The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Form Follows Function: The Importance of Endoplasmic Reticulum Shape
Abstract
The endoplasmic reticulum (ER) has a remarkably complex structure, composed of a single bilayer that forms the nuclear envelope, along with a network of sheets and dynamic tubules. Our understanding of the biological significance of the complex architecture of the ER has improved dramatically in the last few years. The identification of proteins and forces required for maintaining ER shape, as well as more advanced imaging techniques, has allowed the relationship between ER shape and function to come into focus. These studies have also revealed unexpected new functions of the ER and novel ER domains regulating alterations in ER dynamics. The importance of ER structure has become evident as recent research has identified diseases linked to mutations in ER-shaping proteins. In this review, we discuss what is known about the maintenance of ER architecture, the relationship between ER structure and function, and diseases associated with defects in ER structure.
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Cites
Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease
Area‐Gomez, E., del Carmen Lara Castillo, M., Tambini, M. D., Guardia‐Laguarta, C., de Groof, A. J. C., Madra, M., Ikenouchi, J., Umeda, M., Bird, T. D., Sturley, S. L., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.202 · Cited by 638
Spacek, J., & Harris, K. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00190.1997 · Cited by 599
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Kuijpers, M., Kochlamazashvili, G., Stumpf, A., Puchkov, D., Swaminathan, A., Lucht, M. T., Krause, E., Maritzen, T., Schmitz, D., & Haucke, V. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.005 · Cited by 170
Cellular Reorganization during Mitotic Entry
Champion, L., Linder, M. I., & Kutay, U. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.07.004 · Cited by 139
VMP1 Establishes ER-Microdomains that Regulate Membrane Contact Sites and Autophagy
Tábara, L.-C., & Escalante, R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166499 · Cited by 89
ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
Özkan, N., Koppers, M., van Soest, I., van Harten, A., Jurriens, D., Liv, N., Klumperman, J., Kapitein, L. C., Hoogenraad, C. C., & Farías, G. G. (2021) · Nature Communications · doi:10.1038/s41467-021-24713-5 · Cited by 69
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Cremer, T., Voortman, L. M., Bos, E., Jongsma, M. L., ter Haar, L. R., Akkermans, J. J., Talavera Ormeño, C. M., Wijdeven, R. H., de Vries, J., Kim, R. Q., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022111252 · Cited by 35
Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
Petrova, V., Nieuwenhuis, B., Fawcett, J. W., & Eva, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041798 · Cited by 32
CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization
Teixeira, V., Singh, K., Gama, J. B., Moreira, M., Celestino, R., Xavier Carvalho, A., Pereira, P. S., Abreu, C. M. C., Dantas, T. J., Carter, A. P., et al. (2025) · Journal of Cell Biology · doi:10.1083/jcb.202411034 · Cited by 10
Liu, Y., Wang, X., Zheng, T., Niu, F., Sun, R., Yang, C., Xu, S., Zhao, Z., Shen, Z., Huang, W., et al. (2026) · Vita · doi:10.15302/vita.2026.05.0033 · Cited by 3
Metadata
- Authors
- Westrate, L. M., Lee, J. E., Prinz, W. A., & Voeltz, G. K.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2015-06-02
- Volume
- 84
- Issue
- 1
- Pages
- 791-811
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2098293220
- Cited by
- 429
- References
- 2
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
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