Cited by 241

Molecular and cellular pathways contributing to brain aging

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Mitohormesis, an Antiaging Paradigm

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Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

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Cellular Homeostasis and Aging

Hartl, F. U. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011116-110806 · Cited by 141

Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

van Dam, E., van Leeuwen, L. A. G., dos Santos, E., James, J., Best, L., Lennicke, C., Vincent, A. J., Μαρίνος, Γ., Foley, A., Buricova, M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.016 · Cited by 146

The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?

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Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism

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Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling

Cox, C. S., McKay, S. E., Holmbeck, M. A., Christian, B. E., Scortea, A. C., Tsay, A. J., Newman, L. E., & Shadel, G. S. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.011 · Cited by 121

O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress

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Aging: Molecular Pathways and Implications on the Cardiovascular System

de Almeida, A. J. P. O., Ribeiro, T. P., & de Medeiros, I. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7941563 · Cited by 120

Dietary thiols accelerate aging of C. elegans

Gusarov, I., Shamovsky, I., Pani, B., Gautier, L., Eremina, S. Y., Katkova-Zhukotskaya, O. A., Mironov, A. S., Makarov, A. А., & Nudler, E. (2021) · Nature Communications · doi:10.1038/s41467-021-24634-3 · Cited by 111

Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Ding, A., Zheng, S., Huang, X., Xing, T.-K., Wu, G.-S., Sun, H., Qi, S., & Luo, H. (2017) · Natural Products and Bioprospecting · doi:10.1007/s13659-017-0135-9 · Cited by 115

Adipose tissue as a linchpin of organismal ageing

Nguyen, T., & Corvera, S. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01046-3 · Cited by 118

Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity

López-Lluch, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.005 · Cited by 103

Scavenging of superoxide by a membrane-bound superoxide oxidase

Lundgren, C. A. K., Sjöstrand, D., Biner, O., Bennett, M. D., Rudling, A., Johansson, A.-L., Brzezinski, P., Carlsson, J., von Ballmoos, C., & Högbom, M. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0072-x · Cited by 110

mTOR and Aging: An Old Fashioned Dress

Stallone, G., Infante, B., Prisciandaro, C., & Grandaliano, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112774 · Cited by 97

Noncanonical ATG8–ABS3 interaction controls senescence in plants

Jia, M., Liu, X., Xue, H., Wu, Y., Shi, L., Wang, R., Chen, Y., Xu, N., Zhao, J. Y., Shao, J., et al. (2019) · Nature Plants · doi:10.1038/s41477-018-0348-x · Cited by 96

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Romani, M., Sorrentino, V., Oh, C.-M., Li, H., de Lima, T. I., Zhang, H., Shong, M., & Auwerx, J. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108660 · Cited by 92

Build-UPS and break-downs: metabolism impacts on proteostasis and aging

Ottens, F., Franz, A., & Hoppe, T. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00682-y · Cited by 88

Molecular Connections Between Circadian Clocks and Aging

Welz, P.-S., & Benitah, S. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.036 · Cited by 90

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

Denzel, M. S., Lapierre, L. R., & Mack, H. I. D. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.08.001 · Cited by 82

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

Anestopoulos, I., Kiousi, D. E., Klavaris, A., Galanis, Α., Sałek, K., Euston, S. R., Pappa, A., & Panayiotidis, M. I. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070688 · Cited by 82

Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism

Luo, Y., Xu, W., Li, G., & Cui, W. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7838647 · Cited by 77

Local and Physiological Control of Germline Stem Cell Lineages in Drosophila melanogaster

Drummond‐Barbosa, D. (2019) · Genetics · doi:10.1534/genetics.119.300234 · Cited by 76

Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte

Armani, A., Berry, A., Cirulli, F., & Caprio, M. (2017) · The FASEB Journal · doi:10.1096/fj.201601125rrr · Cited by 76

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives

Vaiserman, A. M., & Lushchak, O. V. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1259-8 · Cited by 72

A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation

Miao, Z., Adkins-Threats, M., Burclaff, J., Osaki, L. H., Sun, J.-X., Kefalov, Y., He, Z., Wang, Z.-N., & Mills, J. C. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.03.006 · Cited by 71

