The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.
Signaling Networks Determining Life Span
Abstract
The health of an organism is orchestrated by a multitude of molecular and biochemical networks responsible for ensuring homeostasis within cells and tissues. However, upon aging, a progressive failure in the maintenance of this homeostatic balance occurs in response to a variety of endogenous and environmental stresses, allowing the accumulation of damage, the physiological decline of individual tissues, and susceptibility to diseases. What are the molecular and cellular signaling events that control the aging process and how can this knowledge help design therapeutic strategies to combat age-associated diseases? Here we provide a comprehensive overview of the evolutionarily conserved biological processes that alter the rate of aging and discuss their link to disease prevention and the extension of healthy life span.
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“Mitochondrial dysfunction is associated with the functional decline found in tissues and organs during ageing”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Riera et al., 2016
In the citing paper
“Mitochondrial dysfunction is associated with the functional decline found in tissues and organs during ageing (Riera et al., 2016)”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Riera et al., 2016
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Metadata
- Authors
- Riera, C. E., Merkwirth, C., De Magalhaes Filho, C. D., & Dillin, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Howard Hughes Medical Institute, Chevy Chase, Maryland 20815
- Corresponding author
- Dillin, Andrew
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2016-06-02
- Volume
- 85
- Issue
- 1
- Pages
- 35-64
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2196594270
- Cited by
- 161
- References
- 182
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 8 · 2023: 14 · 2022: 11 · 2021: 23 · 2020: 25 · 2019: 24 · 2018: 19 · 2017: 18 · 2016: 5
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- aging, lifespan, cellular signaling networks, homeostasis, age-related diseases, age-related disease prevention, cellular senescence, stress response
- MeSH terms
- Animals, DNA Damage, Homeostasis, Humans, Inflammation, Insulin-Like Growth Factor I, Longevity, Mitochondria, Signal Transduction, Oxidative Stress, Caloric Restriction, Epigenesis, Genetic, AMP-Activated Protein Kinases, Proteostasis Deficiencies, TOR Serine-Threonine Kinases, Telomere Shortening
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