Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
Open accessAbstract
The liver is a central organ for homeostasis with unique regenerative capacities. Mature hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to discern the role of adult liver stem cells in this process. In contrast, stem/progenitor cells in the developing liver have been extensively characterized, and these investigations have informed efforts to produce functional hepatocytes in vitro for cell therapy and drug screening. In this Review, we describe recent advances in the characterization of liver stem cells and discuss evidence supporting and refuting whether self-renewable and bipotential liver stem cells exist in development, homeostasis, regeneration, and disease.
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Cluster III genes, such as DLK1, KIT, and FOXJ1, were not fully upregulated in ProliHHs.
“Cluster III genes, such as the previously reported progenitor-associated markers DLK1, KIT, and FOXJ1”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Miyajima et al., 2014
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- Authors
- Miyajima, A., Tanaka, M., & Itoh, T.
- Affiliations
- The University of Tokyo (JP)
- National Center for Global Health and Medicine (JP)
- Corresponding author
- Miyajima, Atsushi
- Tanaka, Minoru
- Itoh, Tohru
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 14
- Issue
- 5
- Pages
- 561-574
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2068511028
- Cited by
- 570
- References
- 5
- Citations by year
- 2026: 14 · 2025: 31 · 2024: 45 · 2023: 57 · 2022: 40 · 2021: 54 · 2020: 53 · 2019: 54 · 2018: 62 · 2017: 57 · 2016: 58 · 2015: 34 · 2014: 11
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver stem cells, progenitor cells, liver development, liver homeostasis, liver regeneration, hepatocyte proliferation, self-renewal, cell therapy, drug screening
- MeSH terms
- Animals, Homeostasis, Humans, Liver, Regeneration, Stem Cells
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