Nutrients and Pathways that Regulate Health Span and Life Span

Pignatti, C., D’Adamo, S., Stefanelli, C., Flamigni, F., & Cetrullo, S. (2020) · Geriatrics · doi:10.3390/geriatrics5040095 · Cited by 68

The untapped potential of reptile biodiversity for understanding how and why animals age

Hoekstra, L. A., Schwartz, T. S., Sparkman, A. M., Miller, D. A. W., & Bronikowski, A. M. (2019) · Functional Ecology · doi:10.1111/1365-2435.13450 · Cited by 69

Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on stem cell and organismal aging

Spurlock, B., Tullet, J. M. A., Hartman, J. L., & Mitra, K. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110919 · Cited by 60

Mitochondrial stress-dependent regulation of cellular protein synthesis

Topf, U., Uszczynska-Ratajczak, B., & Chacinska, A. (2019) · Journal of Cell Science · doi:10.1242/jcs.226258 · Cited by 52

The nematode Caenorhabditis elegans as a model for aging research

Mack, H. I. D., Heimbucher, T., & Murphy, C. T. (2018) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2018.11.001 · Cited by 68

Discrete Changes in Glucose Metabolism Define Aging

Ravera, S., Podestà, M., Sabatini, F., Dagnino, M., Cilloni, D., Fiorini, S., Barla, A., & Frassoni, F. (2019) · Scientific Reports · doi:10.1038/s41598-019-46749-w · Cited by 63

Reverse electron transfer is activated during aging and contributes to aging and age‐related disease

Rimal, S., Tantray, I., Li, Y., Khaket, T. P., Li, Y., Bhurtel, S., Li, W., Zeng, C., & Lu, B. (2023) · EMBO Reports · doi:10.15252/embr.202255548 · Cited by 60

Ageing induces tissue‐specific transcriptomic changes in Caenorhabditis elegans

Wang, X., Jiang, Q., Song, Y., He, Z., Zhang, H., Song, M., Zhang, X., Dai, Y., Karalay, O., Dieterich, C., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2021109633 · Cited by 63

Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging

Yuan, W., Weaver, Y. M., Earnest, S., Taylor, C. A., Cobb, M. H., & Weaver, B. P. (2023) · Nature Communications · doi:10.1038/s41467-023-40317-7 · Cited by 56

Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?

López‐Lluch, G., Hernández‐Camacho, J. D., Fernández‐Ayala, D. J. M., & Navas, P. (2018) · Biogerontology · doi:10.1007/s10522-018-9768-2 · Cited by 60

The Exposome in Human Evolution: From Dust to Diesel

Trumble, B. C., & Finch, C. E. (2019) · The Quarterly Review of Biology · doi:10.1086/706768 · Cited by 54

Accelerated aging in serious mental disorders

Bersani, F. S., Mellon, S. H., Reus, V. I., & Wolkowitz, O. M. (2019) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000525 · Cited by 47

Telomere length and fetal programming: A review of recent scientific advances

Whiteman, V. E., Goswami, A., & Salihu, H. M. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12661 · Cited by 44

Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

Guo, S., Zhang, S., Zhuang, Y., Xie, F., Wang, R., Kong, X., Zhang, Q., Feng, Y., Gao, H., Kong, X., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213857120 · Cited by 45

The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models

Giacomello, E., & Toniolo, L. (2021) · Nutrients · doi:10.3390/nu13072346 · Cited by 45

Potential of Caenorhabditis elegans as an antiaging evaluation model for dietary phytochemicals: A review

Ye, Y., Gu, Q., & Sun, X. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12654 · Cited by 43

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Sleiman, M. S. B., Jha, P., Houtkooper, R. H., Williams, R. W., Wang, X., & Auwerx, J. H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108203 · Cited by 39

HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity

Sural, S., Liang, C., Wang, F., Ching, T., & Hsu, A. (2020) · Science Advances · doi:10.1126/sciadv.aaz4452 · Cited by 39

