Signaling Networks Determining Life Span

The Hallmarks of Aging

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Aging: a theory based on free radical and radiation chemistry

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The serial cultivation of human diploid cell strains

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Telomeres shorten during ageing of human fibroblasts

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mTOR: from growth signal integration to cancer, diabetes and ageing

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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A C. elegans mutant that lives twice as long as wild type

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Mechanisms of mitophagy

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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Extending Healthy Life Span—From Yeast to Humans

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

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Inflammatory links between obesity and metabolic disease

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Rejuvenation of aged progenitor cells by exposure to a young systemic environment

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

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Autophagy and Aging

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The Biologic Clock: The Mitochondria?

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Evolution of ageing

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Suppression of Aging in Mice by the Hormone Klotho

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

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Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

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Extension of murine life span by overexpression of catalase targeted to mitochondria

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Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

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Autophagy in mammalian development and differentiation

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Regulation of aging and age-related disease by DAF-16 and heat-shock factor

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Telomere dysfunction induces metabolic and mitochondrial compromise

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Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

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The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

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Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

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Rates of Behavior and Aging Specified by Mitochondrial Function During Development

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

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Dwarf mice and the ageing process

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The role of mitochondria in aging

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Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

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CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

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The sirtuin SIRT6 regulates lifespan in male mice

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The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

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Influence of TOR kinase on lifespan in C. elegans

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Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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Mitonuclear protein imbalance as a conserved longevity mechanism

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Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

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A mutant with a defect in telomere elongation leads to senescence in yeast

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The many faces of insulin-like peptide signalling in the brain

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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

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Opposing activities protect against age-onset proteotoxicity

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Telomeres and telomerase: Their mechanisms of action and the effects of altering their functions

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Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

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Spastic Paraplegia and OXPHOS Impairment Caused by Mutations in Paraplegin, a Nuclear-Encoded Mitochondrial Metalloprotease

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

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Does oxidative damage to DNA increase with age?

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A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

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Overexpression of Atg5 in mice activates autophagy and extends lifespan

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The role of protein clearance mechanisms in organismal ageing and age-related diseases

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Epigenetics and aging: the targets and the marks

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Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

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FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

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Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

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Epigenetic regulation of ageing: linking environmental inputs to genomic stability

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Taking a good look at free radicals in the aging process

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XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

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Regulation of lifespan by sensory perception in Caenorhabditis elegans

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Somatic Mitochondrial DNA Mutations in Mammalian Aging

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Endogenous hydrogen sulfide production is essential for dietary restriction benefits

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4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

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Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

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Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

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PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

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Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondriaPreprint

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Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

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Quality control of mitochondria: protection against neurodegeneration and ageing

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Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis

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mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

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Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

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The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

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A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

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Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

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Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

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