The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Mechanobiology of Aging
Open accessAbstract
Aging is a complex, multifaceted process that induces a myriad of physiological changes over an extended period of time. Aging is accompanied by major biochemical and biomechanical changes at macroscopic and microscopic length scales that affect not only tissues and organs but also cells and subcellular organelles. These changes include transcriptional and epigenetic modifications; changes in energy production within mitochondria; and alterations in the overall mechanics of cells, their nuclei, and their surrounding extracellular matrix. In addition, aging influences the ability of cells to sense changes in extracellular-matrix compliance (mechanosensation) and to transduce these changes into biochemical signals (mechanotransduction). Moreover, following a complex positive-feedback loop, aging is accompanied by changes in the composition and structure of the extracellular matrix, resulting in changes in the mechanics of connective tissues in older individuals. Consequently, these progressive dysfunctions facilitate many human pathologies and deficits that are associated with aging, including cardiovascular, musculoskeletal, and neurodegenerative disorders and diseases. Here, we critically review recent work highlighting some of the primary biophysical changes occurring in cells and tissues that accompany the aging process.
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Cites
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Cited by
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919
Cancer as a disease of old age: changing mutational and microenvironmental landscapes
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White adipose tissue dysfunction in obesity and aging
Reyes-Farias, M., Fos-Domenech, J., Serra, D., Herrero, L., & Sánchez-Infantes, D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114723 · Cited by 250
Gilbert, H. T. J., Mallikarjun, V., Dobre, O., Jackson, M. R., Pedley, R., Gilmore, A. P., Richardson, S. M., & Swift, J. (2019) · Nature Communications · doi:10.1038/s41467-019-11923-1 · Cited by 91
The Matrisome, Inflammation, and Liver Disease
Dolin, C. E., & Arteel, G. E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0039-3402516 · Cited by 38
Metadata
- Authors
- Phillip, J. M., Aifuwa, I., Walston, J., & Wirtz, D.
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2015-12-07
- Volume
- 17
- Issue
- 1
- Pages
- 113-141
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W1885354525
- Cited by
- 301
- References
- 39
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
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