Aging affects circadian clock and metabolism and modulates timing of medication

Sadria, M., & Layton, A. T. (2021) · iScience · doi:10.1016/j.isci.2021.102245 · Cited by 43

Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP–mediated feedforward loop

Lee, Y., Jung, Y., Jeong, D., Hwang, W., Ham, S., Park, H. H., Kwon, S., Ashraf, J. M., Murphy, C. T., & Lee, S. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202006174 · Cited by 40

HSB-1 Inhibition and HSF-1 Overexpression Trigger Overlapping Transcriptional Changes To Promote Longevity in Caenorhabditis elegans

Sural, S., Lu, T., Jung, S. A., & Hsu, A. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400044 · Cited by 37

Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell

Pascual‐Ahuir, A., Fita‐Torró, J., & Proft, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218278 · Cited by 37

Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

Derisbourg, M. J., Wester, L. E., Baddi, R., & Denzel, M. S. (2021) · Nature Communications · doi:10.1038/s41467-021-21743-x · Cited by 42

Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation

Ferreira, N., Perks, K. L., Rossetti, G., Rudler, D. L., Hughes, L. A., Ermer, J. A., Scott, L. H., Kuznetsova, I., Richman, T. R., Narayana, V. K., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2019102155 · Cited by 31

Genetic cartography of longevity in humans and mice: Current landscape and horizons

Hook, M., Roy, S., Williams, E. G., Sleiman, M. S. B., Mozhui, K., Nelson, J. F., Lu, L., Auwerx, J. H., & Williams, R. W. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.026 · Cited by 33

Ageing and sources of transcriptional heterogeneity

Nikopoulou, C., Parekh, S., & Tessarz, P. (2019) · Biological Chemistry · doi:10.1515/hsz-2018-0449 · Cited by 31

Advances in mechanical biomarkers

Eroles, M., & Rico, F. (2023) · Journal of Molecular Recognition · doi:10.1002/jmr.3022 · Cited by 31

Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms

García-Casas, P., Arias-del-Val, J., Álvarez-Illera, P., Fonteríz, R. I., Montero, M., & Álvarez, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00669 · Cited by 29

Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans

Nono, M., Kishimoto, S., Sato, A., Carlton, P. M., Nishida, E., & Uno, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.050 · Cited by 27

A microRNA switch controls dietary restriction‐induced longevity through Wnt signaling

Xu, Y., He, Z., Song, M., Zhou, Y., & Shen, Y. (2019) · EMBO Reports · doi:10.15252/embr.201846888 · Cited by 28

Hallmarks of aging: A user’s guide for comparative biologists

Biga, P. R., Duan, J. E., Young, T. E., Marks, J. R., Bronikowski, A. M., Decena-Segarra, L. P., Randolph, E. C., Pavuluri, A., Li, G., Fang, Y., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102616 · Cited by 33

Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis

Yang, W., & Paschen, W. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17723783 · Cited by 28

SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans

Princz, A., Pelisch, F., & Tavernarakis, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-72637-9 · Cited by 26

How can we modulate aging through nutrition and physical exercise? An epigenetic approach

Rajado, A. T., Silva, N., Esteves, F., Brito, D. V. C., Binnie, A., Araújo, I. M., Nóbrega, C., Bragança, J., & Castelo‐Branco, P. (2023) · Aging · doi:10.18632/aging.204668 · Cited by 32

RNA Polymerase III, Ageing and Longevity

Kulaberoglu, Y., Malik, Y., Borland, G., Selman, C., Alic, N., & Tullet, J. M. A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.705122 · Cited by 25

Glial contributions to neuronal health and disease: new insights from Drosophila

Logan, M. A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.008 · Cited by 24

Mitochondrial stress and aging: Lessons from C. elegans

Chen, P. X., Zhang, L., Chen, D., & Tian, Y. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.02.010 · Cited by 23

Flavonol glycoside complanatoside A requires FOXO/DAF-16, NRF2/SKN-1, and HSF-1 to improve stress resistances and extend the life span of Caenorhabditis elegans

Tan, L., Zheng, Z.-Y., Huang, L., Jin, Z., Sulian, L., Wu, G.-S., & Luo, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.931886 · Cited by 21

A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response

Sheng, Y., Yang, G., Casey, K., Curry, S., Oliver, M., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2021) · GeroScience · doi:10.1007/s11357-021-00327-z · Cited by 19

Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF‐16 in C. elegans

Xu, A., Zhang, Z., Ko, S. H., Fisher, A. L., Liu, Z., & Chen, L. (2019) · Aging Cell · doi:10.1111/acel.12884 · Cited by 17

Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes

Booth, L. N., Maures, T. J., Yeo, R. W., Tantilert, C., & Brunet, A. (2019) · eLife · doi:10.7554/elife.46418 · Cited by 19

Gut bacterium promotes host fitness in special ecological niche by affecting sugar metabolism in Drosophila suzukii

Gao, H., Zhao, S., Wang, R., Qin, D., Chen, P., Zhang, A., Zhuang, Q., Zhai, Y., & Zhou, X. (2023) · Insect Science · doi:10.1111/1744-7917.13189 · Cited by 17

CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells

Li, Q., Zhu, Z., Wang, C., Cai, L., Lu, J., Wang, Y., Xu, J., Su, Z., Zheng, W., & Chen, X. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3666 · Cited by 18

Dietary restriction and gonadal signaling differentially regulate post‐development quality control functions in Caenorhabditis elegans

Shpigel, N., Shemesh, N., Kishner, M., & Ben‐Zvi, A. (2019) · Aging Cell · doi:10.1111/acel.12891 · Cited by 19

Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

Crislip, G. R., Johnston, J. G., Douma, L. G., Costello, H. M., Juffre, A., Boyd, K., Li, W. W., Maugans, C. C., Gutierrez‐Monreal, M. A., Esser, K. A., et al. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210011 · Cited by 36

Review of combinations of experimental and computational techniques to identify and understand genes involved in innate immunity and effector-triggered defence

Stotz, H. U., Almeida, R. D. O., Davey, N., Steuber, V., & Valente, G. T. (2017) · Methods · doi:10.1016/j.ymeth.2017.08.019 · Cited by 17

Nuclear translocation ability of Lipin differentially affects gene expression and survival in fed and fasting Drosophila

Hood, S. E., Kofler, X. V., Chen, Q., Scott, J., Ortega, J., & Lehmann, M. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120001051 · Cited by 17

Reproductive potential does not cause loss of heat shock response performance in honey bees

Shih, S. R., Huntsman, E. M., Flores, M. E., & Snow, J. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-74456-4 · Cited by 16

An evolutionary medicine and life history perspective on aging and disease: Trade-offs, hyperfunction, and mismatch

Aronoff, J. E., & Trumble, B. C. (2025) · Evolution Medicine and Public Health · doi:10.1093/emph/eoaf010 · Cited by 17

Metabolism of sleep and aging: Bridging the gap using metabolomics

Sengupta, A., & Weljie, A. M. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-180043 · Cited by 16

Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity

Guevara‐Aguirre, J., Terán, E., Lescano, D., Guevara, A., Guevara, C., Longo, V. D., & Gavilanes, A. W. D. (2020) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2020.02.004 · Cited by 16

Aging and the Krüppel-like factors.

Hsieh, P. N., Sweet, D. R., Fan, L., & Jain, M. K. (2017) · PubMed · Cited by 15

Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome

Zhou, X., Sen, I., Lin, X.-X., & Riedel, C. G. (2018) · Current Genomics · doi:10.2174/1389202919666180503125850 · Cited by 15

Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans

Wang, X., Jiang, Q., Zhang, H., He, Z., Song, Y., Chen, Y., Tang, N., Zhou, Y., Li, Y., Antebi, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45249-4 · Cited by 13

Mechanism of the lifespan extension induced by submaximal SERCA inhibition in C. elegans

García-Casas, P., Álvarez-Illera, P., Fonteríz, R. I., Montero, M., & Álvarez, J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111474 · Cited by 12

Sirt2 Regulates Radiation-Induced Injury

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CEST‐2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants

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